Clinical trials: Ear Noise
Speech Perception
Improving Perception of Speech in Noise in Children With Communication Disorders
Smarty Ears has developed a prototype of an innovative therapeutic training system to improve speech perception in noise by training children on interrupted noise (which has silent intervals that allow for fragments of the target…
- Trial name
- L2F (NCT04473729)
- Testing
- Audiovisual speech training in noise for children
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Smarty Ears
Tinnitus
Vestipitant Or Vestipitant/Paroxetine Combination In Subjects With Tinnitus And Hearing Loss.
Tinnitus associated to hearing loss is a high prevalent audiologic disorder with important unmet needs as far as therapy is concerned.
- Trial name
- NCT00394056
- Testing
- Vestipitant, Vestipitant + Paroxetine
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- GlaxoSmithKline
Sensorineural Hearing Loss, Tinnitus
Regenerative Medicine and Stem Cell-Based Interventions for Inner Ear Trauma, Tinnitus, and Sensorineural Hearing Loss
The HEAR-RESTORE study is an exploratory clinical research program designed to evaluate new diagnostic and regenerative approaches for individuals experiencing inner ear injury, tinnitus, and temporary or permanent hearing loss.
- Conditions
- Sensorineural Hearing Loss, Tinnitus, Acoustic Trauma, Inner Ear Injury
- Trial name
- HEAR-RESTORE (NCT07472023)
- Testing
- Audiologic Monitoring, Investigational Regenerative Pharmacologic Therapy, Stem Cell Regenerative Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Truway Health, Inc.
Tinnitus
Tinnitus Measured by MEG and Synchronous Neural Interaction™ Test: Template Development
The study is designed to identify specific patterns of brain functional activity associated with chronic, moderate to severe tinnitus through the use of resting-state MEG scans.
- Trial name
- NCT01185990
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Orasi Medical, Inc.
Tinnitus
Clinical Benefit of Hearing Aid Tinnitus Feature on Tinnitus-Related Annoyance in Tinnitus Patients in Belgium
Tinnitus, the perception of sound without an external source, affects around 15% of the global adult population (Jarach et al., 2022).
- Trial name
- NCT07711249
- Testing
- Sonova manufactured hearing aids with built-in Tinnitus feature
- Volunteers
- 170 people
- Sponsor
- Sonova AG
Tinnitus
A Study of the Safety and Efficacy of TRTL-913 in Healthy Volunteers (Part A) and in Adults With Tinnitus (Part B)
This study will consist of two parts. Double blind Part A will assess the safety, tolerability, and pharmacokinetics of 7 days of dosing in healthy adults, while open label Part B will evaluate the safety, tolerability, and…
- Trial name
- NCT07777549
- Testing
- TRTL-913
- Where
- New Zealand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tortugas Neuroscience, Inc.
Tinnitus, Hearing Loss, Cochlear Implant Users
Sound Therapy for Tinnitus Relief in Cochlear Implant Users
The aim of this exploratory study is to evaluate the use and effectiveness of sound therapy for tinnitus relief in cochlear implant users with tinnitus.
- Trial name
- NCT03026829
- Testing
- CART sound therapy
- Where
- 2 sites in Netherlands
- Volunteers
- 32 people
- Sponsor
- Cochlear
Hearing Loss
Evaluation of Novel Noise Reduction Principles in Hearing Instruments
In the study, the speech intelligibility in noise (Outcome) between a novel noise reduction algorithm (Intervention) versus the standard noise reduction (Comparator) will be tested in adults with a N3-N4 hearing loss (Population)…
- Trial name
- NCT05582408
- Testing
- Measures of Standard Noise Reduction NR1, Measures of Noise Reduction Principle NR2, Measure of Noise Reduction Principle NR3
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Sonova AG
Tinnitus
Treatment Evaluation of Neuromodulation for Tinnitus - Stage A2
This is a four arm, patient subtyping and parameter optimisation study for a neuromodulation treatment for tinnitus.
- Trial name
- TENT-A2 (NCT03530306)
- Testing
- PS1-PS4, PS6-PS10, PS7-PS4
- Where
- Ireland
- Volunteers
- 191 people
- Sponsor
- Neuromod Devices Ltd.
Subjective Tinnitus
Efficacy, Safety, Tolerability of Neramexane in Patients With Subjective Tinnitus
The purpose of this study is to investigate the safety and efficacy of neramexane mesylate in the treatment of subjective tinnitus in comparison to placebo.
- Trial name
- NCT00955799
- Testing
- Neramexane mesylate
- Where
- 76 sites in United States, Austria and 3 more
- Volunteers
- 455 people
- Sponsor
- Merz Pharmaceuticals GmbH
Tinnitus
Effect of Audistim® Day/Night on Hearing Comfort and Patient Quality of Life of Patients With Chronic Tinnitus.
Tinnitus is a widespread problem that affects the quality of life of millions globally. Few treatments have been found to be effective for subjective tinnitus and to have a significant improvement on quality of life.
- Trial name
- TINNITY (NCT05300594)
- Testing
- Plant extracts, vitamins and mineral
- Where
- France
- Volunteers
- 110 people
- Sponsor
- CEN Biotech
Meniere's Disease
OTO-104 for the Treatment of Meniere's Disease
The purpose of this study is to evaluate the effectiveness of OTO-104 for the treatment of Meniere's disease.
- Trial name
- NCT01412177
- Testing
- OTO-104
- Where
- 2 sites in United States
- Volunteers
- 154 people
- Sponsor
- Otonomy, Inc.
Tinnitus, Subjective
OTO-313 in Subjects With Subjective Tinnitus
The purpose of this study is to evaluate the safety, tolerability, plasma pharmacokinetics (PK), and exploratory efficacy of OTO-313 administered as an intratympanic injection for the treatment of subjective tinnitus.
- Trial name
- NCT03918109
- Testing
- OTO-313
- Where
- 16 sites in United States
- Volunteers
- 43 people
- Sponsor
- Otonomy, Inc.
Tinnitus, Subjective, Cupping Therapy
Wet Cupping Therapy as an Integrative Medicine Treatment for Subjective Tinnitus
Cupping therapy is an ancient complementary medicine therapy. It was a cornerstone in many ancient healing systems, including Traditional Chinese Medicine, Unani Medicine, Traditional Korean Medicine, and Islamic Medicine.
- Trial name
- NCT07685171
- Testing
- Wet Cupping Therapy plus Usual care, usual care only
- Volunteers
- 142 people
- Sponsor
- Hamad Medical Corporation
Hearing Loss, Sensorineural, Noise Induced Hearing Loss
FX-322 in Adults With Acquired Sensorineural Hearing Loss
This is a Phase 2, prospective, randomized, double-blind, placebo-controlled, single-dose, multicenter study to evaluate the efficacy of FX-322, administered by intratympanic injection, in adults with acquired sensorineural…
- Conditions
- Hearing Loss, Sensorineural, Noise Induced Hearing Loss, Sudden Hearing Loss
- Trial name
- NCT05086276
- Testing
- FX-322
- Where
- 26 sites in United States
- Volunteers
- 142 people
- Sponsor
- Frequency Therapeutics
Hearing Loss
CLEAR Clinical Study
Acute in-booth assessment of a new noise reduction algorithm with cochlear implant recipients.
- Trial name
- NCT03126825
- Testing
- CP910/CP920 with noise reduction on, CP910/CP920
- Where
- 2 sites in Australia
- Volunteers
- 48 people
- Sponsor
- Cochlear
Tinnitus, Subjective
Treatment for Post Acute COVID-19 Syndrome
Post-acute COVID-19 tinnitus has not been treated successfully. As tinnitus may be related to SARS-CoV-2 neurological manifestations.
- Trial name
- NCT05507372
- Testing
- Pimozide 1 MG
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Applied Biology, Inc.
Meniere Disease, Ménière
SPI-1005 for the Treatment of Meniere's Disease
The study is a randomized, double-blind, placebo-controlled, multi-center clinical trial (RCT) with open-label extension study (OLE), of SPI-1005 in adult subjects with definite Meniere's disease with active symptoms within three…
- Trial name
- STOPMD-3 (NCT04677972)
- Testing
- Ebselen
- Where
- 12 sites in United States
- Volunteers
- 220 people
- Sponsor
- Sound Pharmaceuticals, Incorporated
Noise-induced Hearing Loss
Protective Effects of EPI-743 on Noise-Induced Hearing Loss
If effective, administration of EPI-743 should have protective effects against temporary noise-induced hearing loss.
- Trial name
- NCT02257983
- Testing
- EPI-743
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Edison Pharmaceuticals Inc
Hearing Loss
Physiological, Behavioural and Subjective Measures of Listening Effort
Participants will perform two different listening tasks: (1) listening to, and repeating back, sentence lists presented in noise, and (2) listening to short radio excerpts and answering subsequent comprehension questions.
- Trial name
- NCT03761927
- Testing
- Hearing Aid without NR enabled, Hearing Aid with NR(1), Hearing Aid with NR(2)
- Where
- Switzerland
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Sonova AG