Clinical trials: EMERGENCY MEDICINE
Status Epilepticus
Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications
The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.
- Trial name
- RAMPART (NCT00809146)
- Testing
- Intramuscular route of active treatment, Intravenous route of active treatment
- Where
- 17 sites in United States
- Volunteers
- 1,023 people
- Sponsor
- Robert Silbergleit
Ondansetron
Ondansetron and the QT Interval In Adult Emergency Department Patients
The purpose of this study is to assess the use of the medication ondansetron (zofran) in the emergency department. There are studies of the ability of ondansetron to cause a prolongation in the QT interval (a certain measurement…
- Trial name
- NCT01759420
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- C.R.Darnall Army Medical Center
Acute Otitis Media, Acute Otitis Externa
Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto)
Acute otitis media (AOM), defined as acute inflammation in the middle ear, is a leading cause of health encounters and antimicrobial prescriptions in children worldwide.
- Trial name
- NCT02918773
- Testing
- Smartphone otoscope, Conventional otoscope
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Emory University
Opioid-Use Disorder (OUD)
SafetyNet Program for Opioid Use Disorder (OUD)
The principal aim of this study is to determine whether a novel biopsychosocial intervention following opioid overdose (OD) affects 1) the frequency of secondary opioid OD events and 2) the proportion of individuals who remain…
- Trial name
- NCT04253782
- Testing
- Team Intervention
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- Yale University
Reproductive Behavior, Sexual Behavior
Reducing Teen Pregnancy in the Emergency Department
This study will determine the feasibility, acceptability, and potential efficacy of an emergency department-based pregnancy prevention intervention targeting sexually active adolescent female emergency department patients.
- Conditions
- Reproductive Behavior, Sexual Behavior, Adolescent Behavior, Contraception
- Trial name
- ERICA (NCT03866811)
- Testing
- Dr. Erica
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cardiopulmonary Arrest, Resuscitation
Reducing Prehospital Medication Errors & Time to Drug Delivery by EMS During Simulated Pediatric CPR
The study investigators will recruit paramedics in many Emergency Medical Services (EMS) in Switzerland to prepare direct intravenous (IV) emergency drugs during a standardized simulation-based pediatric out-of-hospital cardiac…
- Conditions
- Cardiopulmonary Arrest, Resuscitation, Pediatrics, Medication Errors
- Trial name
- NCT03921346
- Testing
- Mobile device app (PedAMINES™) 1st drug, Mobile device app (PedAMINES™) 2nd drug, Mobile device app (PedAMINES™) 3rd drug
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Syncope
Syncope Decision Aid for Emergency Care
Syncope, or transient loss of consciousness/fainting, is a common emergency department (ED) complaint responsible for over 1 million ED visits yearly.
- Trial name
- SynDA (NCT02971163)
- Testing
- SynDA
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
General Medicine, Emergency Medicine
Improving Follow-Up for Discharged Emergency Care Patients
This study's purpose is to test the effects of an electronic health intervention platform developed by Epharmix (also known as CareSignal), which features two-way SMS text messages and phone calls intended to improve clinical…
- Conditions
- General Medicine, Emergency Medicine, Mobile Health
- Trial name
- NCT03002311
- Testing
- Epharmix/CareSignal eHealth
- Where
- United States
- Volunteers
- 327 people
- Sponsor
- Washington University School of Medicine
Pediatric Disorder
A Comparison of Accuvein to Standard IV Access in Children 0 to 24 Months of Age in the Pediatric ED
Obtaining intravenous (IV) access in children under the age of 2 years is difficult, especially in the emergency department (ED) where the children can be frightened, dehydrated and ill.
- Trial name
- NCT02381392
- Testing
- Accuvein AV400
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Diabetes Mellitus, Type 2, Medication Adherence
The Synergy to Control Emergency Department Hyperglycemia Program for Type 2 Diabetes
A 4 week prospective, randomized controlled study was carried out to assess the impact of a care delivery intervention which focused on blood glucose (BG) management among adults with type 2 diabetes presenting to the Emergency…
- Conditions
- Diabetes Mellitus, Type 2, Medication Adherence, HYPERGLYCEMIA
- Trial name
- STEP-DM (NCT02269098)
- Testing
- Diabetes medication management
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Medstar Health Research Institute
Pain
Geriatric Ketamine for Pain Management Study
This research project is geared towards geriatric analgesia in the Emergency Department (ED) with a goal of reducing the administration of opioid pain medications to elderly patients, thereby avoiding the commonly occurring…
- Trial name
- NCT02673372
- Testing
- Morphine, Ketamine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Antonios Likourezos
Pain
The Effect of Pretreatment With Intravenous Lidocaine for Intravenous Contrast:
Intravenous contrast media is commonly used for CT scans for improved image clarity in pediatric emergency medicine. Children who feel discomfort during the administration of IV contrast media may not remain still during the CT…
- Trial name
- NCT05143489
- Testing
- Preservative Free Lidocaine, Saline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Antonios Likourezos
Pain
An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache
Headaches affect over 50% of patients annually, with close to 4% of ED visits for headache. Most headaches managed in the ED are benign, with 90% of these headaches classified as tension, migraine, or cluster.
- Trial name
- NCT04860713
- Testing
- aspirin and ketamine, Nurtec (Rimegepant)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Antonios Likourezos
Emergencies
Primary Palliative Care for Emergency Medicine (PRIM-ER)
This proposal builds upon the evaluation of Primary Palliative Care Education, Training, and Technical Support for Emergency Medicine (PRIM-ER) implemented in a cluster-randomized, stepped wedge design in 33 Emergency Departments…
- Trial name
- NCT03424109
- Testing
- healthcare service utilization in the six months following the ED visit
- Where
- United States
- Volunteers
- 98,922 people
- Sponsor
- NYU Langone Health
Asthma
Inhaled Corticosteroids After a Pediatric Emergency Visit for Asthma
Specific Aim: To determine whether a prescription for Inhaled Corticosteroids (ICS) added to standard Emergency Department (ED) discharge therapy for young children with persistent asthma symptoms increases ICS use and improves…
- Trial name
- NCT00294398
- Testing
- ICS Prescription + Standard Asthma ED Discharge Therapy, Standard Asthma ED Discharge Therapy
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Children's Hospital of Philadelphia
Aging
Reducing Potentially Inappropriate Medication Prescribing for Older Patients in the ED
This research is being conducted to learn which implementation strategy of EQUIPPED is most effective to improve prescribing practices of ED providers toward older Veterans and determine the factors influencing implementation of…
- Trial name
- EQUIPPED (NCT04004936)
- Testing
- EQUIPPED with Active Feedback, EQUIPPED with Passive Feedback
- Where
- 4 sites in United States
- Volunteers
- 74 people
- Sponsor
- VA Office of Research and Development
Acute Severe Pain
Titration of Intravenous Hydromorphone
This is an exploratory, hypothesis-generating safety and efficacy study for patients who come to the ER in acute (less than 7 days in duration) severe pain. Patients with chronic pain will not be enrolled.
- Trial name
- NCT01892709
- Testing
- Hydromorphone
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Adverse Drug Events, Adverse Drug Reactions
Pharmacogenetic Testing Among Home Health Patients
Patients meeting eligibility criteria will be randomized into two groups, one receiving pharmacogenetic testing and the other not receiving pharmacogenetic testing.
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED
- Trial name
- NCT02378220
- Testing
- Pharmacogenetic testing
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Genelex Corporation
Drug Overdose, Opioid-Related Disorders
Safety & Prevention Outcomes Study
Unintentional poisoning is a developing public health problem in the U.S. Unintentional poisoning (or "overdose") deaths increased 157% among adults between 1999 and 2008.
- Trial name
- SPOS (NCT01894087)
- Testing
- TBI - Cohort 1, TBI - Cohort 2
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- University of Michigan
Pain
Sub-dissociative Ketamine for the Management of Acute Pediatric Pain
The proposed trial is a prospective, double blinded, randomized control trial with the primary aim of determining whether a single, sub-dissociative dose of ketamine will decrease the total narcotic requirements of pediatric…
- Trial name
- NCT01951963
- Testing
- Ketamine, Morphine
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- HealthPartners Institute