Clinical trials: Dyssomnia
Heart Failure (HF)
SchlaHF-XT-Register. Sleep Disordered Breathing in Heart Failure Register
The SchlaHF XT Registry is a longitudinal study of patients with heart failure (HF). The study aims to understand the importance of diagnosis and treatment of sleep disordered breathing (SDB) on HF with the following questions…
- Trial name
- NCT02301689
- Where
- Germany
- Volunteers
- 4,749 people
- Sponsor
- ResMed
Chronic Insomnia
Interest of Auriculotherapy in the Management of Chronic Insomnia
The aim of the study is to show that auriculotherapy is effective in the treatment of chronic insomnia.
- Trial name
- AURICULO-DODO (NCT04471168)
- Testing
- Cryo-Auriculotherapy
- Where
- 4 sites in France
- Volunteers
- 65 people
- Sponsor
- Hopital Foch
Sleep Apnea
Oxytocin on HR in Sleep Apnea Patient
In human volunteers intranasal administration of oxytocin significantly increases parasympathetic and decreases sympathetic cardiac control.
- Trial name
- NCT02564068
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- George Washington University
Obstructive Sleep Apnea
Transoral Robotic Surgery (TORS) for Sleep Apnea
The purpose of this study is to assess if the da Vinci® Robotic Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) allows for "adequate exposure" for transoral resection of hypertrophic lingual tonsils in patients with…
- Trial name
- NCT01187160
- Testing
- Transoral robotic surgery (TORS)
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- University of Pennsylvania
Sleep-disordered Breathing
Leukotrienes Pathway in Chinese Children With Sleep-disordered Breathing
Our goals are to demonstrate an active leukotrienes (LTs) mediated inflammatory response is involved in pathophysiology of sleep-disordered breathing (SDB), and to provide a theoretical evidence for LTs modify therapy in treating…
- Trial name
- NCT01344746
- Where
- China
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Beijing Children's Hospital
Obstructive Sleep Apnea, Insomnia
Multidisciplinary Approach to the Treatment of Insomnia and Comorbid Sleep Apnea
The overall goal of this project is to determine the efficacy of a multidisciplinary treatment model for patients with Obstructive Sleep Apnea (OSA) and comorbid Insomnia.
- Trial name
- MATRICS (NCT01785303)
- Testing
- CBT-I, CPAP
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Northwestern University
Obstructive Sleep Apnea
Assessment of OSA in Latin American and Response to Neuromod Therapy
The purpose of this study is to characterize the upper airway of Latin American subjects who have been diagnosed with moderate/severe obstructive sleep apnea (OSA) and assess response to a neuromodulation therapy to treat OSA.
- Trial name
- Trans-Q DISE (NCT06762873)
- Testing
- Drug Induced Sleep Endoscopy with PNS
- Where
- Paraguay
- Volunteers
- 50 people
- Sponsor
- Lunair Medical
Sleep, Sleep Deprivation
Effects of Acute Sleep Deprivation on Individuals With Different APOE Genotypes
This study aims to investigate the effects of 24-hour acute sleep deprivation on plasma Alzheimer's disease biomarkers and multi-omics in individuals with different APOE genotypes, to elucidate the potential role of acute sleep…
- Trial name
- NCT07085754
- Testing
- Sleep Deprivation
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuhui Qiu
Bronchoscopy, Obstructive Sleep Apnea
Upper Airway Collapsibility Evaluation in Different Sedative Levels by Sleep Endoscopy
The purpose of this study is to evaluate the upper airway collapsibility by sleep endoscopy in different sedative levels. Propofol pump infusion will be used to achieve conscious sedation.
- Conditions
- Bronchoscopy, Obstructive Sleep Apnea, Conscious Sedation
- Trial name
- NCT01100554
- Testing
- Sleep endoscopy
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Disorders of Excessive Somnolence
Improving the Assessment of Hypersomnolence
The overall purpose of this study is to employ a pragmatic, multidimensional assessment of hypersomnolence that "piggybacks" on routine clinical care in patients with suspected disorders of central nervous system (CNS)…
- Trial name
- NCT02884505
- Testing
- Pupillometry, Psychomotor Vigilance Task, Auditory Evoked Potential
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of Wisconsin, Madison
Restless Legs Syndrome
A Study to Evaluate the Efficacy and Safety of Cabergoline Compared With Placebo for the Treatment of RLS
The purpose of this study is to evaluate the efficacy and safety of cabergoline compared with placebo on periodic leg movements (PLMS) arousl index and sleep efficiency in patients with RLS.
- Trial name
- NCT00627003
- Testing
- Cabergoline
- Volunteers
- 43 people
- Sponsor
- Pfizer
Obstructive Sleep Apnea
Inspire® Post-Approval Study / Protocol Number 2014-001
The purpose of this study is to obtain additional long-term safety and efficacy data on the use of Inspire therapy.
- Trial name
- NCT02413970
- Testing
- Inspire® UAS System
- Where
- 14 sites in United States
- Volunteers
- 127 people
- Sponsor
- Inspire Medical Systems, Inc.
Chronic Kidney Disease
Sleep Disturbances as a Risk Factor in Chronic Kidney Disease
This study is designed to determine if either short night time sleep or poor night time sleep could be a risk factor for increasing the rate at which kidney function deteriorates in persons with mild to moderate kidney disease.
- Trial name
- CRIC (NCT00817427)
- Testing
- Controls Short sleep, CKD- sleep extension
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Sleep Apnea, Obstructive
SensAwake™ Sleep Quality Trial
The SensAwake™ modification to the Fisher and Paykel automatically titrating positive airway pressure (APAP) device aims to sense whether the patient is awake via respiratory patterns that differentiate between sleep and wake.
- Trial name
- SASQT (NCT00811213)
- Testing
- SleepStyle 200 Auto Series with SensAwake, SleepStyle 200 Auto Series with out SensAwake
- Where
- Australia
- Volunteers
- 45 people
- Sponsor
- Fisher and Paykel Healthcare
ESRD, Sleep Apnea
Identification of Desaturation Episodes by Means of Continuous Measurement of Oxygen Saturation During Hemodialysis
The clinical diagnosis of sleep apnea is difficult among ESRD patients since the characteristic clinical features of sleep apnea may be absent and since sleep-related symptoms, such as fatigue and sleepiness, may be attributed to…
- Conditions
- ESRD, Sleep Apnea, Oxygen Deficiency
- Trial name
- NCT02987179
- Testing
- Observational
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Renal Research Institute
Obstructive Sleep Apnea
Comparing Auto-adjustable Positive Airway Pressure to Continuous Positive Airway Pressure in Children With Sleep Apnea
The purpose of this research study is to determine if auto-adjustable positive airway pressure (APAP) is an effective way to treat obstructive sleep apnea (OSA) in children.
- Trial name
- NCT01846988
- Testing
- crossover treatment (REMstar Auto A-Flex)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Sleep Disorder, Shift-Work
Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers
The purpose of this study is to test the hypothesis that ingestion of the wake-inhibiting drug suvorexant 30 minutes prior to daytime sleep initiation in individuals working overnight shifts will significantly improve both…
- Trial name
- NCT02491788
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Sleep Deprivation
Characterisation of Gut Microbiota, Bispectral Index Data and Plasma Kynurenine in Patients Undergoing Thyroid Surgery
The study is a case-controlled observational trial. Forty patients will be divided into 2 groups (good or poor sleepers) depending on their first postoperative night Bispectral index data.
- Trial name
- NCT03981770
- Testing
- General anesthesia
- Where
- China
- Volunteers
- 33 people
- Sponsor
- China Medical University, China
Sleep Apnea, Obstructive, Hypopnea Syndrome
Treatment of Refractory Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) Using Nasal Continuous Positive Airway Pressure (nCPAP) Therapy (0249-015)
The purpose of this study is to determine the safety and efficacy of MK0249 in treating refractory excessive daytime sleepiness (EDS) in patients with Obstructive Sleep Apnea/Hypopnea Syndrome (OSA/HS) using nasal continuous…
- Conditions
- Sleep Apnea, Obstructive, Hypopnea Syndrome, Excessive Daytime Sleepiness
- Trial name
- NCT00620659
- Testing
- Comparator: MK0249, Comparator: modafinil
- Volunteers
- 125 people
- Sponsor
- Merck Sharp & Dohme LLC
Narcolepsy
Trial of Xyrem® (Sodium Oxybate) for the Treatment of Narcolepsy
This is a long-term, open-label, extension of the OMC-SXB-7 trial. Participants from the OMC-SXB-7 open-label trial may be entered without any requirement as to length of participation in that trial.
- Trial name
- NCT00132873
- Testing
- Xyrem (sodium oxybate) oral solution
- Where
- Canada
- Volunteers
- 59 people
- Sponsor
- Jazz Pharmaceuticals
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