Clinical trials: Dyspnoea
Idiopathic Pulmonary Fibrosis (IPF)
Morphine for Dyspnea in Pulmonary Fibrosis
"Determination of the effectiveness of nebulized morphine in the treatment of dyspnea in patients with advanced idiopathic pulmonary fibrosis"
- Trial name
- NCT04497831
- Testing
- Morphine hydrochloride
- Volunteers
- 20 people
- Sponsor
- Medical University of Gdansk
Pulmonary Disease, Chronic Obstructive
PEP Buddy Impact on Breathing, Exercise, and Sleep Quality in COPD Patients
Exercise intolerance and sleeping problems are among the most common symptoms experienced by patients with chronic obstructive pulmonary disease (COPD), which is associated with lung dynamic hyperinflation (DH).
- Trial name
- NCT06290245
- Testing
- PEP Buddy, aerobic exercise
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Dyspnea Caused by 2019-nCoV
Bevacizumab in Post-acute Sequelae of COVID-19 : Efficacy and Safety (Pilot Study)
The aim of this research is to evaluate an innovative treatment, Bevacizumab, in patients suffering from respiratory complications related to COVID-19.
- Trial name
- BASECOVID (NCT07089719)
- Testing
- Bevacizumab Injection
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress
Virtual Reality Application During High Flow Nasal Oxygen Therapy in Children Effect on Anxiety Levels
Determination of the effect of virtual reality goggles used during high-flow oxygen therapy on child anxiety in children
- Trial name
- NCT06886828
- Testing
- Virtual reality goggles during HFNC, HFNC oxygen therapy with routine service application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Uskudar University
Pulmonary Disease, Chronic Obstructive
Shortness Of Breath Questionnaire Validation Study
This study will last for approximately 8 weeks and will involve 4 visits. The study is being carried out to validate a shortness of breath questionnaire
- Trial name
- NCT00411372
- Testing
- fluticasone propionate/salmeterol 250/50mcg combination, salmeterol 50mcg
- Sponsor
- GlaxoSmithKline
Dyspnea, Hypercapnia
Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs
This study will evaluate the ability of High Velocity Nasal Insufflation [HVNI] next generation nasal cannula designs to effect ventilation and related physiological responses relative to the conventional legacy cannula design.
- Conditions
- Dyspnea, Hypercapnia, Respiratory Insufficiency
- Trial name
- NCT04512781
- Testing
- Control Cannula - Prosoft Cannula - Unicorn Cannula, Control Cannula - Unicorn Cannula - Prosoft Cannula
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Vapotherm, Inc.
Dyspnea
Pulmonary Function Test, Bronchial Hyperresponsiveness and Quality of Life in Patients With Vocal Cord Dysfunction (VCD)
Vocal cord dysfunction is a rare clinical picture. It is labeled as a sudden and threatening dyspnea. Patients with VCD may also present cough, hoarseness, wheezing, and chest tightness, but an inspiratory stridor is the most…
- Trial name
- VCD (NCT00906867)
- Testing
- Methacholine challenge testing, Rhino-laryngoscopy
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Neonates, Respiratory Distress
Non-invasive Secondary Respiratory Support in Late Preterm and Term Infants
The aim of the present work is to compare between various modes of non-invasive respiratory support (including NCPAP, NIPPV, and NHFOV) as secondary respiratory support modes in late preterm and term neonates as regards the need…
- Conditions
- Neonates, Respiratory Distress, Non- Invasive Ventilation
- Trial name
- NCT07000071
- Testing
- NCPAP, NIPPV, NHFOV
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pulmonary Complications, Quality of Life
Theophylline in Treating Cancer Patients With Shortness of Breath
RATIONALE: Theophylline may help to relieve shortness of breath in patients who have cancer. It is not yet known whether theophylline is more effective than no further treatment for shortness of breath.
- Conditions
- Pulmonary Complications, Quality of Life, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00003684
- Testing
- theophylline, quality-of-life assessment
- Where
- 4 sites in Canada
- Volunteers
- 3 people
- Sponsor
- NCIC Clinical Trials Group
Chest Pain, Dyspnea
Emergency Department Cardiac Ultrasound
This is a prospective observational study evaluating the diagnostic utility of cardiac ultrasound in patients who present to the emergency department with undifferentiated chest pain or shortness of breath.
- Trial name
- NCT02719509
- Testing
- Cardiac Ultrasound
- Where
- United States
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Hennepin Healthcare Research Institute
Pulmonary Artery Hypertension
Evaluation of Respiratory Muscle in Patient With Pulmonary Arterial Hypertension
The aim of the study is that evaluation of basic and accessory respiratory muscles and their relationship of six minute walk test in patient with pulmonary arterial hypertension (PAH)
- Trial name
- NCT05056532
- Testing
- patient assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Giresun University
Pleural Effusion, Dyspnea
Thoracentesis: Symptoms and Prediction of the Need for Therapeutic Thoracentesis
Recurrent fluid surrounding the lungs is associated with poor quality of life, the main symptom being dyspnea. These patients are in need of recurrent removal of the fluid using drainage.
- Conditions
- Pleural Effusion, Dyspnea, Patient Reported Outcomes, Diaphragm Movement
- Trial name
- NCT04236934
- Testing
- Assesment of diaphragm shape and diaphragm movement (by M-mode and the AREA-method) by ultrasound before and after thoracentesis
- Where
- 2 sites in Denmark
- Volunteers
- 107 people
- Sponsor
- Naestved Hospital
Chronic Heart Failure
Dissertation Project Title: Effects of a Mindfulness-Based Intervention in Chronic Heart Failure
Patients with Chronic Heart Failure diagnosed and conventional treated, but still symptomatic (i.e. breathlessness, fatigue) is invited. Eligible patients are randomised to (1) care as usual (i.e.
- Trial name
- NCT04871178
- Testing
- Mindfulness-based intervention
- Volunteers
- 50 people
- Sponsor
- Göteborg University
Allergy, Respiratory Distress
Primary Allergy and Its Impact on the Occurrence of Respiratory Distress in Infants at 12 Months of Age
The number of people with allergies has been steadily increasing over the years. Symptoms in infants, such as bronchiolitis, gastroesophageal reflux, eczema, or atopic dermatitis, can be early warning signs of allergies in…
- Conditions
- Allergy, Respiratory Distress, Atopic Manifestations, Immediate Postnatal Parameters
- Trial name
- AIRE (NCT07832643)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 508 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
COPD, Dyspnea
Improving Quality of Life and Daily Life Activities With Bioarginine in Patients With COPD
Different studies have suggested that COPD is associated with elevated alveolar NO and increased expression of NOS2 in alveolar walls, small airway epithelium and vascular smooth muscle.
- Conditions
- COPD, Dyspnea, Argininemia
- Trial name
- NCT05412160
- Testing
- Arginine
- Where
- Italy
- Volunteers
- 153 people
- Sponsor
- University of Milan
Chronic Obstructive Pulmonary Disease
Benefits and Costs of Home-based Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease
Pulmonary rehabilitation is an effective treatment for people with chronic obstructive pulmonary disease (COPD) which improves symptoms, reduces hospitalisation and lowers healthcare costs.
- Trial name
- HomeBase (NCT01423227)
- Testing
- Home-based pulmonary rehabilitation, Hospital-based pulmonary rehabilitation
- Where
- 2 sites in Australia
- Volunteers
- 144 people
- Sponsor
- La Trobe University
Pulmonary Disease, Chronic Obstructive
Does Pulmonary Rehabilitation Improve Breathing of COPD Patients
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death world-wide. Dyspnea (i.e., sensations of breathlessness) is the hallmark symptom of patients with this disease.
- Trial name
- PR-COPD (NCT01815970)
- Testing
- Pulmonary Rehabilitation
- Where
- Canada
- Sponsor
- University of British Columbia
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs
Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients.
- Trial name
- NCT02436213
- Testing
- Cardiopulmonary exercise test, Blood test
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Idiopathic Pulmonary Fibrosis
Beneficial Effects of Pulmonary Rehabilitation for Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating disease marked by progressive lung scarring leading to multiple life-altering sequelae.
- Trial name
- NCT01107028
- Testing
- Standard pulmonary rehabilitation program
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Jewish Health
Coronary Artery Disease
Stem Cell Mobilization to Treat Chest Pain and Shortness of Breath in Patients With Coronary Artery Disease
This two-part study will determine whether stem cells (primitive cells produced by the bone marrow that can develop into blood cells or other types of cells) can be pushed out into the bloodstream, relocate in the heart, and grow…
- Trial name
- NCT00043628
- Testing
- Stem Cell Mobilization
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
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