Clinical trials: Dysphoria
Dysphoria
Effects of Transcranial Direct Current Stimulation on Reward Learning in Subclinical Depression.
This project will test whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can alter reward learning behaviour in subclinical depression.
- Trial name
- NCT03393312
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Gender Dysphoria
Metabolic Consequences of Cross-sex Hormonal Treatment
Retrospective study in a single academic regional transgender referral center. Analyse VAT, body composition and metabolic parameters in non-obese transgender subjects one year after starting gender-affirming hormone therapy and…
- Trial name
- DysGeMet (NCT04508231)
- Testing
- Gender-affirming hormone therapy
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Central Hospital, Nancy, France
Sleep Disorder, Insulin Resistance
Sleep and IR in Transgender Adolescents
Disordered sleep is a health issue with significant impacts on physical and psychological well-being that has increased in prevalence, but its impact on transgender adolescents has not been fully quantified.
- Conditions
- Sleep Disorder, Insulin Resistance, Gender Dysphoria
- Trial name
- ATP (NCT05489159)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression, Anxiety
A Pychoeducational Intervention for Women With Diabetes
This proposal describes a small randomized study to determine whether usual medical care (UMC) for diabetes combined with a psychoeducational program is more effective than UMC for diabetes alone.
- Conditions
- Depression, Anxiety, Anger
- Trial name
- SWEEP (NCT01185561)
- Testing
- Psychoeducational intervention
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Loyola University
Gender Dysphoria
Subcutaneous Testosterone Project
For people who identify as transgender, there is a strong sense that they were born into the wrong body and that their outward looking body does not match how they truly feel about themselves.
- Trial name
- STP (NCT02229617)
- Testing
- Subcutaneous testosterone
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- University of British Columbia
Gender Dysphoria, Adult
Gender Affirming Vaginoplasty With Tubularized Augmented Peritoneal Cap (TAPCap) Utilizing Fish Skin Xenograft (Kerecis™)
Bottom gender affirming surgery is one of the key steps towards aligning the physical appearance and gender identity in transgender women.
- Trial name
- NCT07286123
- Testing
- Tubularized augmented peritoneal cap vaginoplasty, Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University Hospitals Cleveland Medical Center
Gender Dysphoria, Opioid Use
The Effect of Pectoral Blocks on Perioperative Pain in Gender Affirmation Top Surgery
Despite recent advancements with regional and local anesthesia, postoperative pain continues to be a major concern for patients undergoing breast surgery.
- Conditions
- Gender Dysphoria, Opioid Use, Pain, Postoperative
- Trial name
- NCT04474366
- Testing
- Ropivacaine 0.2% Injectable Solution, Saline (0.9%)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Mood Disorder
Study of Premenstrual Syndrome and Premenstrual Dysphoria
The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS). Women who experience PMS symptoms will complete clinical interviews, self-rating scales, and evaluations of mood and endocrine…
- Trial name
- NCT00001177
- Where
- United States
- Volunteers
- 1,569 people
- Sponsor
- National Institute of Mental Health (NIMH)
Transgenderism, Erectile Dysfunction
Epithesis Versus Prosthesis in Post-phalloplasty Transgender Patients.
Transgender and gender diverse (TGD) individuals most often choose for phalloplasty as a means to create masculine external genitalia.
- Conditions
- Transgenderism, Erectile Dysfunction, Prosthesis Durability, Gender Dysphoria
- Trial name
- EROS (NCT05883553)
- Testing
- Usability and added value of device within sexual activity
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Gender Dysphoria
The Strategic Use of Hyaluronic Acid Fillers and Neurotoxin to Influence Gender Perception in Transgender Individuals
Observational survey study of transgender individuals who have undergone cosmetic neurotoxin and soft tissue filler for the purpose of influencing gender perception.
- Trial name
- NCT04478214
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Mountain Dermatology Specialists
Gender Incongruence, Gender Dysphoria
Sex Hormone Overdose and Misuse in Chinese Transgender and Gender Non-conforming Population
The investigators propose to investigate the definition of hormone overdose and misuse (HODM) in Chinese transgender and gender nonconforming population (TGNCs), address the incidence of HODM in Chinese TGNC population, related…
- Trial name
- HODMChina (NCT05583058)
- Testing
- Hormone Overdose and Misuse
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Gender Dysphoria
Comparison of PKs of 17-Beta-Estradiol Via Sublingual Placement Versus Swallowing in Male-to-Female Transgender Patients
This crossover study will investigate the pharmacokinetics of oral versus sublingual administration of 17-beta-estradiol in the trans-female population.
- Trial name
- NCT05428215
- Testing
- 17beta Estradiol
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Vaginoplasty, Gender Dysphoria, Adult
Can 3D Modeling Enhance Patient Understanding, Education, and Surgical Outcomes in Gender Affirming Peritoneal Vaginoplasty?
The project aims to address both clinical and relational gaps in transgender surgical care by improving understanding, communication, and outcomes through this novel integration of personalized 3D technology.
- Trial name
- 3D Modeling (NCT07412509)
- Testing
- Use 3D printed patient specific models for patient education
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Cognitive Deficits, Depression
Attentional Bias Modification Through Eye-tracker Methodology (ABMET)
Cognitive biases are a hallmark of depression but there is scarce research on whether these biases can be directly modified by using specific cognitive training techniques.
- Conditions
- Cognitive Deficits, Depression, Alteration of Cognitive Function
- Trial name
- ABMET (NCT02847793)
- Testing
- Gaze training
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad Complutense de Madrid
Gender Dysphoria
Transition in Transgender
The aim of this longitudinal, observational study is to investigate the effects of gender-affirming hormone treatment in FTM (female to male) and MTF (male to female) transgender (TG) people with regard to changes in brain…
- Trial name
- NCT04736797
- Where
- 2 sites in Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Gender Dysphoria in Children, Puberty
Skeletal Health and Bone Marrow Composition Among Youth
Children and adolescents experiencing gender dysphoria feel increased distress with the onset of puberty. Gender clinics treat these young adolescents by "blocking" puberty using gonadotropin-releasing hormone (GnRH) agonist…
- Conditions
- Gender Dysphoria in Children, Puberty, Bone Development
- Trial name
- NCT04203381
- Testing
- GnRH Agonist
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Amy DiVasta, MD
Gender Dysphoria, Hormone Therapy Induced Morphologic Change
Gender-Affirming Hormone Therapy and Its Impact on Myocardial Mass and Cardiac Function, Heart, Liver and Pancreatic Fat Content
Background: Gender affirming hormone therapy (GAHT) leads to profound changes in sex hormone levels, carrying a wide range of implications for major physiological processes in the body.
- Trial name
- NCT06291675
- Testing
- gender-affirming hormone therapy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Depressive Disorder, Mood Disorder
Progestin (Progesterone-Like Hormones) Induced Dysphoria (Depressed Mood, Irritability, Anxiety)
Often women are prescribed hormone replacement therapy (HRT) during the perimenopause or menopause. Hormone replacement therapy includes both estrogen and progesterone.
- Conditions
- Depressive Disorder, Mood Disorder, Psychomotor Agitation
- Trial name
- NCT00001770
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Gender Dysphoria
Gynaecological Gender-affirming Surgeries
The goal of this prospective cohort study is to learn about the patient report outcomes after gynaecological gender-affirming surgeries (i.e.
- Trial name
- NCT06098781
- Where
- Netherlands
- Volunteers
- 57 people
- Sponsor
- Amsterdam UMC, location VUmc