Clinical trials: Early Childhood
Promoting Cardiovascular Health in Younger Age Group
Family-based Approach to Promotion of Health - FAMILIA (Project 1)
Problem: Childhood obesity has more than doubled over the past 30 years, with nearly one-third of children aged 6 to 11 years being obese.
- Trial name
- FAMILIA (NCT02343341)
- Testing
- Preschool Health Promotion Education Program
- Where
- 15 sites in United States
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Healthy
Effect of Professional Development in Science
This trial is a randomized controlled trial aimed at assessing the effectiveness of a nine-month-long professional development program to improve early childhood educators' and carers' self-efficacy for science approaches…
- Trial name
- NCT05559294
- Testing
- Professional Development of Early Childhood Education and Care Staff for Science, Education and care as Usual (ECAU)
- Where
- Denmark
- Volunteers
- 1,400 people
- Sponsor
- UCL University College, Denmark
Healthy
PI-SUAS - Impact Evaluation of Home Visits
Background: Early childhood, particularly from 0-36 months, represents a critical period of human development marked by rapid growth and skill acquisition.
- Trial name
- PI-SUAS (NCT06971926)
- Testing
- Home visist
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Premature Birth, Neurodevelopmental Disorders
Childhood Outcomes of Preterm Brain Abnormalities
Prematurely born children are at higher risk of cognitive impairments and behavioral disorders than full-term children. There is growing evidence of significant volumetric and shape abnormalities in subcortical structures of…
- Conditions
- Premature Birth, Neurodevelopmental Disorders, Brain Development Abnormality, Brain Lesion
- Trial name
- NCT03410810
- Testing
- MRI, Neurodevelopmental/Neuropsychological Assessment
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Obesity, Childhood
Parent Mentor Interventions for Early Childhood Obesity
The purpose of this clinical trial is to identify the most effective strategy for intervention to change behaviors and affect weight status in obese children 2-5 years of age within the context of early childhood education…
- Trial name
- NCT03330743
- Testing
- Parent Mentor with Standard Education, Parent Mentor with Positive Deviance
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Resilience
Comparing a Workplace Resilience and a Physical Activity Intervention on Early Childhood Educators Well-being
The goal of this 15-month cluster clinical trial is to compare a resilience and stress management program to a physical activity program for early childhood education (ECE) staff on change in well-being.
- Trial name
- OnWARD (NCT06919952)
- Testing
- Resilience, Physical Activity
- Where
- United States
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Early Childhood Caries (ECC)
Aesthetic and Functional Evaluation of a Universal One-Shade Composite in Primary Maxillary Incisors
Use of tooth-coloured fillings is an essential part of Pediatric dentistry as most patients desire fillings which look like natural teeth.
- Trial name
- NCT07716033
- Testing
- Tokuyama Palfique Omnichroma composite restoration, 3M Filtek Z350 composite restoration
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Goa Dental College
Sleep Problems, Maternal Anxiety
Sleep Patterns in Children Aged 0-36 Months and Maternal Anxiety and Depression
In this study, the investigators aimed to investigate the relationship between the sleep patterns of children aged 0-36 months hospitalized in the general pediatrics clinic and their mothers' anxiety and depression levels.
- Trial name
- NCT07476612
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Child Abuse, Child Neglect
iLookOut for Child Abuse -Online Learning Module for Early Childcare Providers
Phase 1 was a randomized control trial that used a test-retest model to evaluate the impact of iLook Out for Child Abuse, an online, interactive learning module about reporting suspected child abuse.
- Conditions
- Child Abuse, Child Neglect, Child Maltreatment
- Trial name
- iLookOut (NCT02225301)
- Testing
- iLook Out for Child Abuse
- Where
- United States
- Volunteers
- 35,000 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Child Development
The Influence of Interactive Media on Child Development in Early Childhood
Introduction: In the last decade the prevalence of the use of interactive media (smartphone, tablet) by children has grown worldwide.
- Trial name
- IMD (NCT04831229)
- Testing
- Children will perform activities on interactive tablet, Children will perform passive on interactive tablet
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Federal University of the Valleys of Jequitinhonha and Mucuri
Child Development, Mental Health Wellness 1
Home Visiting Programs to Improve Early Childhood Development and Maternal Mental Health
This study evaluates the efficacy and cost-effectiveness of two platforms for delivering home visiting programs in the poor urban setting of Sao Paulo's western region: a program delivered by a newly trained cadre of Child…
- Trial name
- NCT02704000
- Testing
- Home visiting program (Jamaica curriculum)
- Volunteers
- 826 people
- Sponsor
- University of Sao Paulo
Child Development, Early Child Development
Intergenerational Risk and Resilience of Rohingya in Displacement
The iRRRd study is an ongoing prospective longitudinal prenatal birth cohort study based in Cox's Bazar, Bangladesh. Between February 2023 and March 2024, 2,888 pregnant women were enrolled (approximately 80% Rohingya refugees…
- Conditions
- Child Development, Early Child Development, Mental Health, PTSD - Post Traumatic Stress Disorder
- Trial name
- iRRRd (NCT07758283)
- Where
- Bangladesh
- Volunteers
- 2,200 people
- Sponsor
- New York University
Changes in Bone Mineral Content, Changes in Bone Marrow Adipose Tissue
Tissue Partitioning in Early Childhood
Early childhood (~4-6 years of age) is an important window for determining body composition trajectory and may be a critical period for the development of tissue partitioning patterns that influence later disease risk, including…
- Trial name
- NCT01041794
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Early Life Adversity, Trauma
Study of Cannabidiol and Neuroimaging on Stress
Dysregulation in stress responsivity is a growing psychiatry-transdiagnostic fundamental phenomenon, with limited therapeutic strategies.
- Conditions
- Early Life Adversity, Trauma, Stress
- Trial name
- SCANS (NCT07278505)
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Obesity, Water; Lack of
Preventing Early Childhood Obesity, Part 1: Long-term Follow-up
This study extends follow up on of Native American (NA) mothers and their children (now age 3-5 years) enrolled in the 1:1 randomized controlled trial of the Family Spirit Nurture (FSN) intervention designed to prevent early…
- Conditions
- Obesity, Water; Lack of, Childhood Obesity, Feeding Behavior
- Trial name
- PECO1-LTF (NCT05424471)
- Testing
- Family Spirit Nurture (FSN), Control Group - Vehicle Safety
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Early Childhood Caries (ECC)
Goal Attainment-Based Parent Education for ECC Prevention
Preventing early childhood caries (ECC) requires improving parental knowledge and behavior, as parents play a critical role in establishing oral and dental health practices during early childhood.
- Trial name
- GAT-ECC (NCT07460271)
- Testing
- Structured Parent Education
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Stress, Psychological Stress
Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity
The aim of the Everyday Moments of Mindfulness (EMMI) study is to test whether brief mindfulness-based practices will improve daily psychological stress responses in women (age 30-60) who report a history of early life adversity.
- Conditions
- Stress, Psychological Stress, Child Maltreatment, Depressive Symptoms
- Trial name
- EMMI (NCT04606199)
- Testing
- Mindfulness-based intervention, up to 5 minutes 0-3 times/day
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Aging
Childhood Early Oral Aging Syndrome: Prevalence, Etiological Factors, and Consequences on Occlusion
The Early Oral Aging Syndrome (EOAS) is a broad concept concerning changes in oral health caused by systemic diseases of different origins, which are related to the current lifestyle in the pediatric population.
- Trial name
- NCT06381414
- Testing
- Observation
- Where
- Brazil
- Volunteers
- 183 people
- Sponsor
- University of Nove de Julho
Surgery, Surgery in Early Childhood
The Asensus Paediatric Robotic Registry
An open-label, observational, paediatric registry trial in which participating centers enroll subjects who had or will have a laparoscopically-assisted surgery using the Senhance Surgical System.
- Trial name
- miniTRUST (NCT07081828)
- Testing
- Surgery
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- Asensus Surgical
Health Behavior, Mobile Phone Use
HBM for Empowering Parental Toothbrushing and Sugar Intake Control
It has been recognized that oral health education for parents is critical for the prevention of early childhood caries (ECC). Few parents practiced caries prevention procedures for their children in daily life, though.
- Conditions
- Health Behavior, Mobile Phone Use, Early Childhood Caries
- Trial name
- NCT04665219
- Testing
- HBM-based text messages, Standard text message
- Where
- China
- Volunteers
- 518 people
- Sponsor
- The University of Hong Kong