Clinical trials: Early Child Brain Development
Disorder of Speech and Language Development
Language and Motor Skills of Preterm Infants in Pre-school Age: Diagnosis and Early Intervention
The preterm children have more difficulty minor neurological developmental than the general population even without cerebral palsy. Their oral language difficulties of language and writing have been little studied.
- Trial name
- LAMOPRESCO (NCT01426659)
- Testing
- parental stimulation according to protocol
- Where
- 6 sites in France
- Volunteers
- 139 people
- Sponsor
- University Hospital, Rouen
Attention Deficit Hyperactivity Disorder (ADHD)
Methodology of Super-Early Training of Developer Engineers and Leading Analysts With a Diagnosis of ADHD/ASD for Ensuring the Engineering Sovereignty of the State: Time Horizon: 2026-2038-2050
This document outlines a clinical study focused on the transition from diagnosis to profession: the calibration of attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) into a strategic sovereign…
- Trial name
- DOCUMENT (NCT07845292)
- Testing
- Voice of Sleep "MamaBee" training modules (Fairy Tales)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Pisareva Citadel Group LLC
Brain Stimulation
Family Inclusive Early Brain Stimulation
Social interaction (in the form of serve and return exchanges) between child and parent are crucial for psychosocial, physical and cognitive development.
- Trial name
- FINEBRAINS (NCT02697110)
- Testing
- Edutainment based intervention
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of Ibadan
Child Development
A Home Visiting Program for Pregnant Youth to Promote Early Brain Development
Home visiting programs for pregnant women aiming to improve mother-infant relationship has received worldwide attention in the past 30 years.
- Trial name
- NCT02807818
- Testing
- Home visiting Program for Young Pregnant Women
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Down Syndrome, Gross Motor Delay
Up, Down, and All Around: Evaluating Mobility Devices for Young Children With Developmental Disabilities and Delays
This research study will examine young children with Down syndrome's initial experiences with mobility devices. Children's biomechanics and exploration will be quantified while they are using both an overground partial bodyweight…
- Conditions
- Down Syndrome, Gross Motor Delay, Cerebral Palsy
- Trial name
- NCT06591559
- Testing
- Permobil Explorer Mini, Portable Mobility Aid for Children (PUMA)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Washington
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Early Child Brain Development
Enhancing the Ongoing ECD Scale-up Programme (Saving Bangladeshi Babies Brain (SB3) in Bangladesh
Background (brief): 1. Burden: Globally 250 million children under 5 years of age in developing countries do not reach their full potential due to poverty, malnutrition, and lack of a stimulating environment. 2.
- Trial name
- ECD SB3 (NCT07472699)
- Testing
- Psychosocial stimulation, Combined
- Where
- Bangladesh
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Developmental and Epileptic Encephalopathy, Epilepsy in Children
Developmental and Epileptic Encephalopathies Diagnosed Via Long-read Genome Sequencing
This study focuses on children with Developmental and Epileptic Encephalopathy (DEE), a severe form of epilepsy that often has a genetic origin.
- Trial name
- EEPILOG (NCT07396883)
- Testing
- Long-read Whole Genome Sequencing (lrWGS)
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Epilepsy; Seizure, Child Development
Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age
According to estimates by the World Health Organization in 2019, more than 50 million people around the world have epilepsy. Nearly 80% of patients with epilepsy live in developing countries.
- Conditions
- Epilepsy; Seizure, Child Development, Gene Abnormality, Early Onset Disorder
- Trial name
- NCT06278428
- Where
- 2 sites in Vietnam
- Volunteers
- 50 people
- Sponsor
- Number 2 Children's Hospital, Ho Chi Minh City
Brain Developmental Diseases, Autism Spectrum Disorder
The Early Integrated Intervention for Child Brain-developmental Disorders in China
This study is focused on developing the early integrated intervention for child brain-developmental disorders, including globe developmental delay (GDD), autism spectrum disorder (ASD), and attention deficit-hyperactivity…
- Conditions
- Brain Developmental Diseases, Autism Spectrum Disorder, Global Developmental Delay, Attention Deficit-Hyperactivity Disorder
- Trial name
- NCT03847402
- Testing
- The early integrated intervention for GDD, The early integrated intervention for ASD, The early integrated intervention for ADHD
- Where
- China
- Volunteers
- 900 people
- Sponsor
- Children's Hospital of Fudan University
Iron Deficiency, Child Development
Infant Brain Study Follow-Up at 3 and 4 Years of Age
When immediate clamping of the umbilical cord (ICC) occurs at birth, 20 to 30% of the fetal-placental blood volume is left behind in the placenta.
- Trial name
- NCT02619006
- Testing
- Delayed Cord Clamping or Cord Milking
- Volunteers
- 10 people
- Sponsor
- University of Rhode Island
Child Development
A Home Visiting Program for Pregnant Youth to Promote Early Brain Development II
Home visiting programs for pregnant women aiming to improve mother-infant relationship has received worldwide attention in the past 30 years.
- Trial name
- NCT04362098
- Testing
- Home visiting Program for Young Pregnant Women
- Where
- Brazil
- Volunteers
- 167 people
- Sponsor
- University of Sao Paulo
Child Development
Follow up of Long Term Neurodevelopmental Impact of the Type of Feeding During the First Year of Life at 10 Years Old
The Chilean infant Nutrition Trial was a prospective, randomized, double-blind, controlled study conducted in Santiago, Chile, between 2016 and The study aimed to evaluate growth and body composition changes between birth and two…
- Trial name
- NCT06917625
- Testing
- Imaging
- Where
- Chile
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Corporación de Apoyo de la Investigación Científica en Nutrición
Socioemotional Development, Cognitive Ability
Early Institutionalization Intervention Impact Project
The purpose of this study is to determine the effects of early intervention (placement into foster care, and a caregiving training) on physical, cognitive, social and brain development and psychiatric symptomatology in children…
- Conditions
- Socioemotional Development, Cognitive Ability, Behavioral and Neural Patterns of Attention, Brain Function
- Trial name
- EI-3 (NCT04165746)
- Testing
- Foster Care, Caregiving Intervention
- Where
- Brazil
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
ASD
Mental Imagery Therapy for Autism (MITA) - an Early Intervention Computerized Language Training Program for Children With Autism
Mental Imagery Therapy for Autism (MITA) is a highly innovative adaptive language therapy application for children with autism. MITA exercises are limitless in variations, therefore avoiding routinization.
- Trial name
- MITA-RCT (NCT07326423)
- Testing
- Mental Imagery Therapy for Autism (MITA), General executive function
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- ImagiRation, LLC
Maternal Exposure, Health Behavior
Brain Probiotic and LC-PUFA Intervention for Optimum Early Life
Probiotics is suggested to play several roles in promoting health, including alleviating disease symptoms, protection against atopic disease, and modulating the immune system by improving the beneficial gut microbiota…
- Conditions
- Maternal Exposure, Health Behavior, Infant Development, Child Development
- Trial name
- BRAVE (NCT03851120)
- Testing
- Probiotics and LC-PUFA (480 mg DHA), Psychosocial stimulation and healthy eating education
- Where
- Indonesia
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Growth Hormone Deficiency
Efficacy and Safety of a High Dosage Compared to the Label Dosage of Somatropin in Early Pubertal Stage Children With Growth Hormone Deficiency
Multi-center, randomized, controlled, open-label, phase III study comparing the effects of two different dosages of somatropin treatment (in-label or doubled) after 12 and 24 months of treatment, on height velocity in early…
- Trial name
- NCT00191165
- Testing
- Somatropin
- Where
- 10 sites in Italy
- Volunteers
- 27 people
- Sponsor
- Eli Lilly and Company
Obesity, Childhood, Child Development
El Sendero: Pathways to Health Study
This project will continue to follow two birth cohorts of mother-infant Latino dyads through a series of new assessments at age 6y, with an emphasis on examining the the role early nutritional exposures, exposures to…
- Trial name
- NCT05551650
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International
Infant Development
A Community Based Implementation of a Toolkit and Parenting Program for Improving Brain Development in Newborns
The investigators propose to develop and test the efficacy of a low cost evidence based toolkit aimed at improving brain development among newborns a rural setting of Pakistan.
- Trial name
- NCT02290756
- Testing
- Parenting Program, Low cost evidence based toolkit
- Where
- Pakistan
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Manitoba