Clinical trials: Early Childhood
Type 1 Diabetes Mellitus
Strategies to Enhance New CGM Use in Early Childhood (SENCE)
The primary objective of this study is to compare the efficacy and safety of CGM alone and CGM combined with a family behavioral intervention with a control group using home blood glucose monitoring (BGM) alone.
- Trial name
- SENCE (NCT02912728)
- Testing
- CGM + Family Behavioral Intervention, Standard CGM
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Jaeb Center for Health Research
Postpartum Weight Retention, Pregnancy Weight Gain
Healthy for Two-Home Visiting (H42-HV): Health Coaching for Pregnant Women
The purpose of this study is to compare the effectiveness of H42-HV integrated into home visiting compared with usual home visiting services in reducing postpartum weight retention (difference between pre-pregnancy weight and…
- Conditions
- Postpartum Weight Retention, Pregnancy Weight Gain, Overweight and Obesity, Behavior, Health
- Trial name
- NCT05619705
- Testing
- Healthy for Two-Health Coaching (H42), Maintain Healthy in Pregnancy and Postpartum(mHIPP)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Dental Caries Tooth Demineralization, Early Childhood Caries (ECC)
Effects of Calcium-Containing Oral Sprays on Fluorescence-Detectable Plaque Area in Children
This exploratory randomized clinical trial aimed to evaluate the effects of calcium-containing oral sprays on the primary clinical outcome, fluorescence-detectable plaque-associated area measured by quantitative light-induced…
- Trial name
- NCT07269730
- Testing
- oral spray
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Solid Tumor, Childhood
Multicenter, Prospective Observational Study for Early Diagnosis, and Development of Follow-up Protocol and Hearing Rehabilitation Program for Ototoxic Hearing Loss After Chemotherapy for Pediatric Solid Cancer
More than half of all pediatric cancer in Korea are solid cancer. For the treatment of solid cancer, multidisciplinary methods such as surgery, chemotherapy, and radiation therapy are applied, and with the development of the…
- Trial name
- NCT05633719
- Testing
- Chemotherapy involving cisplatin or carboplatin
- Volunteers
- 300 people
- Sponsor
- Seoul National University Hospital
Child Abuse, Intimate Partner Violence
The Unique and Combined Effects of Prenatal and Early Childhood Programming on Child Maltreatment: Examining Mechanisms of Change
Child maltreatment and child exposure to adult intimate partner violence (IPV) often co-occur and are detrimental to the mental and physical health of children, yet few prevention programs address these intersecting forms of…
- Conditions
- Child Abuse, Intimate Partner Violence, Secondary Prevention, Parenting
- Trial name
- NCT06732310
- Testing
- Pregnant Moms' Empowerment Program, Reminiscing and Emotion Training, Pregnancy - Active Control
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Notre Dame
Childhood Obesity, Epigenetics
Early Childhood Obesity Programming by Intrauterine Growth Restriction
The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from…
- Trial name
- NCT03402139
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Infant, Very Low Birth Weight, Infant Malnutrition
Near Infrared Spectroscopy (NIRS) and Superior Mesenteric Artery (SMA) Doppler Patterns as Predictor of Feeding Tolerance in Very Low Birth Weight (VLBW) IntraUterine Growth Restricted (IUGR) and NON IUGR Infants
This study aims at recruiting about twenty very low birth weight infants, either intrauterine growth restricted (IUGR) or NON-IUGR STRATIFICATION:Population will be stratified in two groups: IUGR infants (approximately 10…
- Conditions
- Infant, Very Low Birth Weight, Infant Malnutrition, Feeding Disorder of Infancy or Early Childhood, Splanchnic Oximetry
- Trial name
- NCT01341236
- Testing
- different nutrional regimen, comparison of different feeding regimens
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- San Gerardo Hospital
Autism Spectrum Disorder, Developmental Disabilities
A Self-Instructional Online Program for Early Childhood and Elementary Teachers Supporting Autistic Children and Children With Developmental Delays
The goal of this clinical trial is to evaluate the preliminary effectiveness and acceptability of a self-instructional, web-based teacher training program designed to support the development of autistic children and children with…
- Conditions
- Autism Spectrum Disorder, Developmental Disabilities, Developmental Delay, Teacher Training
- Trial name
- SEED (NCT07524192)
- Testing
- SEED Online Self-Instructional Program, Comparison Educational Materials (Kit for Kids)
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boin Choi
Maltreatment
Reduce Childhood Maltreatment and Promote Development
Background (brief): 1. Burden: The uniqueness of each child is tremendously influenced by interaction between nature and nurture during critical period of brain development that promotes foundation of brain architecture through…
- Trial name
- NCT03031236
- Testing
- Psychosocial stimulation, Cognitive behavioral therapy and positive parenting practice
- Where
- Bangladesh
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Juvenile Chronic Polyarthritis, Juvenile Idiopathic Arthritis
Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic Arthritis
The purpose of this study is to compare two aggressive drug regimens for children with poly-juvenile idiopathic arthritis (JIA) and extended oligo JIA.
- Conditions
- Juvenile Chronic Polyarthritis, Juvenile Idiopathic Arthritis, Juvenile Rheumatoid Arthritis
- Trial name
- NCT00443430
- Testing
- methotrexate, methotrexate - etanercept - prednisolone arm
- Where
- 15 sites in United States
- Volunteers
- 85 people
- Sponsor
- Seattle Children's Hospital
Dietary Assessment
Early Childhood Dietary Assessment Study
The goal of this crossover randomized controlled trial is to develop a proxy reporting protocol for a traditional 24-hour dietary recall (24HR) and an ecological momentary assessment (EMA) assisted 24-HR for use among children…
- Trial name
- ECDAS (NCT07227272)
- Testing
- Ecological Momentary Assessment, Traditional 24-hour dietary recall
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Dental Caries
Fluoride Varnish Randomized Clinical Trial
The purpose of this study is to compare the efficacy of fluoride varnish (FV) applied once or twice a year with counseling to counseling alone in preventing early childhood caries (ECC) (tooth decay in children under the age of…
- Trial name
- NCT00066963
- Testing
- Fluoride Varnish
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
PI-SUAS - Impact Evaluation of Home Visits
Background: Early childhood, particularly from 0-36 months, represents a critical period of human development marked by rapid growth and skill acquisition.
- Trial name
- PI-SUAS (NCT06971926)
- Testing
- Home visist
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Neurodevelopmental Abnormality
Umbilical Cord Milking in Non-Vigorous Infants Developmental Followup (MINVIFU)
A sub-study to evaluate longer-term developmental outcomes in non-vigorous term and near-term newborns who receive umbilical cord milking in comparison to those who undergo early cord clamping at delivery.
- Trial name
- MINVIFU (NCT03621943)
- Testing
- Umbilical Cord Milking, Early Cord Clamping
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 1,207 people
- Sponsor
- Sharp HealthCare
Childhood Obesity, Evidence-Based Practice
Network-Based Support to Help Community Coalition Members Choose and Use Strategies to Improve Child Health
Community coalitions bring together residents and organizations to improve child health, but they may need support to identify and put research-supported strategies into practice.
- Conditions
- Childhood Obesity, Evidence-Based Practice, Food Systems, Food Policy
- Trial name
- NCT07804550
- Testing
- Catalyzing Communities, FICAS Implementation Intervention
- Where
- United States
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Chronic Disease
Influence of Prenatal and Early Childhood Home-Visiting by Nurses on Development of Chronic Disease
This study is a longitudinal cohort study that follows participants in a randomized clinical trial of a program of prenatal and early child home visiting on maternal and offspring risks for chronic disease.
- Trial name
- NCT06160037
- Testing
- Transportation and Developmental Screening, Transportation, Screening, and Nurse-Visitation during Pregnancy and Infancy
- Where
- United States
- Volunteers
- 1,055 people
- Sponsor
- University of Colorado, Denver
Dental Caries, Child Neglect
Improving Family's Adherence to Dental Care After DGA (HECC-CAN-study)
Early childhood caries (ECC) is a common disease. Its prevalence is highest in poor, socially disadvantaged, and minority groups. Dental treatment under General Anaesthesia (DGA) is common, especially among the youngest patients.
- Trial name
- HECC-CAN (NCT04898465)
- Testing
- Social Paediatric Intervention
- Where
- Finland
- Volunteers
- 89 people
- Sponsor
- Helsinki University Central Hospital
Early Childhood Caries
Clinical Efficiency and Treatment Failure of Hall Versus SDF Techniques in the Management of Carious Primary Molar.
This study will compare two non- invasive treatment options: Hall technique and 38% Silver diamine fluoride. Both are methods used to create a more favorable environment without removal of caries leading to the arrest of the…
- Trial name
- NCT04765904
- Testing
- SDF, Hall technique
- Volunteers
- 120 people
- Sponsor
- Cairo University
Early Childhood Caries
A Tele-detection and Referral Pathways Model for Early Childhood Caries Control
The aim of the study is to assess the effectiveness of ECC tele-detection methods combined with referral pathways, with and without user fee removal, in controlling ECC.
- Trial name
- NCT06019884
- Testing
- Caries detection method: Intraoral camera, Caries detection method: Smartphone camera, Referral pathway: User fee removal
- Where
- Egypt
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Stress, Psychological Stress
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
The aim of the Everyday Moments of Mindfulness (EMMI) study is to test whether brief mindfulness-based practices will improve daily psychological stress responses in women (age 30-60) who report a history of early life adversity.
- Conditions
- Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms
- Trial name
- EMMI (NCT04606199)
- Testing
- Mindfulness-based intervention, up to 5 minutes 0-3 times/day
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco