Clinical trials: Early Pregnancy
Post-traumatic Stress Disorder, Miscarriage
Improving Mental Health Following Early PREgnancy Loss Using a Brief Cognitive Task
This is a randomised controlled trial designed to investigate the impact of a brief-cognitive task based intervention on intrusive memories, mental health symptoms and daily functioning, in women following an early pregnancy loss.
- Conditions
- Post-traumatic Stress Disorder, Miscarriage, Ectopic Pregnancy, Pregnancy Loss
- Trial name
- IMPREL (NCT05039853)
- Testing
- Brief cognitive task-based intervention
- Where
- United Kingdom
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Imperial College London
ADPKD
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease
Individuals with a diagnosis of autosomal dominant polycystic kidney disease (ADPKD) often have a family history of the condition although up to 10-15% of cases are sporadic mutations.
- Trial name
- NCT06085807
- Testing
- Survey
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Prematurity, Infections
Antibiotic Stewardship to Prevent Early Sepsis in Preterm Infants
Early onset sepsis (EOS) occurs in newborns within the first 72 hours of life, and is rare, about 0.8 cases per 1000 births (1).
- Trial name
- BACTINEO (NCT06930911)
- Testing
- Antibiotic therapy
- Where
- France
- Volunteers
- 711 people
- Sponsor
- Hospices Civils de Lyon
Dengue
Combating Dengue With Innovative, Paradigm-shift-Strategies: Early Dengue Surveillance in Adult Aedes Mosquitoes
During dengue outbreaks, the Ministry of Health Malaysia employs various methods to control the spread of disease, including killing the larvae of Aedes mosquitoes, fogging, together with educating and disseminating information…
- Trial name
- NCT03799237
- Testing
- GOS trap and dengue NS1 antigen kit
- Where
- Malaysia
- Volunteers
- 7,979 people, healthy volunteers welcome
- Sponsor
- Jonathan Liew Wee Kent
Kidney Failure, Acute, Renal Insufficiency, Acute
Impact of Early Renal Involvement on the Development of Severe In-hospital Renal Failure
The purpose of this study is to determine whether renal team involvement early at the onset of kidney injury will prevent further developement of more severe renal failure and worse hospitalization outcomes.
- Conditions
- Kidney Failure, Acute, Renal Insufficiency, Acute, Kidney Failure, Renal Insufficiency
- Trial name
- EARLI (NCT00806039)
- Testing
- Early Renal Involvement
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Saint Louis VA Medical Center
Carcinoma, Renal Cell
Nexavar Post-marketing Surveillance for RCC in Japan: Early Access Program
This study is an early access program of 'Nexavar post-marketing surveillance (PMS) for renal cell carcinoma (RCC) in Japan' which is a regulatory, local prospective and observational study for patients with unresectable or…
- Trial name
- NCT01412671
- Testing
- Sorafenib (Nexavar, BAY43-9006)
- Where
- Japan
- Volunteers
- 117 people
- Sponsor
- Bayer
Postpartum Hemorrhage, Coagulation Disorder
SWIFT - SWIss Factor XIII Trial in PPH
The goal of this trial is to determine if postpartum blood loss can be reduced by replenishing coagulation factor XIII (FXIII) at an early stage of postpartum hemorrhage (PPH).
- Conditions
- Postpartum Hemorrhage, Coagulation Disorder, Coagulation Factor Deficiency, Hemorrhage
- Trial name
- SWIFT (NCT06481995)
- Testing
- Fibrogammin
- Where
- 9 sites in Switzerland
- Volunteers
- 988 people
- Sponsor
- Christian Haslinger
Benign Prostate Hyperplasia, Bladder Outlet Obstruction
En-bloc With Early Apical Release Versus Lobe-by-lobe LASER Enucleation of the Prostate
Since its introduction in 1998 , and through numerous level 1a evidence, Holmium Laser enucleation of the prostate (HoLEP) has come to be considered a size-independent golden standard treatment for management of bladder outlet…
- Trial name
- NCT07014969
- Testing
- En-bloc HoLEP
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Mansoura University
Lactation Disorders
Influence of Kinesiology Taping Application on Severity of Signs and Symptoms in Breast Engorgement.
The aim of the research is to asses the efficacy of kinesiology taping application in breast engorgement in early postpartum stage. Kinesiology application will be performed by women's health physiotherapist.
- Trial name
- NCT03985579
- Testing
- Kinesiology taping application
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Żelazna Medical Centre, LLC
Premature; Infant, Light-for-dates, Breastfeeding
Probiotics and Early Microbial Contact in Preterm Neonates
Probiotics are live microbes which, when administered in sufficient amounts, confer a health benefit to the host. According to recent clinical trials, administration of probiotics to very low birth weight infants significantly…
- Trial name
- ProPre (NCT01454661)
- Testing
- LGG, LGG+Bb-12
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Labor Pain, Early Labor
Therapeutic Rest to Delay Admission in Early Labor: A Prospective Study on Morphine Sleep
This will be a prospective study on labor characteristics, and obstetric and neonatal outcomes in women who accept and women who decline morphine as a form of pain management in labor.
- Trial name
- NCT03539562
- Testing
- Morphine Sulfate and Promethazine
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Growth Hormone Deficiency
Use of miRNAs in Growth Hormone Deficiency (GHD)
This study aims at improving knowledge about the diagnosis of growth hormone deficiency (GHD) and treatment with growth hormone (GH), with the goal of providing information on the presence of new biomarkers, such as miRNAs, for…
- Trial name
- GH-miRNA2 (NCT06455956)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of Parma
Sepsis, Septic Shock
We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury.
The investigators selected patients diagnosed with sepsis who were admitted to the Intensive Care Unit (ICU) of Huai'an First People's Hospital between June 2022 and December 2023, as well as healthy individuals with normal…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- ELABELA（ELA） (NCT06001294)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xiangcheng Zhang
Hip Fractures, Acute Kidney Injury
Evaluation of Novel Biomarkers in Early Recognition of Acute Kidney Injury After Orthopedic Operations.
Surgical treatment of hip fracture may be complicated by acute kidney injury. The aim of this study is to investigate whether the investigators can find a better biomarker than creatinine to recognize this problem at an earlier…
- Trial name
- NCT05285709
- Testing
- Biomarker, RRI measurement
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Diabetic Kidney Disease, Diabetes Mellitus Type 2
Empaglifozin in Early Diabetic Kidney Disease
Background: Diabetes is common among American Indian people and diabetic kidney disease is a common complication. Kidney disease caused by diabetes can lead to the need for kidney replacement, by dialysis or kidney transplant…
- Trial name
- NCT03173963
- Testing
- Empagliflozin
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Sentinel Lymph Node, Endometrial Cancer
Sentinel Lymph Node in Early-Stage Endometrium Cancer
The aim of this prospective study is to investigate whether the detection rate of sentinel lymph node (SLN) with double tracer injected at two different sites may be increased compared to the standard use of a single tracer with…
- Trial name
- NCT06163963
- Testing
- Sentinel Lymph Node Mapping With Double Tracer and Double Injection Sites in Early-Stage Endometrium Cancer, charcoal injection to uterus to map sentinel lymph nodes
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University
Urinary Retention, Pelvic Organ Prolapse
Early Versus Late Voiding Trials After Prolapse Repair
The primary aim of this study is to determine if normal bladder function (the ability to empty the bladder during spontaneous urination) after surgical repair of pelvic organ prolapse returns faster in patients who have a…
- Trial name
- NCT02739256
- Testing
- Retrograde voiding trial
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Pittsburgh
Pneumonia, Urinary Tract Infections
BetaLACTA® Test for Early De-escalation of Empirical Carbapenems in Pulmonary, Urinary and Bloodstream Infections in ICU
The emergence and rapid worldwide spread of Extended- Spectrum Beta-Lactamase-producing enterobacteriaceae (ESBLE) both in hospital and community, led physicians, and notably intensivists, to prescribe more carbapenems…
- Conditions
- Pneumonia, Urinary Tract Infections, Bloodstream Infection
- Trial name
- BLUE-CarbA (NCT03147807)
- Testing
- betaLACTA® rapid diagnostic test
- Where
- France
- Volunteers
- 75 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oligohydramnios
Amnioinfusion Initiative
The aim of this study is to compare perinatal survival in patients presenting with early spontaneous PPROM and persistent oligohydramnios, managed either conservatively or with serial amnioinfusions.
- Trial name
- NCT00787163
- Testing
- amnioinfusion
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- Università degli Studi di Brescia
High-Risk Pregnancy
Effects of Two In-hospital Antepartum Interventions on Functional Ability and Quality of Life in Early Postpartum Women.
The current standard of care for pregnant women deemed to be high-risk often involves recommending varying levels of activity-restriction, up to and including hospitalization.
- Trial name
- NCT02239341
- Testing
- Music Intervention, Muscle Conditioning Intervention
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Western University, Canada