Clinical trials: Dyssomnia
OSA - Obstructive Sleep Apnea
Parallel Arm Trial of AD109 and AD504 In Patients With OSA
This is a phase 2 randomized double-blind placebo-controlled parallel-arm dose finding study to compare fixed dose combinations of AD109 and AD504 to atomoxetine or placebo in Obstructive Sleep Apnea.
- Trial name
- MARIPOSA (NCT05071612)
- Testing
- AD109, AD504, Atomoxetine Hydrochloride
- Where
- 25 sites in United States
- Volunteers
- 294 people
- Sponsor
- Apnimed
Obesity Hypoventilation Syndrome
AVAPS-AE Efficacy Study
The purpose of this study is to evaluate the feasibility of using of the Average Volume Assured Pressure Support (AVAPS-AE) mode versus Continuous Positive Airway Pressure (CPAP) and bilevel pressure support ventilation (PSV)…
- Trial name
- NCT01368614
- Testing
- AVAPS-AE Mode of Therapy, Respironics OnmiLab BiPAP S mode, Respironics OmniLab Advanced CPAP mode
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Philips Respironics
Narcolepsy
Study of MK-6552 in Participants With Narcolepsy Type 1 (MK-6552-004)
The purpose of this study was to evaluate the safety, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of MK-6552 in participants with Narcolepsy Type 1 (NT1).
- Trial name
- NCT06179407
- Testing
- MK-6552
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- Merck Sharp & Dohme LLC
Insomnia, End Stage Renal Disease
Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis
Insomnia is a common and distressing symptom for patients on hemodialysis (HD), and there is evidence for a much larger impact on the health of patients.
- Trial name
- Sleep-HD (NCT03534284)
- Testing
- Cognitive Behavioral Therapy for Insomnia, Trazodone
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of Washington
Lung Diseases, Sleep Apnea Syndromes
Apnea Positive Pressure Long-Term Efficacy Study
The purpose of this study is to determine the effectiveness of nasal continuous positive airway pressure (CPAP) therapy for the treatment of obstructive sleep apnea syndrome (OSAS).
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Sleep
- Trial name
- APPLES (NCT00051363)
- Testing
- Active CPAP
- Where
- 5 sites in United States
- Volunteers
- 1,105 people
- Sponsor
- Stanford University
Type 2 Diabetes, Sleep Disordered Breathing
Impact of Exenatide on Sleep in Type 2 Diabetes
The investigators propose a pilot study to test the novel hypothesis that Exenatide treatment in patients with type 2 diabetes results in improved sleep duration and quality and to explore the relationship between improvements in…
- Trial name
- NCT01136798
- Testing
- Exenatide
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Chicago
Childhood Cancer, Insomnia
eHealth Insomnia Intervention for Adult Survivors of Childhood Cancer
There is evidence that survivors of childhood cancer have a high prevalence of poor sleep, including symptoms of insomnia. Insomnia is highly comorbid and has been associated with impaired cognitive performance, a range of…
- Conditions
- Childhood Cancer, Insomnia, Neurocognitive Impairment, Survivorship
- Trial name
- NCT04317742
- Testing
- Sleep Healthy Using the Internet (SHUTi) Intervention Group, Online Patient Education (PE) Control Group
- Where
- United States
- Volunteers
- 1,554 people
- Sponsor
- St. Jude Children's Research Hospital
Insomnia, Spinal Cord Injury
Functional Melatonin Replacement for Sleep Disruptions in Individuals With Tetraplegia
The purpose of this study is to determine if replacing melatonin function with a melatonin agonist (ramelteon) in individuals that lack endogenous melatonin production (tetraplegia) helps to alleviate self-reported sleep…
- Conditions
- Insomnia, Spinal Cord Injury, Tetraplegia, Sleep Disorders
- Trial name
- NCT00507546
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Polycystic ovary syndrome (PCOS) affects 5-10% of women in the United States. Its onset is usually at the time of puberty with manifestations of menstrual irregularity, hirsutism, and obesity.
- Trial name
- NCT00203996
- Testing
- continuous positive airway pressure (CPAP), depot leuprolide plus estrogen/progestin replacement, pioglitazone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obstructive Sleep Apnea
Self-Management of Continuous Positive Airway Pressure Settings
Obstructive sleep apnea (OSA) is a major chronic condition affecting the quality of life of millions of Americans. Per the Institute of Medicine new treatment adherence strategies are needed to help improve the quality of care…
- Trial name
- ImPRESS (NCT03536572)
- Testing
- Sleep Apnea Self-Management Program
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- VA Office of Research and Development
Insomnia, Mental Health Issue
Investigating a Sleep Intervention for Adolescents Attending Mental Health Services
The overall objectives of the study are to: 1. To assess the feasibility of delivering the Strathclyde Sleep Intervention to adolescents with co-morbid insomnia and mental health attending a mental health services The following…
- Trial name
- NCT05870228
- Testing
- Strathclyde Sleep Intervention
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Stephanie McCrory
Diabetes, Sleep Apnea
Effective Treatment of Sleep Apnea in Prediabetes to Reduce Cardiometabolic Risk
Although obstructive sleep apnea (OSA) is associated with impaired glucose tolerance and diabetes, it remains unclear whether OSA treatment with continuous positive airway pressure (CPAP) has metabolic benefits.
- Trial name
- NCT01156116
- Testing
- CPAP mask
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Chicago
Sleep Apnea Syndromes
Servo-Ventilation In-lab PSG Evaluation
Continuous Positive Airway Pressure (CPAP) is the most effective treatment for the Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). CPAP stabilizes the airway and prevents instability and collapse.
- Trial name
- NCT02808338
- Testing
- Philips BiPAP AutoSV Advanced System One, Modified Philips BiPAP ASV, ResMed S7 VPAP Adapt
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Philips Respironics
Apnea, Sleep
Radiofrequency Ablation for Multi-level Obstructive Sleep Apnea: A Single-arm, Multicenter Study
The United States is currently experiencing an increase in the incidence and prevalence of obstructive sleep apnea (OSA). With prevalence in middle-aged adults of 2 to 4% of the population, untreated OSA has been implicated in…
- Trial name
- NCT02349893
- Testing
- RFA treatment
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- Olympus Surgical Technologies Europe
Obstructive Sleep Apnea (OSA)
Pilot Study of the Comparison of the Upper Airway Dynamics of Oronasal vs Nasal Masks With PAP Treatment
Our group has recently found that the choice of positive airway pressure mask can significantly affect the pressure required to adequately treat sleep disordered breathing.
- Trial name
- Mask_MRI (NCT01939938)
- Testing
- Nasal and Oronasal PAP Mask
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Insomnia
Effects of Suvorexant in Patients With Chronic Obstructive Pulmonary Disease (MK-4305-032)
This study will evaluate the safety, tolerability, and effect of multiple doses of suvorexant (MK-4305) on respiratory function in participants with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01293006
- Testing
- suvorexant
- Volunteers
- 25 people
- Sponsor
- Merck Sharp & Dohme LLC
HIV-1-infection, Sleep Deprivation
Poor Sleep and Inflammation in HIV-Infected Adults
People living with HIV (PLWH) often have poor sleep, which may put them at a higher risk for many chronic diseases, including cardiovascular disease.
- Conditions
- HIV-1-infection, Sleep Deprivation, Inflammation
- Trial name
- SASH (NCT03848325)
- Testing
- Sleep deprivation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Sleep Apnea, Obstructive
Investigation of a Novel Sleep Surface for Treatment of Positional Sleep Apnea
Body position during sleep influences the severity of obstructive sleep apnea (OSA). The AHI is the number of times per hour of sleep that the airway temporarily collapses at the level of the tongue or soft palate.
- Trial name
- NCT02250417
- Testing
- Wave sleep surface
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ohio State University
Sleep Initiation and Maintenance Disorders
A Study to Assess the Pharmacodynamics of Lemborexant in Korean Participants With Insomnia Disorder
The primary purpose of the study is to evaluate the treatment difference between lemborexant 5 milligram (mg) (LEM5) and placebo (PBO) on latency to persistent sleep (LPS) using polysomnography (PSG) on Day 30.
- Trial name
- NCT05594589
- Testing
- Lemborexant, PBO
- Where
- 9 sites in South Korea
- Volunteers
- 65 people
- Sponsor
- Eisai Co., Ltd.
Insomnia, Fatigue
Cognitive Behavioral Therapy +/- Armodafinil for Insomnia and Fatigue Following Chemotherapy
This is a four-arm, randomized, controlled, clinical trial examining the efficacy of of cognitive behavioral therapy (CBT)-I and armodafinil in reducing insomnia in 226 female breast cancer patients who report sleep disturbances…
- Conditions
- Insomnia, Fatigue, Breast Cancer
- Trial name
- NCT01091974
- Testing
- armodafinil, CBT-I
- Where
- 2 sites in United States
- Volunteers
- 138 people
- Sponsor
- University of Rochester