Clinical trials: Effect Neonatal
Developmental Dysplasia of the Hip
Selective Ultrasound Screening for DDH 1991-2006
Early treatment is considered essential for developmental dysplasia of the hip (DDH), but the choice of screening strategy is debated. The investigators evaluated the effect of a selective ultrasound (US) screening programme.
- Trial name
- NCT01866527
- Where
- Norway
- Volunteers
- 81,564 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Congenital Talipes Equinovarus
Management of Congenital Talipes Equinovarus by Saleem's Protocol
The main objective of this study is to evaluate the effectiveness of Saleem's protocol treatment plan for congenital ideopathic talipes equino varus deformity using early tenotomy and serial foot casting.
- Trial name
- NCT05957627
- Testing
- Saleem's protocol
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Pakistan Society for Rehabilitation of Differently Abled Hospital
Obstructive Sleep Apnea, Sleep Apnea, Obstructive
Orthognathic Surgery and Obstructive Sleep Apnea Assessed by Mandibular Jaw Movement Monitoring (SUNRISE-ORTHO)
Orthognathic surgery changes the skeletal framework of the upper airway, but its functional effect on sleep-disordered breathing remains poorly documented, particularly with respect to respiratory effort.
- Conditions
- Obstructive Sleep Apnea, Sleep Apnea, Obstructive, Dentofacial Deformities
- Trial name
- SUNRISE-ORTHO (NCT07910461)
- Testing
- Orthognathic surgery (BSSO with or without Le Fort I osteotomy), Sunrise mandibular jaw movement monitoring, Facial multidetector CT in natural head position
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- CHR Sambre et Meuse Site Meuse
Labor Complication
Study of the Fluid Intake Effect During Labour
Ingestion during labor is an issue that has attracted the attention of the scientific community in recent decades, with different practices occurring in different countries.
- Trial name
- NCT06371742
- Testing
- Liquid ingestion during labour
- Where
- Portugal
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Hypothermia; Anesthesia
Evaluation of the Active Warming Effects on Maternal and Neonatal Outcome During Cesarean Delivery
A prospective randomized study of healthy term parturients undergoing cesarean delivery was designed to assess the impact of the active warming on perioperative and postoperative temperature.
- Trial name
- NCT03473470
- Testing
- forced air warming and warmed intravenous fluids, warmed intravenous fluids
- Where
- Italy
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Atopic Dermatitis
Probiotic Bacteria to Infants With Atopic Dermatitis
The objective of the study is to examine whether 8 weeks intervention with probiotics influence the eczema in infants suffering from Atopic Dermatitis.
- Trial name
- NCT01007331
- Testing
- Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- University of Copenhagen
Sepsis Newborn
The Effects of Two Different Intravenous Lipid Emulsions on the Outcomes of Preterm Infants With Sepsis
Introduction and objectives: Lipid emulsions play an important role in parenteral nutrition in preterm infants. We aim to evaluate the effect of two different intravenous lipid emulsions on the outcomes of neonatal sepsis in…
- Trial name
- NCT03275090
- Testing
- Smoflipid ®
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University Children Hospital
Feeding; Difficult, Newborn
Effect of SINC Feeding Protocol on Weight Gain, Transition to Oral Feeding and the Length of Hospitalization
Feeding is one of the most common problems encountered by preterm infants. Besides, effective and safe feeding is one of the important discharge criteria.
- Trial name
- NCT03371927
- Testing
- SINC Feeding Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Sickle Cell Disease, Pain
Effect of EMDR for Reduction of Pain Interference in Children With Sickle Cell Disease
Children with sickle cell disease may experience frequent painful episodes. This, together with the traumatic experiences during a hospitalization, can lead to the development of posttraumatic stress reactions.
- Conditions
- Sickle Cell Disease, Pain, Pain, Chronic Disease
- Trial name
- RELAX (NCT07001631)
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Anxiety, Parents
The Effect of Mandala Coloring Activity on Stress and Anxiety in Mothers With Babies in NICU
The aim of this study was to evaluate the effect of mandala painting activity on stress and anxiety levels in mothers whose babies were hospitalized in the neonatal intensive care unit (NICU).
- Conditions
- Anxiety, Parents, Psychological Stress
- Trial name
- NCT06499259
- Testing
- Mandala coloring
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Hypnosis, Virtual Reality Therapy
Virtual Reality Hypnosis and Nurses' Stress
The practice of nursing is based on helping relationships and empathy. The work is physically, mentally and emotionally demanding.
- Conditions
- Hypnosis, Virtual Reality Therapy, Stress, Compassion Fatigue
- Trial name
- HYPNOVRNEO (NCT06786962)
- Testing
- Virtual reality Hypnosis, Control arm (SEQ):
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- CARESP: Cellule d'animation régionale en soins palliatifs
Healthy Participants
A Study to Investigate the Effect of Food on Balcinrenone/Dapagliflozin Pharmacokinetics in Fed and Fasted State and Pharmacokinetics of Balcinrenone When Dosed With a P-gp Inhibitor in Healthy Participants.
The main purpose of this study is to assess the effect of food on balcinrenone/ dapagliflozin pharmacokinetics in fed and fasted state and pharmacokinetics of balcinrenone when dosed with a P-gp inhibitor in healthy participants.
- Trial name
- NCT06979388
- Testing
- balcinrenone/ dapagliflozin, quinidine
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypothalamic Obesity
Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity
The proposed multicenter study will test the effect of glucagon-like peptide (GLP)-1 agonist exenatide once weekly extended-release (ExQW, Bydureon®) on clinical outcomes and metabolic parameters in a double-blind…
- Trial name
- ECHO (NCT02664441)
- Testing
- Exenatide
- Where
- 3 sites in United States
- Volunteers
- 42 people
- Sponsor
- Seattle Children's Hospital
Atopic Dermatitis, Sleep Disturbance
A Study to Assess the Effect of Upadacitinib in Atopic Dermatitis-induced Sleep Disturbance in Adults With Moderate to Severe Atopic Dermatitis
Many people with atopic dermatitis (AD) experience sleep disturbances. Greater sleep disturbances are associated with greater burden including increased sick days and impaired cognition.
- Trial name
- Sleep Up (NCT06390722)
- Testing
- Upadacitinib
- Sponsor
- AbbVie
Duchenne Muscular Dystrophin (DMD)
An Open-label, Multidose Dose-escalation Study to Understand the Safety of CRISPR Gene-editing Therapy and Its Long-Lasting Effects in DMD Patients (MUSCLE)
Duchenne muscular dystrophin (DMD) is an X-linked, fatal muscle-wasting disease caused by mutations in the DMD gene encoding the dystrophin proteins, with symptom onset before age of 6 years in boys.
- Trial name
- MUSCLE (NCT06594094)
- Testing
- HG302
- Where
- China
- Volunteers
- 4 people
- Sponsor
- HuidaGene Therapeutics Co., Ltd.
Eisenmenger Complex, Hypertension, Pulmonary
Effects Oxygen Supplementation Determined Better Exercise Capacity in Eisenmenger Syndrome
The purpose of this study was to evaluate the acute effects of oxygen supplementation during a submaximal exercise test in patients with Eisenmenger's Syndrome.
- Trial name
- NCT02661802
- Testing
- Oxygen Supplementation
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Adult Atopic Dermatitis
Probiotics in Adults: do They Improve Atopic Dermatitis?
Probiotics are suggested to have beneficial effects in atopic dermatitis (AD) treatment and prevention but their precise role is not yet clear.
- Trial name
- NCT01500941
- Testing
- probiotics, maltodextrin
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Rett Syndrome, Dysbiosis
Protective Role of Pre-/ Post-biotics on Gut Inflammation, Dysbiosis, and Life Quality in Rett Syndrome (Biotics_RTT)
The study will examine the potential efficacy and safety of two pre- and post-biotics on markers for gut inflammation and intestinal microbiota ecology in patients with Rett syndrome.
- Conditions
- Rett Syndrome, Dysbiosis, Epilepsy, Quality of Life
- Trial name
- Biotics_RTT (NCT05420805)
- Testing
- ALAC, inulin, FOS, and sodium butyrate, Sodium butyrate and zinc oxide
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Azienda Ospedaliera Universitaria Senese
Left Ventricular Hypertrophy
Postnatal Steroids Effects on Cardiac Function in Extremely Preterm
Hypothesis/Study question In infants born at less than 29 weeks of estimated gestational age, what are the effects of dexamethasone use on cardiac structure/performance and lung water content? Study objectives To measure effects…
- Trial name
- SPEC (NCT04644094)
- Testing
- Echocardiography (ECHO) and lung ultrasound (LUS) studies before and after Dexamethasone administration
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ankyloglossia, Oral Mucoceles
The Effect of Pre-emptive Analgesia on the Postoperative Pain in Children Undergoing Pediatric Stomatology Day Surgeries
The aim of this double-blinded, randomized, controlled trial was to test whether pre-emptive analgesia with ibuprofen suppository is effective for children undergoing pediatric stomatology day surgeries in the postoperative…
- Conditions
- Ankyloglossia, Oral Mucoceles, Supernumerary Teeth
- Trial name
- NCT05878262
- Testing
- ibuprofen suppository
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
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