Clinical trials: Dyspnea; Cardiac
Chronic Obstructive Pulmonary Disease (COPD), Heart Failure
Breathlessness Patterns in Patients With Cancer, COPD and Heart Failure: an fMRI Feasibility Study
Dyspnea that persists despite optimal pathophysiological treatment is defined as persistent dyspnea. Currently all brain functional magnetic resonance imaging (fMRI) studies conducted to evaluate breathlessness have done so using…
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Heart Failure, Cancer, Volunteers
- Trial name
- BREACH-fMRI (NCT07319039)
- Testing
- Cerebral fMRI, Immersive virtual reality
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Heart Failure, Dyspnea
Study of Electrical Bioimpedance in Heart Failure.
The purpose of this study is to determine how electrical impedance is modified in relation to extracellular space body fluid retention detected by an electrical bioimpedance method in patients with heart failure.
- Trial name
- BELIC (NCT00843245)
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Dyspnea, Cardiopulmonary Dysfunction
Effect of Different Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery
Open heart surgery is often associated with postoperative pulmonary complications, reduced lung expansion, dyspnea, and impaired cardiopulmonary function.
- Conditions
- Dyspnea, Cardiopulmonary Dysfunction, Postoperative Respiratory Dysfunction, Coronary Artery Disease
- Trial name
- NCT07591987
- Testing
- Segmental Breathing Exercises, Active Cycle Breathing Technique, Standard postoperative care
- Where
- 3 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Post-cardiac Surgery
Comb Effect of 4-7-8 Breathing Technique and Stationary Cycle on PP, QOL and Dyspnea in Post CABG Patients.
To determine the combined effects of 4-7-8 breathing technique and stationary cycle on physical performance, quality of life and dyspnea in post CABG patients.
- Trial name
- NCT06460740
- Testing
- 4-7-8 breathing technique, Stationary Cycling
- Where
- Pakistan
- Volunteers
- 58 people
- Sponsor
- Riphah International University
Chest Pain, Shortness of Breath
Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction
The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart…
- Trial name
- NCT06927973
- Testing
- Echocardiogram
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Covid19, Cardiopulmonary Disease
Physiological Studies in Post-COVID-19 Syndrome, and the Association With DNA Methylation
The physiological derangements in subjects suffering from long-term symptoms following a Covid-19 infection (Post-COVID-19 Syndrome) are poorly understood and evaluated.
- Conditions
- Covid19, Cardiopulmonary Disease, Dyspnea, Lung Function Decreased
- Trial name
- NCT04859894
- Testing
- Physiological testing
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
Acute Dyspnea
Evaluation of Rapid Emergency Echography for Acute Dyspnoea
Elderly people constitute the largest proportion of emergency room patients, representing 12% of all emergency room admissions. The need for diagnostic tests or therapeutic interventions is much greater in this patient…
- Trial name
- READ (NCT02531542)
- Testing
- Echocardiography according to the READ method.
- Where
- 5 sites in France
- Volunteers
- 461 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Heart Failure, Chronic Obstructive Pulmonary Disease
Triage of Reduced Exercise Tolerance in Frail Elderly
Background of the study: Many elderly suffer from reduced exercise tolerance or exercise induced shortness of breath (dyspnoea) which causes decreased mobility and restrictions in physical, psychological and social functioning.
- Trial name
- TREE (NCT01148719)
- Testing
- Index group
- Where
- Netherlands
- Volunteers
- 841 people
- Sponsor
- UMC Utrecht
Dyspnea, Paroxysmal, Heart Failure, Left Sided
Management of Cardiogenic Pulmonary Edema (RENAU-OAP)
The prevalence of heart failure is estimated to 2.3 percent of the adult population and strongly increases with age, according to french disability-health surveys.
- Trial name
- RENAU-OAP (NCT03148847)
- Testing
- Baseline care, Referential's dissemination
- Where
- France
- Volunteers
- 859 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Chronic Heart Failure
Effect of Upper Extremity Aerobic Exercise Training on Exercise Capacity Patients With Chronic Heart Failure
Heart failure is a cardiac structural or functional disorder that, despite normal filling pressures, leads to inability to deliver enough oxygen to meet the metabolic needs o tissue.
- Trial name
- NCT03675113
- Testing
- Upper extremity aerobic exercise, Control Group
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- Gazi University
Dyspnea,, Acute Heart Failure Syndrome
Fluid Status of Outpatients With Dyspnea
The purpose of this study is to determine the distribution of lung fluid status as reported by the IMED-4 system in patients presenting to the emergency department or urgent care facility with shortness of breath.
- Conditions
- Dyspnea,, Acute Heart Failure Syndrome, Pulmonary Congestion
- Trial name
- FLOOD (NCT02111525)
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Intersection Medical, Inc.
Acute Heart Failure (AHF)
Evaluation of Fibroscan® Performance in Diagnosing Acute Heart Failure in Patients Presenting to the Emergency Department
Acute heart failure (AHF) is a major cause of acute dyspnea in emergency departments (EDs), driven primarily by venous congestion, which can lead to hepatic congestion and risk of subsequent liver dysfunction.
- Trial name
- FIBROSCAF (NCT07449377)
- Testing
- FibroScan®
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Failure, Congestive, Dyspnea
The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure
The purpose of this study is to test the hypothesis that treatment with oral ALT-711 twice daily for 16 weeks will improve aortic distensibility, exercise tolerance, and quality of life in elderly patients with isolated diastolic…
- Conditions
- Heart Failure, Congestive, Dyspnea, Pulmonary Edema
- Trial name
- NCT00043836
- Testing
- ALT-711
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Synvista Therapeutics, Inc
Cancer, COPD
SELF-BREATHE RCT for Chronic Breathlessness
A feasibility RCT comprising two groups: 1. Intervention (SELF-BREATHE in addition to standard NHS care) 2. Control group (standard / currently available NHS care)
- Conditions
- Cancer, COPD, Asthma, Bronchiectasis Adult
- Trial name
- NCT04574050
- Testing
- SELF-BREATHE
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- King's College Hospital NHS Trust
Heart Failure, Heart Failure - NYHA II - IV
Effects of a 20-Minute Mindfulness-Based Breathing Exercise on Dyspnea, Fatigue, and Sleep Quality in Patients With Heart Failure
Heart failure (HF) is a chronic condition that leads to incapacity. Despite significant progress in optimizing pharmacological treatment for HF patients, the personal and social burden of this disease is still characterized by…
- Trial name
- NCT07046091
- Testing
- 20-minute mindfulness-based breathing exercise, Control (Standard treatment)
- Volunteers
- 72 people
- Sponsor
- Firat University
Chest Pain, Dyspnea
Emergency Department Cardiac Ultrasound
This is a prospective observational study evaluating the diagnostic utility of cardiac ultrasound in patients who present to the emergency department with undifferentiated chest pain or shortness of breath.
- Trial name
- NCT02719509
- Testing
- Cardiac Ultrasound
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Congestive Heart Failure, Chronic Heart Failure
Evaluation of Combined Action Between Natrecor and Furosemide on Kidney and Neurohormone Responses in Chronic Heart Failure: A Phase-IV study704.351 / DSS
This is a randomized, open-label, three-way crossover design study with 3 treatment groups:TREATMENT A: Furosemide;TREATMENT B: Nesiritide administered IV bolus, followed by an infusion for 6 hours;TREATMENT C: Treatment B for at…
- Trial name
- NCT00652652
- Testing
- nesiritide, furosemide
- Sponsor
- Scios, Inc.
Asthma, Heart Failure
The General Breathing Record Study
This study will test the use of a new handheld device (called the N-Tidal C), that measures a person's tidal breath carbon dioxide, in diagnosing the cause of someone's breathlessness.
- Conditions
- Asthma, Heart Failure, Pneumonia, Motor Neuron Disease
- Trial name
- GBRS (NCT03356288)
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TidalSense
Cancer, Dyspnea, Paroxysmal
Fentanyl Buccal Tablet for the Relief of Episodic Breathlessness in Cancer Patients
"Episodic breathlessness (or dyspnea) is one form of chronic refractory breathlessness characterized by a severe worsening of breathlessness intensity or unpleasantness beyond usual fluctuations in the patient's perception.
- Trial name
- EFFENDYS (NCT04635852)
- Testing
- Fentanyl, Immediate release morphine
- Where
- 3 sites in Germany
- Volunteers
- 10 people
- Sponsor
- University of Cologne
Acute Myocardial Infarction, Heart Failure
SHORTness of Breath In the Emergency Department (SHORTIE)
SHORTIE is a two-phase study to determine the impact of the Triage Profiler S.O.B. (Shortness Of Breath) Panel on patient management, outcome, and cost.
- Conditions
- Acute Myocardial Infarction, Heart Failure, Pulmonary Embolism
- Trial name
- NCT00206830
- Testing
- Triage Profiler S.O.B. Panel
- Where
- 5 sites in United States
- Volunteers
- 306 people
- Sponsor
- Abbott RDx Cardiometabolic