Clinical trials: Dyssomnia
Primary Insomnia, Chronic Insomnia
Chamomile for Chronic Primary Insomnia
The purpose of this study is to determine if an herb called chamomile can help to treat insomnia (difficulty in going to sleep or getting enough sleep) by increasing the amount of time that you sleep and/or improving the quality…
- Trial name
- NCT01286324
- Testing
- Chamomile High Grade Extract
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Central Sleep Apnea
Post Approval Study of the remedē System
Prospective, single arm cohort study to evaluate the long-term safety, long-term effectiveness, and survival rate in subjects implanted with the remedē System.
- Trial name
- NCT03425188
- Where
- 17 sites in United States, Germany
- Volunteers
- 53 people
- Sponsor
- Respicardia, Inc.
Major Depressive Disorder
Omega-3 Fatty Acids as Adjunct Treatment for Major Depressive Disorder
The primary objective of the study was to determine the effects of 10-week adjunctive supplementation with 2 doses of LCn-3 fatty acids (fish oil) on cortical functional activity and biochemistry in adolescents with MDD.
- Trial name
- NCT00511810
- Testing
- Low Dose Fish Oil, High Dose Fish Oil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Cincinnati
Sleep Apnea
A Novel Pharmacological Therapy for Obstructive Sleep Apnea
A pharmacological, non-mechanical therapy for OSA that is efficacious and tolerable remains elusive. Here the investigators study the effect on sleep apnea severity of a combination of pharmacological agents (atomoxetine and…
- Trial name
- NCT03919955
- Testing
- Atomoxetine, Oxybutynin
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Brigham and Women's Hospital
Obstructive Sleep Apnea
The Evaluation of a Nasal Pillows Mask for the Treatment of Obstructive Sleep Apnea (OSA) in NZ
This investigation is designed to evaluate the performance (leak and comfort) as well as the participant's overall acceptance of the nasal pillows mask amongst Obstructive Sleep Apnea (OSA) participants.
- Trial name
- NCT02741635
- Testing
- New Nasal Pillows Mask
- Where
- New Zealand
- Volunteers
- 15 people
- Sponsor
- Fisher and Paykel Healthcare
Chronic Insomnia
Brief Behavioral Treatment for Insomnia in Cancer Survivors
The purpose is to determine whether brief behavioral treatment is effective for insomnia in cancer survivors.
- Trial name
- NCT03810365
- Testing
- Brief behavioral treatment for insomnia, Healthy Eating Control
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- State University of New York at Buffalo
Insomnia Disorder
Brief Behavioral Insomnia Treatment Study
The purpose of this study is to determine whether a brief, behavioral treatment for insomnia is effective in addressing social and occupational functioning and overall health among Veterans with insomnia disorder.
- Trial name
- BBTI (NCT02571452)
- Testing
- Brief Behavioral Treatment for Insomnia, Progressive Muscle Relaxation
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Sleep Disorders
Prazosin vs Paroxetine in Combat Stress-Related Post-Traumatic Stress Disorder (PTSD) Nightmares & Sleep Disturbance
The purposes of this study are: to evaluate the efficacy and tolerability of the drug prazosin compared to placebo for combat stress-related nightmares, sleep disturbance and overall function in recently combat-exposed returnees…
- Trial name
- NCT00202449
- Testing
- prazosin, paroxetine
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
OSA
Parallel-Arm Study to Compare AD109 to Placebo With Patients With OSA (SynAIRgy Study)
This is a Phase 3 Randomized Double-Blind Placebo-Controlled 6-month Parallel-Arm Study to Compare a Fixed Dose Combination of AD109 to Placebo in Obstructive Sleep Apnea.
- Trial name
- NCT05813275
- Testing
- AD109
- Where
- 73 sites in United States, Canada
- Volunteers
- 646 people
- Sponsor
- Apnimed
Restless Legs Syndrome
Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome
Periodic Limb Movements (PLMs) during sleep in patients with Restless Legs Syndrome (RLS) have been shown to be associated with elevations in Blood Pressure (BP).
- Trial name
- ENCORE (NCT01455012)
- Testing
- Rotigotine
- Where
- 6 sites in Germany
- Volunteers
- 81 people
- Sponsor
- UCB BIOSCIENCES GmbH
Autism Spectrum Disorder, Insomnia
SweetDreams Sleep Study for Children With Autism
This proposal will acquire preliminary data on the feasibility and effectiveness of an innovative and scalable strategy for improving access to effective sleep health care for preschool-aged children with Autism Spectrum Disorder…
- Trial name
- NCT04452045
- Testing
- SweetDreams
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sleep Apnea Syndromes
Improving Obstructive Sleep Apnea Management Via Wireless Telemonitoring
Obstructive sleep apnea (OSA) is a major chronic condition affecting the quality of life of up to one-fifth of all Veterans. Because of disappointingly low adherence to the gold-standard treatment (continuous positive airway…
- Trial name
- NCT00682838
- Testing
- Self-management, Telemonitored care
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- VA Office of Research and Development
Insomnia Disorder
Tele-Self CBTI Trial
Insomnia is one of the most common complaints among service-members and Veterans of recent military conflicts. Insomnia has been shown to play a causal role in mental health, hypertension, obesity, and other health conditions…
- Trial name
- Tele-Self CBTI (NCT03727438)
- Testing
- Tele-Self CBTI, Health Education Control
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- VA Office of Research and Development
Idiopathic Hypersomnia
A Study of a Single Intravenous Infusion Dose of TAK-925 in Participants With Idiopathic Hypersomnia
The purpose of this study is to evaluate the safety and tolerability of administering a single intravenous (IV) infusion dose of TAK-925 to adult participants with idiopathic hypersomnia (IH).
- Trial name
- NCT04091438
- Testing
- TAK-925
- Where
- 22 sites in United States, Japan
- Volunteers
- 28 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Healthy Subjects, Sleep Initiation and Maintenance Disorders
An Evaluation of Potential Next-day Residual Effects of Eszopiclone in Healthy Volunteers.
This study will explore potential next-day residual effects of a single evening dose of 3mg of the hypnotic, eszopiclone, 7.5mg of zopiclone, and placebo, in healthy adult subjects.
- Trial name
- NCT00699608
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obstructive Sleep Apnea, Stroke
Sleep Apnea Treatment After Stroke (SATS)
The purpose of this study is to determine if treating stroke patients who have obstructive sleep apnea with continuous positive airway pressure will improve symptoms caused by the stroke.
- Trial name
- NCT00282815
- Testing
- continuous positive airway pressure or CPAP
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Michigan
Sleep Apnea, Obstructive
ThermoSmart® Versus Conventional Humidification in Continuous Positive Airway Pressure (CPAP)
That ThermoSMart humidification will result in greater compliance (mask on time, objective and subjective sleep quality than conventional humidification.
- Trial name
- NCT00751335
- Testing
- CPAP with ThermoSmart, then CPAP without ThermoSmart, CPAP without ThermoSmart, then CPAP with ThermoSmart
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Fisher and Paykel Healthcare
Obstructive Sleep Apnea, Tonsillitis
Pediatric Pain Optimization After Tonsillectomy
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery.
- Conditions
- Obstructive Sleep Apnea, Tonsillitis, Pain, Procedural
- Trial name
- NCT05244226
- Testing
- Fentanyl/Hydromorphone, Methadone
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Insomnia
Transcranial Magnetic Stimulation for Treatment of Insomnia
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that has been approved as a treatment of depression in patients that have not responded to a trial of one antidepressant medication.
- Trial name
- TMSI (NCT02196025)
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Florida
Obstructive Sleep Apnea
Continuous Positive Airway Pressure (PAP) Titration and Treatment Versus Auto-adjusting PAP Treatment for Sleep Apnea
The purpose of this randomized prospective study is to compare the efficacy of two approaches to initiate Positive Airway Pressure (PAP) treatment in patients diagnosed as having obstructive sleep apnea (OSA) by portable…
- Trial name
- NCT00988351
- Testing
- Continuous positive airway pressure, Auto-adjusting positive airway pressure treatment
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- North Florida Foundation for Research and Education