Clinical trials: Early Parkinson's Disease
Parkinson Disease
REal-life ON PARKinson's - ITaly (REONPARK-IT)
The present study aims to evaluate the effectiveness and safety of opicapone in a real-world setting at centers for Parkinson's disease located in Italy.
- Trial name
- NCT07403799
- Testing
- Opicapone 50 mg
- Where
- 20 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Bial - Portela C S.A.
Early Onset Parkinson Disease, Early Stage Parkinson Disease
Dual-task Performance in Young-onset PD
This study aimed to investigate the effects of Game based dual-task training with treadmill on executive function and dual-task performance in individuals with early-onset PD and discuss the correlation between the change values…
- Trial name
- NCT04033393
- Testing
- Game based dual-task training, Treadmill training
- Volunteers
- 40 people
- Sponsor
- National Yang Ming Chiao Tung University
Early Parkinson Disease
PROSEEK: A Phase 2 Study In Early Parkinson's Disease Patients Evaluating The Safety And Efficacy Of Abl Tyrosine Kinase Inhibition Using K0706
This study consists of 2 parts. Part 1 of the study is conducted to evaluate the efficacy, safety, and tolerability of two doses of K0706 compared to placebo in subjects with early Parkinson's Disease who are not receiving…
- Trial name
- NCT03655236
- Testing
- K0706
- Where
- 78 sites in United States, Hungary and 4 more
- Volunteers
- 513 people
- Sponsor
- Sun Pharma Advanced Research Company Limited
Parkinson Disease, Neurodegenerative Diseases
Study Assessing Tolerability and Safety of AFFITOPE® PD03A in Patients With Early Parkinson's Disease
Study AFF011 is a randomized controlled parallel Group phase I study to investigate the safety and tolerability of two doses of the vaccine AFFITOPE® PD03A given to patients with early Parkinson's disease.
- Trial name
- AFF011 (NCT02267434)
- Testing
- Low dose AFFITOPE® PD03A + Adjuvant, High dose AFFITOPE® PD03A + Adjuvant, Adjuvant without active component
- Where
- 2 sites in Austria
- Volunteers
- 36 people
- Sponsor
- Affiris AG
Parkinson Disease
DAT SPECT and Procedural Motor Skills in Parkinson's Disease
Patients with Parkinson's disease (PD) are known to be affected by subtle cognitive impairment early in the disease course, mostly in the executive field.
- Trial name
- NCT03076307
- Testing
- Procedural Motor Skills with mirror-drawing of figures
- Where
- Switzerland
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Parkinson Disease
Study on the Safety, Tolerance and Pharmacokinetics of Phenlarmide Tablets
1. To evaluate the safety and tolerability of Phenlarmide tablets in patients with Parkinson's disease in the early and middle stages. 2.
- Trial name
- NCT04693039
- Testing
- Phenlarmide
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shijiazhuang Yiling Pharmaceutical Co. Ltd
Parkinson Disease
Earlier Diagnosis and Better Treatment Mission Related to the Cohort Programme
The Luxembourg Parkinson's Study is an ongoing longitudinal nationwide monocentric observational study. It collects extensive clinical, molecular, genetic, and digital device-based longitudinal data, as well as foreseen…
- Trial name
- LuxPARK (NCT05266872)
- Testing
- Observational study with sample and data collection
- Where
- 2 sites in Luxembourg
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Parkinson Disease
Study of the Neuro-protective Effect of Granulocyte-colony Stimulating Factor on Early Stage Parkinson's Disease
The purpose of this study is to evaluate the effectiveness of neuroprotection from granulocyte colony-stimulating factor on Parkinson disease
- Trial name
- NCT01227681
- Testing
- G-CSF
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Parkinson's Disease, DBS
Prospective Study to Compare Results of STN-DBS Between Early Treated and Late-treated PD Patient
The aim of this study is to investigate the impact of DBS not only no motor outcomes, but also on neuropsychological and psychiatric aspects and on quality of life in young patients with a short history of disease.
- Conditions
- Parkinson's Disease, DBS, Deep Brain Stimulation, STN
- Trial name
- DeBraStE (NCT01274832)
- Testing
- Deep Brain Stimulation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Early Stage Parkinson's Disease
The Effects of Aplindore on the Treatment of Signs and Symptoms of Parkinson's Disease
The purpose of this study is to demonstrate the safety, tolerability, efficacy and pharmacokinetics of aplindore in patients with early stage Parkinson's Disease (PD) who are not currently taking any dopamine agonists or who are…
- Trial name
- NCT00623324
- Testing
- Aplindore
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ligand Pharmaceuticals
Parkinson Disease
A Randomized Controlled Trial of Nicotinamide Riboside Supplementation in Early Parkinson's Disease
NOPARK is a double-blinded randomized controlled phase II trial, with the aim to assess the efficacy of nicotinamide adenine dinucleotide (NAD)-replenishment therapy in the form of oral nicotinamide riboside (NR) in delaying the…
- Trial name
- NOPARK (NCT03568968)
- Testing
- Nicotinamide Riboside
- Where
- 11 sites in Norway
- Volunteers
- 410 people
- Sponsor
- Haukeland University Hospital
Parkinson's Disease
Pharmacokinetics and Safety Study of LY03003 in Patients With Early-stage Parkinson's Disease
The purpose of this study is to characterize the pharmacokinetics (PK) of LY03003 following multiple escalating intramuscular injections, as compared to Neupro patch and to evaluate the safety and tolerability and preliminary…
- Trial name
- 03003MAD (NCT02055274)
- Testing
- LY03003, Neupro
- Where
- 5 sites in United States
- Volunteers
- 39 people
- Sponsor
- Luye Pharma Group Ltd.
Parkinson Disease
Clinical Study of Stalevo in the Treatment of Early Parkinson's Disease
The main goal of PD research is to develop disease-modifying drugs to delay or prevent the underlying neurodegenerative process.
- Trial name
- NCT04952194
- Testing
- Stalevo, Carbidopa and Levodopa Controlled Release Tablets
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson's Disease
Dose-Finding Safety Study of BIIB014 in Early-Stage Parkinson's Disease
The main purpose of this study is to determine the safety of BIIB014 and how well BIIB014 is tolerated when given at different doses to patients with early-stage Parkinson's Disease.
- Trial name
- MOBILE (NCT00442780)
- Testing
- BIIB014
- Where
- 10 sites in Israel, Poland and 1 more
- Volunteers
- 36 people
- Sponsor
- Biogen
Parkinson Disease, Progression, Disease
Neuromelanin MRI: A Progression Marker in Early PD
Prospective observational study to qualify NM-MRI as progression marker in early Parkinson's.
- Trial name
- InsIghtPD (NCT05631158)
- Testing
- MRI
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Parkinson Disease
Randomized, Double-Blind Clinical Trial for Parkinson's Disease (Early and Moderate)
This is a randomized, double-blind, single center, phase 2 study to assess efficacy and safety of multiple HB-adMSCs vs Placebo for the treatment of Parkinson's disease.
- Trial name
- PD (NCT04928287)
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences Research Foundation
Parkinson Disease
Study to Evaluate the Effect of Lixisenatide in Patient With Parkinson's Disease
The main objective of the study is to evaluate the effect of lixisenatide (20 μg/d), versus placebo, administered as add-on therapy with the usual antiparkinsonian treatment, on the progression of motor disability in patients…
- Trial name
- LixiPark (NCT03439943)
- Testing
- Lixisenatide
- Where
- 20 sites in France
- Volunteers
- 156 people
- Sponsor
- University Hospital, Toulouse
Parkinson Disease
The Impact of a Diagnosis of Parkinson's on Work
Parkinson's disease leads to loss of employment on average within less than 10 years of disease onset and has been found to be associated with an increased absence from work.
- Trial name
- NCT03905954
- Testing
- Usual care
- Where
- United Kingdom
- Volunteers
- 696 people
- Sponsor
- Oxford Brookes University
Parkinson Disease
A Clinical Study of KDT-3594 in Japanese Patients With Early Parkinson's Disease
Objective of this study is to investigate the safety, pharmacokinetics and efficacy of KDT-3594 in patients with early Parkinson's disease without a concomitant medication of L-dopa.
- Trial name
- NCT04867551
- Testing
- KDT-3594
- Where
- Japan
- Volunteers
- 7 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Parkinson's Disease
Assessing the Role of Exercise Intensity in Slowing Disease Progression in Early Parkinson's Disease
Participants will complete a self-selected intensity of exercising over a 6 month period, with detailed clinical assessments at commencement and completion to determine the rate of progression of parkinsonism and gait…
- Trial name
- NCT00385073
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Austin Health