Clinical trials: Dyspnoea
Acute Respiratory Distress Syndrome, Coronavirus
Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS).
This is a multicenter, randomized, double-blind, parallel group study to investigate the efficacy of pemziviptadil (PB1046) by improving the clinical outcomes in hospitalized COVID-19 patients at high risk for rapid clinical…
- Conditions
- Acute Respiratory Distress Syndrome, Coronavirus, Hypoxic Respiratory Failure, Hypoxemic Respiratory Failure
- Trial name
- VANGARD (NCT04433546)
- Testing
- Pemziviptadil (PB1046), Low Dose (10 mg) Control
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- PhaseBio Pharmaceuticals Inc.
Acute Respiratory Failure, Oxygen Inhalation Therapy
External Validation of the BREF Models
Introduction High-flow oxygen therapy is increasingly used to treat acute respiratory failure (ARF). It can reduce intubation rates without increasing mortality.
- Conditions
- Acute Respiratory Failure, Oxygen Inhalation Therapy, Respiratory Distress
- Trial name
- BREF2 (NCT06669312)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Istituto Clinico Humanitas
Spinal Cord Injury
Respiratory Event-Related Potentials in Patients With Spinal Cord Injury
Dyspnea is "a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity".
- Trial name
- NCT02163551
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Charlotte
Neuromuscular Disease, Inspiratory Muscle Training
Manual Therapy and Inspiratory Muscle Training in Neuromuscular Disease
The benefits of inspiratory muscle training (IMT) have been reported in neuromuscular diseases. However, its effects are limited.
- Conditions
- Neuromuscular Disease, Inspiratory Muscle Training, Manual Therapy
- Trial name
- NCT07416929
- Testing
- inspiratory muscle training, Manual therapy, Conventional physiotherapy programme
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- Istinye University
Dyspnea, Heart Failure
The Triple A Initiative Study ("Aktionsbündnis Akute Atemnot")
Acute dyspnea is a common chief complaint of patients presenting to the emergency department. Patients with acute dyspnea display a high mortality rate.
- Trial name
- NCT02049853
- Testing
- NTproBNP measurement with point of care device "Cobash232" in the POCT group
- Where
- 6 sites in Germany
- Volunteers
- 67 people
- Sponsor
- Prof. Dr. Michael Christ
Parkinson Disease
DBS and Respiration
Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease.
- Trial name
- NCT04058457
- Testing
- DBS
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Oxford
Pulmonary Disease, Chronic Obstructive (COPD)
Comparative Effects of Coherent Breathing and Regular Paced Breathing on Dyspnea and Pulmonary Function in Patients With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory condition of airways characterized by recurrent episodes of coughing, respiratory muscle weakness, lung hyperinflation and air trapping which ultimately leads to…
- Trial name
- NCT07875036
- Testing
- Coherent Breathing Group A, Regular Paced Breathing Group B
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Foundation University Islamabad
Lung Diseases, Cystic Fibrosis
CF Bronchodilation
It is estimated that one in every 3,600 children in Canada has cystic fibrosis (CF). CF is a genetic disease that affects the glands that produce mucus and sweat.
- Trial name
- NCT03522831
- Testing
- Salbutamol
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Lung Disease, Acute Respiratory Distress Syndrome
Palliative Use of High-flow Oxygen Nasal Cannula in End-of-life Lung Disease Patients
The prevalence of severe dyspnoea among terminally ill patients has been reported as 70% and 90% for lung cancer and chronic obstructive pulmonary disease (COPD) patients, respectively.
- Trial name
- NCT02253667
- Testing
- HFONC, Conventional oxygen therapy
- Where
- Portugal
- Sponsor
- Hospital Sao Joao
Dyspnea, Cough
Respiratory Complaints Checklist Trial
This is a randomized clinical trial that evaluates the impact of using an internet-based checklist for systematic assessment of patients reporting respiratory complaints with the conventional assessment, without using the…
- Trial name
- RCC (NCT02283892)
- Testing
- Checklist, Conventional evaluation
- Where
- Brazil
- Volunteers
- 39 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Pulmonary Artery Hypertension
Evaluation of Respiratory Muscle in Patient With Pulmonary Arterial Hypertension
The aim of the study is that evaluation of basic and accessory respiratory muscles and their relationship of six minute walk test in patient with pulmonary arterial hypertension (PAH)
- Trial name
- NCT05056532
- Testing
- patient assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Giresun University
Asthma (Diagnosis)
Longitudinal Phenotyping and Endotyping Study in Adult Patients With Mild, Moderate, or Severe Asthma
Background and study aims: The purpose of this research registry is to understand how asthma varies from person to person and monitor changes that may occur over time.
- Trial name
- MAPLE-UK (NCT07189806)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Hvivo
COPD
The Effect On Self-Care and Self-Efficacy of Inhaler Training in COPD
This study aims to evaluate the effect of planned inhaler medication training on self-care agency and self-efficacy level.
- Trial name
- NCT04052906
- Testing
- Training
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people
- Sponsor
- Nevsehir Haci Bektas Veli University
Chronic Obstructive Pulmonary Disease
Functional Tests in Individuals With Chronic Obstructive Pulmonary Disease (COPD)
Objectives: to evaluate and compare the responses to the various functional tests, and the concordance between the six-minute walk test in hallway (6MWT) and the of oval track (6MWToT), of treadmill (6MWTT), and of treadmill with…
- Trial name
- NCT00660738
- Where
- Brazil
- Volunteers
- 11 people
- Sponsor
- Universidade Federal de Sao Carlos
Acute Respiratory Failure
Low Dose Morphine to Relieve Dyspnea in Acute Respiratory Failure (OPIDYS)
This study evaluates a pharmacological intervention to relieve dyspnea in intensive care unit patients. Indeed, opioids can be particularly beneficial since 1) dyspnea and pain share many similarities, 2) the benefit of opioids…
- Trial name
- OPIDYS (NCT04358133)
- Testing
- Chlorhydrate de morphine, NaCl 0,9%,
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Transplant Surgery
Benefits of Pulmonary Rehabilitation to Patients Post Liver Transplant
The goal of this clinical trial was to access the benefits of a 12-week home-based pulmonary rehabilitation regimen on pulmonary function recovery in post-liver transplant patients.
- Trial name
- NCT06606184
- Testing
- Inspiratory muscle Training, Routine Care
- Where
- Taiwan
- Volunteers
- 78 people
- Sponsor
- Chang Gung University
Asthma
Non-invasive Measures of Effects of Xolair in Asthma
The purpose of this study is to look at the effectiveness of Xolair® (omalizumab) in people with asthma taking Advair Diskus®. The study will look at the effects of Xolair® on lung function using high resolution computed…
- Trial name
- NCT00784485
- Testing
- Xolair injections
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of California, Los Angeles
Pulmonary Fibrosis
Dyspnea and Idiopathic Pulmonary Fibrosis
Longitudinal prospective exploratory study on the evolution of dyspnea, in its sensory and affective dimensions, in patients followed for idiopathic pulmonary fibrosis (IPF), between inclusion and a 6-month evaluation
- Trial name
- DYS-PID (NCT04864990)
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Lille
Hydrostatic Pulmonary Edema, Acute Respiratory Failure
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema.
- Conditions
- Hydrostatic Pulmonary Edema, Acute Respiratory Failure, Dyspnea
- Trial name
- DYSP-ED-US (NCT07324980)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Pain Intractable, Delirium
Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients
Cancer patients with very difficult to control symptoms at the Abbotsford (AC) and Fraser Valley (FVC) Cancer Centers are referred and admitted to the Tertiary Palliative Care Units at the Abbotsford Regional Hospital and Cancer…
- Conditions
- Pain Intractable, Delirium, Dyspnea, Nausea
- Trial name
- NCT01687751
- Testing
- Dexmedetomidine, Midazolam
- Where
- Canada
- Sponsor
- Fraser Health
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