Clinical trials: Dyssomnia
Narcolepsy
Safety and Efficacy of THN102 on Sleepiness in Narcoleptic Patients
This Phase 2 study is a 8-site, double-blind, randomised, placebo-controlled, 3-way cross-over trial, involving 3 treatments with Modafinil 300 mg or the combination drug THN102 (Modafinil/Flecainide 300 /3 mg…
- Trial name
- NCT02821715
- Testing
- THN102 300/3, THN102 300/27
- Where
- 8 sites in Belgium, France
- Volunteers
- 51 people
- Sponsor
- Theranexus
Dyslipidemia, Sleep Apnea Syndrome
Effect of Fenofibrate on Sleep Apnea Syndrome
Objectives: to investigate for the potential effect of fenofibrate on symptoms and biological changes associated with sleep apnea syndrome.
- Conditions
- Dyslipidemia, Sleep Apnea Syndrome, Overweight, Obesity
- Trial name
- NCT00816829
- Testing
- Fenofibrate
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Solvay Pharmaceuticals
Insomnia
Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1)
This study will be conducted to demonstrate, using polysomnography, that lemborexant 10 milligrams (mg) and 5 mg is superior to placebo on objective sleep onset as assessed by latency to persistent to sleep (LPS) after the last 2…
- Trial name
- SUNRISE 1 (NCT02783729)
- Testing
- Lemborexant, Zolpidem tartrate
- Where
- 102 sites in United States, Canada and 5 more
- Volunteers
- 1,006 people
- Sponsor
- Eisai Inc.
Obstructive Sleep Apnea
Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep Apnea
The purpose of this study is to evaluate the benefits and risks of hypoglossal nerve stimulation with the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System as a potential therapeutic option for individuals with moderate…
- Trial name
- NCT01446601
- Testing
- Hypoglossal Nerve Stimulation (HGNS) System (Apnex Medical )
- Where
- 14 sites in United States, Australia
- Volunteers
- 132 people
- Sponsor
- Apnex Medical, Inc.
Restless Legs Syndrome
Long-Term Safety Of Ropinirole XR In Patients With Restless Legs Syndrome
The primary objective of this study is to assess the safety and tolerability of ropinirole XR in the long-term treatment (up to 52 weeks)of adults with RLS.
- Trial name
- NCT00355641
- Testing
- Ropinirole Extended Release (XR)
- Where
- 65 sites in United States, Canada
- Volunteers
- 450 people
- Sponsor
- GlaxoSmithKline
Obstructive Sleep Apnea, Sleep Apnea
Severe OSA Study (SOS)
This study is a prospective, multi-center, single-arm, open-label study evaluating the safety and effectiveness of therapy with the ProSomnus EVO Sleep and Snore Device in individuals with severe obstructive sleep apnea.
- Trial name
- NCT05445869
- Testing
- ProSomnus® EVO Sleep and Snore Device
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- ProSomnus Sleep Technologies
Obstructive Sleep Apnea (OSA)
Clinical Trial of the Cryosa System for the Treatment of Obstructive Sleep Apnea (ARCTIC_AUS)
This is a prospective, multicenter, non-randomized single-arm safety and performance study to collect data to evaluate the safety of the Cryosa procedure to treat obstructive sleep apnea (OSA) in patients with moderate to severe…
- Trial name
- NCT07021833
- Testing
- Cryosa Procedure
- Sponsor
- Cryosa, Inc.
Sleep Initiation and Maintenance Disorders, Alzheimer Disease
Safety and Efficacy of Suvorexant (MK-4305) for the Treatment of Insomnia in Participants With Alzheimer's Disease (MK-4305-061)
This study aims to examine the safety and efficacy of suvorexant (MK-4305) to improve sleep in individuals with Alzheimer's disease (AD).
- Trial name
- NCT02750306
- Testing
- Suvorexant
- Volunteers
- 285 people
- Sponsor
- Merck Sharp & Dohme LLC
Sleep Apnea, Obstructive
Oxygen Saturation Monitoring During Surgery
Patients with Obstructive Sleep Apnea (OSA) have cyclical patterns of lower blood oxygen during sleep because of repeated episodes of upper airway obstruction that cause their breathing to stop.
- Trial name
- NCT01098851
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Medtronic - MITG
Narcolepsy
Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Armodafinil in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy
This study is to evaluate the pharmacokinetics, pharmacodynamics, and safety of single and multiple doses of armodafinil (50, 100, and 150 mg/day) in children and adolescents with excessive sleepiness associated with narcolepsy.
- Trial name
- NCT01624480
- Testing
- Armodafinil
- Where
- 24 sites in United States, Finland
- Volunteers
- 40 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Sleep Initiation and Maintenance Disorders, Sleep Disorders
A Double-blind, Group-comparison Study Using Zolpidem (Myslee) as a Comparative Drug in Patients With Insomnia
The purpose of this study is to investigate the efficacy and safety of FK199B (Zolpidem MR Tablet) in patients with insomnia by a randomized, double-blind, group-comparison study using zolpidem (Myslee) as a comparative drug
- Trial name
- NCT00283946
- Testing
- Zolpidem MR, Zolpidem
- Where
- 8 sites in Japan
- Volunteers
- 876 people
- Sponsor
- Astellas Pharma Inc
Obstructive Sleep Apnea
Crossover Trial of AD109 in Obstructive Sleep Apnea
This is a randomized, 4-period, placebo-controlled, crossover, phase 2 clinical study to examine the efficacy and safety of AD109 versus its individual components or placebo in patients with obstructive sleep apnea.
- Trial name
- NCT04580394
- Testing
- AD109, Atomoxetine, R-oxybutynin
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Apnimed
Sleep Disturbance
A Study of a Sleep Supplement to Improve Sleep in Women Going Through Menopause
This study evaluated whether a daily dietary sleep supplement could improve sleep in women aged 40 to 65 who experience moderate sleep disturbances during menopause.
- Trial name
- NCT07375095
- Testing
- Sleep Supplement
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Bonafide Health
Obstructive Sleep Apnea, Snoring
LinguaFlex Tongue Retractor (LTR) for the Treatment of OSA and Snoring in Adults
The LinguaFlex™ Tongue Retractor (LTR) is an investigational medical device that is inserted into the tongue to lessen its backward movement during sleep.
- Trial name
- NCT04129229
- Testing
- LinguaFlex Tongue Retractor (LTR)
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Linguaflex, Inc.
Insomnia
The Assessment of Human Sleep and Its Functions
The purpose of this study is to look at the effects of targeted brain stimulation when falling asleep and on sleep quality.
- Trial name
- SS_Sleep (NCT07211646)
- Testing
- Fixed tES, Personalized tES
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- StimScience Inc.
Obesity, Overweight
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have knee osteoarthritis (OA)…
- Conditions
- Obesity, Overweight, Osteoarthritis, Knee, Obstructive Sleep Apnea
- Trial name
- TRIUMPH-1 (NCT05929066)
- Testing
- Retatrutide
- Where
- 134 sites in United States, Australia and 10 more
- Volunteers
- 2,335 people
- Sponsor
- Eli Lilly and Company
Narcolepsy Type 1 (NT1), Narcolepsy With Cataplexy
A Trial of TAK-861 for the Treatment of Narcolepsy With Cataplexy
The main aim of this study is to assess how effective TAK-861 is for treating narcolepsy type 1 and if this effect is maintained over time.
- Trial name
- NCT07363720
- Testing
- TAK-861
- Where
- 25 sites in United States, France and 5 more
- Volunteers
- 98 people
- Sponsor
- Takeda
Insomnia
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Neu-P11 in Subjects With Primary Insomnia
The primary objective of the study is to evaluate the safety and tolerability of Neu-P11, following the administration of multiple ascending oral doses (2, 5, 20, 50 mg or matching placebo) given nightly over 2 periods of 5 days…
- Trial name
- NCT01114126
- Testing
- Neu-P11
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Neurim Pharmaceuticals Ltd.
Obstructive Sleep Apnea
Study of TAK-925 in Participants With Obstructive Sleep Apnea (OSA) Who Are Experiencing Excessive Daytime Sleepiness (EDS) Despite Adequate Use of Continuous Positive Airway Pressure (CPAP)
The purpose of this study is to evaluate the safety and tolerability of administering a single intravenous (IV) infusion dose of TAK-925 to adults with obstructive sleep apnea (OSA) who are experiencing excessive daytime…
- Trial name
- NCT04091425
- Testing
- TAK-925
- Where
- 18 sites in United States
- Volunteers
- 25 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS)
Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation
To evaluate the safety and effectiveness of the Automatic Expiratory Positive Airway Pressure (Auto-EPAP) feature versus manual expiratory positive airway pressure (EPAP) in the Vivo 45 LS Ventilator.
- Conditions
- Obstructive Sleep Apnea, Obesity Hypoventilation Syndrome (OHS), Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Diseases (NMD)
- Trial name
- Vivo NOVA (NCT06560411)
- Testing
- Non-Invasive Ventilation
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Breas Medical, Inc.
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