Clinical trials: Dysphonia, open to volunteers
Laryngeal Nerve Injuries, Thyroidectomy
Effectiveness of Intraoperative Neuromonitoring of External Branch of Superior Laryngeal Nerve in Thyroid Surgery
The frequent occurrence of impaired function in the external branch of the superior laryngeal nerves following thyroid surgery is recognized as a prevalent complication leading to a diminished quality of life.
- Conditions
- Laryngeal Nerve Injuries, Thyroidectomy, Voice Change
- Trial name
- NCT06002984
- Testing
- Using Neuromonitoring to find EBSLN
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Laryngeal Dystonia, Spasmodic Dysphonia
Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
The researchers will examine functional neural correlates that differentiate between laryngeal dystonia and voice tremor and contribute to disorder-specific pathophysiology using a cross-disciplinary approach of multimodal brain…
- Conditions
- Laryngeal Dystonia, Spasmodic Dysphonia, Tremor
- Trial name
- NCT05216770
- Testing
- Brain imaging, Laryngeal sensory block with topical bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pain, Anxiety
Active vs. Passive VR During Office-based ENT Procedures
The purpose of this research is to evaluate whether active virtual reality reduces pain and anxiety more effectively than passive virtual reality during office-based ENT procedures.
- Conditions
- Pain, Anxiety, Chronic Rhinosinusitis (CRS), Nasal Obstruction
- Trial name
- NCT07599826
- Testing
- Passive virtual reality headset or goggles, Active virtual reality headset or goggles
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Cedars-Sinai Medical Center
Tracheal Intubation, Postoperative Complications (Cardiopulmonary)
Tracheal Cuff Pressure and Postoperative Complications
This prospective observational study aims to identify risk factors for tracheal mucosal injuries caused by orotracheal tube use during the intraoperative period in patients undergoing elective surgeries at the Hospital de…
- Trial name
- TCP-POC (NCT07264179)
- Where
- Brazil
- Volunteers
- 362 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Laryngeal Dystonia, Spasmodic Dysphonia
Transcranial Magnetic Stimulation in Laryngeal Dystonia
This randomized clinical trial with a crossover design aims to investigate the effects of neuromodulation through repetitive transcranial magnetic stimulation (rTMS) applied to patients diagnosed with laryngeal dystonia.
- Trial name
- NCT07683767
- Testing
- Active rTMS, Speech-Language Therapy
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Postoperative Sore Throat, Cough, Hoarseness
Effect Of Intracuff Dexamethasone On Postoperative Sore Throat In Patients Undergoing Laparoscopic Cholecystectomy
Postoperative sore throat is the most common complication following general anesthsia with endotracheal intubation with incidence ranging from 21 to 65% Although usually self-limiting, it significantly affects patient's comfort…
- Trial name
- NCT07760272
- Testing
- Dexamethasone (0.1 mg/kg), Normal Saline (0.9% NaCl)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Laryngeal Dystonia
tDCS for Laryngeal Dystonia
This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
- Trial name
- NCT06830174
- Testing
- Starstim system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Postoperative Sore Throat, Hoarseness
A Randomized, Comparative, Controlled Study of Differences in the Incidence of Postoperative Sore Throat (POST) by Inner Diameter Size of the TaperGuardTM Endotracheal Tube (ETT)
Postoperative sore throat (POST) is a common complication following general anesthesia involving endotracheal intubation, often leading to decreased patient satisfaction.
- Trial name
- NCT07511998
- Testing
- TaperGuard™ Endotracheal Tube
- Where
- South Korea
- Volunteers
- 246 people
- Sponsor
- Kyungpook National University Chilgok Hospital
Post-Thyroidectomy Dysphonia
Effects of Therapeutic Exercise With and Without Nerve Stimulation on Dysphonia in Post Thyroidectomy Patients
This clinical trial evaluates rehabilitation strategies for post-thyroidectomy dysphonia. Voice impairment is a frequent complication following thyroid surgery. It often occurs even without direct laryngeal nerve transection.
- Trial name
- NCT07811154
- Testing
- therapeutic exercise, therapeutic exercise + transcutaneous nerve stimulation
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Airway Complications, Postoperative Sore Throat
Effect of Cuff Pressure Assessment Methods on Postoperative Complications in Breast Surgery
Endotracheal intubation is a standard procedure used to secure the airway during general anesthesia. A key component of the breathing tube is the "cuff," a balloon-like device that is inflated to seal the airway and prevent…
- Conditions
- Airway Complications, Postoperative Sore Throat, Hoarseness, Dysphagia
- Trial name
- NCT07341646
- Testing
- Continuous Cuff Pressure Indicator, Manual Cuff Pressure Manometer, Minimal Occlusive Volume Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Izmir Katip Celebi University
Dystonia, Drug Induced Dystonia
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated Dystonia
This research involves retrospective and prospective studies for clinical validation of a DystoniaNet deep learning platform for the diagnosis of isolated dystonia.
- Conditions
- Dystonia, Drug Induced Dystonia, Parkinson Disease, Essential Tremor
- Trial name
- NCT05317390
- Testing
- DystoniaNet-based diagnosis of isolated dystonia
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Laryngeal Dystonia, Adductor Spastic Dysphonia of Dystonia
Deep Brain Stimulation for Laryngeal Dystonia: From Mechanism to Optimal Application
Deep Brain Stimulation (DBS) is a neurosurgical procedure used to treat tremors, and dystonia. This study will enroll people who have a form of focal dystonia that affects their vocal cords called Adductor Laryngeal dystonia…
- Trial name
- NCT05506085
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Indiana University
Cough, Vocal Cord Atrophy
Usefulness and Feasibility of Ultrasound in Office Laryngology Procedures
Investigators will assess the usefulness of using ultrasound in office procedures for laryngology interventions. Participants who qualify will be adults who are undergoing superior laryngeal nerve block, injection laryngoplasty…
- Conditions
- Cough, Vocal Cord Atrophy, Vocal Cord Paresis, Vocal Cord Paralysis
- Trial name
- NCT06579989
- Testing
- Ultrasound for cough, Ultrasound for vocal fold atrophy or vocal fold paresis/paralysis, Ultrasound for dysphagia
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Myasthenia Gravis, Fatigue
Capturing Key MG-symptoms Using Smartphone Recordings.
This study will make use of a cross-sectional design of MG patients and non-MG participants to quantitatively assess key MG symptoms, and to explore the applicability of machine learning algorithms to their measurement.
- Trial name
- CAPTURE - MG (NCT06743490)
- Where
- 2 sites in Netherlands
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Postoperative Sore Throat, Cough, Hoarseness, Thyroid and Parathyroid Surgery
Sore Throat After Open Neck Elective Surgery
This randomized clinical trial aims to evaluate the effectiveness of two medications-hydrocortisone ointment and lidocaine solution-applied to the endotracheal tube in reducing postoperative throat pain, hoarseness, and cough…
- Trial name
- STONES (NCT07124650)
- Testing
- Hydrocortisone Acetate 1% Ointment, Lidocaine hydrochloride 0,05% with chlorhexidine
- Where
- Russia
- Volunteers
- 764 people
- Sponsor
- Saint Petersburg State University, Russia
Functional Voice Disorder, Psychogenic Voice Disorder
Autonomic Dysfunction in Functional Dysphonia
The first objective of this research project is to compare the occurrence and frequency of symptoms and/or disorders related to autonomic dysfunction in patients with functional dysphonia with gender- and age-matched vocally…
- Conditions
- Functional Voice Disorder, Psychogenic Voice Disorder, Muscle Tension Dysphonia
- Trial name
- NCT06100601
- Testing
- ANS regulation therapy, conventional voice therapy (CVT), ANS regulation therapy + CVT
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Ghent
Oropharyngeal Leak Pressure, Airway Management
Effects of Video LMA Cuff Pressure in Tympanoplasty.
This prospective observational study aims to evaluate the effects of different cuff pressure levels of the Video Laryngeal Mask Airway (Video LMA) on airway safety, ventilation efficacy, and postoperative pharyngeal symptoms in…
- Conditions
- Oropharyngeal Leak Pressure, Airway Management, Postoperative Sore Throat, Cough, Hoarseness
- Trial name
- NCT07849322
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Samsun University
Laryngeal Dystonia, Focal Dystonia
Effects of Neuromodulation in Laryngeal Dystonia
Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life.
- Trial name
- NCT05095740
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Spasmodic Dysphonia
EMG-Guided Versus Endoscopic-Catheter Botulinum Toxin Injection for Spasmodic Dysphonia
This randomized, controlled non-inferiority trial will compare two established botulinum toxin injection techniques for adductor spasmodic dysphonia: percutaneous electromyography-guided injection and transnasal endoscopic…
- Trial name
- NCT07894172
- Testing
- Intervention A - Electromyography (EMG)-Guided BTX Injection, Intervention B - Endoscopic Catheter BTX Injection
- Volunteers
- 17 people
- Sponsor
- Chinese University of Hong Kong
Spasmodic Dysphonia, Laryngeal Dystonia
Extended-release Sodium Oxybate (Lumryz) in Spasmodic Dysphonia and Voice Tremor
Using a comprehensive approach of clinico-behavioral testing and neuroimaging, the researchers will examine the clinical effects of the extended-release formulation of sodium oxybate on voice symptoms in spasmodic dysphonia in an…
- Conditions
- Spasmodic Dysphonia, Laryngeal Dystonia, Voice Tremor
- Trial name
- NCT07041203
- Testing
- sodium oxybate
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Kristina Simonyan