Clinical trials: ED
Seizures
Seizure Therapy With Intravenous Levetiracetam and Lorazepam
The overarching aim of STILL is assessment of IV LEV in the management of seizures in the ED setting. The main study endpoints are considered in the two patient groups of interest (SE and non-SE): For non-SE patients, STILL will…
- Trial name
- STILL (NCT00465244)
- Testing
- Levetiracetam 1 g IV + Lorazepam 2 mg IV
- Sponsor
- Massachusetts General Hospital
Intravenous Administration
Clinical Trial Testing Buzzy Bee vs Vapocoolant During IV Placement
The purpose of this study is to compare the anxiety and pain levels of patients when using Buzzy with ice, Vapocoolant, and placebo when inserting IV's line for IV fluids and/or phlebotomy in pediatric patients in the pediatric…
- Trial name
- NCT06182631
- Testing
- Buzzy Bee, Vapocoolent
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Emergency Service, Hospital
Nudging High Emergency Department Utilizers to Consider Non-emergent Healthcare Resources
The goal of this campaign is to reduce unnecessary ED visits by providing patients who are high ED utilizers (with a visit of any acuity) with alternative resources to manage their health outside of the ED.
- Trial name
- NCT06818825
- Testing
- Automated interactive messages, Live outreach
- Where
- United States
- Volunteers
- 1,126 people
- Sponsor
- Geisinger Clinic
Sickle Cell Disease, Genetic Disease
Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease
The overall purpose of this proposed study is to improve management of vaso-occlusive episodes (VOEs) in adult EDs. We aim to implement NHLBI recommendations for VOE treatment by embedding Individualized Pain Plans (IPPs) in the…
- Conditions
- Sickle Cell Disease, Genetic Disease, Hematologic Diseases, Anemia, Sickle Cell
- Trial name
- ALIGN (NCT04584528)
- Testing
- Electronic Health Record (EHR) Embedded Individualized Pain Plan (IPP)
- Where
- 8 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Duke University
Acute Musculoskeletal Pain
Virtual Reality and Standard Care vs. Standard Care Alone for Acute MSK Pain in Geriatric ED Patients
The proposed Virtual Reality as an Adjunct to Pain Management for Geriatric Patients in the ED (VRAP-ED) project will take place in the Emergency Medicine Department at Maimonides Medical Center.
- Trial name
- NCT06685107
- Testing
- Standard of Care Analgesia, Standard of Care Analgesia + Virtual Reality
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Antonios Likourezos
Presyncope, Arrhythmias, Cardiac
The IPED (Investigation of Palpitations in the ED) Study
Palpitations (noticeable pounding, fluttering or irregular heart beat) and pre-syncope (near blackout) are common ED problems sometimes due to an abnormal cardiac rhythm.
- Conditions
- Presyncope, Arrhythmias, Cardiac, Tachycardia, Supraventricular, Atrial Fibrillation
- Trial name
- IPED (NCT02783898)
- Testing
- AliveCor Heart Monitor
- Where
- 10 sites in United Kingdom
- Volunteers
- 243 people
- Sponsor
- NHS Lothian
Renal Colic
Treatment of Renal Colic in the Emergency Departement (ED).
to evaluate the analgesic effect of a standard dose of intravenous magnesium added to intramuscular diclofenac compared to intravenous lidocaine combined to intramuscular diclofenac or intramuscular diclofenac alone in patients…
- Trial name
- NCT03199924
- Testing
- Diclofenac, Magnesium Sulfate, Lidocaine
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Acute Kidney Injury
An Educational Intervention to Prevent Acute Kidney Injury in Primary Care. The ED-AKI-P Implementation Study
Patients with abnormal kidney function are common in primary care, particularly in people with other long standing illnesses. Some of these patients have long standing weakness of their kidneys, others develop new kidney weakness…
- Trial name
- ED-AKI-P (NCT03165552)
- Testing
- Acute kidney injury education
- Volunteers
- 28 people
- Sponsor
- University of Leicester
Emergency Treatment, Telephone Hotlines
Decreasing ED Utilization by Nudging Patients to Call Their Providers
In the present study, patients will be sent a message shortly after completing a medical procedure that informs or reminds them that they can reach out to Geisinger, and how to do it, if they have any medical issues or concerns.
- Trial name
- NCT04567849
- Testing
- message, provider, tele-nurse
- Where
- United States
- Volunteers
- 11,546 people
- Sponsor
- Geisinger Clinic
Erectile Dysfunction, Urinary Incontinence
Male Pelvic Floor Muscle Rehabilitation Exercises
Phase I G128 Study Objective The ischiocavernosus (IC) and bulbospongiosus (BS) muscles are vital components of the superficial perineal layer, serving as the foundation for male sexual health and performance.
- Conditions
- Erectile Dysfunction, Urinary Incontinence, Premature Ejaculation
- Trial name
- NCT07451808
- Testing
- Male Pelvic Floor Rehabilitation #1
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dream Video LLC
Pain
A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain
Acute Pain is one of the most frequent chief complaints and the main reason for visiting the Emergency Department (ED). The acute pain in the ED is largely prevalent across the country with recent literature demonstrating that…
- Trial name
- NCT04860804
- Testing
- Aspirin and Ketamine, Oral Ketamine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Antonios Likourezos
Coronary Artery Disease
Assessing Diagnostic Value of Non-invasive FFR-CT in Coronary Care in the Emergency Department
This is a prospective multi-center study. All clinically stable, symptomatic patients who present to the emergency department (ED) or observation unit with suspected coronary artery disease (CAD) and who have at least one ≥40%…
- Trial name
- ADVANCE-ED (NCT05325112)
- Testing
- FFR-CT
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- HeartFlow, Inc.
Uveitis, Intermediate, Macular Edema
Randomized, Controlled Trial to Test the Efficacy of Interferon Beta in the Treatment of Intermediate Uveitis
The purpose of this study is to investigate if interferon beta is superior to the standard treatment with Methotrexate for the treatment of intermediate uveitis and macular edema.
- Conditions
- Uveitis, Intermediate, Macular Edema, Multiple Sclerosis
- Trial name
- NCT00344253
- Testing
- Interferon beta, Methotrexate
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Heidelberg University
Heart Failure
Accelerating Access and Improving Imaging in Heart Failure Care (A2I2HF) Pilot Study
This is a prospective, multicenter, cluster randomised trial which will assess the feasibility and acceptability of AI-assisted point of care echocardiography on HF detection and downstream care processes for patients with…
- Trial name
- NCT07624565
- Testing
- AI-assisted point-of-care ultrasound (POCUS)
- Volunteers
- 84 people
- Sponsor
- University of Alberta
Sepsis, Septic Shock
DIAGNOSis of Infection in Emergency Department
Septic pathology is an extremely frequent reason for consultation in our emergency services, with an annual incidence of severe forms between 50 to 95 cases per 100,000 inhabitants and a constant increase estimated at 9% per…
- Conditions
- Sepsis, Septic Shock, Sepsis, Severe, Infection
- Trial name
- DIAGNOSED (NCT03708796)
- Testing
- SIRS, qSOFA, NEWS, RETTS scores evaluation
- Where
- 7 sites in France
- Volunteers
- 759 people
- Sponsor
- Association pour la Formation l'Enseignement et la Recherche du Service de l'Accueil des Urgences
Type 1 Diabetes Mellitus, Eating Disorders
iOmit: Reducing Intentional Insulin Misuse in Type 1 Diabetes
Individuals with type 1 diabetes who intentionally omit insulin to lose weight are at high risk for diabetes-related medical complications and premature death.
- Trial name
- iOmit (NCT02980627)
- Testing
- Therapy with Mobile App Enhancement
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Duke University
Trauma
Combined Analgesia to Control Pain in Children Seen in Emergency Department (ED) for a Trauma of a Limb
Prospective study to evaluate the additive value of codeine on ibuprofen in the management of pediatric patient with a trauma of a limb.
- Trial name
- NCT01189773
- Testing
- ibuprofen and codeine
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- St. Justine's Hospital
Acute Coronary Syndrome, Chest Pain
Cost Comparison of Cardiac Magnetic Resonance Imaging (MRI) Use in Emergency Department (ED) Patients With Chest Pain
The purpose of this study is to investigate the best way to evaluate patients with chest pain in the emergency department. It compares receiving treatment in an observation unit with admission to the hospital.
- Trial name
- NCT00678639
- Testing
- Observation unit care, coupled with cardiac MRI
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Wake Forest University Health Sciences
Heart Failure, Heart Failure Acute
B-lines Lung Ultrasound Guided ED Management of Acute Heart Failure Pilot Trial
Nearly 80% of acute heart failure (AHF) patients admitted to the hospital are initially treated in the emergency department (ED). Once admitted, within 30 days post-discharge, 27% of patients are re-hospitalized or die.
- Conditions
- Heart Failure, Heart Failure Acute, Acute Cardiac Pulmonary Edema, Acute Cardiac Failure
- Trial name
- BLUSHED-AHF (NCT03136198)
- Testing
- LUS-guided strategy-of-care, Usual Care, Intravenous Loop Diuretic
- Where
- 6 sites in United States
- Volunteers
- 130 people
- Sponsor
- Indiana University
High Fall Risk
ALERT-ED: Awareness and Linkage to Resources for At-Risk Emergency Department Patients
Falls are the leading reason for injury-related emergency department (ED) visits in older adults with high rates of ED revisits for falls.
- Trial name
- ALERT-ED (NCT07028463)
- Testing
- ALERT-ED
- Where
- United States
- Volunteers
- 20,700 people
- Sponsor
- University of Colorado, Denver