Clinical trials: EMBRYO IMPLANTATION
Retinitis Pigmentosa
Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation
Phase I/II open-label, safety, tolerability and preliminary efficacy study of implantation into one eye of hESC-derived RPE (Human Embryonic Stem Cell Derived Retinal Pigment Epithelium (RPE)) in patients with retinitis…
- Trial name
- NCT03963154
- Testing
- Human Embryonic Stem Cell Derived Retinal Pigment Epithelium (RPE)
- Where
- France
- Volunteers
- 7 people
- Sponsor
- Centre d'Etude des Cellules Souches
Dental Implantation, Bone Remodeling
Bone Remodeling Around Implants With Two Different Surfaces Placed in Horizontally Augmented Bone
The aim of this prospective controlled clinical trial is to evaluate the clinical and radiographical outcomes of two implant surfaces inserted in a crest that has been horizontally augmented at least 6 months prior to the implant…
- Trial name
- NCT04343066
- Testing
- Implant insertion
- Where
- Lebanon
- Volunteers
- 15 people
- Sponsor
- Saint-Joseph University
Spinal Cord Injuries
Motor, Sensory, and Autonomic Function in Traumatic Spinal Cord Injury After the LION Procedure.
Possover pioneered a minimally invasive and fully reversible laparoscopic technique, laparoscopic implantation of neuroprosthesis (LION), for precise placement of an implantable pulse generator and one to four leads for…
- Trial name
- SCI-LION (NCT03441256)
- Testing
- LION procedure, NMES
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Spinal Cord Injury Centre of Western Denmark
Oncology
Comparaison Between Digital and Drug Induced Sedation in Veinous Access Device Implantation
The goal of this clinical trial is to compare in patients who need an implantation of a veinous access device the sedation with anesthesiologic drugs and with hypnosis using virtual reality material.
- Trial name
- NCT05815056
- Testing
- Sedakit (R) using hypnosis induced by the virtual reality device, drug intervention
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Regional de Huy
Ataxia - Other, Dystonia Disorder
Stimulation of the Dentate Nucleus of the Cerebellum for the Treatment of Refractory Spasticity With or Without Dystonia
Electrical stimulation (DBS) through electrodes implanted in the dentate nucleus of the cerebellum for the treatment of tremor intractable with medication, dystonia due to cerebrovascular disease (stroke), sequelae of traumatic…
- Conditions
- Ataxia - Other, Dystonia Disorder, Tremor, Essential, Choreatic Disorder
- Trial name
- DN_DBS (NCT07231302)
- Testing
- Analytical observation
- Volunteers
- 20 people
- Sponsor
- Kleber Paiva Duarte
Histology
Teosyal RHA® Histology and Intradermal Implantation Evaluation Study
The Teosyal RHA® family of products (RHA® 1, RHA® 2, RHA® 3, and RHA® 4) is approved in Canada for the correction of facial wrinkles and folds.
- Trial name
- NCT04846530
- Testing
- RHA® 1, RHA® 2, RHA® 3, and RHA® 4
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Chest Pain, Pain, Procedural
Evaluation of the Effectiveness of Two Methods of Regional Anesthesia During S-ICD Implantation Procedure.
Our study consists of a combination of regional blockade ('local' anesthesia) of the anterior and lateral chest wall in the form of a thin needle prick and the supply of local anesthetic drugs to the area of the relevant chest…
- Conditions
- Chest Pain, Pain, Procedural, Pain, Postoperative, Analgesia
- Trial name
- NCT06520150
- Testing
- Regional anaesthetic combined fascial plane block, Ropivacaine 0.125% Injectable Solution +Lignocaine 0,25% Injectable Solution
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Overactive Bladder, Urinary Incontinence
Percutaneous Nerve Evaluation With Fluoroscopy Versus Without
The investigators propose a randomized control trial comparing the rate of implantation of the InterStim device following Percutaneous Nerve Evaluation (PNE) performed with or without fluoroscopic guidance.
- Conditions
- Overactive Bladder, Urinary Incontinence, Fecal Incontinence
- Trial name
- NCT02677753
- Testing
- Fluoroscopy
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Knee Chondral or Osteochondral Defect
Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial
Numerous surgical techniques have been developped for the treatment of chondral and osteochondral defects of the knee. Among those techniques autologous chondrocyte transplantation (ACT) was promising but have potential…
- Trial name
- Cartipatch (NCT00560664)
- Testing
- Autologous chondrocytes transplantation, Mosaicoplasty
- Where
- 12 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Brest
Cardiac Arrest, Transcatheter Aortic Valve Implantation
The Clinical Characteristics, Management and Prognosis of Patients Developing Intraoperative Cardiac Arrest During Transcatheter Aortic Valve Implantation
This study was aimed to investigate the clinical characteristics, management and prognosis of patients developing intraoperative cardiac arrest during transcatheter aortic valve implantation
- Trial name
- NCT04687202
- Testing
- follow up and record
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Infection, Driveline Heart-assisted Device Related Infection
Postoperative Infections and Immune Profiles in Patients Undergoing LVAD Implantation
The objective of this study is to investigate the incidence of infection and changes in the immune profile following left ventricular assist device implantation.
- Conditions
- Infection, Driveline Heart-assisted Device Related Infection, Pneumonia, Sepsis
- Trial name
- NCT07255716
- Testing
- none intervention
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China National Center for Cardiovascular Diseases
Single-sided Deafness
Cochlear Implants for Adults With Single-sided Deafness
The purpose of this investigation is to determine the safety and preliminary efficacy of implanting a cochlear implant (CI) in the profoundly deaf ear of an adult with one normal hearing (NH) ear (termed "single-sided deaf"…
- Trial name
- SSD (NCT02259192)
- Testing
- MED-EL Maestro Cochlear Implant
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Robert Shannon
Optical Coherence Tomography, Intravascular Ultrasound
OCT vs IVUS vs QCA to Guide Moderate-to-severe Calcified Lesion Stent Implantation
This study is a prospective, multi-center, randomized controlled clinical trial, aims to assess the safety and effectiveness of Optical Coherence Tomography or Intravascular Ultrasound or Quantitative Coronary Analysis to guide…
- Conditions
- Optical Coherence Tomography, Intravascular Ultrasound, Angiography
- Trial name
- NCT03574636
- Testing
- OCT guidance, IVUS guidance, QCA
- Where
- China
- Volunteers
- 375 people
- Sponsor
- Shanghai MicroPort Medical (Group) Co., Ltd.
Glaucoma
A Study Evaluating the Safety and Efficacy of MINIject S+ in Subjects With Open Angle Glaucoma
This is a prospective, multi-center, international, cohort expansion study. Part 1 will be conducted in subjects with open angle glaucoma to identify the best insertion tool for MINIject S+.
- Trial name
- STAR VII (NCT07009236)
- Testing
- MIGS
- Where
- 5 sites in Honduras, United Kingdom
- Volunteers
- 60 people
- Sponsor
- iSTAR Medical
Coronary Heart Disease, Medicine, Chinese Traditional
HuoXin Pills Intervention on Patients With Coronary Heart Disease After Drug-Coated Balloon Implantation
This trial is a multi-center, randomized, double-blind, placebo, parallel controlled study. Objectively evaluates the curative effect of Huoxin Pills (concentrated pills) intervention on improving the prognosis of patients with…
- Trial name
- HAPPY-DCB (NCT05489016)
- Testing
- Yuekang Huoxin Pills (concentrated pills), Yuekang Huoxin Pills (concentrated pills)simulant
- Where
- 3 sites in China
- Volunteers
- 440 people
- Sponsor
- China National Center for Cardiovascular Diseases
Recurrent Miscarriage
Effect of Prednisolone Treatment on Uterine Natural Killer Cells
This study aims to investigate the role of uNK cells and the association with prednisolone.
- Trial name
- NCT03902912
- Testing
- Prednisolone
- Where
- Hong Kong
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Heart Failure, Left Ventricular Assist Device
A Study of Metformin to Improve Cardiac Function After LVAD Implantation
This study investigates whether metformin, compared with placebo, improves cardiac function in patients after Left Ventricular Assist Device (LVAD) implantation.
- Trial name
- NCT07666698
- Testing
- Metformin Hydrochloride
- Where
- 5 sites in China
- Volunteers
- 108 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cataract
Bilateral Monofocal Versus Monofocal-EDOF IOL Implantation: Quality of Vision Comparison
The goal of this clinical trial is to compare visual quality after cataract surgery between two groups: bilateral monofocal intraocular lenses (IOL) and monofocal and contralateral extended depth-of-focus (EDOF) IOL implantation.
- Trial name
- COMEDI (NCT06002399)
- Testing
- cataract surgery
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Hearing Loss, Partial Deafness
Implantation of the HiRes90K™ Advantage Cochlear Implant With HiFocus™ Mid-Scala and Development of a Combined Electric and Acoustic Stimulation Technology in Adults With Partial Deafness
The purpose of this feasibility study is to evaluate whether low-frequency acoustic hearing sensitivity can be preserved in newly implanted adults with partial deafness (considerable low frequency acoustic hearing profiles with…
- Conditions
- Hearing Loss, Partial Deafness, Hearing Disorders, Ear Diseases
- Trial name
- NCT02189798
- Testing
- HiRes 90K™ Advantage implant with HiFocus™ Mid-Scala electrode, EAS sound processor
- Where
- 11 sites in United States
- Volunteers
- 67 people
- Sponsor
- Advanced Bionics
Myocardial Ischemia
Endocardial Stem Cells Approach Efficacy
The primary objective of this study is to test that endocardial stem cells implantation in patients who have CAD, low ejection fraction and signs of HF without possibility of CABG and PCI or despite on previous revascularization…
- Trial name
- ESCAPE (NCT00841958)
- Testing
- Autologous bone marrow mononuclear stem cells or peripheral blood stem cells
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
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