Clinical trials: EMBRYO IMPLANTATION
Coronary Artery Calcification, Restenosis
Neointimal Features in Patients With Restenosis of Calcified Lesions
Previous studies have suggested that restenosis (RS) after stenting is mainly due to smooth muscle cell proliferation and migration, but recent evidence suggests that in-stent restenosis（ISR） is associated with a number of…
- Conditions
- Coronary Artery Calcification, Restenosis, Neointima, Neoatherosclerosis
- Trial name
- NCT05451368
- Testing
- Coronary artery calcification lesions
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenyang Northern Hospital
Cartilage Defect
REcycled CartiLage Auto/Allo IMplantation
This is an FDA phase I study to evaluate the safety of allogeneic culture-expanded adipose-derived mesenchymal stem cells (AMSCs) combined with autologous cartilage cells to treat focal knee cartilage defects in one stage surgery.
- Trial name
- NCT03672825
- Testing
- REcycled CartiLage Auto/Allo IMplantation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Cataract, Presbyopia Correction
Night Driving After Trifocal Versus Monofocal IOL Implantation
This prospective observational cohort study will compare night-driving visual difficulty and visual disturbances after bilateral implantation of an Alcon trifocal intraocular lens or an Alcon monofocal intraocular lens in adults…
- Trial name
- TriIOL (NCT07755189)
- Testing
- AcrySof IQ PanOptix TFNT00 Trifocal Intraocular Lens, Alcon Monofocal Intraocular Lens
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jin Yang
Unresectable Solid Tumors
SEED-CRYO: Sequential 125I Seed Implantation Followed by Cryoablation vs Single-Modality Local Therapy in Unresectable Solid Tumors
This open-label, randomized Phase II trial evaluates whether sequential iodine-125 seed implantation followed by cryoablation improves local tumor control versus single-modality local therapy (125I seeds alone or cryoablation…
- Trial name
- NCT07450352
- Testing
- Iodine-125 (125I) Seed Implantation, cryoablation, Sequential 125I Seed Implantation Followed by Cryoablation
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Li Min
Dental Implants
Five Year Survival Study Evaluating the Genesis Dental Implant System
The purpose of this research study is to document the use if the Keystone Dental Genesis Dental Implant System in standard clinical use and to provide 5 year survival data.
- Trial name
- Genesis Dental (NCT01573026)
- Where
- 8 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Keystone Dental, Inc.
Coronary Artery Stenosis, Transcatheter Aortic Valve Implantation
Complete Functional Assessment of Intermediate Coronary Artery Stenosis Before and After Transcatheter Aortic Valve Implantation (TAVI) in Patients With Severe Symptomatic Aortic Valve Stenosis
The purpose of the current study is to assess complete coronary physiology (FFR, RFR, CFR, IMR, and CT-FFR) in TAVI candidates with intermediate coronary artery stenosis before and 6 months after TAVI.
- Trial name
- CHOICE-FR (NCT05133843)
- Testing
- Assession of complete coronary physiology
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Helios Health Institute GmbH
Fertility Disorders
The Effect of Granulocyte Colony Stimulating Factor Versus Human Chorionic Gonadotropin in Females With a History of RIF
One hundred patients who suffered from recurrent implantation failure in intracytoplasmic sperm injection (ICSI) were allocated in the study.
- Trial name
- NCT04604054
- Testing
- Granulocyte Colony Stimulated Factor, Human Chorionic Gonadotropins
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Heart Failure, Cardiomyopathy
Correlating QLV Interval to Left Ventricular (LV) Lead Position in Patients Receiving Cardiac Resynchronization Therapy.
This is a prospective clinical trial to determine the optimal QLV interval during implantation to achieve the best possible response from cardiac resynchronization therapy for heart failure patients.
- Conditions
- Heart Failure, Cardiomyopathy, Cardiac Arrhythmia
- Trial name
- QLV (NCT02166762)
- Testing
- QLV interval measurement
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Sleep-disordered Breathing (SDB), Aortic Valve Stenosis
Impact of Transcatheter Aortic Valve Implantation and Mitral Valve Repair on Sleep-Disordered Breathing
This prospective observational study aims to investigate the impact of transcatheter aortic valve implantation (TAVI) and transcatheter mitral valve edge-to-edge repair (M-TEER) on sleep-disordered breathing (SDB) in patients…
- Conditions
- Sleep-disordered Breathing (SDB), Aortic Valve Stenosis, Mitral Valve Regurgitation
- Trial name
- SLEEP-VALVE (NCT07520656)
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Aristides Plaitis
Intervertebral Disc Displacement
Comparison of Software-assisted Implantation of Elastic Spine Pad (TM) With Respect to Postoperative Change in Neck Disability Index (NDI) With the Conventional Disc Spacer Squale (TM) After Anterior Cervical Discectomy for Cervical Disc Prolapse
This is an investigator-initiated study. The primary goal is to evaluate the efficacy of two different cervical disc devices (prosthesis vs rigid spacer) with respect to postoperative change in neck disability index.
- Trial name
- NCT02936765
- Testing
- Anterior cervical discectomy with prosthetic disc replacement / ESP., Anterior cervical discectomy with prosthetic disc replacement / Squale.
- Where
- Germany
- Volunteers
- 52 people
- Sponsor
- Technische Universität Dresden
Angina Pectoris
Myocardial Ischemia After Coronary Sinus Reduction Stent Implantation
Chronic angina pectoris refractory to medical and revascularization therapies is a disabling medical condition and a major public health problem. Patients with refractory angina have limited treatment options.
- Trial name
- MICS-Reduce (NCT06033495)
- Testing
- Coronary sinus reduction stent
- Volunteers
- 15 people
- Sponsor
- Oslo University Hospital
Heart Failure, Circulatory Disorders Postprocedural Complication
Observational Hemodynamic Monitoring During LVAD Implantation Among Individuals With Advanced Heart Failure
The overall objective of this pilot analysis is to characterize the hemodynamic changes that occur during implantation of a left ventricular assist device (LVAD) in patients with advanced heart failure - specifically, how right…
- Conditions
- Heart Failure, Circulatory Disorders Postprocedural Complication, Cardiomyopathy, Congestive, Surgery
- Trial name
- BATMAN (NCT03464981)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Coronary Heart Disease
Healing Response to Everolimus-eluting Stent Implantation; Serial Assessment With opticaL Coherence Tomography
The purpose of this study is to evaluate serial changes of neointimal coverage after everolimus-eluting stent implantation at 3-, 6- and 12-months by OCT examination.
- Trial name
- HEAL (NCT01689688)
- Where
- Japan
- Volunteers
- 40 people
- Sponsor
- Kobe University
Cataracts
Clinical Investigation of Visual Function After Bilateral Implantation of Two Presbyopia-Correcting Trifocal Intraocular Lenses (IOL)
The purpose of this study is to clinically evaluate the visual performance of two commercially available presbyopia-correcting Trifocal IOLs.
- Trial name
- NCT02691741
- Testing
- AcrySof® IQ PanOptix™ Presbyopia-Correcting IOL, AT LISA® tri IOL
- Volunteers
- 215 people
- Sponsor
- Alcon Research
Recurrent Implantation Failure, T-Shaped Uterus
Effect of Hysteroscopic Metroplasty on Reproductive Outcome in Patients with RIF
In recent years with the continuous improvement of ART technology, it has brought new hope to infertile couples, however more than half of the patients still experience multiple transfer failures.
- Trial name
- NCT06847386
- Testing
- Hysterocopic metroplasty
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Acute Coronary Syndrome
Index of Microcirculatory Resistance After Drug-Eluting Stent Implantation With High Dose Atorvastatin Loading
Pre-treatment with statins decreased the incidence of cardiac enzyme increase after percutaneous coronary intervention (PCI) and distal embolization suspected to cause post-PCI myocardial damage.
- Trial name
- RESIST-ACS (NCT01491256)
- Testing
- Pre-procedural High dose atorvastatin loading, No pre-procedural high-dose atorvastatin loading
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- The Korean Society of Circulation
Coronary Artery Disease
Intra-Individual Comparison of Sirolimus and Paclitaxel Coated Stent (FRE-RACE Study)
The main objective of this study is to assess the safety and effectiveness of the Sirolimus eluting Cypher Select(TM) stent in reducing angiographic in-stent late loss in de novo native coronary lesions as compared to the…
- Trial name
- NCT00130546
- Testing
- Paclitaxel-eluting TAXUS(TM), Sirolimus eluting Cypher Select(TM)
- Where
- Germany
- Volunteers
- 112 people
- Sponsor
- University Hospital Freiburg
Pulmonary Valve; Failure, Percutaneous Pulmonary Valve Implantation
Transcatheter Pulmonary Valve Implantation With SAPIEN 3 Valve
Background Transcatheter pulmonary valve implantation (TPVI) is indicated to treat right ventricular outflow tract dysfunction in patients with congenital heart diseases.
- Conditions
- Pulmonary Valve; Failure, Percutaneous Pulmonary Valve Implantation, Infective Endocarditis, Congenital Heart Disease
- Trial name
- EUROPULMS3 (NCT05264181)
- Testing
- Percutaneous pulmonary valve implantation
- Where
- France
- Volunteers
- 600 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Premature Ovarian Failure
Human Amniotic Epithelial Cells Treatment for Ovarian Insufficiency
This project will investigate the safety and effectiveness of human amniotic epithelial cells in primary ovarian insufficiency patients and provide a new cell therapy against infertility.
- Trial name
- NCT03207412
- Testing
- hAECs, Minimally invasive implantation
- Volunteers
- 20 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Coronary Artery Disease, Atrial Fibrillation
Rivaroxaban Estimation With Warfarin in Atrial Fibrillation Patients With Coronary Stent Implantation Study (REWRAPS)
Antiplatelet therapy is indispensable for the prevention of stent thrombosis in patients who underwent coronary artery stenting.
- Conditions
- Coronary Artery Disease, Atrial Fibrillation, Stroke, Fetal Blood Loss
- Trial name
- REWRAPS (NCT02024230)
- Testing
- Rivaroxaban or Warfarin
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Fujita Health University
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