Clinical trials: Dyssomnia
Major Depressive Disorder, Insomnia
Time to Remission of Depressive Symptoms With Combined SSRI and Ramelteon
Hypothesis I: Patients in the SSRI + ramelteon treatment group will achieve remission (defined as an IDS-C30 score of 11 or less) more quickly than those in the SSRI + placebo group.
- Trial name
- TAKEDA (NCT00642694)
- Testing
- Escitalopram, Ramelteon
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Texas Southwestern Medical Center
Insomnia
High-resolution, Relational, Resonance-based, Electroencephalic Mirroring (HIRREM) to Relieve Insomnia
The purpose of this study is to determine whether the addition of High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) to usual care will improve insomnia symptoms based on changes in the Insomnia…
- Trial name
- NCT01971567
- Testing
- HIRREM
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Wake Forest University Health Sciences
Sleep Apnea
The Role of Oxidative Stress in the Cardiovascular Consequences of Sleep Apnea
Obstructive Sleep Apnea (OSA) is the most common sleep disorder affecting up to 9-24 percent of middle aged adults, and is becoming increasingly implicated in the pathogenesis of hypertension, and other cardiovascular disorders.
- Trial name
- NCT00701441
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rami Khayat
Obstructive Sleep Apnea
The Effect of Eszopiclone on the Arousal Threshold in Sleep Apnea Syndrome
The purpose of this study is to find out whether taking eszopiclone (Lunesta) changes the breathing effort required to briefly wake people with obstructive sleep apnea from sleep (respiratory arousal threshold).
- Trial name
- NCT01102270
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brigham and Women's Hospital
Sleep Disorder, Restless Legs Syndrome
Oral Iron Frequency for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder
The purpose of this research study is to see if the level of serum ferritin differs based on how often oral iron (in the form of ferrous sulfate) is given to children with restless leg syndrome/periodic limb movement disorder.
- Conditions
- Sleep Disorder, Restless Legs Syndrome, Periodic Limb Movement Sleep Disorder, Iron-deficiency
- Trial name
- NCT04610827
- Testing
- Ferrous sulfate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Parkinson Disease
Trial of Xyrem for Excessive Daytime Sleepiness and Sleep Disturbance in Parkinson's Disease (PD)
This clinical trial is designed to evaluate the safety and potential efficacy of Xyrem for the treatment of excessive daytime sleepiness (EDS) and nocturnal sleep disturbance in patients with mild to moderate Parkinson's Disease…
- Trial name
- Xyrem (NCT00641186)
- Testing
- sodium oxybate
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Obstructive Sleep Apnea, Pregnancy
Auto-PAP Therapy For Improved Fetal Growth
The purpose of this study is to see whether the presence of night-time breathing disturbances ("sleep-disordered breathing") in pregnant women is related to fetal growth patterns.
- Trial name
- NCT03318003
- Testing
- Auto-PAP
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Michigan
Primary Insomnia, Secondary Insomnia
An Efficacy Study of Compound LY2624803 in the Treatment of Patients With Chronic Insomnia
The purpose of this study is to compare an investigational drug (LY2624803) with placebo and with zolpidem in the treatment of outpatients with chronic insomnia.
- Trial name
- SLUMBER (NCT00784875)
- Testing
- LY2624803, zolpidem
- Where
- 49 sites in United States
- Volunteers
- 643 people
- Sponsor
- Eli Lilly and Company
Hypersomnia
Transcranial Direct Current Stimulation Therapy for Central Hypersomnia Without Cataplexy
1. To determine the effects of transcranial direct current stimulation (tDCS) on vigilance in subjects with central hypersomnia without cataplexy. 2.
- Trial name
- tDCS (NCT03198156)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Ohio State University
Sleep Disturbance, Heart Failure
Improving Sleep Quality in Heart Failure
Poor sleep quality is common in patients with heart failure. The limited available evidence intimates that improving sleep quality in patients with heart failure may improve morbidity and quality of life in this patient…
- Trial name
- NCT03307005
- Testing
- Zolpidem Tartrate
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Obese, Pregnancy
Sleep Disordered Breathing, Obesity and Pregnancy Study (SOAP)
The purpose of this study is to better understand how sleep apnea, a common sleep disorder in which a person has one or more pauses in breathing or shallow breaths while sleeping, may affect pregnancy and to determine the effect…
- Conditions
- Obese, Pregnancy, Sleep Disordered Breathing
- Trial name
- SOAP (NCT02086448)
- Testing
- CPAP, Sleep hygiene
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Francesca Facco, MD
Sleep Disturbance
Developing and Testing a Spanish-Language Intervention to Reduce Cancer-Related Sleep Disturbance
The purpose of this study is to learn about how to provide treatment to cancer survivors who have difficulty sleeping.
- Trial name
- NCT04101526
- Testing
- Spanish-language Cognitive-Behavioral Therapy for Insomnia (CBT-I) delivered via videoconference
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 30 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Restless Legs Syndrome
Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication Reduction
Prospective open-label single-arm feasibility study assessing the tolerability of opioid medication reduction in conjunction with noninvasive peripheral nerve stimulation (NPNS) for patients taking prescription opioids to treat…
- Trial name
- NCT04698343
- Testing
- Noninvasive Peripheral Nerve Stimulation (NPNS)
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Noctrix Health, Inc.
Obstructive Sleep Apnea
Metabolic Impact of Intermittent CPAP
Obstructive sleep apnea is a risk factor for diabetes and cardiovascular disease, by unknown mechanisms. The investigators hypothesize that sleep apnea changes glucose and lipid metabolism during sleep, which over time could lead…
- Trial name
- MIIC (NCT02824263)
- Testing
- CPAP withdrawal
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Johns Hopkins University
Insomnia, Sleep Initiation and Maintenance Disorders
Efficacy and Safety Study of Org 50081 (Esmirtazapine) in Elderly Participants (P05709)
This study was conducted to investigate the efficacy of treatment with Org 50081 (Esmirtazapine) compared to placebo in elderly participants with chronic primary insomnia.
- Conditions
- Insomnia, Sleep Initiation and Maintenance Disorders, Mental Disorders, Dyssomnias
- Trial name
- NCT00561821
- Testing
- Esmirtazapine
- Volunteers
- 538 people
- Sponsor
- Merck Sharp & Dohme LLC
Obstructive Sleep Apnea
Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA)
In children with mild apnea combined therapy with an inhaled nasal steroid and a medication that decreased nasal congestion (montelukast) was shown to be effective.
- Trial name
- NCT01089647
- Testing
- budesonide and montelukast
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Romaker & Associates
Primary Insomnia
Phase IIB 2-Period Crossover Polysomnography Study in Participants With Primary Insomnia (MK-4305-006)
A cross-over, polysomnography study to test the safety, tolerability and effectiveness of different doses of suvorexant (MK-4305) in the treatment of patients with primary insomnia.
- Trial name
- NCT00792298
- Testing
- Suvorexant
- Volunteers
- 254 people
- Sponsor
- Merck Sharp & Dohme LLC
Obstructive Sleep Apnea Syndrome
Cerebral Blood Flow and Childhood Obstructive Sleep Apnea
Obstructive sleep apnea syndrome (OSAS) causes hypoxemia and hypercapnia, which may impair cerebral blood flow and cause deficits in behavior.
- Trial name
- NCT02995837
- Testing
- Sleep Study, Neurocognitive Testing, CBF During Wakefulness
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Alcoholism, Sleep Initiation and Maintenance Disorders
The Effects of Quetiapine (Seroquel XR) on Sleep During Alcohol Abstinence
The primary purpose of this study is to determine how efficacy of quetiapine (seroquel XR) in improving the sleep in recovering alcohol dependent subjects.
- Trial name
- NCT00434876
- Testing
- Quetiapine XR
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Subhajit Chakravorty
Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease
Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA
The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in the same patient has been termed overlap syndrome, affecting 1% of the U.S.
- Conditions
- Obstructive Sleep Apnea, Chronic Obstructive Pulmonary Disease, Overlap Syndrome
- Trial name
- NCT02244957
- Testing
- Bi-level positive airway pressure (BPAP), Nocturnal oxygen
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Diego