Clinical trials: Early Parkinson Disease (Early PD)
Parkinson's Disease
A Study of Weekly Subcutaneous Injections of SER-214 in Subjects With Parkinson's Disease (PD), to Determine the Safety, Tolerability and Pharmacokinetic (PK) Profile of SER-214
SER-214 is a poly (2-ethyl-2oxazoline)(POZ) polymer conjugate of rotigotine, a potent dopamine agonist that has high affinity for the subclass of dopamine receptors in the brain that mediate dopamine signaling.
- Trial name
- NCT02579473
- Testing
- SER-214
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Serina Therapeutics
Parkinson's Disease (PD), Parkinson Disease 6, Early-Onset
Phase Ⅲ Clinical Trial to Evaluate the Efficacy and Safety of TJ0113 Capsules in Patients With Early-Onset Parkinson's Disease
This study is a randomized, double-blind, multicenter, placebo-controlled Phase III clinical trial designed to evaluate the efficacy, safety, and Pop PK characteristics of TJ0113 Capsules in treating EOPD patients.
- Trial name
- NCT07741045
- Testing
- TJ0113 200mg, TJ0113 400mg
- Where
- 21 sites in China
- Volunteers
- 300 people
- Sponsor
- Hangzhou PhecdaMed Co., Ltd.
Alzheimer Disease, Parkinson Disease
Posiphen® Dose-Finding, Biomarker Study in Early Alzheimer's and Parkinson's Patients
Annovis is conducting a clinical study to investigate Posiphen in patients with Early Alzheimer's Disease (AD) and Early Parkinson's Disease (PD). Investigators are looking to recruit 68 patients in two parts of the study.
- Trial name
- NCT04524351
- Testing
- Posiphen
- Where
- 13 sites in United States
- Volunteers
- 75 people
- Sponsor
- Annovis Bio Inc.
Parkinsons Disease
First-in-Human Study of ALN-SNCA in Adult Participants With Early Parkinson's Disease (PD)
This study is researching an experimental drug called ALN-SNCA (called "study drug"). The study is focused on people with early Parkinson's disease, a disorder of the nervous system that affects movement.
- Trial name
- NCT07216066
- Testing
- ALN-SNCA
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 46 people
- Sponsor
- Regeneron Pharmaceuticals
Breast Neoplasms, Triple Negative Breast Neoplasms
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Researchers are looking for new ways to treat types of breast cancer that are both: High-risk, which means the cancer may have a higher chance of getting worse or coming back after treatment Early-stage, which means the cancer is…
- Conditions
- Breast Neoplasms, Triple Negative Breast Neoplasms, HR Low-Positive/HER2-Negative Breast Neoplasms
- Trial name
- NCT06966700
- Testing
- Sacituzumab tirumotecan, Pembrolizumab, Rescue Medication
- Where
- 331 sites in United States, Argentina and 39 more
- Volunteers
- 2,400 people
- Sponsor
- Merck Sharp & Dohme LLC
Parkinson Disease
A Clinical Trial to Evaluate the Pharmacodynamics/Pharmacokinetics and Safety of LY03003 in Early PD Patients
A Clinical Trial to Evaluate the Pharmacodynamics/Pharmacokinetics and Safety of LY03003 in Early PD Patients
- Trial name
- NCT04629404
- Testing
- LY03003
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Luye Pharma Group Ltd.
Parkinson's Disease (PD)
Novel Shoe Device NUSHU to Measure Gait Analysis in Parkinson's Patients
Gait changes in Parkinson's disease are complex, variable, and difficult to detect during short clinic assessments. The aim of this study is to collect gait measurements in Parkinson's patients through sensors in a novel shoe…
- Trial name
- NCT06975059
- Testing
- NUSHU shoe
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Parkinson Disease
Early Versus Late Application of STN DBS to PD Patients With Motor Complications
Although deep brain stimulation of the subthalamic nucleus(STN DBS) has become the surgical treatment of choice for Parkinson's disease(PD), a consensus on the timing of surgery is lacking.
- Trial name
- ELASS (NCT01922388)
- Testing
- Bilateral deep brain stimulation of the subthalamic nucleus
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chen Ling
Parkinson Disease (PD)
Idiopathic Parkinson's Disease: Interest of an Early Group-Based Cognitive Rehabilitation Program (LIFECOG-PD)
Current pharmacological treatments have not demonstrated significant improvement in cognitive impairment in Parkinson's disease (PD).
- Trial name
- LIFECOG-PD (NCT07813156)
- Testing
- cognitive rehabilitation program
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson's Disease
Early Parkinson's Disease (PD) Cross-Sectional
Purpose: 1. To see if cytokine levels and oligomeric alpha-synuclein levels in blood and cerebrospinal fluid could be used as biological markers for Parkinson's disease (PD) onset and progression. 2.
- Trial name
- EPDX (NCT00817453)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Parkinson Disease
Wearable Assessments in the Clinic and Home in PD
The purpose of this study is to evaluate disease progression in persons with early Parkinson disease, as assessed by digital and electronic sensor data collection to be correlated with typical clinical assessments.
- Trial name
- WATCH-PD (NCT03681015)
- Where
- 17 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Parkinson Disease (PD)
Clinical Study to Evaluate XS411 in Treatment of Early-onset Parkinson's Disease
This study is a Phase I/II clinical study to evaluate the safety, tolerability, and efficacy of XS411 in the treatment of EOPD. The study consists of two phases: Phase I and Phase II.
- Trial name
- NCT07166757
- Testing
- human allogeneic induced pluripotent stem cell (iPSC)-derived dopaminergic neural progenitor cell injection
- Where
- China
- Volunteers
- 90 people
- Sponsor
- XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
TMS Protocols in the Treatment of PD
Standardization and Optimization of TMS Protocols for the Treatment of PD With Depression or Cognitive Impairment
The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in Parkinson's disease patients with depression or cognitive impairment.
- Trial name
- NCT03552861
- Testing
- repetitive transcranial magnetic stimulation(rTMS)
- Where
- 10 sites in China
- Volunteers
- 252 people
- Sponsor
- Guangdong Provincial People's Hospital
Parkinson's Disease (PD)
Non-Invasive Fundus Retinal Detection Technology for Early Diagnosis of Parkinson's Disease
The objective of this observational study is to investigate whether non-invasive fundus retinal detection technology can be used for the early diagnosis of parkinson's disease (PD).
- Trial name
- NCT07244640
- Testing
- non-invasive fundus retinal detection
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Very Early Stage of Parkinson's Disease
Clinical Trial for Near Infrared Endoventricular Illumination for Neuroprotection in Very Early Cases of Parkinson's Disease (Ev-NIRT)
Parkinson's disease has only pharmacological (essentially dopaminergic) and surgical treatment (essentially high-frequency deep brain stimulation), that are symptomatically effective.
- Trial name
- Ev-NIRT (NCT04261569)
- Testing
- Ev-NIRT
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Grenoble
Early Parkinson Disease (Early PD)
Efficacy, Safety, Tolerability of Pramipexol ER Versus Pramipexol IR Versus Placebo in Early PD Patients
The objectives of this trial conducted in early Parkinson's Disease (PD) patients are to determine the efficacy (as measured by the change from baseline to the end of the maintenance phase in the total score for the Unified…
- Trial name
- NCT00479401
- Testing
- Pramipexol Extended Release, Pramipexol Immediate Release
- Where
- 95 sites in United States, Argentina and 12 more
- Volunteers
- 539 people
- Sponsor
- Boehringer Ingelheim
Dementia (Diagnosis), Parkinson Disease Dementia (PDD)
Enhancing Utility of Neuropsychological Evaluation for Earlier and Effective Diagnosis of Dementia in Parkinson's Disease
Dementia is observed in 80% of people living with advanced stage Parkinson's disease, however, there are inadequate opportunities for early and effective diagnosis of dementia in current clinical practice.
- Conditions
- Dementia (Diagnosis), Parkinson Disease Dementia (PDD), Parkinson Disease (PD)
- Trial name
- PDCogniCare (NCT07114354)
- Testing
- PDCogniCare platform
- Volunteers
- 275 people
- Sponsor
- The University of Queensland
Parkinson's Disease (PD)
Acupuncture and Moxibustion for Motor Symptoms in Early Parkinson's Disease
This study evaluates the clinical effect and safety of acupuncture combined with moxibustion in improving motor symptoms of early-stage Parkinson's Disease (PD) patients, by assessing the changes in UPDRS scores.
- Trial name
- WARMED (NCT06874803)
- Testing
- Acupuncture and Moxibustion (AM)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiani Wu
Parkinson Disease
Clinical Trial for Parkinson's Disease Using Allogeneic HB-adMSCs (Early and Moderate PD)
This is a randomized, double-blind, single center, phase 2 study to assess efficacy and safety of multiple allogeneic HB-adMSCs vs Placebo for the treatment of Parkinson's disease.
- Trial name
- NCT04995081
- Testing
- Biological/Vaccine: Allogeneic HB-adMSCs
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hope Biosciences Research Foundation