Clinical trials: Dysphagia of Newborn
Niemann-Pick Disease, Type C
Adrabetadex to Treat Niemann-Pick Type C1 (NPC1) Disease
Due to different study designs, the sponsor separated Part C into this separate registration (NCT04958642), leaving Parts A/B in NCT02534844.
- Trial name
- NCT04958642
- Testing
- Adrabetadex
- Where
- 30 sites in United States, Australia and 7 more
- Volunteers
- 66 people
- Sponsor
- Mandos LLC
Gastroesophageal Reflux, Infant, Newborn, Diseases
Treatment of Gastroesophageal Reflux Disease in Infants
Gastroesophageal reflux disease in infants is not fully understood. Infants are prescribed medical treatments that may not be effective or that contribute to adverse side effects and lead to concerns and expenses for the parents…
- Trial name
- NCT06255886
- Testing
- Protein pump inhibitor., Mother or infant diet
- Where
- 3 sites in Denmark
- Volunteers
- 96 people
- Sponsor
- Odense University Hospital
Deglutition Disorders
Comparing FEES to VFSS in Diagnosing Laryngeal Penetration and Aspiration in Infants in the NICU
The main purpose of the study is to determine whether the Fiberoptic Endoscopic Evaluation of Swallowing (FEES) is effective in detecting laryngeal penetration and tracheal aspiration when compared with the Videofluoroscopic…
- Trial name
- NCT02003287
- Testing
- VFSS, FEES
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Baylor Research Institute
Dysphagia of Newborn
The Effects of Pacifier-Activated Lullaby on Oral Feeding Among Preterm Infants
Preterm infants often have difficulty learning how to feed by mouth because the coordination of sucking, swallowing, and breathing develops later in pregnancy.
- Trial name
- Music therapy (NCT07819734)
- Testing
- Pacifier-Activated Lullaby (PAL) Therapy
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
GERD, Apnea Neonatal
Effects of Vented Base Feeding Bottle in Preterm Infants With GERD Symptoms.
Aim of the study is to evaluate the effects of vented base bottles on respiration-swallow patterns and on gastroesophageal refluxes in preterm infants with clinical suspect of gastroesophageal reflux disease (GERD).
- Trial name
- FeedGERD (NCT03031288)
- Testing
- A, B
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Nutrition Disorders, Gastrointestinal Disease
Review of Infant Oral Feeding and Skills
This study evaluates the infant's feeding skill level at discharge from the neonatal intensive care unit. The goal is to determine whether the ability to "full feed by volume" implies "full skill development" for infant oral…
- Conditions
- Nutrition Disorders, Gastrointestinal Disease, Deglutition Disorder, Feeding Difficulties
- Trial name
- RIOS (NCT06736743)
- Testing
- SMART Tool for Feeding Skill Assessment
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Wake Forest University Health Sciences
Cystic Fibrosis
The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration.
- Trial name
- NCT00164021
- Testing
- Physiotherapy, exercise, percutaneous gastrostomy feeds, Anti-reflux pharmacotherapy
- Where
- Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Dysphagia of Newborn
Evaluating Dysphagia in Neonates With CHD
The overall goal of this study is to describe the oral motor skills of neonates born with congenital heart defects, both before and after cardiac surgery, and to evaluate current measures of feeding motor skills and feeding…
- Trial name
- NCT03045757
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Recessive Dystrophic Epidermolysis Bullosa, Dysphagia
Treatment of Dysphagia in Patients With Dystrophic Epidermolysis Bullosa With Budesonide: a Retrospective Bicentric Study Nice - Paris St Louis / Necker (EBUDE Study)
Budesonide is an anti-inflammatory medication that works by decreasing the immune system's overreaction. In the treatment of eosinophilic esophagitis, especially with Jorveza or a preparation made in a pharmacy, it reduces the…
- Conditions
- Recessive Dystrophic Epidermolysis Bullosa, Dysphagia, Esophageal Stenosis
- Trial name
- EBUDE (NCT07684105)
- Testing
- The retrospective data collected will be entered into an eCRF and then analyzed centrally
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Esophageal Atresia
Respiratory Complications of Operated Esophageal Atresia in Children
The respiratory complications of esophageal atresia have already been identified. They are mainly related to tracheomalacia linked to the esophageal malformation, and are aggravated by frequently associated gastroesophageal…
- Trial name
- ATRESIA (NCT05527873)
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Strasbourg, France
Myotonic Dystrophy 1, Dysphagia, Oropharyngeal
Profile of Dysphagia in Myotonic Dystrophy Type 1 (DM1)
The goal of this observational study is to learn about swallowing difficulties (dysphagia) in patients living with myotonic dystrophy type 1 (DM1).
- Trial name
- SwallowDM1 (NCT05865483)
- Where
- United Kingdom
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University College, London
Gastroesophageal Reflux, Esophageal Atresia
Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.
The purpose of this study is to compare the efficacy of oral and rectal omeprazole treatment in infants with gastroesophageal reflux due to esophageal atresia or congenital diaphragmatic hernia.
- Conditions
- Gastroesophageal Reflux, Esophageal Atresia, Hernia, Diaphragmatic
- Trial name
- NCT00226044
- Testing
- Omeprazole rectally 1mg/kg
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Rijnstate Hospital
Gastroesophageal Reflux, Presumed Sepsis
Impact of Maternal-infant Therapeutics on Safety, Mortality, and Disability
The purpose of this research is to address the comparative effectiveness and harm of the therapeutics frequently given to pregnant women and their young infants including antibiotics, tocolytic agents, non-steroidal…
- Conditions
- Gastroesophageal Reflux, Presumed Sepsis, Patent Ductus Arteriosus, Chronic Lung Disease
- Trial name
- NCT01028183
- Where
- United States
- Sponsor
- Duke University
Functional Gastrointestinal Disorders, Gastroesophageal Reflux
Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants.
The goal of this observational study is to learn about the prevalence and characteristics of functional gastrointestinal disorders (FGID) in at risk infants (former preterm infants and those with birth asphyxia) during the first…
- Conditions
- Functional Gastrointestinal Disorders, Gastroesophageal Reflux, Constipation - Functional, Diarrhea
- Trial name
- FUSID (NCT06031025)
- Testing
- Questionnaire, clinical examination
- Where
- Italy
- Volunteers
- 71 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Oculopharyngeal Muscular Dystrophy, Muscular Dystrophies
Expiratory Muscle Strength Training (EMST) in Neuromuscular Disorders
The purpose of this study is to investigate the impact of expiratory muscle strength training (EMST) on the swallowing, breathing, oral intake, quality of life and cough function of people with oculopharyngeal muscular dystrophy…
- Conditions
- Oculopharyngeal Muscular Dystrophy, Muscular Dystrophies, Myopathy; Hereditary
- Trial name
- NCT04009408
- Testing
- Expiratory muscle strength therapy (EMST150, Aspire LLC)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Cystinosis
Neuromuscular Characterisation in Late Adolescent and Adult Cystinosis Patients
The primary objective of the study is to evaluate the change in motor function of patients with cystinosis. The secondary objectives of the study: assessment of the respiratory function; assessment of the muscle function…
- Trial name
- Cystinose (NCT05545774)
- Where
- 2 sites in France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Laryngomalacia, Acid Reflux
In Infants With Laryngomalacia, Does Acid-Blocking Medication Improve Respiratory Symptoms?
All neonates, ages 0 to 4 months, presenting to LPCH pediatric ENT clinic for airway difficulties or stridor will be screened for inclusion.
- Conditions
- Laryngomalacia, Acid Reflux, Stridor
- Trial name
- NCT02700087
- Testing
- ranitidine or famotidine
- Where
- United States
- Sponsor
- Stanford University
Oculopharyngeal Muscular Dystrophy (OPMD)
Natural History of Oculo-Pharyngeal Muscular Dystrophy (OPMD) - Israel National OPMD Registry
The goal of this open prospective multi-disciplinary observational study of patients with OPMD at various stages of clinical manifestations is to explore the natural history of the disease in the Israeli population.
- Trial name
- Isr-OPMD (NCT07146256)
- Testing
- Non-interventional observational study
- Where
- Israel
- Volunteers
- 300 people
- Sponsor
- Sheba Medical Center
Dysphagia, Disorder; Feeding, Newborn
Effects of the Application of PIOMI in the Oral Feeding of Premature
The goal of this clinical trial is assess whether the application of the premature oral motor intervention (PIOMI) combined with the Newborn Individualized Developmental Care and Assessment Program (NIDCAP), allows withdrawal of…
- Conditions
- Dysphagia, Disorder; Feeding, Newborn, Premature
- Trial name
- PIOMI (NCT06395298)
- Testing
- Experimental group PIOMI, Control group NIDCAP
- Where
- Spain
- Volunteers
- 35 people
- Sponsor
- Fundació Sant Joan de Déu
Pierre-Robin Syndrome, Dysphagia
Intermittent Oro-Esophageal Tube Feeding vs. Nasogastric Tube Feeding in Infants With Pierre Robin Syndrome
This was a randomized controlled study. The infants enrolled were randomly divided into the IOE group (with Intermittent Oro-Esophageal Tube Feeding, n=25) and the PNG group (with Nasogastric Tube Feeding, n=23), all receiving…
- Trial name
- PRS (NCT06178562)
- Testing
- systematic therapy, PNG, IOE
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zeng Changhao