Clinical trials: Early Detection
Breast Cancer
Oncoliq: Test for Early Breast Cancer Detection.
Oncoliq is a novel early breast cancer detection test based on liquid biopsies and microRNAs. This innovative test will allow improving the accuracy of cancer detection which will impact on health, reducing the patient mortality…
- Trial name
- NCT04906330
- Testing
- Oncoliq: test for early breast cancer detection.
- Where
- Argentina
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospital Militar Central Cirujano Mayor Dr. Cosme Argerich
Hypertension, High Blood Pressure
Pre-clinical Cardiac Dysfunction Among Asymptomatic Hypertensive Patients
This project will evaluate the clinical and cost effectiveness of a novel, multidisciplinary approach to identify and treat pre-clinical cardiac dysfunction (PCCD) in asymptomatic hypertensive patients identified in a single…
- Conditions
- Hypertension, High Blood Pressure, Ventricular Hypertrophy, Diastolic Dysfunction
- Trial name
- NCT00689819
- Testing
- Exercise, Weight Loss, Low Sodium Diet
- Where
- United States
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Triple Negative Breast Cancer
Early Detection of Triple Negative Breast Cancer Relapse (CUPCAKE)
CUPCAKE is a randomized, non-comparative, multicenter, proof-of-concept phase II trial, using the Trials within Cohorts concept(1) to assess the clinical utility of ctDNA monitoring combined with 68Ga-FAPI-46-PET-CT imaging upon…
- Trial name
- CUPCAKE (NCT06225505)
- Testing
- ctDNA monitoring, 68Ga-FAPI-46-PET-CT
- Where
- 13 sites in France
- Volunteers
- 450 people
- Sponsor
- Institut Curie
Psychosis
Predicting Psychotic Relapse Using Speech-Based Early Detection
Psychotic disorders, including schizophrenia and affective psychosis, are severe mental health conditions marked by recurrent episodes that contribute to long-term disability.
- Trial name
- MOTS+ (NCT06978894)
- Where
- 3 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Douglas Mental Health University Institute
ALS (Amyotrophic Lateral Sclerosis)
Developing a Comprehensive Biomarker Panel for Monitoring Progression and Early Detection in ALS Patients
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease for which reliable biomarkers for early diagnosis, prognosis, and patient stratification remain limited.
- Trial name
- UNZUELUZON ALS (NCT07737977)
- Testing
- peripheral venous blood collection, collection of medical data related to patient care
- Where
- 2 sites in France, Spain
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Atherosclerosis, Cardiovascular Diseases
Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases.
The incidence of cardiovascular diseases is still high and further efforts should be done in primary prevention. The main objective is to quantify the burden of subclinical atherosclerosis using non-invasive techniques,and to…
- Trial name
- PRIMARIA (NCT00734123)
- Testing
- Simvastatin or Atorvastatin, Enalapril, Aspirin or clopidogrel
- Where
- Spain
- Volunteers
- 2,948 people, healthy volunteers welcome
- Sponsor
- Hospital Arnau de Vilanova
Postpartum Hypertension
Trauma-informed Approach to Timely Detection and Management of Early Postpartum Hypertension
The investigators primary project goal is to improve clinical outcomes, including mental health outcomes, among postpartum at-risk women experiencing health disparities by increasing awareness, detection, and timely care of…
- Trial name
- NCT05884190
- Testing
- Remote Medical Model (RMM), Community Health Model (CHM), SoC
- Where
- 3 sites in United States
- Volunteers
- 6,030 people
- Sponsor
- Yale University
Gastric Cancer, Gastric Intestinal Metaplasia
Cytosponge for Gastric Intestinal Metaplasia
Gastric cancer has a very poor prognosis. The disease is often diagnosed at a late stage, when curative treatment options are limited or ineffective.
- Conditions
- Gastric Cancer, Gastric Intestinal Metaplasia, Gastric Atrophy
- Trial name
- CyGIM (NCT05657080)
- Testing
- Cytosponge-TFF3
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- University of Cambridge
Clinical Decision-Making, Early Detection of Cancer
Evaluation of the Cell Detachment Ratio on pH-responsive Chitosan as a Prognostic Factor in Lung Cancer
Biomaterial-based cell culture models have been gaining increasing attention as potential therapeutic strategies. The purpose of this project is to evaluate whether the cell detachment ratio on pH-responsive chitosan could be…
- Trial name
- NCT04218188
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Lung Cancer, Chronic Obstructive Airway Disease
Early Detection of Lung Tumors by Sniffer Dogs - Evaluation of Sensitivity and Specificity
Some groups reported that sniffer dogs can be applied to detect lung cancer in the exhaled breath of patients. Therefore, breath samples (BS) of patients are collected.
- Trial name
- NCT01141842
- Testing
- exhalation analysis of breath sample
- Where
- 2 sites in Germany
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Schillerhoehe Hospital
Cardiovascular Diseases, Vascular Stiffness
The Assessment of Large and Small Artery Elasticity for the Early Detection of Cardiovascular Disease
Efforts to identify individuals at a higher risk for adverse cardiovascular outcomes focus on traditional risk factors, such as age, gender, smoking status, blood pressure, and cholesterol; however, this approach does not…
- Trial name
- NCT02863211
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- St. Boniface Hospital
Optical Enhancement Endoscopy
Early Detection of Head and Neck Superficial Squamous Cell Carcinoma in Patients With Esophagus Squamous Cell Carcinoma
the investigators randomly divide the eligible objects into two groups:1. objects in this group will first receive OE endoscopy observation and subsequent white light imaging(WLI) observation during oropharynx and hypopharynx; 2.
- Trial name
- NCT03700398
- Testing
- first OE, first WLI
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Shandong University
Lymphedema of Upper Arm, Breast Cancer
Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema
Breast-cancer related lymphoedema (BCRL) is a common phenomenon. Early diagnosis and treatment is very important to alter the normal progression of this disease.
- Conditions
- Lymphedema of Upper Arm, Breast Cancer, Diagnoses Disease
- Trial name
- DEARLY (NCT03210311)
- Testing
- compression
- Where
- Belgium
- Volunteers
- 128 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mild Cognitive Impairment, Alzheimer's Disease
Alzheimer's Disease Neuroimaging Initiative Grand Opportunity
The purpose of this study is to build upon the information obtained in the original Alzheimer's Disease Neuroimaging Initiative (ADNI1), to examine how brain imaging technology can be used with other tests to measure the…
- Trial name
- ADNI-GO (NCT01078636)
- Where
- 55 sites in United States, Canada
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Liver Transplant; Complications, Immunosuppression
Blood-Bile Ratio Tacrolimus After Liver Transplantation
Tacrolimus is the most widely used immunosuppressive drug in the prevention of rejection after solid organ transplantation. Pharmacokinetic studies in healthy volunteers and in transplanted patients have shown that this molecule…
- Conditions
- Liver Transplant; Complications, Immunosuppression, Transplant Failure, Transplant; Complication, Rejection
- Trial name
- BBRT (NCT03882164)
- Testing
- Blood-Bile Ratio of Tacrolimus
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lung Cancer
Early Lung Cancer Detection Using Computed Tomography
Early detection of lung cancer may improve treatment outcomes. Risk factors have been identified, suggesting a population which might benefit from regular screening.
- Trial name
- NCT00188734
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Compartment Syndrome of Leg
Early Diagnosis of Compartment Syndrome by Multimodal Detection Technique
compartment syndrome has a high incidence in patients with a variety of diseases, including fractures, and delayed diagnosis or without intervention can lead to severe adverse prognosis, such as limb deformities, amputations and…
- Trial name
- MMCS (NCT04442672)
- Testing
- acute compartment syndrome model of health volunteer
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Inflamatory Bowel Disease, Spondylarthritis
Screening Questionnaires and Musculoskeletal Ultrasound for Early Detection of Spondyloarthritis in IBD Patients
This study aims to evaluate the screening performance of the DETAIL and IBIS-Q questionnaires followed by musculoskeletal ultrasound (MSUS) for the early detection of spondyloarthritis in patients previously diagnosed with…
- Trial name
- IBD-MSUS (NCT07721844)
- Testing
- DETAIL .IBIS_Q . MSUS
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Congestive Heart Failure
Evaluation of Cardiac Compass With OptiVol in the Early Detection of Decompensation Events for Heart Failure
The purpose of the PRECEDE-HF study is to collect data to compare patients whose heart failure is managed using Cardiac Compass with OptiVol (which is a tool in the device that records information about the heart that doctors can…
- Trial name
- PRECEDE-HF (NCT00510198)
- Testing
- Cardiac Compass with OptiVol Fluid Status Monitoring, Standard of Care alone (clinical assessment)
- Where
- 33 sites in United States
- Volunteers
- 120 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Pregnancy
Effectiveness of Online-Based "Pregnant Women Care Cadres" Intervention on Husband Support in Early Detection of High Risk in Medan Maimun Area
The goal of this quasi-experimental study is to evaluate whether an online-based "Caring for Pregnant Women" intervention delivered through community health cadres can improve husband support in the early detection of high-risk…
- Trial name
- NCT07430033
- Testing
- Online-Based "Caring for Pregnant Women" Intervention Through Community Health Cadres to Enhance Husband Support in Early Detection of High-Risk Pregnancy
- Where
- Indonesia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Siti Saidah Nasution