Clinical trials: Eardrum Perforation
Tympanic Membrane Perforation
Composite Cartilage Perichondrium Graft for Air Bone Gap Closure in Chronic Suppurative Otitis Media (CSOM) Without Posterior Meatal Flap
Composite Cartilage Perichondrium Graft for tympanoplasty in chronic suppurative otitis media (CSOM) Air Bone Gap (AB Gap) Closure will be taken as successful outcome Endoscopic technique without posterior meatal flap elevation
- Trial name
- NCT05086718
- Testing
- Endoscopic ear surgery
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital Quetta
Middle Ear Effusion, Tympanic Membrane Perforation
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers
PneuMum is a randomised controlled trial that aims to find out if pneumococcal vaccination for Australian Indigenous mothers, in the last few months of pregnancy or at delivery, can prevent ear disease in infants.
- Conditions
- Middle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal Infections
- Trial name
- PneuMum (NCT00714064)
- Testing
- 23vPPV, dTpa (Pneumovax, Boostrix)
- Where
- Australia
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Tympanic Membrane Perforation
Microscopic Versus Endoscopic Tympanoplasty
In this study, The investigatirs will compare surgical and anatomical outcomes of endoscopic and microscopic tympanoplasty type 1(myringoplasty) using tragal perichondrum and cartilage, and conduct a post-treatment survey…
- Trial name
- NCT06257602
- Testing
- Tragal graft tympanoplasty
- Volunteers
- 80 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation, Tempanoplasty
Anatomical and Functional Results of Surgery of the Tympanic Membrane Perforation of the Child
This study is a retrospective cohort of patients minors during the operation of cartilage tympanoplasty for tympanic membrane perforation
- Trial name
- PERFOPED (NCT02296944)
- Testing
- Collection of anatomical and functional results in the appearance of the tympanic membrane after surgery
- Where
- France
- Volunteers
- 980 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tympanic Membrane Perforation, Tympanic Membrane Inflammation
Effect of Chitodex Gel in Tympanoplasty Surgery
The general purpose of this study is to compare Chitosan-dextran (Chitodex) gel versus current standard of care, Gelfoam, as a middle ear (ME) and external auditory canal (EAC) packing agent as part of tympanoplasty…
- Conditions
- Tympanic Membrane Perforation, Tympanic Membrane Inflammation, Surgery, Otitis Media
- Trial name
- NCT06260618
- Testing
- Gelfoam, Chitodex
- Where
- 2 sites in Australia
- Volunteers
- 44 people
- Sponsor
- Central Adelaide Local Health Network Incorporated
Chronic Tympanic Membrane Perforation
A Study to Assess ASP0598 Otic Solution Following Topical Application in the Ear in Subjects With Chronic Tympanic Membrane Perforation (CTMP)
The primary purpose of this study was to evaluate the safety and tolerability of ASP0598 Otic Solution. This study also evaluated the efficacy of ASP0598 otic solution.
- Trial name
- NCT04305184
- Testing
- ASP0598
- Where
- 10 sites in United States
- Volunteers
- 36 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Tympanic Membrane Perforation
Tympanoseal Clinical Study
The purpose of this investigational study is to assess the ability of Tympanoseal (sodium/calcium alginate), an investigational device, to act as a scaffold during healing of the tympanic membrane.
- Trial name
- NCT05849844
- Testing
- Tympanoseal
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Grace Medical, Inc.
Tympanic Membrane Perforation
Efficacy of Platelet Enriched Plasma in Preventing Surgery for Patients With Chronic Tympanic Membrane Perforation
By doing this study, researchers hope to find out if platelet rich plasma (PRP) can heal holes in the eardrum as an alternative to surgery.
- Trial name
- NCT03837665
- Testing
- Platelet Rich Plasma
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Kansas Medical Center
Tympanic Membrane Perforation
A Study on the Regenerative Treatment of Tympanic Membrane With NPC-18 and FBG-18
To assess the efficacy and safety of the regeneration treatment of tympanic membrane with NPC-18 and FBG-18.
- Trial name
- NCT02550314
- Testing
- fiblast,gelatin sponge,fibrin glue
- Volunteers
- 20 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Tympanic Membrane Perforation
Perf-Fix Study for Chronic Tympanic Membrane Repair
The purpose of the study is to assess the effectiveness of Perf-Fix as a gel patch to aid in the natural healing process to close chronic, >25% tympanic membrane perforation.
- Trial name
- NCT06083181
- Testing
- Perf-Fix Otologic Gel Patch
- Where
- 7 sites in United States
- Volunteers
- 71 people
- Sponsor
- Tympanogen
Serous Otitis, Tympanic Membrane Perforation
Otological Study of Facial Cleft Patients Over 10 Years of Age (Excluding Isolated Cleft Lip) (EFEOF)
Studies published on the placement of transtympanic ventilatory tubes in children with cleft palate show heterogeneous results, highlighting the need for a new study with strong statistical power and long-term follow-up to…
- Conditions
- Serous Otitis, Tympanic Membrane Perforation, Retraction Pocket, Cholesteatoma
- Trial name
- EFEOF (NCT06738927)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Brest
Chronic Otitis Media, Tympanic Membrane Perforation
A Prospective Comparative Study of Dry vs Wet Temporalis Fascia Graft in Tympanoplasty
This study was conducted to compare two methods of using temporalis fascia graft in tympanoplasty, namely wet temporalis fascia graft and dry temporalis fascia graft.
- Trial name
- NCT07595484
- Testing
- Wet Temporalis Fascia Graft Tympanoplasty, Dry Temporalis Fascia Graft Tympanoplasty
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Middle Ear Effusion, Tympanic Membrane Perforation
PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See if it Protects Their Babies From Ear Disease
PneuMum is a randomised controlled trial that aims to find out if pneumococcal vaccination for Australian Indigenous mothers, in the last few months of pregnancy or at delivery, can prevent ear disease in infants.
- Conditions
- Middle Ear Effusion, Tympanic Membrane Perforation, Acute Otitis Media, Pneumococcal Infections
- Trial name
- NCT00310349
- Testing
- 23 valent pneumococcal polysaccharide vaccine
- Where
- Australia
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Chronic Suppurative Otitis Media
Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical Study
This study aimed to compare the effect of adding HA versus PRP to endoscopic FGM in cases of small or medium-sized central TM perforation in the form of: 1. Evaluation of the graft uptake rate. 2.
- Trial name
- NCT06505252
- Testing
- enoscopic Myringoplasty
- Volunteers
- 60 people
- Sponsor
- Assiut University