Clinical trials: Dystonia
Dystonia, Epilepsy in Children
A Multicenter Pediatric Deep Brain Stimulation Registry
There is limited data on outcomes for children who have undergone deep brain stimulation (DBS) for movement disorders, and individual centers performing this surgery often lack sufficient cases to power research studies…
- Conditions
- Dystonia, Epilepsy in Children, Cerebral Palsy, Tourette Syndrome
- Trial name
- DBS-R (NCT06585618)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Deep Brain Stimulation, Parkinson's Disease and Parkinsonism
Sleep-specific DBS Therapy in Parkinson's Disease
Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide.
- Conditions
- Deep Brain Stimulation, Parkinson's Disease and Parkinsonism, Dystonia
- Trial name
- NCT05962489
- Testing
- Clinically optimized deep brain stimulation
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Minnesota
Task-Specific Focal Dystonia
MRgFUS Pallidotomy for the Treatment of Task Specific Focal Hand Dystonia (TSFD)
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused ultrasound (MRgFUS) for treating task specific focal hand dystonias (TSFD).
- Trial name
- FUS Dystonia (NCT06367608)
- Testing
- ExAblate Transcranial treatment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Maryland, Baltimore
Stroke, Hypertonia
Validity and Reliability of the Hypertonia Assessment Tool (HAT) in Stroke Patients
In this study, the validity and reliability of the Hypertonia Assessment Tool (HAT), which has previously been validated in the pediatric cerebral palsy (CP) population, will be evaluated in adult individuals who have experienced…
- Conditions
- Stroke, Hypertonia, Dystonia, Rigidity
- Trial name
- NCT07429383
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Laryngeal Dystonia, Focal Dystonia
Effects of Neuromodulation in Laryngeal Dystonia
Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life.
- Trial name
- NCT05095740
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Idiopathic Cervical Dystonia
UltraSound-Guided Versus Non-Ultrasound-Guided Botulinum Toxin Injections in Cervical Dystonia [CUSTODY]
Cervical dystonia is a condition that causes the neck muscles to tighten or spasm, leading to abnormal head positions and pain. The main questions it aims to answer are: Do ultrasound-guided BoNT injections improve quality of…
- Trial name
- CUSTODY (NCT07233993)
- Testing
- Ultrasound-guided botulinum toxin injection, Non-ultrasound-guided botulinum toxin injection
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Limb Dystonia, Idiopathic Dystonia
Focused Ultrasound Unilateral Pallidotomy for Medication-Refractory Limb Dystonia
The goal of this clinical trial is to find out if a non-invasive procedure called focused ultrasound can safely and effectively treat limb dystonia in adults who have not improved with medications or botulinum toxin injections.
- Conditions
- Limb Dystonia, Idiopathic Dystonia, Medication-refractory Dystonia, Dystonia, Focal
- Trial name
- FUTURE (NCT07168850)
- Testing
- Exablate MR-guided Focused Ultrasound Pallidotomy
- Where
- 4 sites in Italy
- Volunteers
- 34 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Laryngeal Dystonia
tDCS for Laryngeal Dystonia
This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).
- Trial name
- NCT06830174
- Testing
- Starstim system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
GNAO1, Dystonia
Prospective Pilot Trial to Address Feasibility and Safety of Oral Zinc in GNAO1 Associated Disorders
The goal of this clinical trial is to investigate feasibility and safety of an oral therapy with zinc in patients affected by Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1) associated disorders.
- Conditions
- GNAO1, Dystonia, Epilepsy, Development Delay
- Trial name
- ZINCGNAO1 (NCT06412653)
- Testing
- Zinc Acetate Dihydrate
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- Children's University Hospital Cologne, Germany
Myoclonus-Dystonia, DYT11
EMOTION & COGNITION IN MYOCLONUS DYSTONIA (AGENT10-ECODYST)
Background: Myoclonus dystonia (DYT-SGCE) is characterized by myoclonus and dystonia. Such condition is associated with a high prevalence of psychiatric symptoms which are part of the phenotype.
- Trial name
- NCT05671068
- Where
- France
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Vocal Fold Paresis, Laryngeal Dystonia
Monitoring of the Safety and the Performance of the Endoscopic Cap Electrode (ECE50)
The objective of this registry is to confirm the safety and the performance of the ECE50 in medical routine by collecting data.
- Trial name
- ECE50 (NCT05245942)
- Where
- Austria
- Volunteers
- 384 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Movement Disorders, Parkinson Disease
Abbott DBS Post-Market Study of Outcomes for Indications Over Time
The purpose of this international study is to evaluate long-term safety and effectiveness of Abbott deep brain stimulation (DBS) systems for all indications, including Parkinson's disease, essential tremor or other disabling…
- Conditions
- Movement Disorders, Parkinson Disease, Essential Tremor, Tremor
- Trial name
- ADROIT (NCT04071847)
- Testing
- Deep Brain Stimulation (DBS)
- Where
- 48 sites in United States, Australia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Dystonia
Predicting DBS Outcomes in Dystonia Using Wearable Gait Sensors
This study aims to investigate whether preoperative gait characteristics, measured by wearable sensors, can predict the clinical outcomes of Deep Brain Stimulation (DBS) in patients with dystonia.
- Trial name
- NCT07323602
- Testing
- Wearable Gait Sensor Analysis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Dystonia, Dystonia, Focal
Local Field Potentials in Dystonia
The goal of this clinical trial is to learn whether local field potential (LFP) signals recorded from the globus pallidus interna (GPi) using the Medtronic Percept™ deep brain stimulation (DBS) device can help optimize DBS…
- Conditions
- Dystonia, Dystonia, Focal, Dystonia, Primary
- Trial name
- LFP-DYT (NCT07309133)
- Testing
- Deep Brain Stimulation System
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Cervical Dystonia, Primary, Blepharospasm
Analysis of Gait Before and After Botulinum Toxin Treatment in Patients With Focal Dystonia
Efficient gait requires effective postural control, both static and dynamic. Hence, postural disorders may affect gait. Yet, very little is known about the specific effects of focal postural disorders such as cervical dystonia…
- Trial name
- GAIT-TOX (NCT03938363)
- Testing
- Treadmill, Botulinum Toxin injection, Severity scale of the disease
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Cervical Dystonia
Three-dimensional Analysis of Obliquus Capitis Inferior Muscle Function in the Rotatory Form of Cervical Dystonia
Cervical dystonia is the most common form of focal dystonia in adults (50-82%). It manifests itself by a abnormal attitude of the head, intermittent or permanent, due to involuntary contraction of the cervical muscles which…
- Trial name
- STOCI (NCT05327985)
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Spasmodic Dysphonia, Singer's Dystonia
Brain Networks in Dystonia
To date, there is only limited knowledge about the distinct neural abnormalities that lead to the development of different forms of focal dystonia.
- Conditions
- Spasmodic Dysphonia, Singer's Dystonia, Writer's Cramp, Musician's Focal Hand Dystonia
- Trial name
- NCT03042962
- Testing
- MRI, Blood draw
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Dystonia, Primary
Agency in Dystonia
In this study, using computerized cognitive assessments combined with multi-modal neuroimaging approach investigators aim to address three specific questions on patients with cervical and myoclonus dystonia: (i) investigate…
- Trial name
- AGENT10 (NCT03351218)
- Testing
- Behavioral testing - computerized tasks
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Laryngeal Dystonia, Unaffected Relatives of Laryngeal Dystonia Patients
Imaging Genetics of Laryngeal Dystonia
The contribution of genetic risk factors to the development of focal dystonias is evident. However, understanding of how variations in the causative gene expression lead to variations in brain abnormalities in different…
- Conditions
- Laryngeal Dystonia, Unaffected Relatives of Laryngeal Dystonia Patients, Voice Tremor, Muscle Tension Dysphonia
- Trial name
- NCT03042975
- Testing
- MRI, Blood draw
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- Kristina Simonyan
Laryngeal Dystonia
Brain-Computer Interfaces in Laryngeal Dystonia
The researchers will develop and evaluate the use of adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystonia.
- Trial name
- NCT04421365
- Testing
- neurofeedback brain-computer interface (BCI)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kristina Simonyan