Clinical trials: Dysphoric Mood
Depression
Behavioral Study of Effects of Low-Level Light Therapy on Mood and Reaction Time
The goal of this project is to use low-level light therapy (LLLT) to enhance neural metabolism in the prefrontal cortex of humans, and measure the effects of LLLT on attentional bias change following a single session of attention…
- Trial name
- NCT02390076
- Testing
- Left Low Level Light Therapy, Attention bias modification, Right Low Level Light Therapy
- Volunteers
- 51 people
- Sponsor
- Seth Disner
Premenstrual Disorder
Kinesio Taping vs Tele-Pilates for PMS
Premenstrual Syndrome (PMS) has a wide variety of signs and symptoms, including physical, psychological, and behavioral symptoms severe enough to disrupt daily activities.
- Trial name
- premensterual (NCT07063472)
- Testing
- Tele- pilates, Kinesio taping application for the KT group
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Transgender Individuals, Gender Incongruence
Swiss ProspectivE Cohort of TRAnsgender and Gender Diverse Individuals - The SPECTRA Study
The goal of this observational study is to understand the factors influencing the well-being and health of transgender and gender-diverse (TGD) individuals undergoing gender-affirming therapies in Switzerland.
- Trial name
- SPECTRA (NCT06774053)
- Testing
- Group A (start of GAHT), Group B (on-going GAHT), Group C (GAS)
- Where
- 3 sites in Switzerland
- Volunteers
- 600 people
- Sponsor
- University Hospital, Basel, Switzerland
Gender Dysphoria
Evaluation of the Effectiveness of Hormonal Treatment in Adolescents Suffering From Gender Dysphoria
Gender dysphoria (GD) is a significant suffering lasting more than 6 months in a subject, with regard to the discrepancy felt between his or her gender identity and his or her birth sex.
- Trial name
- TRANSADO (NCT06351501)
- Testing
- hormonal treatment with cross sex hormones (testosterone or oestrogenes) started at 14 years old +/- 6 months, Cross sex hormones ( œstrogenes or testosterone) started at 15.5 years old +/- 6 months
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Premenstrual Disorder, Premenstrual Dysphoric Disorder
Pilot Study of the 'Thriving With PMDs' Program
This study is testing a self-help mental health program that was designed to help people cope with the challenges of living with a premenstrual disorder.
- Trial name
- NCT06648382
- Testing
- Self-directed psychotherapy program for premenstrual disorders
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Regina
Rokitansky Kuster Hauser Syndrome, Vaginal Neoplasms
Peritoneum Vaginoplasty; Implementation According to IDEAL Framework
This study aims to assess if a single flap peritoneum vaginoplasty is safe and feasible.The IDEAL framework for evaluation and implementation of surgical techniques will be used.
- Conditions
- Rokitansky Kuster Hauser Syndrome, Vaginal Neoplasms, Gender Incongruence, Vaginal Obstruction
- Trial name
- PeriVaS (NCT05925361)
- Testing
- Laparoscopic pedicled single flap peritoneum vaginoplasty
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Amsterdam UMC, location VUmc
Premenstrual Dysphoric Disorder
Emotional Processing and Oxytocin Mechanisms in Premenstrual Dysphoric Disorder: A Pilot Study
This research study will look at brain and symptom differences among women with severe premenstrual mood symptoms. One goal of this study is to look at the effects of taking a nasal spray containing oxytocin (a hormone made in…
- Trial name
- NCT02508103
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Gender Dysphoria
Transition in Transgender
The aim of this longitudinal, observational study is to investigate the effects of gender-affirming hormone treatment in FTM (female to male) and MTF (male to female) transgender (TG) people with regard to changes in brain…
- Trial name
- NCT04736797
- Where
- 2 sites in Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Gender Identity Disorder
Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity
This ultrahigh-field MRI study gives us the unique opportunity to measure changes in brain function and structure induced by long-term opposite-sex steroid hormone administration in transsexual subjects. Our aim is 1.
- Trial name
- NCT01292785
- Testing
- Hormones
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Gender Incongruence, Gender Dysphoria
Sex Hormone Overdose and Misuse in Chinese Transgender and Gender Non-conforming Population
The investigators propose to investigate the definition of hormone overdose and misuse (HODM) in Chinese transgender and gender nonconforming population (TGNCs), address the incidence of HODM in Chinese TGNC population, related…
- Trial name
- HODMChina (NCT05583058)
- Testing
- Hormone Overdose and Misuse
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Premenstrual Dysphoric Disorder, PMDD
The SPARK-PMDD Study
Scientists have found that the immune system, the body's system dedicated to fighting infections, can be in a state of "hyperactivity" (i.e., more active than you would normally expect) in some people with depression and…
- Conditions
- Premenstrual Dysphoric Disorder, PMDD, Premenstrual Dysphoric Disorder ( PMDD), Premenstrual Dysphoric Disorder (PMDD)
- Trial name
- SPARK-PMDD (NCT07771426)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- King's College London
Cognitive Deficits, Depression
Attentional Bias Modification Through Eye-tracker Methodology (ABMET)
Cognitive biases are a hallmark of depression but there is scarce research on whether these biases can be directly modified by using specific cognitive training techniques.
- Conditions
- Cognitive Deficits, Depression, Alteration of Cognitive Function
- Trial name
- ABMET (NCT02847793)
- Testing
- Gaze training
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad Complutense de Madrid
Gender Dysphoria, Emotion Regulation
Internet-delivered Treatment for Transgender Individuals With Co-occurring Mental Health Problems
This project aims to develop and evaluate if an internet delivered psychological intervention for transgender individuals undergoing assessment for gender dysphoria and a support person, is feasible, acceptable and effective in…
- Conditions
- Gender Dysphoria, Emotion Regulation, Internet Delivered Treatment
- Trial name
- IERGD (NCT05534763)
- Testing
- IERGD, IER SUPPORT
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska Institutet
Premenstrual Dysphoric Disorder, Bipolar Disorder
Oral Contraceptives for Treating Premenstrual Dysphoric Disorder in Bipolar Disorder
This study is a pilot, randomized, placebo-controlled trial evaluating the treatment of Premenstrual Dysphoric Disorder comorbid with Bipolar Disorder using combined oral contraceptives.
- Trial name
- NCT05098574
- Testing
- Yaz
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Dysphoria
Neuromodulation for Dysphoria
This is an open label prospective pilot study of two neuromodulation interventions for patients suffering from dysphoria. Dysphoria is a transdiagnostic symptom of unease or dissatisfaction experienced across a range of…
- Trial name
- NCT05061745
- Testing
- Guided Meditation VR for Wellness, Accelerated Transcranial Magnetic Stimulation: MagVenture Transcranial Magnetic Stimulation (Treatment Coil Cool B70 AP), Accelerated Transcranial Magnetic Stimulation: MagVenture Transcranial Magnetic Stimulation (Cool D-B80 AP)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Florida State University
Premenstrual Dysphoric Disorder, Premenstrual Syndrome
A Placebo-Controlled Study to Investigate the Onset of Action of Paroxetine in Premenstrual Dysphoria
The objective of this study is to explore the onset of action when serotonin reuptake inhibitors are used to treat premenstrual dysphoric disorder
- Trial name
- NCT00516113
- Testing
- paroxetine
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Karolinska Institutet
Depression, Major Depressive Disorder
Single Session of tACS in a Depressive Episode
Purpose: Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on healthy participants and participants with mood disorders.
- Conditions
- Depression, Major Depressive Disorder, Premenstrual Dysphoric Disorder, Depressive Episode
- Trial name
- SSDE (NCT03449979)
- Testing
- XCSITE100 Stimulator tACS
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Gender Dysphoria, Adult
GLOW: Gender-Affirming Care and Mental Health: A Longitudinal Study On Quality of Life, Work Life, and Healthcare Outcomes
Gender-Affirming Care and Mental Health (GLOW) investigates the psychological, medical, and social factors that influence the outcomes of gender-affirming care, as well as its impact on mental health, work capacity, and quality…
- Trial name
- GLOW (NCT07480590)
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Region Skane
Dysphoria
Effects of Transcranial Direct Current Stimulation on Reward Learning in Subclinical Depression.
This project will test whether transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) can alter reward learning behaviour in subclinical depression.
- Trial name
- NCT03393312
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Gender Dysphoria, Adolescent
Counseling Among Gender Diverse Adolescents Who Use Depot Medroxyprogesterone
Recommendations regarding contraceptive counseling and reproductive health differ amongst transgender and gender diverse (TGD) youth compared to cis-gender youth.
- Trial name
- NCT05726903
- Testing
- Depo-subQ Provera Injectable Product
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver