Clinical trials: ENT Surgery, open to volunteers
Sensorineural Hearing Loss, Bilateral Hearing Loss
Comparative Analysis of Hearing Outcomes: Robotic vs. Manual Insertion of Cochlear Implants
This research study is evaluating two different methods of cochlear implant (CI) insertion - robotic-assisted insertion and manual insertion - to better understand how they affect hearing outcomes.
- Conditions
- Sensorineural Hearing Loss, Bilateral Hearing Loss, Cochlear Implantation, Hearing Disorders
- Trial name
- NCT07081542
- Testing
- IotaSoft Robotic Insertion System, Manual Cochlear Implant Insertion
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- AdventHealth
Head and Neck Cancer (H&N), Cancer of the Head and Neck
Online Perioperative Education Program on Patient Satisfaction and Clinical Outcomes for Head and Neck Surgery
CareOrbit is a digital perioperative patient-education and care navigation platform developed by the St. Louis-based venture Total Orbit in collaboration with Washington University's CORTEX Business Incubator.
- Trial name
- NCT07848841
- Testing
- CareOrbit, Standard perioperative education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Cervical Surgery, Endonasal Surgery
Effect of Passive Music Therapy Via an App on Anxiety Prevention in ENT Surgery
Music therapy is a controlled method of listening to music, utilizing its physiological, psychological, and emotional effects on humans during the treatment of illness or trauma.
- Conditions
- Cervical Surgery, Endonasal Surgery, Otologic Disease, Oropharyngeal Disease
- Trial name
- MUSICORL (NCT06600919)
- Testing
- Preoperative Music Therapy Session
- Where
- Reunion
- Volunteers
- 500 people
- Sponsor
- Clinique Saint-Vincent
Otorhinolaryngologic Neoplasms
Support Pathway for ENT Cancer Patients in a Support Care Day Hospital
Cancers of the upper respiratory / digestive tract are a major public health problem, ranking 5th among the most common cancers. Surgery plays a central role in the recommended treatments for this type of pathology.
- Trial name
- PAKO-HDJ (NCT06512662)
- Testing
- Consultations with paramedics
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Clinique Pasteur Lanroze
Head Neck Cancer, Mouth Cancer
CApecitabine Prior to TUmor Resection in Ent Oncology (CAPTURE)
head and neck squamous cell carcinoma (HNSCC) is a type of cancer that affects areas such as the mouth, throat, and voice box. Despite medical progress, little has changed in the care for patients with HPV-negative cancer.
- Conditions
- Head Neck Cancer, Mouth Cancer, Throat Cancer, Larynx Cancer
- Trial name
- CAPTURE (NCT07254962)
- Testing
- Capecitabine, Standard of Care (SOC)
- Volunteers
- 75 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Muskuloskeletan Pain
Ergonomic Evaluation of Exoskeleton Use in Transoral, Endoscopic, and Transcervical ENT Surgery: A Single Site Non-blinded Study
The goal of this observational study is to learn whether the use of an exoskeleton system can reduce musculoskeletal strain and fatigue during ENT surgical procedures in ENT surgeons performing transoral, endoscopic, and…
- Trial name
- ExoskeletonENT (NCT07855159)
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- East and North Hertfordshire NHS Trust
Tonsil Hypertrophy
Effect of the Combination of Dexamethasone and BIS Monitoring on Reducing Postoperative Nausea and Vomiting in Children
This study will investigate the impact of combining dexamethasone and bispectral index (BIS) monitoring on the incidence of postoperative nausea and vomiting, emergence delirium and recovery trajectories in children undergoing…
- Trial name
- BISDEX (NCT07299435)
- Testing
- BIS monitoring
- Where
- 5 sites in Czechia
- Volunteers
- 1,508 people
- Sponsor
- University Hospital Ostrava
ENT Disorder, Nasal Procedures
Pharmacokinetics, Safety, and Tolerability Study of GOPRELTO® Nasal Solution and NUMBRINO™ Nasal Solution
The purpose of this study is to assess the pharmacokinetic (PK) properties, safety and tolerability following a single dose administration of GOPRELTO® or NUMBRINO™ as an anesthetic for diagnostic procedures and surgeries on or…
- Conditions
- ENT Disorder, Nasal Procedures, Nasal Anesthesia, Nasal Mucosa Surgery
- Trial name
- NCT04792034
- Testing
- Cocaine Hydrochloride Nasal Solution
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- LXO Ireland
Workplace Violence, Perceived Safety
Workplace Violence and Safety Perception Among ENT Physicians in Turkey
This multicenter, cross-sectional survey study aims to evaluate the perceived level of safety and security against workplace violence among otolaryngology-head and neck surgery (ENT-HNS) physicians in Turkey.
- Conditions
- Workplace Violence, Perceived Safety, Occupational Health, Otolaryngology-Head and Neck Surgery Physicians
- Trial name
- NCT07311629
- Testing
- Online Survey Questionnaire
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
ENT Cancers
Evaluation of the Superficial Cervical Plexus Block in Oncological Throat and Neck Surgery
This national, prospective, multicenter, randomized study aims to reduce the amount of intravenous morphine (titration + PCA morphine) during the first 24 postoperative hours via a locoregional anesthesia technique in patients…
- Trial name
- BCS-ORL (NCT07110857)
- Testing
- Cervical plexus block with 0.2 % Naropeine
- Where
- 7 sites in France
- Volunteers
- 346 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Cancer
Effect of Prehabilitation on Head and Neck Cancer Patients
The primary aim of the study is to investigate the feasibility of a prehabilitation program, which consists of a set of strategies including physical activity, nutritional support, and psychological counseling, carried out before…
- Trial name
- HNCANCERFIT (NCT06593639)
- Testing
- Prehabilitation before surgery, Prehabilitation before and during CRT
- Where
- 5 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Laura Deborah Locati
Glottic Carcinoma, Supraglottic Carcinoma
Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC)
For early stage laryngeal carcinoma and hypohparyngeal carcinoma (T1 and T2), transoral laser microsurgery, open partial laryngectomy, radiotherapy, and transoral robotic surgery were performed according to NCCN guidelines…
- Conditions
- Glottic Carcinoma, Supraglottic Carcinoma, Subglottic Carcinoma, Pyriform Sinus Carcinoma
- Trial name
- NCT04908696
- Testing
- routines
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Anxiety, Acute Post Operative Pain
Gender-specific Preoperative Anxiety Level and Postoperative Opioid Requirement After ENT Surgery.
The study will be designed to investigate the impact of the preoperative anxiety level on postoperative opioid requirement during the PACU stay, in order to improve postoperative pain treatment in the long term after ENT surgery.
- Trial name
- NCT05141591
- Testing
- Anxiety level assessment
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pain Management
Local Anesthesia for Facial Fractures
The study is a double-blind randomized, placebo controlled trial examining the impact of perioperative bupivacaine nerve block on PACU recovery metrics.
- Trial name
- LAFF (NCT06429501)
- Testing
- Bupivacaine/Epinephrine, Saline
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Head and Neck Cancer
Study Evaluating Near-infrared Imaging Coupled With Indocyanine Green for Intraoperative Control of Resection Margins in ENT Surgery
Assess the sensitivity of real-time near-infrared fluorescence imaging to detect microscopic residual disease in the operating room after a complete macroscopic surgical resection of head and neck cancers
- Trial name
- MAGNOLIA (NCT04842162)
- Testing
- indocyanine green
- Where
- 2 sites in Belgium, France
- Volunteers
- 65 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Frailty
SCM Muscle as a Marker for Frailty in Patients Undergoing ENT Surgery
This study focuses on evaluating the relationship between physical frailty and measurements of the muscles of the neck in patients undergoing non-cancer Head and Neck surgery.
- Trial name
- NCT06704256
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Head and Neck Neoplasms, UADT Neoplasm
Post-Operative Antibiotic Efficacy in Clean Contaminated Head and Neck Surgery: A Randomized Controlled Trial
The "Post-Operative Antibiotic Efficacy in Clean Contaminated Head and Neck Surgery" (PEACH) trial is a study designed to assess the necessity of post-operative antibiotics for preventing surgical site infections (SSIs) in…
- Conditions
- Head and Neck Neoplasms, UADT Neoplasm, Cancer of the Head and Neck, Antibiotic Resistant Infection
- Trial name
- PEACH (NCT06672471)
- Testing
- No Post Operative Antibiotics for intervention group, Post Operative Antibiotics for one day
- Where
- Pakistan
- Volunteers
- 170 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Postoperative Hypoxemia
Preoperative ROX Index for Predicting Early Postoperative Hypoxemia in ENT Surgery
Early postoperative hypoxemia is a frequent complication after elective ear, nose, and throat (ENT) surgery and may adversely affect recovery in the post-anesthesia care unit (PACU).
- Trial name
- NCT07344103
- Testing
- rox ındex
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istinye University