Clinical trials: ENT Disease
HNSCC,Larynx, Pharynx and Oral Cavity, Squamous Cell Carcinoma
Study Evaluating the Safety and Feasibility of Panitumumab-IRDye800 and [18F]NOTA-ABY-030 for Targeted Dual-Modality Imaging (TDMI) in Head and Neck Squamous Cell Carcinoma
The goal of this clinical trial is to learn whether using two imaging agents-Panitumumab-IRDye800 (Pan800) and[18F]NOTA-ABY-030-is safe and feasible for helping surgeons identify tumors and cancer-containing lymph nodes during…
- Conditions
- HNSCC,Larynx, Pharynx and Oral Cavity, Squamous Cell Carcinoma, Head and Neck Cancer, Head and Neck Surgery
- Trial name
- NCT07741643
- Testing
- Panitumumab-IRDye800, [18F]NOTA-ABY-030
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Quality of Life (QOL), Communication Barriers
The Mental Cost and Burden of Listening
This randomised controlled trial aims to test the effect of hearing adjustment using hearing aids, on the ease and effectiveness of communication such as listening effort, fatigue, and sentence recognition in noise, in addition…
- Conditions
- Quality of Life (QOL), Communication Barriers, Cognitive Performance, Fatigue, Mental
- Trial name
- NCT06951815
- Testing
- Hearing aids programmed to each participant's hearing loss.
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Rhinitis
Effect Of Probiotic Lactobacillus Paracasei Lp-33 For The Management Of Rhinitis In People Sensitized To Allergens
The aim of the study is to show an improvement of quality of life on the 5th week of product consumption (probiotic Lactobacillus paracasei LP-33)(as assessed by RQLQ global score) in subjects with persistent allergic rhinitis…
- Trial name
- BionAtlanta (NCT01096615)
- Testing
- Lactobacillus paracasei LP-33
- Where
- 125 sites in France
- Volunteers
- 500 people
- Sponsor
- Merck Medication Familiale
Asthma, Respiratory Tract Infections
VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma
The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma/persistent wheeze during the first three years of life as we hypothesize that…
- Conditions
- Asthma, Respiratory Tract Infections, Gastrointestinal Infection, Croup
- Trial name
- VICTORY (NCT06570889)
- Testing
- Cholecalciferol D3, Olive oil
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Professor Klaus Bønnelykke
Tinnitus, Hearing Loss
Correlation Analysis of Hearing Thresholds, Validated Questionnaires and Psychoacoustic Measurements in Tinnitus Patients
Objective: To evaluate the correlation between audiometric thresholds, pitch matching (PM), minimum masking level (MML), Tinnitus Handicap Inventory (THI) and the Beck Depression Inventory (BDI) in tinnitus patients.
- Conditions
- Tinnitus, Hearing Loss, Depression
- Trial name
- NCT00976547
- Where
- 2 sites in Brazil
- Volunteers
- 48 people
- Sponsor
- Faculdade de Medicina de Valenca
Swallowing Function, Swallowing Risk
DDK Acoustic Analysis and Swallowing Indicators
This study examines whether simple speech tasks and a swallowing screening test can help identify swallowing risk in adults of different ages.
- Conditions
- Swallowing Function, Swallowing Risk, Dysphagia
- Trial name
- AAP-DDK (NCT07626749)
- Where
- Taiwan
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University
Allergic Rhinitis, Sleep Disorder
Establishing the Collaborative Care Model for Pediatric Allergic Rhinitis With Sleep Disorder
The purpose of study is to compared the impact of the integrative care clinic to ordinary western medicine among patients of moderate persistent allergic rhinitis combined with sleep disorder and establishing the collaborative…
- Trial name
- NCT05031793
- Testing
- TCM, Western medicine
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- China Medical University Hospital
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
China CRSwNP Registry Study
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory disease of the nose and sinuses that can cause nasal blockage, loss of smell, nasal discharge, facial discomfort, sleep problems, and reduced…
- Trial name
- POLARIS (NCT07795658)
- Testing
- Routine Clinical Care for CRSwNP
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Beijing Tongren Hospital
Otitis Media With Effusion, Chronic Otitis Media
Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy
To investigate the incidence of tuba dysfunction (TD) and middle ear (ME) morbidity after radiotherapy (RT) to the Head \& Neck and test the effect of auto-inflation of the Eustachian tube (ET) on middle ear effusion with a…
- Conditions
- Otitis Media With Effusion, Chronic Otitis Media, Hearing Loss
- Trial name
- NCT02716376
- Testing
- Otovent®
- Volunteers
- 30 people
- Sponsor
- Zealand University Hospital
Nasal Polyps
Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS
This study aimed to show the effect of sphinopalatine ganglion blockade on surgical field, hemodynamics and postoperative pain in FEES operation.
- Trial name
- NCT04996576
- Testing
- infrazygomatic approach sphinopalatine ganglion block, intranasal injection approach of sphinopalatine ganglion block
- Where
- 2 sites in Egypt
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Otitis Media
Tympanostomy Tube Placement in Children in the Office (Inova Study)
The objective of the study is to evaluate the safety and efficacy of the Acclarent Tula TDS for the placement of tympanostomy tubes under local anesthesia in an office/clinic setting.
- Trial name
- Inova (NCT01496287)
- Testing
- Tube Delivery System (TDS)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Integra LifeSciences Corporation
Noise-induced Hearing Loss
Test of Hearing Health Education Programs for Farm and Rural Youth
Farm and rural youth have frequent exposure to hazardous noise on the farm and recreationally, and have an increased prevalence of noise-induced hearing loss (NIHL).
- Trial name
- FARMYOUTHEAR (NCT02472821)
- Testing
- Interactive youth educational program, Internet-based educational booster
- Where
- United States
- Volunteers
- 2,093 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hearing Loss
Protection From Cisplatin Ototoxicity by Lactated Ringers
The purpose of this study is to determine if Lactated Ringer's solution is effective in patients undergoing chemotherapy with cisplatin for head and neck cancer in regards to cisplatin-induced hearing loss.
- Trial name
- NCT00584155
- Testing
- Normal Saline and 0.3% ofloxacin, Lactated Ringer's with 0.03% Ofloxacin
- Where
- United States
- Sponsor
- University of Oklahoma
Seasonal Allergic Rhinitis
Phase II/III Seamless Clinical Study of MG-K10 Humanized Monoclonal Antibody Injection in Treatment of Seasonal Allergic Rhinitis
A multicenter, randomized, double-blind, placebo-controlled Phase II/III seamless clinical study evaluating the efficacy, safety, pharmacokinetic (PK) profile, pharmacodynamic (PD) profile, and immunogenicity of MG-K10 humanized…
- Trial name
- NCT06846385
- Testing
- MG-K10 Humanized Monoclonal Antibody Injection
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Mabgeek Biotech.Co.Ltd
Asthma, House Dust Mite Allergy
Safety Study of Sublingual Immunotherapy Tablets of House Dust Mite Allergen Extracts
The purpose of this study is to investigate the safety of different doses of sublingual tablets of house dust mite allergen extracts in adults with house dust mite-associated allergic asthma.
- Trial name
- NCT01608243
- Testing
- SLIT tablets of house dust mite allergen extracts
- Where
- France
- Volunteers
- 94 people
- Sponsor
- Stallergenes Greer
Allergic Rhinitis
The Use of Hydrogen Ion Water (Shan Shang Water) in the Treatment of Allergic Rhinitis
The goal of this clinical trial is to evaluate whether Shan Shang Water (hydrogen ion water) can help treat allergic rhinitis in adults and affect immune markers.
- Trial name
- SSWAR (NCT06756243)
- Testing
- Hydrogen Ion Water（Shan Shang Water）, Budesonide Nasal Spray therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Respiratory Insufficiency, Fasting
Non-inferiority of Continuing Oral Intake Versus Fasting in Patients With Acute Respiratory Failure
Fasting in intensive care is mainly studied in mechanically ventilated patients or those in the weaning phase. Recent research challenge the common assumption of fasting and suggests that continuing enteral nutrition before…
- Conditions
- Respiratory Insufficiency, Fasting, Dysphagia, Swallowing Disorder
- Trial name
- JEUN-TUBE (NCT06510972)
- Testing
- Oral intake continuation strategy, Fasting strategy
- Where
- 14 sites in France
- Volunteers
- 754 people
- Sponsor
- University Hospital, Tours
Nasopharyngeal Carcinoma, EBV-Related Gastric Carcinoma
Nanatinostat Plus Valganciclovir in Advanced EBV+ Solid Tumors and in Combination With Pembrolizumab in EBV+ RM-NPC
This study will evaluate the safety and efficacy of nanatinostat in combination with valganciclovir in patients with relapsed/refractory EBV-positive solid tumors and in combination with pembrolizumab in patients with…
- Conditions
- Nasopharyngeal Carcinoma, EBV-Related Gastric Carcinoma, EBV-Related Leiomyosarcoma, EBV Related Carcinoma
- Trial name
- NCT05166577
- Testing
- Nanatinostat, Valganciclovir, Pembrolizumab
- Where
- 13 sites in United States, Australia and 6 more
- Volunteers
- 26 people
- Sponsor
- Viracta Therapeutics, Inc.
DYSPHAGIA
Evaluation Of The Effectiveness Of Safe Nutrition Program Applied To Acute Stroke Patients With Dysphagia
It was planned in a quasi-experimental design with a non-randomized control group. The study was planned to be completed in three stages: control, preparation and intervention periods.
- Trial name
- NCT06269575
- Testing
- SAFE NUTRITION PROGRAM
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Istanbul University - Cerrahpasa
Dysphagia
Validation of the Gugging Swallowing Screen for the Intensive Care Unit
Aetiology of dysphagia after extubation is unknown and considered to be multifactorial. Use of a standardized dysphagia- screening permits an early diagnosis.
- Trial name
- GUSS-ICU (NCT04532398)
- Testing
- Gugging swallowing screen - ICU (GUSS-ICU) index test, Flexible Endoscopic Evaluation of Swallowing (FEES) reference test
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University Hospital, Basel, Switzerland