Clinical trials: Edema Lung
Fluid Overload, Organ Edema
"The Effect of Reduced Fluid Load After Cardiac Surgery"
The purpose of this study is to verify that an infusion of hypertonic saline/colloids during cardio-pulmonary-bypass will reduce fluid overload and organ edema for cardiac patients with expected long-CPB-time.
- Conditions
- Fluid Overload, Organ Edema, Organ Function
- Trial name
- NCT01438502
- Testing
- HyperHAES® (hypertonic saline/HES)
- Sponsor
- Haukeland University Hospital
Heart Failure, Congestive
A Method Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure
Transient receptor potential vanilloid 4 (TRPV4) channel blockade may be promising in the treatment of pulmonary oedema and dyspnoea in heart failure (HF) and acute decompensated heart failure (ADHF) patients by re-establishing…
- Trial name
- NCT02135861
- Testing
- DCE-MRI scans, Gadobutrol
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Ventilator Weaning
Interaction Diaphragm and Cardiac Function During Ventilator Weaning
Weaning failure is associated with prolonged duration of mechanical ventilation that itself can worsen patient's prognosis. Therefore, identification of the causes and mechanisms leading to weaning failure is important in daily…
- Trial name
- I-DISCO (NCT03486249)
- Testing
- Repetition of medical examinations performed as part of the care
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Altitude Pulmonary Hypertension
Highlanders With High Altitude Pulmonary Hypertension (HAPH), 6 Minute Walk Distance (6MWD) Assessed at 3200m With and Without Supplemental Oxygen Therapy (SOT)
The investigators aim to study the effect of SOT in highlanders with high altitude pulmonary hypertension (HAPH) who permanently live >2500m on 6-minute walk distance (6MWD) assessed at 3200m.
- Trial name
- NCT06489743
- Testing
- 6-minute walk test (6MWT)
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Pulmonary Edema, Respiratory Distress Syndrome
Performance Evaluation of Clinical Ultrasound in Management of Acute Pulmonary Edema in Elderly Patient
The main objective is to assess the validation of the diagnosis early acute pulmonary edema in elderly patients with acute respiratory distress, admitted in a host of vital emergency services by lung ultrasound associated with…
- Trial name
- ECHOP (NCT02638350)
- Testing
- Strategy with lung ultrasound
- Where
- France
- Volunteers
- 123 people
- Sponsor
- University Hospital, Toulouse
Acute Kidney Injury
A Study to Support the Development of the Enhanced Fluid Assessment Tool for Patients With Acute Kidney Injury
Acute Kidney Injury (AKI) is the sudden and recent reduction in kidney function. This can be detected by measuring a rise in blood creatinine level or from a reduction in urine.
- Trial name
- NCT05538351
- Testing
- Body Composition Monitor (BCM)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Hertfordshire
COVID-19
Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL)
In COVID-19, pulmonary edema has been attributed to "cytokine storm". However, it is known that SARS-CoV-2 promotes angiotensin-converting enzyme 2 deficiency, it increases angiotensin II and this triggers volume overload.
- Trial name
- NCT05304702
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Clinica Colon
Hydrostatic Pulmonary Edema, Acute Respiratory Failure
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema.
- Conditions
- Hydrostatic Pulmonary Edema, Acute Respiratory Failure, Dyspnea
- Trial name
- DYSP-ED-US (NCT07324980)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Fluid Overload, POCUS
Concordance and Discordance in the Assessment of Volume Status in Home Dialysis Patients: A Comparison of Modified Medical Research Council Dyspnea Scale, Physical Exam, and Point of Care Ultrasound (POCUS)
Fluid overload (when the body has too much fluid), is one of the reasons why people on home dialysis need to go to the hospital. Fluid overload commonly presents as trouble breathing and leg swelling.
- Conditions
- Fluid Overload, POCUS, Lung Ultrasound, Volume Status
- Trial name
- NCT07178470
- Testing
- point-of-care ultrasound (POCUS), specifically lung ultrasound (LUS), Modified Medical Research Council (mMRC) Dyspnea scale, Physical Exam
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
High Altitude Pulmonary Hypertension, Sleep Apnea
HAPH Registry: Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study.
- Trial name
- NCT06489730
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Zurich
High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation
Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
- Conditions
- High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation, Hypoxia
- Trial name
- NCT04288219
- Testing
- Non-Invasive Positive Pressure Ventilation, Nifedipine, supplemental oxygen
- Where
- Nepal
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Low Cardiac Output Syndrome, Cardiogenic Shock
Milrinone Versus Dobutamine in Critically Ill Patients
The investigators are interested in determining if there is a meaningful difference between two of the most commonly used medications used to improve the pumping function of the heart among critically ill patients admitted to the…
- Conditions
- Low Cardiac Output Syndrome, Cardiogenic Shock, Acute Coronary Syndrome, Pulmonary Edema
- Trial name
- NCT03207165
- Testing
- Milrinone, Dobutamine
- Where
- Canada
- Volunteers
- 192 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hypoxia-Induced Pulmonary Artery Hypertension
Effects of Bosentan (Tracleer) in the Course of Pulmonary Artery Hypertension Induced by Hypoxia
Excessive rise in pulmonary artery pressure induced by low oxygen tension (hypoxia) is one of the factors implicated in high-altitude pulmonary oedema.
- Trial name
- NCT00260819
- Testing
- Bosentan, Bosentam TRACLEER
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
High Altitude Pulmonary Edema
Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction
It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia.
- Trial name
- NCT00559442
- Testing
- Altitude Exposure:
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Pulmonary Edema
Pulmonary Function at High-Altitude
Based on the findings of decreased vital capacity, decreased FEV1 and increased closing volume after ascent to high altitude, some investigators suggest the presence of a subclinical high altitude pulmonary edema (HAPE).
- Trial name
- NCT00604227
- Testing
- Hypoxic Exposure
- Where
- Germany
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Healthy
Hypoxia Impairs Endothelial Function in HAPEs
Aim of the study is to investigate the function of the systemic vascular endothelium in individuals susceptible to high-altitude pulmonary oedema during normoxia and normobaric hypoxia.
- Trial name
- NCT00176007
- Testing
- Hypoxia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Heidelberg University
Pulmonary Hypertension
Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension
The purpose of this study is to determine the effects of spironolactone on collagen markers in a large number of patients with pulmonary hypertension.
- Trial name
- NCT01468571
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Congestive Heart Failure, Cardiomyopathy
FAST (Fluid Accumulation Status Trial)
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Conditions
- Congestive Heart Failure, Cardiomyopathy, Dyspnea, Pulmonary Edema
- Trial name
- NCT00289276
- Testing
- Fluid Status Monitoring (OptiVol™)
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 156 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
High Altitude Pulmonary Hypertension
The Safety Evaluation of Aminophylline and Ambrisentan When Administered Orally Alone and in Combination to Healthy Volunteers
This is a Phase I, three period, two sequence, open-label, randomized, crossover study, with the primary objective of testing the safety and tolerability of combined oral doses of aminophylline and ambrisentan in healthy human…
- Trial name
- GQ01 (NCT01530464)
- Testing
- Aminophylline, Ambrisentan, Aminophylline plus ambrisentan
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Thies Schroeder
Pulmonary Edema
Predictors of Pulmonary Edema in Severe Preeclampsia
Pre-eclampsia is a multisystem major cardiovascular disease of pregnancy with hypertension its main clinical manifestation. Acute pulmonary edema, which signifies severe disease, is a leading cause of death in women with…
- Trial name
- NCT05095974
- Testing
- ultrasonography, echocardiography, thoracic electrical bioimpedence
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Assiut University