Clinical trials: Early Rheumatoid Arthritis
Rheumatoid Arthritis, Inflammatory Arthritis
Prognostic Evaluation of Inflammatory Polyarthritis of Recent Onset
Inflammatory joint diseases are major causes of invalidity and morbidity. Rheumatoid arthritis (RA), the most frequent of chronic arthritides, affects close to 1% of the Canadian population.
- Trial name
- EUPA (NCT00512239)
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Gilles Boire
Rheumatoid Arthritis
A Long-Term Extension Study of WA19926 on the Safety of Tocilizumab (RoActemra/Actemra) in Participants With Early Moderate to Severe Rheumatoid Arthritis
This open-label, single arm, multicenter long-term extension study will evaluate the safety and efficacy of tocilizumab (RoActemra/Actemra) in participants with moderate to severe rheumatoid arthritis who have completed the…
- Trial name
- NCT01655381
- Testing
- Tocilizumab
- Where
- 6 sites in France
- Volunteers
- 15 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Active Conventional Therapy Compared to Three Different Biologic Treatments in Early Rheumatoid Arthritis With Subsequent Dose Reduction
This is an international (Sweden, Finland, Norway, Denmark, Iceland and the Netherlands) trial designed to compare the safety and efficacy of active conventional therapy (ACT) and three biologic treatments in subjects with early…
- Trial name
- NCT01491815
- Testing
- Non-biological DMARD's, Cimzia, Orencia
- Where
- 30 sites in Denmark, Finland and 4 more
- Volunteers
- 812 people
- Sponsor
- Karolinska Institutet
Rheumatoid Arthritis, Interstitial Lung Disease
Interstitial Lung Disease in Early Rheumatoid Arthritis
The purpose of this study is to determine how interstitial lung disease can be predicted over time in early rheumatoid arthritis.
- Trial name
- ILD-Early RA (NCT03977415)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- National Jewish Health
Rheumatoid Arthritis (RA)
Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent.
The purpose of this study is to assess the clinical response to IL-6 inhibition defined as Low Disease Activity (DAS44) <2.4) at the follow-up visit at 12 months and the correlation between the biomarkers and treatment response.
- Trial name
- NCT01835613
- Testing
- Biomarkers Measures
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Osservatorio Epidemiologico GISEA
Rheumatoid Arthritis
Early Access Program of the Safety of Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects With Active Rheumatoid Arthritis
Multicenter Early Access Program of the Safety of Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects with Active Rheumatoid Arthritis
- Trial name
- ReAct (NCT00650026)
- Testing
- adalimumab
- Sponsor
- Abbott
Rheumatoid Arthritis
A Long Term Extension Study of WA19926 (NCT01007435) of Tocilizumab (RoActemra/Actemra) in Participants With Early, Moderate to Severe Rheumatoid Arthritis (RA)
This open-label, single arm, multicenter long-term extension study of WA19926 (NCT01007435) will evaluate the safety and efficacy of tocilizumab in participants with early, moderate to severe RA who have completed the 104-week…
- Trial name
- NCT01668966
- Testing
- Tocilizumab
- Where
- 6 sites in Brazil
- Volunteers
- 23 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)
The purpose of this study is to 1)to determine if it is better to treat all early RA patients with methotrexate in combination with hydroxychloroquine plus sulfasalazine or in combination with etanercept or reserve this treatment…
- Trial name
- TEAR (NCT00259610)
- Testing
- methotrexate, sulfasalazine, hydroxychloroquine
- Where
- United States
- Volunteers
- 755 people
- Sponsor
- University of Alabama at Birmingham
Rheumatoid Arthritis
A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler Ultrasonography
The purpose of the study is to assess early signs of response to abatacept+methotrexate in metacarpophalangeal joints in both hands using power Doppler ultrasonography in patients with active rheumatoid arthritis.
- Trial name
- NCT00767325
- Testing
- Abatacept, Methotrexate
- Where
- 21 sites in Denmark, France and 6 more
- Volunteers
- 104 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
A Long-Term Safety Extension Study of WA19926 in Participants With Rheumatoid Arthritis
This extension study of WA19926 will assess the long-term safety and the efficacy of RoActemra/Actemra (tocilizumab) treatment in participants with rheumatoid arthritis.
- Trial name
- NCT01649804
- Testing
- tocilizumab [RoActemra/Actemra]
- Where
- 3 sites in Hungary
- Volunteers
- 12 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Fibrocytes in Early and Longstanding Rheumatoid Arthritis
This study will focus on a rare cell population called fibrocytes in peripheral blood and synovial tissue in Rheumatoid Arthritis (RA). One group of patients with early RA and one group with long-standing RA.
- Trial name
- NCT02652299
- Testing
- Synovial biopsy
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Systemic Lupus Erythematosus, Rheumatoid Arthritis
Early Clinical Study of UTAA91 Injection for the Treatment of Relapsed/Refractory Autoimmune Diseases
This clinical trial is designed as a single - arm, open - label, single - center, investigator - initiated early - phase clinical study.
- Conditions
- Systemic Lupus Erythematosus, Rheumatoid Arthritis, Dry Syndrome, Idiopathic Inflammatory Myopathies
- Trial name
- NCT06970951
- Testing
- UTAA91 injection
- Where
- China
- Volunteers
- 15 people
- Sponsor
- PersonGen BioTherapeutics (Suzhou) Co., Ltd.
Rheumatoid Arthritis
Registry for African Americans With Early Rheumatoid Arthritis
The purpose of this study is to better understand the causes of rheumatoid arthritis (RA), particularly in African Americans.
- Trial name
- CLEAR (NCT00074555)
- Where
- 5 sites in United States
- Volunteers
- 357 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Rheumatoid Arthritis
Long-term Prognosis and Quality of Life in Early Rheumatoid Arthritis Patients Treated by 2015 ACR Guideline (LELAND)
To focus on the real world treat-to-target rate of early rheumatoid arthritis patients who will be treated according to the 2015 American College of Rheumatology Guideline for the Treatment of RA.
- Trial name
- LELAND (NCT03508713)
- Testing
- disease modified antirheumatic drugs or biological agents
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Early Rheumatoid Arthritis
Early RA Vascular Randomised Controlled Study
To investigate the effect of two tight-control treatment strategies, aiming at 1) 2011 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) definition of remission compare with 2) minimal disease…
- Trial name
- NCT01768923
- Testing
- SDAI remission, Minimal disease activity remission
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Chinese University of Hong Kong
Arthritis, Rheumatoid, Pain
Chronic Pain in Rheumatoid Arthritis
The objective is to identify modifiable clinical factors and neurobiological pathways that lead to the development of chronic pain in patients with early rheumatoid arthritis.
- Trial name
- CPIRA-2 (NCT05038553)
- Testing
- No intervention
- Where
- 5 sites in United States
- Volunteers
- 125 people
- Sponsor
- Northwestern University
Rheumatoid Arthritis
Prospective Study on Intensive Early Rheumatoid Arthritis Treatment
Hypothesis: Early intensive treatment with anti-TNF agent plus methotrexate plus high dose prednisone may increase remission rate and may induce stable remission in Rheumatoid Arthritis Objective: to evaluate induction of…
- Trial name
- CURE (NCT00480272)
- Testing
- adalimumab, plus prednisone
- Where
- Italy
- Volunteers
- 251 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Rheumatoid Arthritis
Study of the Response and Cardiorespiratory Endurance in Early RA Patients Treated With Tocilizumab or Methotrexate
To measure the CRE by a work capacity index obtained in a submaximal testing (W65%/kg) in early RA patients treated with tocilizumab compared to Methotrexate alone.
- Trial name
- TOMERA (NCT01245452)
- Testing
- Tocilizumab, Methotrexate
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Patrick Durez
Rheumatoid Arthritis, Arthritis
Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis
Evaluation of two treatment modalities in early potentially severe early arthritis ( Methotrexate alone or in combination with adalimumab)
- Trial name
- NCT00291915
- Testing
- Adalimumab, Methotrexate
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Goupe d'Etudes et de Recherche Clinique En Rhumatologie
Rheumatoid Arthritis
The Clinical Effectiveness of Static Resting Splints in Early Rheumatoid Arthritis
This study tested the hypothesis that there would be a difference in the 12 month progression of structural hand impairment and hand function between a group of patients with early RA who received static resting splints and those…
- Trial name
- NCT00474877
- Testing
- Static resting splints
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Southampton