Clinical trials: Early Cancer Detection
Lung Cancer
Empowering Patients' Lung Cancer Screening Uptake
Lung cancer is the leading cause of cancer related mortality. Lung cancer screening (LCS) with low dose computed tomography (LDCT) decreases mortality rate of lung cancer by 20%.
- Trial name
- Empower-LCS (NCT06000683)
- Testing
- Patient education, Referral to financial navigation resources, Patient Reminders
- Where
- 7 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Colorectal Cancer, Advanced Adenocarcinoma
Colorectal Cancer and Pre-Cancerous Adenoma Non-Invasive Detection Test Study
This study was a prospective analysis conducted by Geneoscopy Inc. to evaluate the ColoSense test, which is a multi-target stool RNA test for colorectal cancer screening.
- Conditions
- Colorectal Cancer, Advanced Adenocarcinoma, Serrated Polyp
- Trial name
- CRC-PREVENT (NCT04739722)
- Testing
- ColoSense
- Where
- 2 sites in United States
- Volunteers
- 14,263 people, healthy volunteers welcome
- Sponsor
- Geneoscopy, Inc.
Depression, Low Back Pain
A Trial Comparing Approaches to Shared Decision Making Skills Training for Clinicians
The Health Decision Sciences Center (HDSC) staff has deployed different approaches to training clinicians to engage patients in shared decision making for common medical tests and treatments.
- Trial name
- NCT02871739
- Testing
- Webinar, DA viewing, SPI feedback
- Volunteers
- 23 people
- Sponsor
- Massachusetts General Hospital
Cervical Cancer
mHealth-supported Telecolposcopy for Cervical Cancer Programs in Low-resource Settings: Evaluation (mIVAA)
The central hypothesis is that use of mIVAA (mobile Inspección Visual con Ácido Acético - Spanish for Visual Inspection with Acetic Acid (VIA)) will increase the proportion of VIA positive women who complete follow-up clinical…
- Trial name
- NCT04421131
- Testing
- Pocket colposcope/Mobile phone camera, mIVAA
- Where
- Peru
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer
Assessment of Periodic Screening of Women With Denser Breast Using WBUS and DBT
The purpose of this study is to evaluate the role of technologist-performed whole breast ultrasound for detecting breast cancer in the screening population of women with dense breasts.
- Trial name
- DBTUST (NCT02643966)
- Testing
- Whole breast ultrasound
- Where
- 2 sites in United States
- Volunteers
- 6,266 people, healthy volunteers welcome
- Sponsor
- Wendie Berg
Colorectal Cancer
A Smartphone-Based Intervention to Improve Colorectal Cancer Screening in African American Men
The goal of this clinical trial is to test a new smartphone-based program designed to help African American men get screened for colorectal cancer (CRC).
- Trial name
- NCT06052202
- Testing
- CRC mHealth, Control
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- ISA Associates, Inc.
Lung Cancer
Assessing Social Determinants of Health to Increase Cancer Screening
A multilevel lung screening intervention that pairs Social Determinants of Health (SDoH) screening and referral with a tailored health communication and decision support tool for lung screening has the potential to significantly…
- Trial name
- NCT06052449
- Testing
- Social determinants of health screening assessment and referral process, Current practice - Community-based lunch cancer screening (LungTalk)
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Cervical Cancer
Using CHWs or Mailing Self Sampling Home Tests to Increase Cervical Cancer Screening in South Florida
The study will test the significance of community health worker (CHW) participation by comparing self-sampling provided by a community health worker and self-sampling provided by mail.
- Trial name
- NCT02202109
- Testing
- CHW and Self-sampling for Cervical Cancer, Mailed Self Sampler
- Where
- United States
- Volunteers
- 602 people
- Sponsor
- University of Miami
Lung Cancer
Co-Design and Pilot Testing of Peer-led Community Outreach to Improve Equity, Veteran-Centeredness and Uptake of Lung Cancer Screening
Co-design will be implemented to develop an innovative, Veteran-centered intervention (Vet Peer Connects program) that meets the needs of Black Veterans.
- Trial name
- VPC (NCT06389981)
- Testing
- Veterans peer connect Program
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Screening Mammogram
Increasing Breast Cancer Screening in Chinese Immigrants
The long-term goal of this research is to increase breast cancer screening rates in NYC Chinese immigrants. The researchers plan to accomplish this objective by developing and testing a culturally- and linguistically-adapted…
- Trial name
- NCT05089292
- Testing
- Narrative breast health education
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prostate Carcinoma
Screening for Prostate Cancer in Older Patients (PLCO Screening Trial)
This clinical trial studies whether screening methods used to diagnose cancer of the prostate, lung, colon, rectum, or ovaries can reduce deaths from these cancers.
- Trial name
- NCT00002540
- Testing
- Laboratory Biomarker Analysis, Medical Examination Assessment, Screening Questionnaire Administration
- Where
- United States
- Volunteers
- 76,685 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Neoplasms, Digestive System Diseases
Multi-Target Colorectal Cancer Screening Test for the Detection of Colorectal Advanced Adenomatous Polyps and Cancer
The primary objective is to determine the sensitivity and specificity of the Exact Colorectal Cancer (CRC) screening test for colorectal cancer, using colonoscopy as the reference method.
- Conditions
- Colorectal Neoplasms, Digestive System Diseases, Colonic Diseases, Colorectal Cancer
- Trial name
- DeeP-C (NCT01397747)
- Where
- 184 sites in United States, Canada
- Volunteers
- 12,776 people, healthy volunteers welcome
- Sponsor
- Exact Sciences Corporation
Influenza
Evaluation of a Screen and Treat Protocol for Influenza
This study seeks to demonstrate that the laboratory can mitigate respiratory virus transmission in underserved populations by using laboratory data to identify communities at risk for increase vial activity (hot spots) and…
- Trial name
- NCT06207058
- Testing
- Baloxavir Marboxil
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Tricore, Inc
Colorectal Cancer
Study to Increase Colorectal Screening
The purpose of this study is to determine whether inreach and outreach strategies will be superior to usual care, and combination of both will be superior to either strategy alone.
- Trial name
- NCT02870049
- Testing
- Inreach strategy, Outreach strategy, Both Inreach and Outreach strategies
- Volunteers
- 673 people
- Sponsor
- University of California, San Diego
Breast Cancer
Low Dose Molecular Breast Imaging as a Screening Tool for Women With Dense Breasts
A new test for breast cancer screening, molecular breast imaging (MBI) may be more sensitive than mammography for detecting breast cancer in women with dense breasts.
- Trial name
- NCT01925170
- Testing
- Molecular Breast Imaging, Conventional Mammography, Technetium (99mTc) sestamibi
- Where
- United States
- Volunteers
- 1,638 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Breast Cancer
Study of Dual-energy (DE) Contrast-enhanced (CE) Digital Mammography
This is a feasibility study to evaluate dual-energy (DE) contrast-enhanced (CE) digital mammography to detect breast cancer in patients with increased breast density (BI-RADS category c or d).
- Trial name
- NCT02995980
- Testing
- Dual-Energy Contrast-Enhanced (DECE) mammography, digital mammography
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hepatocellular Carcinoma
68Ga-PSMA-Dual-Contrast PET/MRI or PET/CT for Early Detection of Liver Cancer
This phase II trial studies how well 68Ga-PSMA PET/MRI or PET/CT works in early detection of liver cancer. 68Gallium-PSMA is a radioactive tracer designed to circulate through the body and attach itself to the prostate- specific…
- Trial name
- NCT04762888
- Testing
- Computed Tomography, Gallium Ga 68 Gozetotide, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Mayo Clinic