Clinical trials: Dyssomnia
Obstructive Sleep Apnea
Clinical Study for the BONGO Device in the Treatment of Obstructive Sleep Apnea (OSA)
Prospective, non-randomized, open label study
- Trial name
- NCT02878590
- Testing
- BONGO DEVICE
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- InnoMed Healthscience Inc.
Chronic Insomnia
CBT-I or Zolpidem/Trazodone for Insomnia
This study is a randomized (1:1:1) comparative effectiveness trial of medication (zolpidem or trazodone), cognitive-behavioral therapy for insomnia (CBT-I), and the combination (medication + CBT-I) for the treatment of chronic…
- Trial name
- COZI (NCT04468776)
- Testing
- Zolpidem, Internet Cognitive Behavioral Therapy for Insomnia (CBT-I), Trazodone
- Where
- 7 sites in United States
- Volunteers
- 155 people
- Sponsor
- California Pacific Medical Center Research Institute
Restless Legs Syndrome
Bupropion and Restless Legs Syndrome
The purpose of this study is to determine if bupropion will improve the symptoms of restless legs syndrome (RLS).
- Trial name
- NCT00621517
- Testing
- Bupropion
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Restless Legs Syndrome
Clinical Evaluation of Ropinirole CR-RLS ( SK&F101468)Tablets in Restless Legs Syndrome
This study was designed to evaluate the safety, pharmacokinetic profile and efficacy in Restless Legs Syndrome patients.
- Trial name
- NCT00530790
- Testing
- ropinirole controlled release (CR)-RLS
- Where
- 11 sites in Japan
- Volunteers
- 35 people
- Sponsor
- GlaxoSmithKline
Non-24-Hour-Sleep-Wake Disorder
Open Label Study to Assess the Absolute Bioavailability of Tasimelteon (HETLIOZ™)
Hetlioz™ (tasimelteon) is used in the treatment of Non-24-Hour-Sleep-Wake Disorder (Non-24). Non-24 is very common in people who are totally blind because light can not reset their body clock.
- Trial name
- NCT02130999
- Testing
- tasimelteon 20 mg capsule, tasimelteon 2 mg I.V.
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Sleep Apnea, Obesity
The Effects of Treating Obese and Lean Patients With Sleep Apnea
The investigators' overall goal is to compare the effect of CPAP treatment on intermediate cardiovascular risk measures in obese versus lean patients with obstructive sleep apnea (OSA).
- Trial name
- PISA (NCT01578031)
- Testing
- Positive Airway Pressure During Sleep (ResMed S9 Elite), Usual Care
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sleep Apnea, Obstructive, Hypotonia
Pilot Study of a Self-Supporting Nasopharyngeal Airway in Hypotonia
Children with hypotonic upper airway obstruction have a high prevalence of severe obstructive sleep apnea, which if not treated has significant clinical consequence.
- Conditions
- Sleep Apnea, Obstructive, Hypotonia, Child, Only
- Trial name
- ssNPA (NCT04846400)
- Testing
- ssNPA
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Obstructive Sleep Apnea
The Impact of Arousal Threshold in Obstructive Sleep Apnea
The investigators hypothesis is that obstructive sleep apnea (OSA) patients with a low arousal threshold may wake up too early during a respiratory event, before upper airway muscles can be activated to achieve stable…
- Trial name
- NCT02264353
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of California, San Diego
Sleep Deprivation, Insufficient Sleep Syndrome
A Study of the Effectiveness and Efficacy of the PowerSleep Device
This study is a randomized, double-blind, placebo-controlled cross-over study designed to evaluate the effectiveness and efficacy of 2 consecutive work days of nightly use of active versus sham PowerSleep devices in adults with…
- Conditions
- Sleep Deprivation, Insufficient Sleep Syndrome, Healthy
- Trial name
- NCT03162328
- Testing
- PowerSleep Stim
- Where
- 7 sites in United States
- Volunteers
- 84 people
- Sponsor
- Philips Respironics
Excessive Sleepiness
Efficacy and Tolerability of Armodafinil in Adults With Excessive Sleepiness Associated With Shift Work Disorder
The primary objective of the study is to determine whether armodafinil treatment is more effective than placebo treatment in patients with excessive sleepiness associated with shift work disorder (SWD) by measuring improved…
- Trial name
- NCT01080807
- Testing
- Armodafinil
- Where
- 63 sites in United States
- Volunteers
- 385 people
- Sponsor
- Cephalon
Obstructive Sleep Apnea, Snoring
Novel Myofunctional Water Bottle to Reduce OSA and Snoring Study
This research study is being done to determine whether the repetition and resistance from the daily use of the myofunctional therapy (MT) nozzle will improve obstructive sleep apnea and primary snoring.
- Trial name
- NCT05371509
- Testing
- Myofunctional therapy (MT) nozzle
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Sleep Disorders, Fibromyalgia
The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia
Fibromyalgia is a condition of chronic widespread pain, sleep disturbance and fatigue. Most of the patients with fibromyalgia complain of either non-restorative sleep or complaints of disturbed sleep due to pain.
- Conditions
- Sleep Disorders, Fibromyalgia, Sleep
- Trial name
- NCT01234675
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mansoor Ahmed M.D.
Non Alcoholic Fatty Liver Disease, Obstructive Sleep Apnea
The Sleep, Liver Evaluation and Effective Pressure Study
This research is being done to examine: 1) how common obstructive sleep apnea (OSA) is in patients with non-alcoholic fatty liver disease (NAFLD), 2) whether the severity of OSA is related to the severity of NAFLD, and 3) whether…
- Trial name
- SLEEP (NCT01482065)
- Testing
- CPAP (ResMed S9 autoset CPAP)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Johns Hopkins University
Sleep Apnea, Obstructive
Effect of Desipramine on Upper Airway Collapsibility and Genioglossus Muscle Activity in Patients With Obstructive Sleep Apnea - Study B
Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. OSA patients show a marked reduction in upper airway (UA) dilator muscle activity at sleep onset and this phenomenon…
- Trial name
- DESOSA (NCT02436031)
- Testing
- Desipramine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
Cost Effectiveness of Ambulatory Management for Veterans With Sleep Apnea
This research study is comparing home and in-laboratory testing of veterans with suspected obstructive sleep apnea, a common breathing disorder during sleep.
- Trial name
- VSATT (NCT00880165)
- Testing
- Continuous positive airway pressure apparatus
- Where
- 2 sites in United States
- Volunteers
- 296 people
- Sponsor
- US Department of Veterans Affairs
Narcolepsy
Safety and Efficacy of THN102 on Sleepiness in Narcoleptic Patients
This Phase 2 study is a 8-site, double-blind, randomised, placebo-controlled, 3-way cross-over trial, involving 3 treatments with Modafinil 300 mg or the combination drug THN102 (Modafinil/Flecainide 300 /3 mg…
- Trial name
- NCT02821715
- Testing
- THN102 300/3, THN102 300/27
- Where
- 8 sites in Belgium, France
- Volunteers
- 51 people
- Sponsor
- Theranexus
Insomnia Disorder
Sleep Well 24 (SWELL24) Healthy Sleep-Wake Behaviors in Older Adults
To finalize daytime intervention components for a comprehensive sleep-wake intervention for frail older adults and explore feasibility and acceptability using a pilot trial.
- Trial name
- SWELL24 (NCT05780983)
- Testing
- education and coaching on developing healthy nighttime sleep and daytime activity behaviors
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Wake Forest University Health Sciences
Dyslipidemia, Sleep Apnea Syndrome
Effect of Fenofibrate on Sleep Apnea Syndrome
Objectives: to investigate for the potential effect of fenofibrate on symptoms and biological changes associated with sleep apnea syndrome.
- Conditions
- Dyslipidemia, Sleep Apnea Syndrome, Overweight, Obesity
- Trial name
- NCT00816829
- Testing
- Fenofibrate
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Solvay Pharmaceuticals
Insomnia
Study of the Efficacy and Safety of Lemborexant in Subjects 55 Years and Older With Insomnia Disorder (SUNRISE 1)
This study will be conducted to demonstrate, using polysomnography, that lemborexant 10 milligrams (mg) and 5 mg is superior to placebo on objective sleep onset as assessed by latency to persistent to sleep (LPS) after the last 2…
- Trial name
- SUNRISE 1 (NCT02783729)
- Testing
- Lemborexant, Zolpidem tartrate
- Where
- 102 sites in United States, Canada and 5 more
- Volunteers
- 1,006 people
- Sponsor
- Eisai Inc.
Chronic Insomnia, Primary Insomnia
Mindfulness Versus Pharmacotherapy for Chronic Insomnia: A Pilot Study
Chronic insomnia is a major public health problem that affects about 10% of adults and is associated with serious and distressful health consequences such as depression, anxiety and reduced quality of life.
- Trial name
- MVP#1 (NCT00515177)
- Testing
- Mindfulness-Based Stress Reduction, eszopiclone
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota