Clinical trials: Dyssomnia
Major Depressive Disorder, Insomnia
Brain Mechanisms and Targeting Insomnia in Major Depression
Preliminary studies suggest that the response to antidepressant medication can be accelerated by targeting insomnia with adjunctive use of eszopiclone.
- Trial name
- NCT00628914
- Testing
- escitalopram and eszopiclone, Escitalopram
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Stress, Physiological, Stress, Emotional
Psychophysiological Effects of Controlled Respiration and Mindfulness
The investigators aim to understand the effectiveness of 3 types of breathwork exercises and a mindfulness meditation control on improving psychological and physiological measures of wellbeing.
- Conditions
- Stress, Physiological, Stress, Emotional, Insomnia
- Trial name
- PECRM (NCT05304000)
- Testing
- Mindfulness Meditation, Cyclic Sighing Breathing, Box Breathing
- Where
- 2 sites in United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obstructive Sleep Apnea
Efficacy Study of CPAP on Nitrate and Norepinephrine Levels in Severe and Mild-moderate Sleep Apnea (SABIO)
Reduced plasma nitrate (NOx) levels and increased urinary norepinephrine (U-NE) levels have been described in severe obstructive sleep apnea (OSA), and are reverted by continuous positive airway pressure (CPAP).
- Trial name
- SABIO (NCT01769807)
- Testing
- CPAP
- Where
- Portugal
- Volunteers
- 67 people
- Sponsor
- University of Lisbon
Obstructive Sleep Apnea
Impact of Sugammadex vs. Neostigmine Reversal on Post-Operative Recovery and Complications
Sugammadex or neostigmine are given at the end of the surgery to reverse neuro muscular blocking drugs (NMBD). This study will evaluate whether reversal of NMBD with sugammadex is associated with faster recovery than neostigmine…
- Trial name
- Sugammadex (NCT03679611)
- Testing
- Sugammadex Sodium, Neostigmine
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Sickle Cell Disease
Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events
Hypothesis is that the occurrence of nocturnal Vaso-Occlusive Crisis (VOC) and priapism in adults might be related to episodes of nocturnal desaturation secondary to a sleep apnea syndrome.
- Trial name
- DREPASOM (NCT02539771)
- Testing
- Polysomnography and blood sample
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Mountain Sickness, High Altitude
CO2 Supplement for Treatment of Acute Mountain Sickness
It was reported that up to 76% people who rapidly ascend to the altitude higher than 4500 m without sufficient acclimatization will have AMS which often develops 6-8 hours after reaching at high altitude.
- Conditions
- Acute Mountain Sickness, High Altitude, Inhalation; Gas
- Trial name
- NCT06393998
- Testing
- Breathing with CO2 during daytime and night at high altitude, Sleep and doing exercise test under inhalation of air
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- State Key Laboratory of Respiratory Disease
Obesity, Chronic Sleep Deprivation
Chronic Sleep Deprivation as a Risk Factor for Metabolic Syndrome and Obesity
OBJECTIVE: Obesity and chronic sleep deprivation have both become increasingly pervasive medical problems in recent years. The prevalence of adult obesity has doubled over the past 30 years and continues to increase.
- Trial name
- NCT00261898
- Testing
- Increase sleep
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Neck Pain
Sustained Natural Apophysial Glides (SNAGs) Technique in Non-Specific Neck Pain Patients
Mechanical neck pain is defined for the absence of cervical spinal pathologies.With the SNAGs mobile mobilization method, it reveals effective results in cases of limitation and pain in the cervical joints.Although there are…
- Trial name
- NCT05425706
- Testing
- application of SNAGs technique
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Thoracic Aortic Aneurysm
Incidence of Major Complication in Case of Thoracic Aortic Aneurysm
Thoracic aneurysm is a silent disease with a potential mid-term high risk of death or major complications. Few data are available on the real incidence of major complications in case of small and moderate thoracic aneurysm.
- Trial name
- MOTAAR (NCT05395598)
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Lille
Obstructive Sleep Apnea
Evaluation of a Nasal Mask for the Treatment of Obstructive Sleep Apnea in New Zealand
Currently, Fisher and Paykel Healthcare (FPH) is developing a new nasal mask. This investigation is designed to evaluate the performance of the trial nasal mask, focused specifically on how the different seal sizes will perform…
- Trial name
- NCT02541214
- Testing
- Trial Nasal Mask
- Where
- 2 sites in New Zealand
- Volunteers
- 39 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea
Whole Body Vibration for OSA
Obstructive Sleep Apnea (OSA) is a serious medical condition which is increasing in the United States and significantly increases risks for other diseases, morbidity and mortality.
- Trial name
- NCT03377621
- Testing
- Whole Body Vibration
- Where
- United States
- Sponsor
- University of California, Los Angeles
Sleep Deprivation, Hippocampal Atrophy
Chronic Sleep Deprivation and Changes in Cortical and Hippocampal Volume
Sleep is a physiological state that is essential for human performance, including academic, occupational, interpersonal, and psychological aspects.
- Conditions
- Sleep Deprivation, Hippocampal Atrophy, Cortical Irregularity
- Trial name
- NCT06260280
- Testing
- Cerebral Nuclear Magnetic Resonance
- Where
- Mexico
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Insomnia Chronic
Prescription Digital Therapeutic for the Treatment of Insomnia
This will be a prospective multi-center controlled trial of 100 patients conducted to assess the real-world effectiveness of a mobile-delivered, prescription digital therapeutic (PDT) device delivering Cognitive Behavioral…
- Trial name
- SLEEP-I (NCT04909229)
- Testing
- PEAR-003b PDT Intervention, Fitbit, Sleep education materials
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Obstructive Sleep Apnea
Arousal Analysis by Pulse Wave Amplitude in Patients With Obstructive Sleep Apnea
Photoplethysmography is an easy non-invasive method to detect the pulse wave amplitude (PWA) from a finger. This can be measured using the Somnocheck micro system.
- Trial name
- NCT01690429
- Testing
- Somnocheck micro
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Institut für Pneumologie Hagen Ambrock eV
Gambling Disorder Treatment
Behavioral and Cognitive Therapy for Insomnia in the Treatment of Pathological Gambling
Gambling is a public health risk. The wide panel of games available (poker, sport bets, scratch card games, slot machines, stock speculation …) and the advent of the Internet means that this behaviour is increasingly monitored on…
- Trial name
- SOMJEU (NCT06026722)
- Testing
- cognitive behavioral therapy for insomnia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Music Intervention, Sleep Disturbance
Mixed Music Intervention on Sleep Disturbance in Patients With Parkinson's Disease
Parkinson's disease is a disease that is prevalent in the elderly, and the risk increases with age. Sleep disturbance is a common complaint of patients with Parkinson's disease, with a prevalence of 60% to 96%.
- Conditions
- Music Intervention, Sleep Disturbance, Parkinson's Disease
- Trial name
- NCT05489653
- Testing
- mixed music
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Taipei Medical University
Obstructive Sleep Apnea
Personal Therapy Comfort Settings Pilot Clinical Study
350 participants will be enrolled in this study. The target population are patients newly diagnosed with OSA and starting CPAP treatment.
- Trial name
- NCT05376137
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Australia
- Volunteers
- 66 people
- Sponsor
- ResMed
Obesity, Obstructive Sleep Apnea
Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
This Phase 3 clinical trial is designed to evaluate the efficacy and safety of maridebart cafraglutide compared to placebo over a 52-week period in adults with obstructive sleep apnea (OSA) who are receiving positive airway…
- Trial name
- MARITIME-OSA-1 (NCT07225686)
- Testing
- Maridebart cafraglutide
- Where
- 61 sites in United States, Australia and 9 more
- Volunteers
- 250 people
- Sponsor
- Amgen
Restless Legs Syndrome
Effect of Ropinirole on Spinal Cord Reflexes and Restless Legs Syndrome
This study will examine the effects of the drug Ropinirole on spinal cord reflexes and on symptoms of restless legs syndrome (RLS).
- Trial name
- NCT00051961
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Apnea Syndrome
Comparison of Efficacy of Two Mandibular Advancement Devices (MADs) During Sleep
Mandibular Advancement Devices (MADs) are now a reliable alternative to continuous positive airway pressure (CPAP) treatments for Obstructive Sleep Apnea (OSA) .
- Trial name
- SONAR (NCT04474756)
- Testing
- custom-made adjustable mandibular advancement device
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.