Clinical trials: Dyspnoea
Breathlessness, Cancer
Management of Breathlessness with High-flow Nasal Therapy or a Fan
Airflow directed to the face by a fan is shown to relief breathlessness in palliative care and some studies have suggested High-Flow nasal airflow therapy beneficial as well. However, these two treatments have not been compared.
- Trial name
- NCT05257850
- Testing
- High-flow nasal therapy, Airflow directed to face by a fan
- Where
- 2 sites in Finland
- Volunteers
- 36 people
- Sponsor
- Tampere University Hospital
Pulmonary Arterial Hypertension
Bronchodilator's Effects on Exertional Dyspnoea in Pulmonary Arterial Hypertension
Activity-related dyspnoea appears to be the earliest and the most frequent complaint for which patients with PAH seek medical attention.
- Trial name
- BD-HTAP (NCT02782052)
- Testing
- Nebulized ipratropium bromide, Nebulized combination ipratropium bromide with salbutamol
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) and Advance Directives
The aim of this study is to evaluate if the participation of COPD patients to a workshop on advance directives increases the number of patients who write them.
- Trial name
- DIABPCO (NCT04459143)
- Testing
- Advance directives
- Where
- France
- Volunteers
- 525 people
- Sponsor
- Hôpital NOVO
Chronic Obstructive Pulmonary Disease
Asymptomatic Versus Symptomatic Mild COPD: Comparisons at Rest and at Exercise
The current definition of chronic obstructive pulmonary disease (COPD) is based on the presence of persistent airflow obstruction assessed by spirometry. About half of the subjects with mild COPD (i.e.
- Trial name
- NCT02235025
- Testing
- Cardio-pulmonary exercise testing
- Where
- France
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Respiratory Symptoms
Belgian Pulmonary Function Study
Pulmonary function tests including spirometry, lung volumes, measurements of resistance and diffusing capacity are essential in the diagnosis of several pulmonary diseases.
- Trial name
- BPFS (NCT01297881)
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Marc Decramer
Thoracic Discopathy, Back Pain
Physiotherapy in Thoracic Discopathy
Background and Objective: Information regarding the effects of physiotherapy on quality of life and alterations in pulmonary function tests among patients with thoracic discopathy is notably limited in the literature.
- Conditions
- Thoracic Discopathy, Back Pain, Respiratory Dysfunction
- Trial name
- NCT07749248
- Testing
- Traditional Physiotherapy, Breathing Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Medipol University
Asthma
Epinephrine Inhalation Aerosol USP, CLINICAL STUDY-B3 FOR ASSESSMENT OF PHARMACOKINETICS
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA134a propelled Metered Dose Inhaler (MDI) (E004), using a stable isotope deuterium-labeled epinephrine…
- Trial name
- NCT01255709
- Testing
- Arm T1: Primatene Mist HFA, Arm T2: Primatene Mist HFA, Arm C: Primatene Mist (epinephrine inhalation aerosol, USP)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Interstitial Lung Disease (ILD)
Efficacy of L-menthol on Breathlessness in Interstitial Lung Disease
The purpose of this study is to assess the effect of L-menthol on breathlessness and exercise capacity in patients with Interstitial lung disease (ILD).
- Trial name
- Ment-ILD (NCT07398287)
- Testing
- L-menthol
- Where
- 2 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Region Skane
Healthy
Effects of Chronic Acid-Base Changes on Ventilatory and Perceptual Responses
Approximately 30% of people aged 65 years and older experience breathlessness (perceived respiratory difficulty) during daily activity.
- Trial name
- NCT00946933
- Testing
- NH4Cl (ammonium chloride)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Queen's University
COPD, Dyspnea
The Effect of Transcranial Direct Current Stimulation (tDCS) on Dyspnoea Perception, Pulmonary Function and Functional Level During COPD Exacerbation
Chronic obstructive pulmonary disease (COPD) is a treatable disease characterized by irreversible and progressive airflow limitation, which is a cause of high morbidity and mortality.
- Conditions
- COPD, Dyspnea, tDCS
- Trial name
- NCT06944626
- Testing
- tDCS, Conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Okan University
COVID-19
Pulmonary Rehabilitation in Post-Acute Period of COVID-19 Infection
The aim of this study is to investigate the efficacy of pulmonary rehabilitation(PR) applied in the isolation processes of post-acute patients with mild and moderate symptoms who had positive COVID-19 test on dyspnea,muscle…
- Trial name
- NCT04365738
- Testing
- Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Istanbul Bilgi University
Pulmonary Disease, Chronic Obstructive
12-week Treatment With Inhaled Tiotropium (18 mcg Once Daily) on Lung Function and Static Lung Volumes in Stable, Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Patients. Correlation to Dyspnoea Scales
Determine the effect of 12-week treatment with inhaled tiotropium bromide on lung function and static lung volumes, correlate this effect with dyspnoea in COPD patients.
- Trial name
- NCT02172378
- Testing
- Tiotropium inhalation capsules
- Volunteers
- 116 people
- Sponsor
- Boehringer Ingelheim
Acute Respiratory Failure
Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS)
This study evaluates a pharmacological intervention to relieve dyspnea in intensive care unit patients. Indeed, opioids can be particularly beneficial since 1) dyspnea and pain share many similarities, 2) the benefit of opioids…
- Trial name
- OPIDYS (NCT04358133)
- Testing
- Chlorhydrate de morphine, NaCl 0,9%,
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Patient Adherence
Efficacy Of An Education Plan And Adherence Follow-Up To The Exercise In Patients With COPD
Chronic obstructive pulmonary disease is one of the main causes of morbidity and mortality worldwide, according to recent publications of the World Health Organization, its main feature is the response to noxious particles of…
- Trial name
- NCT05204498
- Testing
- Education plan and adherence to exercise
- Where
- Colombia
- Volunteers
- 31 people
- Sponsor
- Clínica de Occidente S.A
Chronic Obstructive Pulmonary Disease (COPD)
129-Xe MRI Study of Single Triple Therapy Inhaler Effects in COPD Patients With Moderate-severe Dyspnea and/or Poor Health Status With High or Low Risk of Exacerbation
The goal of this study is to study how 12-weeks daily (and optional 48-weeks) single inhaler triple therapy (fluticasone furoate (FF)-an inhaled corticosteroid; umeclidinium (UMEC)-a long-acting muscarinic antagonist; vilanterol…
- Trial name
- MUST (NCT07192016)
- Testing
- fluticasone furoate(FF)/umeclidinium (UMEC)/vilanterol(VI) (100/62.5/25) mcg
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Hepatopulmonary Syndrome
Supine Exercise in Hepatopulmonary Syndrome Patients With Orthodeoxia
Hepatopulmonary syndrome (HPS) is a rare condition that presents in about a quarter of patients with liver cirrhosis. In addition, a small subset of these HPS patients also have orthodeoxia, defined as a drop in oxygen levels…
- Trial name
- NCT04004104
- Testing
- Upright Exercise, Supine Exercise
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Pediatric Acute Respiratory Distress Syndrome
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced.
- Trial name
- NCT06684119
- Testing
- Electrical Impedance Tomography positive end-expiratory pressure titration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Los Angeles
Chronic Obstructive Pulmonary Disease, Respiratory Failure
Automated Oxygen Titration During Walking in Patients With COPD
Purpose: to evaluate the immediate effect of automated oxygen titration compared to usual fixed-dose oxygen treatment during exercise in patients with COPD on long-term oxygen treatment.
- Trial name
- NCT04123730
- Testing
- Fixed-dose compared to variable oxygen flow supplementation during walking
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Hvidovre University Hospital
Chronic Obstructive Pulmonary Disease
Elastic Tape Relieves Symptoms and Improves Health-related Quality of Life in COPD (Chronic Obstructive Pulmonary Disease)
The goal of this randomized controlled trial is to investigate the effects of elastic tape in individuals with mild to very severe COPD.
- Trial name
- COPD (NCT04415957)
- Testing
- Elastic Tape
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Dyspnea, Peripheral Edema
NT-proBNP and New Biomarkers in Patients With Dyspnea and/or Peripheral Edema
The objectives of this study are to: Evaluate the sensitivity and specificity of NT-proBNP (N-terminal prohormone brain natriuretic peptide) and new biomarker measurements for the diagnosis of heart failure in patients with acute…
- Trial name
- MANPRO (NCT00143793)
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Universitätsmedizin Mannheim
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