Clinical trials: Early Pregnancy Loss
Abortion Early
Dry vs Wet Misoprostol for Cervical Dilation in First Trimester Abortion
This study aims to verify whether the moisture of 400 µg of misoprostol pre uterine evacuation increases the dilatation of uterine cervix compared to dry misoprostol
- Trial name
- MisoWet (NCT02522078)
- Testing
- dry misoprostol, wet misoprostol
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Etiology, Cohort Study
A Cohort Study for Occupational Stress Induced Early Embryonic Death
Occupation stress can be the risk factors of early embryonic death
- Conditions
- Etiology, Cohort Study, Early Embryonic Death, Occupational Stress
- Trial name
- NCT02115438
- Volunteers
- 3,405 people
- Sponsor
- Peking University Third Hospital
Unwanted Pregnancies
Comparing Methotrexate Followed by Misoprostol to Misoprostol Alone for Early Abortion
Background: In most countries in which abortion is legal, medical abortions are induced with mifepristone and misoprostol. Since mifepristone is expensive and unavailable in many countries, it is important to find other regimens.
- Trial name
- NCT00129506
- Testing
- methotrexate + misoprostol, misoprostol
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Wiebe, Ellen, M.D.
Early Pregnancy Loss
Cell-free DNA Analysis of Chromosome Anomalies in Early Pregnancy Loss
The study assesses the accuracy of cell-free DNA (cfDNA) analysis in detecting whole chromosomal aneuploidies from maternal plasma of patients with early, missed miscarriage.
- Trial name
- NCT04935138
- Testing
- cfDNA analysis
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Quest Diagnostics-Nichols Insitute
Early Pregnancy
ClinicaI Observation of Induced Abortion With Disposable Tissue Suction Tube
The purpose of this study is to explore the clinical effect of disposable tissue suction tube set for induced abortion and make comparison with traditional metal instruments．
- Trial name
- NCT02847910
- Testing
- the disposable tissue suction set, traditional metal instruments of abortion
- Where
- China
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Infertility
Evaluation of SiD's System for Improving Assisted Reproduction Treatments
According to the WHO, infertility affects 15% of reproductive age couples worldwide. Among the assisted reproductive technologies available for patients with infertility, intracytoplasmic sperm injection (ICSI) has become one of…
- Trial name
- NCT05611164
- Testing
- Software assisted selection of individual spermatozoa for intracytoplasmic sperm injection
- Where
- 2 sites in Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IVF 2.0 Limited
Post-Partum Haemorrhage
A Clinical Trial to Study the Effectiveness of a Care Bundle to Prevent Bleeding After a Woman Has Given Birth
Every six minutes a mother dies from postpartum haemorrhage (PPH) in low-resource countries, in the prime of her life and often leaving behind a young family.
- Trial name
- E-MOTIVE (NCT04341662)
- Testing
- E-MOTIVE intervention, Usual care
- Where
- 6 sites in Kenya, Nigeria and 3 more
- Volunteers
- 99,659 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Preeclampsia, Premature Birth
Cohort Study on the Levels of Placental Growth Factor and Nucleosomes in Early Pregnancy and Adverse Pregnancy Outcomes
Objective: This study aims to investigate the association between maternal serum placental growth factor (PLGF) and nucleosome levels in early pregnancy and adverse pregnancy outcomes, and to evaluate their predictive value for…
- Conditions
- Preeclampsia, Premature Birth, Fetal Growth Restriction, Recurrent Miscarriage
- Trial name
- NCT07841197
- Testing
- Measurement of plasma nucleosome and placental growth factor (PLGF) levels
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pregnancy Loss, Early
Patient Satisfaction With the Management of a Stopped Pregnancy in the First Trimester
The clinical practice recommendations highlight the fact that the patient's choice concerning the management of her aborted pregnancy in the first trimester should be privileged, after clear and appropriate information on the…
- Trial name
- MYFEFACY (NCT05049980)
- Testing
- Medical treatment with Mifégyne® and MisoOne®, Endo-uterine aspiration
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Toulouse
Abortion Early, Abortion in First Trimester
Delivery of Audiovisual Information on Early Medical Abortion
The majority of abortions in the United Kingdom (UK) are performed before 9 weeks (63 days) gestation using a method known as Early Medical Abortion (EMA).
- Trial name
- EMAVID (NCT03417362)
- Testing
- Animation
- Where
- 3 sites in France, Sweden and 1 more
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Placenta; Implantation
The Accuracy of Ultrasound in the Detection of Placenta Site in the First Trimester.
The investigators speculate that ultrasound examination in the first trimester can accurately detect placental location. By performing both transabdominal ultrasound and later hysteroscopy on women with a first trimester missed…
- Trial name
- NCT04579796
- Testing
- ultrasound exam, hysteroscopy diagnostic
- Where
- Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Early Pregnancy Loss, Abortion, Spontaneous
Surgical vs. Medical Abortion on Sexual Function After Early Pregnancy Loss
This study compares the medium-term effects of surgical and medical abortion on sexual function in women who have experienced early pregnancy loss (6-12 weeks gestation).
- Conditions
- Early Pregnancy Loss, Abortion, Spontaneous, Miscarriage, Pregnancy, Unwanted
- Trial name
- SF-EPL (NCT07646275)
- Testing
- mifepristone and misoprostol, Vacuum Aspiration
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Harran University
Abortion Early
Point of Care Tests in the Management of Very Early Medical Abortion
This study will investigate the use of a point of care test in patients who are having an abortion at a gestation of <6 weeks (known as a very early medical abortion).
- Trial name
- POCT VEMA (NCT07417787)
- Testing
- Blood test, Participant Questionnaire
- Where
- 3 sites in Sweden, United Kingdom
- Volunteers
- 130 people
- Sponsor
- University of Edinburgh
Uterine Evacuation
The Impact of Doulas in Early Pregnancy Management
The purpose of the study is to examine the impact of doula support for women undergoing a manual vacuum aspiration (MVA) for an early pregnancy failure or undesired pregnancy.
- Trial name
- NCT02165540
- Testing
- Doula
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pregnancy of Unknown Location, Ectopic Pregnancy
Assessment of Biomarkers in Pregnancy on Unknown Location and Ectopic Pregnancy
To further develop the patient care pathway for women classified with a pregnancy of unknown location (PUL) and ectopic pregnancy (EP).
- Conditions
- Pregnancy of Unknown Location, Ectopic Pregnancy, Early Pregnancy, Early Pregnancy Loss
- Trial name
- ABPEP (NCT04738370)
- Testing
- Sample collection
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Abortion Early
Medication Abortion With Autonomous Self-Assessment Project
In this study, the investigators propose to create and pilot-test an asynchronous medication abortion provision service.
- Trial name
- MA-ASAP (NCT05278780)
- Testing
- Screening for eligibility
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy Related, Abortion Early
Medication Abortion Via Pharmacy Dispensing
This mixed-methods study follows a prospective cohort of patients receiving Mifeprex ® (mifepristone) for medication abortion dispensed by pharmacists after undergoing standard clinical evaluation.
- Trial name
- NCT03320057
- Testing
- Mifepristone, Training on mifepristone dispensing
- Where
- 6 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Daniel Grossman
Early Pregnancy Loss, Early Pregnancy
Conversational Artificial Intelligence (AI) to Improve PeRiconception Care Access
The goal of this project, Conversational Artificial Intelligence (AI) to Improve PeRiconception Care Access (CIRCA), is to engage patients in care early in pregnancy (before prenatal care starts) and safely triage concerns to…
- Trial name
- CIRCA (NCT06618144)
- Testing
- Texting platform
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of Pennsylvania
Early Pregnancy Termination, Medical Abortion
Quickstart of Nexplanon® at Medical Abortion
Women having abortions are at high risk for subsequent unintended pregnancy and repeat abortion. Clearly, encouraging contraceptive use after abortion is a high priority.
- Conditions
- Early Pregnancy Termination, Medical Abortion, Postabortion Contraception
- Trial name
- NCT01920022
- Testing
- Mifepristone, etonorgestrel
- Where
- 7 sites in Sweden, United Kingdom
- Volunteers
- 551 people
- Sponsor
- Karolinska Institutet
Early Pregnancy Loss
Evaluation of a Decision Aid for Early Pregnancy Loss
This study aims to determine the effect of the Healthwise decision aid on shared decision making in women undergoing management of early pregnancy loss.
- Trial name
- NCT04410029
- Testing
- Healthwise Decision Aid, Control informational handout
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania