Clinical trials: Early Psychosis
Mental Health Promotion
Designing and Evaluating a Classroom-Based Mental Health Programme for Adolescents.
This study is a mixed-methods feasibility trial designed to examine whether a universal classroom-based psychoeducational programme which covers unusual sensory experiences, psychosis, mental health stigma, and coping strategies…
- Trial name
- NCT07660874
- Testing
- School-Based Mental Health Programme
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Family Members
Family Peer Navigator for Early Psychosis for Black Families
Building upon formative research, this mixed methods study will be conducted in three phases to develop, refine, and pilot-test a multi-component Family Peer Navigator model designed to increase access to and initial engagement…
- Trial name
- NCT05284721
- Testing
- Family Peer Navigator for Early Psychosis, Care Coordination
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Washington State University
Schizophrenia, Psychotic Disorder
tDCS for Cognitive Impairment Associated With Recent-onset Schizophrenia
Background: In parallel to the traditional symptomatology, deficits in cognition (memory, attention, reasoning, social functioning) contribute significantly to disability and suffering in individuals with schizophrenia.
- Trial name
- STICOG (NCT05440955)
- Testing
- left fronto-temporal transcranial Direct Current Stimulation (tDCS)
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Schizophrenia, Major Depressive Disorder
Identification of Multi-modal Bio-markers for Early Diagnosis and Treatment Prediction in Schizophrenia Individuals
This study aims to screen and validate multi-scale bio-markers for early diagnosis and medication monitoring for early schizophrenia, including the genetic, neurobiochemistry, neuroimaging and eletrophysiological measures.
- Conditions
- Schizophrenia, Major Depressive Disorder, Anxiety Disorders
- Trial name
- NCT03790085
- Testing
- Risperidone, Olanzapine, Aripiprazole
- Where
- China
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Schizophrenia
Effect of Memantine on ERP in Early Schizophrenia and Healthy Subjects
Patients with schizophrenia are deeply affected by the positive symptoms, negative symptoms and cognitive impairment. A generalized cognitive deficit could be frequently observed and traced back to early stage of the disease.
- Trial name
- NCT02233556
- Testing
- Memantine
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Psychosis
Psychosis TMS Study
The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI.
- Trial name
- NCT05857137
- Testing
- Active TMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Schizophreniform Disorder, Bipolar I Disorder
Prevention of Weight Gain in Early Psychoses
The purpose of this study is to determine whether individuals with psychotic spectrum disorders ( Schizophrenia, Schizoaffective disorder,Schizophreniform Disorder, Bipolar Disorder (Type I),Bipolar Disorder (Type II),Major…
- Conditions
- Schizophreniform Disorder, Bipolar I Disorder, Bipolar II Disorder, Major Depressive Disorder
- Trial name
- NCT01075295
- Testing
- Behavioural Intervention for the Prevention of Weight Gain, TAU
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Centre for Addiction and Mental Health
Child, Parents
The VIA Family 2.0 - a Family Based Intervention for Families with Parental Mental Illness
VIA Family 2.0 - a Family Based Intervention for families with parental mental illness Background: Children born to parents with mental illness have consistently been shown to have increased risks for a range of negative life…
- Conditions
- Child, Parents, Mental Disorder, Child of Impaired Parents
- Trial name
- NCT06312410
- Testing
- VIA Family 2.0
- Where
- Denmark
- Volunteers
- 1,452 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Treatment Resistant Psychosis, Psychosis
Stratification and Treatment in Early Psychosis Study -ASSIST
The purpose of this trial is: To investigate whether the response to clozapine treatment can be enhanced by adding cannabidiol (CBD), compared to placebo, in treatment resistant psychosis patients.
- Trial name
- STEP-ASSIST (NCT07326124)
- Testing
- CBD 100 mg/mL Oral Solution, Placeb
- Where
- 15 sites in Germany, Greece and 6 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Schizophrenia, Psychosis
Minnesota Community-Based Cognitive Training in Early Psychosis
The purpose of this study is to determine whether cognitive training exercises can improve cognitive functioning in young patients with recent-onset psychosis who are being treated in community mental health settings using the…
- Conditions
- Schizophrenia, Psychosis, Schizoaffective Disorder, Schizophreniform Disorders
- Trial name
- Mini-COTES (NCT03079024)
- Testing
- Targeted Cognitive Training, General Cognitive Exercises, Coordinated Specialty Care for First Episode Psychosis
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Early Psychosis
PSYCHE Cognitive Remediation & Social Recovery Study
This study is a pilot feasibility study embedded in the Early Intervention in Psychosis (EIP) services in Ireland. It explores the feasibility and acceptability of a combined cognitive remediation training and social recovery…
- Trial name
- NCT06032182
- Testing
- CRESTR Intervention, CRESTR Control
- Where
- 5 sites in Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University of Ireland, Galway, Ireland
Caregiver to a Young Adult With Early Psychosis
Bolster: Caregiver App to Reduce Duration of Untreated Psychosis
The proposed research project aims to develop and test a mobile health intervention designed to improve caregivers' illness knowledge and caregiving skills through interactive cognitive-behavioral modules, and through these…
- Trial name
- NCT04949542
- Testing
- Bolster, Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Schizophrenia
NRX-1074 in Early Course Schizophrenia
This study seeks to examine the effectiveness of NRX-1074 in the treatment of negative symptoms and cognition in schizophrenia compared to other agents at the glycine site which have demonstrated inconsistent results for negative…
- Trial name
- NCT02603458
- Testing
- NRX-1074
- Where
- 2 sites in United States
- Sponsor
- NYU Langone Health
Clinical High Risk, Early Psychosis
Digital Strategies to Advance Help-Seeking - Aim 3
This proposal aims to establish a Digital Laboratory focused on advancing help-seeking and expediting treatment initiation in youth ages 12-29 who are at Clinical High-Risk (CHR) for developing psychosis.
- Conditions
- Clinical High Risk, Early Psychosis, First Episode Psychosis
- Trial name
- NCT06774417
- Testing
- Digital nudge
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- Columbia University
Schizophrenia
Continued Early Intervention for Recent-onset Schizophrenia
The purpose of this study was to determine whether outreach integrated treatment of first episode schizophrenia was more effecive than standard outpatient treatment.
- Trial name
- NCT00184509
- Testing
- integrated psychosocial treatment (behavior)
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Norwegian University of Science and Technology
Schizophrenia
Study of the Impact on the Therapeutic Alliance of a Short Initial Psychoeducation Programme in Patients With Early Schizophrenia
Schizophrenia is a serious, disabling and unfortunately common disease. Its prevalence is in the order of 0.6 to 1% in the general population, a figure that remains relatively stable in the various cultures.
- Trial name
- EPPICS (NCT04867681)
- Testing
- Psycho-education programme
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Schizophrenia, Psychosis
Psychological Intervention for Persons in the Early Initial Prodromal State
The purpose of this randomized controlled trial is to develop a cognitive behavioral therapy (CBT) for persons with at risk mental states in the early initial prodromal state and to evaluate CBT in comparison to supportive…
- Trial name
- NCT00204087
- Testing
- Cognitive behavioral therapy (CBT), Supportive Counselling (SC)
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- University of Cologne
Schizophrenia
rTMS as a Probe of Episodic Memory Neurocircuitry in Schizophrenia
This will be a single site pilot study. 30 subjects with Early Phase Psychosis (EPP), defined as medical record documentation of the onset of clinically significant psychotic symptoms within the past ten years, will be enrolled.
- Trial name
- rTMS-EM (NCT04182113)
- Testing
- 1 Hz rTMS Stimulation
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Indiana University
Caregiver, Caregiver Distress
mHealth for Early Psychosis Caregivers in Statewide Program Outreach
The purpose of this study is to pilot the delivery of an mHealth intervention for caregivers to young people with early psychosis within a network of early psychosis intervention programs in the state of North Carolina.
- Conditions
- Caregiver, Caregiver Distress, Caregiver to a Young Adult With Early Psychosis, Family Caregivers
- Trial name
- Bolster-NC (NCT07225179)
- Testing
- Bolster
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Schizophrenia
Transcranial Direct Current Stimulation and Effects on Early Auditory Processing in Schizophrenia
Individuals with schizophrenia have difficulties in functioning in the community. No one really knows what factors determine how well patients manage in the real world.
- Trial name
- NCT03537703
- Testing
- Active tDCS + Auditory Training, Active tDCS + Control Condition
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- VA Greater Los Angeles Healthcare System