Clinical trials: Early Childhood
Depression
Depression, Adversity, and Stress Hormones (DASH) Study
The stress-related hormone cortisol has been studied in depression for decades. However, relatively little is known about the role of cortisol in psychological features of depression.
- Trial name
- DASH (NCT03195933)
- Testing
- Cortisol
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Sleep Onset Latency
Circadian Light Exposure Adjustment for Restfulness
Many young children are exposed to light int he evening hours before bedtime. Children's biological clocks are highly sensitive to evening light exposure, which can delay the timing of the clock and make it harder to fall asleep.
- Trial name
- CLEAR (NCT07391852)
- Testing
- Amber Tinted Glasses, Clear Glasses, Smart Lightbulbs
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Arizona
Early Childhood Caries (ECC), Dental Caries Prevention
Evaluating the Effect of Xylitol Wipes on Cariogenic Bacteria in Infants and Toddlers
This clinical study evaluates whether cleaning infants' and toddlers' teeth and gums with xylitol-containing wipes can help reduce oral bacteria associated with early childhood caries.
- Conditions
- Early Childhood Caries (ECC), Dental Caries Prevention, Oral Bacterial Colonization, Pediatric Oral Health
- Trial name
- NCT07245433
- Testing
- Xylitol Dental Wipes
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Social Withdrawal of Childhood or Adolescence, Preterm Infant
The Effect of a Neonatologist's Standardized Guidance Intervention on Preterm Infants With Relational Withdrawal.
The objective of this project is to determine the effect of the verbal intervention on the decrease in sustained social withdrawal in late and moderately late preterm infants.
- Trial name
- NCT03212547
- Testing
- Verbal Intervention
- Where
- 2 sites in Chile
- Volunteers
- 110 people
- Sponsor
- Clinica Alemana de Santiago
Obesity, Child Obesity
Linking Activity, Nutrition, and Child Health
Leading health organizations have identified prevention of obesity in young children as a critical public health challenge. Low levels of physical activity and high levels of sedentary behavior may contribute to the development…
- Trial name
- LAUNCH (NCT04189926)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of South Carolina
Early Childhood Caries (ECC)
Preventing Early Childhood Caries With a Silver Diamine Fluoride Gel
The objective is to compare the efficacy of SDF gel with that of NaF varnish in preventing carious lesions in preschool children when applied at half-yearly intervals over a 24-month period.
- Trial name
- NCT07455604
- Testing
- Silver diamine fluoride gel, Sodium Fluoride varnish
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Early Childhood Caries
The Caries-arresting Effect of Incorporating fTCP to NaF Varnish Applied Following AgNO3 in Preschool Children
The objective of this study is to compare the effectiveness of 25% AgNO3 solution plus 5% NaF varnish and 25% AgNO3 solution plus 5% NaF varnish with fTCP when applied semi-annually over 30 months in arresting dentine caries of…
- Trial name
- NCT03423797
- Testing
- 25% AgNO3 solution followed by 5% NaF, 25% AgNO3 solution followed by 5% NaF with fTCP
- Where
- China
- Volunteers
- 408 people
- Sponsor
- The University of Hong Kong
Feeding Behavior, Feeding Disorder of Infancy or Early Childhood
iKanEat: A Randomized-controlled, Multi-center Trial of Megestrol for Chronic Oral Food Refusal in Children
This is a multi-center, randomized, placebo-controlled, double-blind clinical trial. The primary focus of the study is the evaluation of the effectiveness of treatment with megestrol as part of a 24 week behavioral feeding…
- Trial name
- iKanEat (NCT03815019)
- Testing
- Megestrol Acetate, iKanEat Behavioral Intervention
- Where
- 8 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Conduct Disorder, ADHD
Intervening Early With Neglected Children
This study will assess early and middle childhood outcomes of an intervention for neglecting parents that was implemented in the children's infancy.
- Conditions
- Conduct Disorder, ADHD, Depression
- Trial name
- NCT02093052
- Testing
- Attachment and Biobehavioral Catch-up, Developmental Education for Families
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- University of Delaware
Early Childhood Caries
Effectiveness Fluoride Varnishes in Children With Early Childhood Caries
The study was carried out in 88 children with severe early childhood caries (dmfs≥age +1) who were referred to the investigators' clinic.
- Trial name
- NCT03625310
- Testing
- Sodium Fluoride, Sodium Fluoride with TCP, Sodium Fluoride with CXP
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Merve Erkmen Almaz
Early Childhood Caries
Clinical Efficiency and Treatment Failure of Hall Versus SDF Techniques in the Management of Carious Primary Molar.
This study will compare two non- invasive treatment options: Hall technique and 38% Silver diamine fluoride. Both are methods used to create a more favorable environment without removal of caries leading to the arrest of the…
- Trial name
- NCT04765904
- Testing
- SDF, Hall technique
- Volunteers
- 120 people
- Sponsor
- Cairo University
Disruptive Behavior Disorders
The Parenting Young Children Check-up: Proof-of-Concept Trial
The Parenting Young Children Check-up (PYCC) is a 3-part system for parents of children with Disruptive Behavior Problems (DBPs).
- Trial name
- NCT04113304
- Testing
- Parenting Young Children Check-up (PYCC)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wayne State University
Anxiety Disorders
Neurally Targeted Interventions to Reduce Early Childhood Anxiety
Clinically significant anxiety affects up to 20% of preschool-aged children and often fails to respond to currently available treatments.
- Trial name
- NCT03093376
- Testing
- Effortful Control Camp
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Michigan