Clinical trials: ECMO, open to volunteers
Extracorporeal Membrane Oxygenation Complication
Distal Perfusion Timing, Early or Conservative, to Prevent Limb Ischemia During Peripheral VA-ECMO
Peripheral VA-ECMO is widely used in refractory cardiogenic shock patients as a salvage therapy. In most cases, the femoral artery and vein are used for the vascular approach.
- Trial name
- DECIDE-ECMO (NCT05698628)
- Testing
- Distal perfusion catheterization
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Min-Seok Kim
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
ExtraCorporeal Membrane Oxygenation (ECMO), Cardiac Arrest
Plasma Biomarkers and Platelet Morphology of Extracorporeal CardioPulmonary Resuscitation
Extracorporeal cardiopulmonary resuscitation (ECPR) constitutes a pivotal emergency intervention for cardiac arrest (CA) patients.
- Trial name
- ECPR (NCT07113769)
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Central China Fuwai Hospital of Zhengzhou University
ECMO
PACE: Prostacyclin AntiCoagulation in ECMO
Extracorporeal membrane oxygenation (ECMO) is a machine that temporarily supports the heart and/or lungs and is a critical rescue therapy for refractory cardiac and respiratory failure in pediatric populations.
- Trial name
- PACE (NCT07837869)
- Testing
- Dose-escalation study of epoprostenol as adjunct anticoagulation in ECMO
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Garrett Keim
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Efficacy and Safety of Synchronized Cardiac Support in Cardiogenic Shock Patients
The study aims to investigate the safety and efficacy of the Synchronized Cardiac Support treatment wit the icor kit and the Xenios console with modified sensor box ECG and Software Version 3.2.4
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, ECLS, VA ECMO
- Trial name
- PulseSE (NCT05106491)
- Testing
- Synchronized Cardiac Support with the icor kit
- Where
- 2 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Xenios AG
Acute Hypoxemic Respiratory Failure, Mechanical Ventilation
Safety and Efficacy of Low-Flow ECMO in a Multi-modal Cohort of Adults in Respiratory Failure
The current standard of care (SOC) for treatment of patients with acute respiratory distress syndrome (ARDS), inhalation injury, volume overload, and/or pulmonary dysfunction is mechanical ventilation (MV).
- Conditions
- Acute Hypoxemic Respiratory Failure, Mechanical Ventilation, Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT06938217
- Testing
- Low-flow ECMO
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Institute for Extracorporeal Life Support
Muscle Mass Loss
Effect of Neuromuscular Electrical Stimulation on Muscle Mass in ECMO Patients
The goal of this clinical trial study: is to determine the effectiveness of neuromuscular electrical stimulation in critically ill patients undergoing extracorporeal membrane oxygenation.
- Trial name
- NMES-ECMO (NCT07566702)
- Testing
- NMES, Conventional physiothrapy program
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Cardiogenic Shock
Pharmacokinetic Modelling of Levosimendan in Adults
In the light of current knowledge of the PK of levosimendan and its use in ECMO weaning, deciphering the mechanisms of inter-individual variability in exposure and response to levosimendan appears essential in order to better…
- Trial name
- MILADECMO (NCT06993584)
- Testing
- Adult patients in cardiogenic shock
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Rouen
Septic Shock, Extracorporeal Membrane Oxygenation Complication
Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock
Severe sepsis and septic shock remain the leading causes of child mortality worldwide. Sepsis is a complex process that ultimately leads to circulation disorders, organ perfusion abnormalities, capillary leakage, tissue hypoxia…
- Trial name
- NCT03948048
- Testing
- ECMO
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Cardiogenic Shock
Genomic Determinants of Outcome in Cardiogenic Shock
The aim of this project is to understand the heterogeneity of both the immune consequences and treatment responses in CS. We will explore this heterogeneity through identification of transcriptomic sub-phenotypes and their…
- Trial name
- Goldilocs (NCT05728359)
- Testing
- Observational study
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Barts & The London NHS Trust
ECMO
A Novel Strategy of ECMO Management Using Nafamostat for Regional Combined With Low Intensity Systematic Anticoagulation
ECMO is widely used in patients with refractory respiratory and/or circulatory failure.The data shows that the incidence of bleeding and thrombotic events is still above 40%,and it is closely related to the increase in mortality…
- Trial name
- NCT06676085
- Testing
- Nafamostat, Heparin
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Chao Yang Hospital
Severe Aortic Stenosis, Cardiogenic Shock
Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR
The goal of this clinical trial is to evaluate the feasibility, effectiveness, and safety of pre-emptive left atrial veno-arterial extracorporeal membrane oxygenation (LAVA-ECMO) in patients undergoing complex and high-risk…
- Conditions
- Severe Aortic Stenosis, Cardiogenic Shock, Cardiogenic Shock, ECMO, Trans-catheter Aortic Valve Implantation
- Trial name
- PROTECT-TAVR (NCT07309029)
- Testing
- Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Atlantic Health System
Cardiogenic Shock Acute
Early Preventive Left Ventricle Unloading After VA-ECMO for Refractory Cardiogenic Shock
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used worldwide to treat severe cardiogenic shock.
- Trial name
- EULODIA (NCT07027202)
- Testing
- Early Left Ventricle unloading
- Where
- 12 sites in France
- Volunteers
- 298 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
VA-ECMO
Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO
The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by…
- Trial name
- ECMO-VP (NCT07141524)
- Testing
- Physiology measurements
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Beth Israel Deaconess Medical Center
Gastric Emptying, Delayed Gastric Emptying
Prevalence and Measurement of Delayed Gastric Emptying in Patients Receiving Extracorporeal Membrane Oxygenation
The goal of this observational study is to learn whether the stomach takes longer to empty in patients on the intensive care unit who are receiving ECMO (a machine that temporarily takes over the role of the lungs and heart)…
- Conditions
- Gastric Emptying, Delayed Gastric Emptying, Critical Illness, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- PROPEL-ECMO (NCT07779174)
- Testing
- Gastric (stomach) ultrasound measurement, 'Residual volume' measurement, Scintigraphy (standard research method)
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Cardiogenic Shock
Optimal ECMO Flow in the Critical Phase of Cardiogenic Shock to Optimize Peripheral Organ Perfusion and Myocardial Stress
Veno-arterial ECMO (VA ECMO) is considered the ultimate lifesaving technique in refractory cardiogenic shock (CS). However, VA ECMO is associated with potentially serious adverse effects and complications.
- Trial name
- ECMO-FLOW (NCT06936839)
- Testing
- Obversation
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Respiratory Failure
Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane Oxygenation
The goal of this study is to design a pilot trial evaluating the safety, feasibility, pharmacokinetic modeling, and physiological effects of a volatile anesthetic, sevoflurane, directly administered in extracorporeal membrane…
- Trial name
- Vol-ECMO (NCT05680545)
- Testing
- Sevoflurane vaporized in ECMO machines
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications
Closed Incision NPWT to Prevent Wound Complications Post-ECMO
Patients undergoing extracorporeal membrane oxygenation (ECMO) are at increased risk of wound complications at the vascular access site after decannulation. These complications may delay recovery and increase healthcare burden.
- Conditions
- ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications, Surgical Site Infection (SSI)
- Trial name
- PREVENT-ECMO (NCT07709546)
- Testing
- Prophylactic Closed-Incision Negative Pressure Wound Therapy, Standard Wound Dressing
- Volunteers
- 144 people
- Sponsor
- St. Antonius Hospital
Critically Ill, Acute Respiratory Failure
The EXCEL Registry of Patients Requiring ECMO
ECMO is associated with significant costs, risks and requires specialist training and expertise. EXCEL is a novel, high-quality, detailed prospective registry of patients requiring ECMO in Australia and New Zealand.
- Conditions
- Critically Ill, Acute Respiratory Failure, Acute Heart Failure, Cardiac Arrest
- Trial name
- NCT03793257
- Where
- 29 sites in Australia, New Zealand
- Volunteers
- 3,000 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre