Clinical trials: EMERGENCY MEDICINE
Opioid Use Disorder
Contingency Management to Improve Medication for Opioid Use Disorder Continuation After the Emergency Department
Project Summary The goal of this pilot clinical trial is to assess contingency management (CM) for increasing attendance at outpatient clinics after Medication for Opioid Use Disorder (MOUD) prescription and clinic referral…
- Trial name
- CM+ED+MOUD (NCT07129902)
- Testing
- Contingency Management, Usual care as prescribed by the ED physicians
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Vermont
Covid19
A Study to Assess if a Medicine Called Bamlanivimab is Safe and Effective in Reducing Hospitalization Due to COVID-19
The purpose of this research is to test whether a new medication called bamlanivimab is safe and effective at reducing the need for hospitalization due to COVID-19.
- Trial name
- B-EPIC (NCT04796402)
- Testing
- Bamlanivimab, Standard of Care
- Where
- Canada
- Volunteers
- 576 people
- Sponsor
- Fraser Health
Pediatric Emergency Medicine
Testing of Medication Dosing Software
The goal of this clinical study is to evaluate the clinical efficiency of a medication dosing software in simulated pediatric emergency care.
- Trial name
- NCT06129370
- Testing
- Standard practice, Medication dosing software
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nura Medical
Medical Education, ICU
Case-Based Learning for Bedside Lung Ultrasound Teaching in ICU
This single-center randomized controlled study aims to evaluate the effectiveness of Case-Based Learning (CBL) compared with traditional teaching in clinical training of bedside lung ultrasound (BLUE) for emergency medicine…
- Conditions
- Medical Education, ICU, Emergency Medicine, Lung Ultrasound
- Trial name
- NCT07594470
- Testing
- Case-Based Learning (CBL), Traditional lecture-based teaching
- Where
- China
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Urinary Tract Infections
Single Dose Amikacin for Uncomplicated Cystitis in the ED: A Feasibility Study
The purpose of this study is to determine if a single dose of amikacin (a type of antibiotic) can be used to effectively treat emergency department patients with uncomplicated cystitis (inflammation of the bladder).
- Trial name
- NCT05227937
- Testing
- Amikacin
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Emergency Medicine, Artificial Intelligence (AI)
Diagnostic Accuracy of GPT-4o and Claude for HEART Score Calculation in Chest Pain
This prospective observational diagnostic accuracy study evaluates whether large language models (LLMs) - GPT-4o (OpenAI, gpt-4o-2024-11-20) and Claude (Anthropic, claude-sonnet-4-6) - can accurately calculate HEART scores from…
- Conditions
- Emergency Medicine, Artificial Intelligence (AI), Artificial Intelligence (AI) in Diagnosis, Chest Pain Rule Out Myocardial Infarction
- Trial name
- LLM-HEART (NCT07626060)
- Testing
- GPT-4o HEART Score Calculator, Claude HEART Score Calculator, Three-Expert Consensus HEART Score
- Where
- Turkey (Türkiye)
- Volunteers
- 690 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Intubation, Intratracheal
Different Techniques for Emergency Cricothyroidotomy
This educational study will examine two different techniques for training emergency residents and staff on achieving a surgical airway (called a cricothyroidotomy).
- Trial name
- CRIC (NCT01107561)
- Testing
- Seldinger technique, Surgical Airway Approach
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Drug Abuse
Screening, Brief Intervention, and Referral to Treatment for Drug Use
Screening, Brief Intervention, and Referral to Treatment (SBIRT) is a comprehensive, integrated public health approach to identify and deliver a spectrum of early detection and intervention services for substance use in general…
- Trial name
- SBIRT (NCT01683227)
- Testing
- Screening/motivational drug intervention
- Where
- 2 sites in United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Social Isolation, Loneliness
COVID-19 and Social Isolation and Loneliness Trial
Social isolation and loneliness worsen older peoples' quality of life, risk of dementia, and contributes to 45,000 deaths/year in Canada - as much as smoking.
- Conditions
- Social Isolation, Loneliness, Geriatric
- Trial name
- SIL (NCT05228782)
- Testing
- HOW R U? Intervention
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Dyspnea
Feasibility and Functionality Test of Ada's DDSS Prototype
This study is to explore with a feasibility and functionality test the potential of the Ada DDSS prototype with cases of dyspnea patients using the data collected at the Emergency Department (ED) and the ward of Internal medicine…
- Trial name
- Ada4dyspnoe (NCT04827342)
- Testing
- data collection in the Ada DDSS prototype
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Hospital, Basel, Switzerland
Chest Pain, Emergencies
RCT aiTriage Chest Pain Risk Stratification
Chest pain is one of the most common reasons people visit the Emergency Department (ED). While most cases are not serious, a small number may lead to life-threatening heart problems, known as Major Adverse Cardiac Events (MACE).
- Trial name
- NCT07074808
- Testing
- aiTriage risk score
- Where
- 2 sites in Singapore
- Volunteers
- 1,120 people
- Sponsor
- Singapore General Hospital
Social Isolation, Loneliness
Intergenerational Program for Social Isolation and Loneliness in Older Adults Discharged From the Emergency Department
Social isolation and loneliness worsens older adults' risk of dementia, quality of life, and death as much as smoking. Older adults are more likely to use emergency services and are also more likely to experience social isolation…
- Conditions
- Social Isolation, Loneliness, Geriatric
- Trial name
- SIL (NCT05998343)
- Testing
- Intergenerational HOW R U?, Same-Generation Peer Support HOW R U?
- Where
- Canada
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Nausea, Vomiting
Value of Ondansetron Medication vs Inhaled Isopropyl Therapy in the Emergency Department (VOMIITED)
This study will compare two different ways to relieve nausea and vomiting in the Emergency Department. The usual treatment for nausea/vomiting is a drug called Zofran, but new studies have suggested that smelling alcohol pads can…
- Trial name
- VOMIITED (NCT03125811)
- Testing
- Inhaled Isopropyl Alcohol (IPA), Oral Dissolvable Tablet Zofran (ondansetron)
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Status Epilepticus, Non-Convulsive Status Epilepticus
Point-of-care EEG in the Pediatric Emergency Department
The researchers investigate the use of a simplified electroencephalogram (point-of-care EEG) in the pediatric emergency department for children with impaired consciousness or an ongoing epileptic seizure ("status epilepticus").
- Conditions
- Status Epilepticus, Non-Convulsive Status Epilepticus, Altered Mental Status
- Trial name
- NCT05418634
- Testing
- point of care EEG
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Children's Hospital, Zurich
Seasonal Mood Disorder
Vitamin D Supplementation and Effects on Mood in Emergency Medicine Residents
Seasonal mood changes, and even feelings of depression, appear to have an association with decreased amounts of vitamin D in people living in geographic areas where exposure to sunlight during the winter months is relatively low.
- Trial name
- NCT03739671
- Testing
- Vitamin D, No Vitamin D
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Corewell Health South
Agitation
Naturalistic Adasuve Clinical Trial Study
There is limited information on the best psychoactive medication to treat agitated patients in the emergency department. The intent of this study is to fill in knowledge gaps in the current practice of treating psychiatric…
- Trial name
- NCT02877108
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mt Sinai Hospital, Chicago
Medication Compliance, Drug-Related Side Effects and Adverse Reactions
Improving Drug Safety in Emergency Patients -a Randomized Controlled Trial
Aim/Objective: Investigate the effect of implementing a working model for performing medication reconciliation (MR) and medication review (MRe) in the emergency department (ED), on readmissions, patient safety and efficiency of…
- Conditions
- Medication Compliance, Drug-Related Side Effects and Adverse Reactions, Remission, Medicinal Substance; Adverse Effect
- Trial name
- EPIMERR (NCT03123640)
- Testing
- Medication reconciliation and medication review
- Where
- Norway
- Volunteers
- 806 people
- Sponsor
- Diakonhjemmet Hospital
Operational Metrics of the Emergency Department
Prospective Evaluation of Computerized Physician Order Entry in the Emergency Department
This study will evaluate various performance metrics of emergency department operations after the implementation of computerized physician order entry in an academic emergency department.
- Trial name
- CPOE (NCT01444768)
- Testing
- Computerized Physician Order Entry
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Analgesics, Opioid, Delivery of Health Care
A Quality Improvement Project to Investigate Individual Provider Variation in Opioid Prescribing From the Emergency Department
This is a study of emergency physicians' prescribing patterns related to opioid (narcotic) medications. We are trying to determine whether giving providers access to their own prescribing data influences their prescribing…
- Conditions
- Analgesics, Opioid, Delivery of Health Care, Drug Prescribing, Over Prescribing
- Trial name
- NCT02665429
- Testing
- Individual prescribing data profile and self-assessment
- Where
- 3 sites in United States
- Volunteers
- 109 people
- Sponsor
- University of Massachusetts, Worcester
Burnout, Professional, Depression
Does a Phone-based Meditation Application Improve Mental Wellness in Emergency Medicine Personnel?
Emergency medicine is notorious for its high rate of burnout and mental health issues. The emergency department (ED) is a high paced work environment dealing with life and death issues.
- Conditions
- Burnout, Professional, Depression, Anxiety, Stress
- Trial name
- NCT03811990
- Testing
- Cleveland Clinic Stress Free Now Meditations For Healers
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin