Clinical trials: Early Childhood
Host and Microbiome, Pregnancy Outcomes
Human Genes and Microbiota in Early Life
The long-term goal of the Human Genes and Microbiota in Early Life (HuGME) is to explore the short- and long-term effects of maternal microbiota during pregnancy and the microbiota colonization of their offspring early in life…
- Conditions
- Host and Microbiome, Pregnancy Outcomes, Pregnancy Complications, Neurodevelopmental Disorders
- Trial name
- HuGME (NCT06926166)
- Testing
- No intervention
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Dietary Assessment
Early Childhood Dietary Assessment Study
The goal of this crossover randomized controlled trial is to develop a proxy reporting protocol for a traditional 24-hour dietary recall (24HR) and an ecological momentary assessment (EMA) assisted 24-HR for use among children…
- Trial name
- ECDAS (NCT07227272)
- Testing
- Ecological Momentary Assessment, Traditional 24-hour dietary recall
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Childhood Obesity, Excessive Weight Gain in Pregnancy With Baby Delivered
Preventing Childhood Obesity: A Two-pronged Approach Starting in Pregnancy and the First Year Postpartum
Our longitudinal aim is to reduce childhood obesity using our two-pronged intervention program, which includes healthy food choices and increased physical activity initiated during pregnancy and re-instated in the early period…
- Conditions
- Childhood Obesity, Excessive Weight Gain in Pregnancy With Baby Delivered, Dietary Modification, Healthy Lifestyle Habits
- Trial name
- NCT01129505
- Testing
- Nutrition & Exercise Lifestyle Intervention Program (NELIP)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Caries,Dental
Evaluation of Different Cementation Materials Used in Prefabricated Pediatric Zirconia Crowns
Today, with increasing aesthetic demands; the need for materials that are both durable and compatible with the appearance of natural teeth is increasing in paediatric dentistry.
- Trial name
- NCT06690229
- Testing
- glass ionomer cement, self-adhesive resin cement, resin modified glass ionomer cement
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Aydin Adnan Menderes University
Child Development
School-Based Mental Health Effectiveness Study
This study involves efforts to advance the science of prevention in early childhood mental health in low-resource communities. Investigators will assess the effectiveness, practical implementation strategies, and underlying…
- Trial name
- NCT04383327
- Testing
- ParentCorps-Professional Development (PD), T-Wellness
- Where
- 2 sites in Uganda
- Volunteers
- 2,444 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Gut Microbiota, Early Child Development
Gut Microbiota and Metabolic Development in Early Childhood: A 3-Year Follow-Up Study
This prospective observational birth cohort study aims to characterize the longitudinal development of the gut microbiome during early childhood and to investigate its associations with prenatal, perinatal, and postnatal…
- Trial name
- NCT07762729
- Where
- 5 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Pregnancy
Early Prevention of Childhood Obesity: an Active Pregnancy
The main aim of this study was to examine the effect of a supervised physical exercise program on the prevention of childhood obesity and its impact on the motor development of the offspring.
- Trial name
- NCT02109588
- Testing
- A supervised physical exercise program
- Where
- Spain
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Technical University of Madrid
Parenting, Child Nutrition Disorders
Partnering for Prevention: Building Healthy Habits in Underserved Communities
This pilot study will estimate the unique and additive benefits of two parent-training programs (Cooking Matters for Parents and Promoting Routines of Exploration and Play during Mealtime) offered in undeserved communities.
- Trial name
- P4P (NCT03559907)
- Testing
- Cooking Matters for Parents, Mealtime PREP
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Head Start Participation
American Indian and Alaska Native Head Start Family and Child Experiences Survey
The Head Start Family and Child Experiences Survey (FACES) is a major source of information on Head Start programs and the children and families they serve.
- Trial name
- AI/AN FACES (NCT03842111)
- Where
- United States
- Volunteers
- 1,194 people
- Sponsor
- Mathematica Policy Research, Inc.
Overweight , Obesity
Long-term Follow-up After Childhood Obesity
The goal of this observational study is to learn about the long-term effects on health and well-being of treatment for overweight in childhood or adolescence using the Children's Obesity Clinic Treatment protocol (the Holbæk…
- Trial name
- AFTER (NCT07857018)
- Testing
- The AFTER study - Assessing Future Trajectories of hEalth- and well-being among childhood obesity treatment Recipients
- Volunteers
- 6,100 people, healthy volunteers welcome
- Sponsor
- Ulla Toft
Child Development
Implementation and Adoption of Care for Child Development in Day Care Centers
Background: Responsive stimulation and/or enhanced nutrition interventions delivered to children through health programs shows improved cognitive, language, and motor, and the social-emotional status.
- Trial name
- NCT02545491
- Testing
- Care for Child Development (CCD) program, Infant and Young Child feeding training by World Vision
- Where
- Lebanon
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Social Behavior
Toddlers' Responses to Strangers
The study will assess if toddlers show differences in stranger wariness according to race, temperament, social network diversity, and neighborhood diversity.
- Trial name
- NCT06550206
- Testing
- Children's stranger wariness response to strangers
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California Santa Cruz
Diet, Growth
The prEgnanCy and eArly Childhood nutrItion triaL (ECAIL)
The purpose of this study is to conduct a randomized controlled trial among 800 socially disadvantaged pregnant women and their families to test the effectiveness of a multi-component home visitation nutrition program, compared…
- Conditions
- Diet, Growth, Infant, Physical Activity
- Trial name
- ECAIL (NCT03003117)
- Testing
- Experimental: Intervention Program, Active comparator: Usual Care
- Where
- 2 sites in France
- Volunteers
- 607 people, healthy volunteers welcome
- Sponsor
- French Red Cross
Stress, Early Life Stress
How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play?
The study aims to investigate sex differences in the effect of mu-opioid receptor (MOR) activation on stress response and social behaviour modulated by early life stress.
- Conditions
- Stress, Early Life Stress, Sex Differences, Opioid
- Trial name
- MOR-SAFE (NCT07778511)
- Testing
- Morphine
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sara L. Kroll
Language Development
Thirty Million Words-Early Childhood Educator (TMW-ECE)
The purpose of the proposed study is to determine the efficacy of an eight-module interactive, online multi-media professional development course on our target population: individuals over the age of 18, who have no more than a…
- Trial name
- NCT04027673
- Testing
- TMW ECE Curriculum
- Where
- United States
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Child Development, Motor Skills
Motor-Focused Exercise and Brain Development in Preschool Children
This study will test whether a structured motor-focused exercise program can improve both brain function and gross motor skills in preschool children.
- Conditions
- Child Development, Motor Skills, Neurodevelopment, Brain Function
- Trial name
- MoBraD (NCT07307742)
- Testing
- Motor-Focused Physical Education, Ordinary Physical Education
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Hunan Normal University
Anxiety, Anxiety Disorders
Transdiagnostic, Cognitive and Behavioral Intervention for in School-aged Children With Emotional and Behavioral Disturbances
Background Impairing emotional and behavioural problems are common in children and adolescents and mark a three-fold increased risk of mental disorder in young adulthood.
- Conditions
- Anxiety, Anxiety Disorders, Depressive Symptoms, Depressive Disorders
- Trial name
- MindMyMind RCT (NCT03535805)
- Testing
- Mind My Mind (MMM), Treatment as Usual (TAU)
- Where
- Denmark
- Volunteers
- 396 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Obesity, Childhood, Antibiotic Side Effect
Microbiome, Antibiotics, and Growth Infant Cohort
This cross-disciplinary study will assemble and longitudinally follow a large, diverse birth cohort to determine the relationships between early life antibiotic exposure, microbiome development, growth, antibodies, and…
- Trial name
- MAGIC (NCT03001167)
- Where
- United States
- Volunteers
- 509 people
- Sponsor
- Children's Hospital of Philadelphia
Pediatric Obesity
Texas Childhood Obesity Research Demonstration (TX CORD) Project -Primary Prevention Study
A systems approach emphasizes the linkage between individual behavior change strategies and social and physical environmental changes, which act synergistically to facilitate (or inhibit) healthy eating and active living.
- Trial name
- TXCORDPRIM (NCT04625998)
- Testing
- Enhanced CATCH Elementary School Program, CATCH Early Childhood (CEC)
- Volunteers
- 4,378 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Breast Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Effects of Fetal, Infant, and Early Childhood Exposures on Adult Cancer Risk in Women
RATIONALE: Gathering information about pregnancy, infancy, and early childhood exposures may help doctors identify cancer risk factors, and may help the study of cancer.
- Trial name
- NCT00559039
- Testing
- questionnaire administration, evaluation of cancer risk factors
- Where
- United States
- Volunteers
- 128,700 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)