Clinical trials: Dyssomnia
Major Depressive Disorder, Sleep Disturbance
A Transdiagnostic Sleep and Circadian Treatment for Major Depressive Disorder
This study will examine the use of a transdiagnostic Sleep and Circadian Treatment (TranS-C) in treating Major Depressive Disorder (MDD) in Chinese adults.
- Trial name
- NCT03786731
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Restless Legs Syndrome
Sequential Compression Devices for Treatment of Restless Legs Syndrome
The purpose of this study is to determine if sequential compression devices (SCD) when worn for an hour per day by patients suffering from Restless Legs Syndrome (RLS) are helpful for the improvement of the RLS symptoms and sleep.
- Trial name
- NCT00479531
- Testing
- AirCast Sequential Compression Device
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Walter Reed Army Medical Center
Caregiver Burden
A Study on the Relationship Between Caregiver Burden, Resilience, and Sleep Quality in Individuals Providing Care for Bedridden Patients
This observational study aims to examine the relationship between caregiver burden, psychological resilience, and sleep quality in individuals providing care for bedridden patients, particularly in the context of palliative care.
- Trial name
- Caregiver (NCT07131930)
- Testing
- Caregiver Burden, Psychological Resilience, Sleep Quality
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- UĞUR UZUN
Sleep Disturbance, Sleep Problems
Transdiagnostic Sleep Intervention to Improve Mental Health in Adolescents
This cluster randomized controlled trial will evaluate whether a brief, school-based group adaptation of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) improves sleep and mental health in…
- Conditions
- Sleep Disturbance, Sleep Problems, Substance Use (Drugs, Alcohol), Anxiety
- Trial name
- SLEEP-TEEN (NCT07865728)
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction, Healthy habits psychoeducation
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Sleep Disorder, Sleep, Inadequate
Measuring Sleep Quality In Patients That Posterior Spinal Instrumentatıon Plannıng
Postoperative sleep disorders have serious problems with cognition, pain perception, sustained circadian rhythm, psychomotor function, metabolic function, catabolic responses, and continuity.
- Conditions
- Sleep Disorder, Sleep, Inadequate, Total ıntravenous Anesthesia, Inhalation Anesthesia
- Trial name
- NCT06269328
- Testing
- Total ıntravenous anesthesia with propofol and remifentanil for anesthetic maintenance, Inhalation anesthesia with sevoflurane for anesthetic maintenance
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Uludag University
Obstructive Sleep Apnea Syndrome
Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients
To study the effect of Xyrem (9 g), Xyrem (9 g) plus modafinil 200 mg administered the morning prior to Xyrem, positive control (zolpidem 10 mg), and placebo on the frequency and outcome of events of sleep-disordered breathing in…
- Trial name
- NCT00086281
- Testing
- Xyrem (X), Zolpidem (Z), Modafinil (M)
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- Jazz Pharmaceuticals
Obstructive Sleep Apnea (OSA)
Post-extubation Boussignac CPAP System in Adults With Moderate to Severe Obstructive Sleep Apnea
The purpose of this study is to assess the efficacy of the Boussignac positive airway pressure system (a mask) applied immediately following post-operative extubation in improving lung function in patients with obstructive sleep…
- Trial name
- NCT01877928
- Testing
- Boussignac CPAP device, standard CPAP
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Queen's University
Insomnia
Efficacy and Safety of Longan Syrup in Healthy Volunteers With Insomnia
The objectives of this study were to evaluate efficacy and safety of longan syrup in healthy volunteers with insomnia. Subjects will take 15 ml of longan syrup once a day for 3 months.
- Trial name
- longan (NCT04300036)
- Testing
- longan syrup
- Where
- Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Cancer, Insomnia Chronic
Device Feasibility and Acceptability to Improve Insomnia in Cancer
Sleep disruption is common among young adult cancer survivors for a variety of reasons. Cognitive behavioral therapy for insomnia (CBT-I) has been shown to improve chronic sleep disorders.
- Trial name
- NCT05875129
- Testing
- VAVA prototype
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Medstar Health Research Institute
Obstructive Sleep Apnea
Impact of Automated Education and Follow-up Mechanisms on Patient Engagement
The primary and well-known challenge with continuous positive airway pressure (CPAP) is the incomplete adherence of patients to this therapy.
- Trial name
- EmmiUSleep (NCT02279901)
- Testing
- Telemedicine Education, IVR
- Where
- United States
- Volunteers
- 1,873 people
- Sponsor
- Kaiser Permanente
Insomnia
The Effect of Family History on Insomnia During Sobriety in Alcoholics
The investigators intend to assess the following: the efficacy of CBTi in treating insomnia during recovery, does a family history of alcoholism moderate the insomnia symptoms, does an improvement in insomnia lead to a decrease…
- Trial name
- NCT01603381
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Pain, Head, Sleep Disturbance
Efficacy of Fluoroscopic Guided Atlantoaxial Joint Injection on Head and Neck Pain and Sleep Quality in RA Patients
Efficacy of intra-articular steroid injection for inflamed atlantoaxial joint in patients with rheumatoid arthritis Inclusion criteria Patients with rheumatoid arthritis with MRI findings of atlantoaxial joint inflammation and…
- Trial name
- NCT03606707
- Testing
- Steroids
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Insomnia, Cognitive Disorder
Study on Cognitive Impairment of Insomnia Based on MRI
Insomnia is a common sleep disorder. In recent years, the incidence of insomnia is increasing worldwide. Studies point out that insomnia plays an important role in the pathogenesis of cognitive impairment.
- Conditions
- Insomnia, Cognitive Disorder, MRI
- Trial name
- NCT05659511
- Testing
- MRI
- Where
- China
- Volunteers
- 684 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Prader-Willi Syndrome
A Study of Pitolisant in Patients With Prader-Willi Syndrome
This is a Phase 3, randomized, double-blind, placebo-controlled, multicenter, global clinical study to assess the efficacy and safety of pitolisant in patients living with Prader-Willi syndrome.
- Trial name
- NCT06366464
- Testing
- Pitolisant tablet
- Where
- 57 sites in United States, Australia and 11 more
- Volunteers
- 134 people
- Sponsor
- Harmony Biosciences Management, Inc.
Insomnia
A Preliminary Study of Model-driven Individualized Transcranial Electrical Stimulation for Insomnia
This study is designed to evaluate the efficacy and to explore the best individualized stimulus paradigm of transcranial Electrical Stimulation for insomnia patients.
- Trial name
- NCT05445999
- Testing
- High-Definition transcranial electrical stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Mental Health Center
Narcolepsy Without Cataplexy, Narcolepsy With Cataplexy
Expanded Access Program to Provide Treatment With Pitolisant to Adult Patients in the U.S. With Excessive Daytime Sleepiness Associated With Narcolepsy With or Without Cataplexy
This EAP will be open to provide access to treatment with pitolisant while a U.S. New Drug Application (NDA) is being prepared and submitted for review for marketing approval.
- Trial name
- NCT03433131
- Testing
- Pitolisant
- Where
- 71 sites in United States
- Sponsor
- Harmony Biosciences Management, Inc.
Insomnia Chronic
Efficacy of Sleeping Without Pills (SWOP), an Online Drug Tapering Program
The aims of the study are to determine whether an online drug tapering program can lead to successful drug tapering in hypnotic dependent insomnia and whether such tapering is associated with improved daytime functioning and…
- Trial name
- NCT03194802
- Testing
- Sleeping Without Pills Program, Self-monitoring
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hip Fracture, Delirium
Incidence of Delirium in Hip Fracture Patients Randomized to Regular Hypnotics vs Placebo
To examine the influence of regular hypnotic therapy on the incidence of delirium after hip fracture surgery
- Trial name
- NCT00286936
- Testing
- Zolpidem
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Hvidovre University Hospital
Obstructive Sleep Apnea
Optimal Dosage of Acetazolamide for OSA Treatment
Acetazolamide, a carbonic anhydrase inhibitor, has received some attention as potential treatment for obstructive sleep apnea (OSA).
- Trial name
- NCT04726982
- Testing
- Acetazolamide
- Where
- Belgium
- Volunteers
- 91 people
- Sponsor
- University Hospital, Antwerp
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