Clinical trials: EV71
Hand, Foot and Mouth Disease
Safety and Immunogenicity Study of an Inactivated Vaccine Against Hand, Foot and Mouth Disease Caused by Enterovirus 71
The purpose of this study is to evaluate the safety and immune response of an inactivated vaccine to prevent hand, foot and mouth disease (HFMD) caused by Enterovirus 71 (EV71).
- Trial name
- NCT01376479
- Testing
- INV21 Low Dose, INV21 High Dose
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Inviragen Inc.
EV71-associated Disease
A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children
Hand, foot, and mouth disease (HFMD) is a common viral illness in infants and children caused by viruses that belong to the enterovirus genus of the picornavirus family.
- Trial name
- NCT01734408
- Testing
- alum-adjuvant 160U /0.5ml, alum-adjuvant 320U /0.5ml, alum-adjuvant 640U /0.5ml
- Where
- China
- Volunteers
- 773 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Hand, Foot, and Mouth Disease, Enterovirus Infections
A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants
Hand, foot, and mouth disease (HFMD) is a common viral illness in infants and children caused by viruses that belong to the enterovirus genus of the picornavirus family.
- Trial name
- NCT01313715
- Testing
- 160U /0.5ml, 320U /0.5ml, 640U /0.5ml
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Systems Biology, Early Gene
Systems Biology of Vaccination for EV71 Vaccine in Humans
Recently, an inactivated vaccine (vero cell) against EV71 has been investigated in Phase 1 and Phase 2 clinical trials. Data from these trials showed that the EV71 vaccine has good safety profile and was immunogenic.
- Conditions
- Systems Biology, Early Gene, EV71 Vaccine
- Trial name
- NCT01679665
- Testing
- 320U /0.5ml
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Safety of Inactivated EV71 Vaccine, Immunization of Inactivated EV71 Vaccine
The Phase IVa of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17)
Enterovirus 71 (EV71), a major pathogen causing hand-foot-and-mouth disease (HFMD) worldwide, is a member of the Human Enterovirus species A, family Picornaviridae.
- Trial name
- NCT02999828
- Testing
- inactivated EV71 vaccine (KMB-17)
- Where
- China
- Volunteers
- 20,770 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences
Hand Foot & Mouth Disease
Safety & Immunogenicity of Enterovirus Type 71 Vaccine in Healthy Adults and Children 6-71months
1. Burden: Hand-foot-and-mouth disease (HFMD) characterized by skin rash in extremities, mouth ulcer and fever among <5 years children.Primarily caused by Enterovirus- predominantly human Enterovirus (EV) 71 and Coxsackie virus…
- Trial name
- NCT04467541
- Testing
- Inactivated Enterovirus Type 71 (EV71) Vaccine (Vero Cell)
- Where
- Bangladesh
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Hand, Foot and Mouth Disease, Herpangina
A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months
Since its discovery in 1969, enterovirus 71 (EV71) has been recognised as a frequent cause of epidemics of hand-foot-mouth disease (HFMD) associated with severe neurological sequelae in a small proportion of cases.
- Conditions
- Hand, Foot and Mouth Disease, Herpangina, Other EV71-associated Diseases
- Trial name
- NCT01508247
- Testing
- inactivated vaccine (Vero Cell) against EV71
- Where
- 4 sites in China
- Volunteers
- 10,245 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Enterovirus Infections
Extension Study of Protocol EV-BR1701 Group B1
The main study was a randomized, multi-nation, multi-centered, double-blinded, phase III study on subjects aged 2 months to <6 years old (<72 months). Two parts were conducted in Taiwan (Group A) and Vietnam (Group B).
- Trial name
- NCT07630493
- Where
- Vietnam
- Volunteers
- 126 people
- Sponsor
- Enimmune Corporation
Immunogenicity, Safety
A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants
Hand, foot, and mouth disease (HFMD) is a common viral illness in infants and children caused by viruses that belong to the enterovirus genus of the picornavirus family.
- Trial name
- NCT01399853
- Testing
- 160U /0.5ml EV71 Vaccine, 320U /0.5ml EV71 vaccine, 640U /0.5ml EV71 vaccine
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Enterovirus 71 Infection
A Study to Evaluate the Efficacy, Safety, and Immunogenicity of an EV71 Vaccine
Subjects will receive the first IM injection of study vaccine on Day 1 and will receive a second dose 56 days later. A booster vaccine will be given 365 days after the first dose in subjects 2 months to < 2 years of age.
- Trial name
- NCT03865238
- Testing
- EV71vac
- Where
- 6 sites in Taiwan, Vietnam
- Volunteers
- 3,061 people, healthy volunteers welcome
- Sponsor
- Medigen Vaccine Biologics Corp.
Hand, Foot and Mouth Disease
Phase IV Clinical Trial, Immunogenicity and Safety of EV71 Vaccine
The purpose of this study is to evaluate the immunogenicity and safety of EV71 vaccine in infants aged 6 to 35 months old, by detecting the dynamic changes of neutralizing antibody at different time after vaccination
- Trial name
- NCT03278132
- Testing
- EV71 vaccine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Enterovirus Infection
A Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine
This study is aims to evaluate the safety, reactogenicity and immunogenicity of EV71 vaccine at a 0.25ml or 0.5ml dose in health volunteers
- Trial name
- NCT01268787
- Testing
- EV71 vaccine
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
Hand, Foot and Mouth Disease
Clinical Trial of Enterovirus 71（EV71） Inactivated Vaccine in Children Aged 36-71 Months
The purpose of this study is to evaluate the non-inferiority of experimental EV71 vaccine compared to the control EV71 vaccine in children aged 36-71 months, to evaluate the non-inferiority of EV71 vaccine used in children aged…
- Trial name
- NCT03909074
- Testing
- 36-71 months old children-experimental EV71 vaccine., 36-71 months old children-control EV71 vaccine., 6-35 months old children-experimental EV71 vaccine.
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Sinovac Biotech Co., Ltd
Hand, Foot and Mouth Disease
Efficacy Evaluation for Inactivated Vaccine (Vero Cell) Against EV71
This study is a multicenter, case-control phase IV clinical trial to evaluate the effectiveness of the EV71 vaccine. About 40000 children in the town aged 6-35 months will be recruited and vaccinated with EV71 vaccines, which…
- Trial name
- NCT03582761
- Testing
- EV71 vaccine
- Where
- 2 sites in China
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention