Clinical trials: Effect Neonatal
Hemophilia a, Muscle Strength
Effect of Kinetic Chain Exercises on Muscle Strength, Joint Position Sense and Quality of Life in Children with Haemophilia.
The goal of this clinical trial is to learn if there are effect of close kinetic chain exercises on muscle strength, joint position sense and Quality of life in children with haemophilia? Null hypothesis It will be hypothesized…
- Conditions
- Hemophilia a, Muscle Strength, Joint Position Sense, Quality of Life (QOL)
- Trial name
- NCT06649175
- Testing
- Exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Single-ventricle
Fibrosis and the Fontan
The purpose of this study is to non-invasively characterize the fibrotic consequences of single ventricle physiology, its possible solution and effect on lymphatics.
- Trial name
- NCT04901975
- Testing
- Spironolactone
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Children's Hospital of Philadelphia
Pulmonary Arterial Hypertension
Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome
Clinical study to assess the efficacy, safety, and tolerability of macitentan in subjects with Eisenmenger Syndrome.
- Trial name
- MAESTRO (NCT01743001)
- Testing
- Macitentan 10 mg
- Where
- 55 sites in United States, Austria and 19 more
- Volunteers
- 226 people
- Sponsor
- Actelion
Nursing Education
The Effect of Hybrid Simulation on Evaluating Neonatal Jaundice
This study will be conducted as a single-blind randomized control group intervention trial to determine the effectiveness of the hybrid simulation method using standard patient and low-fidelity baby simulators in the intervention…
- Trial name
- NCT05677477
- Testing
- simulation training
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Atopic Dermatitis
Vaccine Responses in Tralokinumab-Treated Atopic Dermatitis - ECZTRA 5 (ECZema TRAlokinumab Trial No. 5)
The purpose of this trial is to test if treatment with the trial drug, tralokinumab, can affect the body's immune response to vaccines.
- Trial name
- ECZTRA 5 (NCT03562377)
- Testing
- Tralokinumab, Tdap vaccine, Meningococcal vaccine
- Where
- 51 sites in United States, Canada
- Volunteers
- 215 people
- Sponsor
- LEO Pharma
Umbilical Hernia
Effect of Reoperation for Recurrence After Open Umbilical Hernia Repair
background Operation for small umbilical hernias is one of the most common surgical procedures, but the best surgical technique, including the choice of suture or mesh remains unknown.
- Trial name
- UMBI-REC (NCT01607801)
- Where
- Denmark
- Volunteers
- 4,847 people
- Sponsor
- Zealand University Hospital
Gastro Esophageal Reflux
Effect of Right Lateral Position on Ventilated Preterm Neonates
Objective: to evaluate the effect of right lateral positioning in comparison with supine positioning on tracheal aspirate pepsin levels as a marker of aspiration of gastric contents in ventilated preterm neonates.
- Trial name
- NCT03258528
- Testing
- positioning
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Kidney, Polycystic, Autosomal Dominant
High Water Intake to Slow Progression of Polycystic Kidney Disease
Polycystic kidney disease (PKD) is a genetic disease that occurs in 1 in 500 individuals and leads to kidney failure in half of all affected. Currently, no treatments exist for PKD.
- Trial name
- NCT00784030
- Testing
- Water
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Atopic Dermatitis
The Effect of Isosorbide Diesters Based Moisturizer on Skin Health
The overall objective of this study is to assess how a natural ingredient, isosorbide diesters (IDEAS), works in association with colloidal oatmeal for eczema.
- Trial name
- NCT04831892
- Testing
- Moisturizer Containing Isosorbide Diesters and Colloidal Oatmeal, Moisturizer containing Colloidal Oatmeal only
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Integrative Skin Science and Research
Endothelial Dysfunction, Hyperhomocysteinemia
Effect of L-Arginine and Pycnogenol on Light to Moderate Hypertension and Endothelial Function
The effect of a combination product (Verum ) with L-arginine, Pycnogenol, vitamin K2, R-(+)-alpha-lipoic acid and vitamins B6, B12 and folic acid is investigated in a double blind placebo-controlled cross-over study.
- Conditions
- Endothelial Dysfunction, Hyperhomocysteinemia, Hypertension Grade I, Subgroup "Borderline" (WHO)
- Trial name
- NCT02392767
- Testing
- Verum
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Dr. Loges & Co. GmbH
Neonatal Hyperbilirubinemia
The Effect of Intravenous Oxytocin Infusion Using Different Diluents on Neonatal Bilirubin & Sodium Levels
Objective: To evaluate the relationship between intravenous (IV) infusion of oxytocin using either saline 0.9% or glucose 5% \& neonatal Bilirubin \& sodium level. Study Design: A randomized case - controlled study.
- Trial name
- NCT02602301
- Testing
- Oxytocin
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Coarctation of Aorta
The Effect of Paravertebral Block With Dexamethasone on Intraoperative and Postoperative Analgesia in Children Undergoing Surgery for Coarctation of Aorta
Anesthetic management for surgery of aortic coarctation needs special care due to severe pain during lateral thoracotomy incision, the intraoperative hemodynamic instability related to skin incision at lateral thoracotomy…
- Trial name
- NCT03074773
- Testing
- Dexamethasone, ultrasound, paravertebral block
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Preterm, Chronobiology
The Effect of Oral Feeding Model With a Chronobiological Approach in Neonates
The ideal food for healthy term babies as well as preterm babies and sick term babies is breast milk. There are many studies showing that the composition of breast milk can vary from mother to mother, according to the baby's…
- Conditions
- Preterm, Chronobiology, Human Milk/Breastfeeding, Bottle Feeding
- Trial name
- NCT06821672
- Testing
- Chronobiological Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Gout, Hyperuricemia
SAD,MAD and Food Effect Study of SAP-001 Tablets in Chinese Subjects
To evaluate the pharmacokinetics (PK) profile of single or multiple oral doses of SAP-001 tablets in healthy Chinese subjects and gout patients with hyperuricemia.
- Trial name
- NCT06678581
- Testing
- SAP-001
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shanton Pharma Co., Ltd.
Patellofemoral Pain Syndrome
Effects of Agility Training With and Without Foot Mobilization In Patellofemoral Pain Syndrome.
Patellofemoral pain syndrome (PFPS) is referred to as peripatellar or retro-patellar pain, which is characterized by alterations in the physical and biomechanical features of the patellofemoral joint.
- Trial name
- NCT06674707
- Testing
- Agility Training with Foot mobilization., Agility Training without Foot mobilization
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Mandibular Retrognathia
The Effect of Mandibular Advancement With Clear Aligners on Maxillary and Mandibular Volumes
The aim of this study is to compare the effectiveness of two different orthodontic treatment methods used in patients with skeletal Class II malocclusion, a condition in which the lower jaw is positioned backward.
- Trial name
- NCT07056829
- Testing
- Mandibular Advancement Appliance (Invisalign MA), Activator Appliance
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Batman University
Osteogenesis Imperfecta
Effect of High-Dose Vitamin D on Bone Density in Osteogenesis Imperfecta
Overall Objective: To test the hypothesis that oral vitamin D supplementation at higher than currently prescribed doses has a beneficial effect on the skeleton of young patients with osteogenesis imperfecta (OI).
- Trial name
- NCT01713231
- Testing
- standard-dose vitamin D (400IU per day), high-dose vitamin D (2000 IU per day)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Louis-Nicolas Veilleux Ph.D.
Atopic Dermatitis
Evaluating the Effects of Cleansers on the Skin
This will be a single visit study that will take approximately 2 hours. Up to 50 subjects (up to 25 healthy subjects, and up to 25 subjects with AD) from BUMC dermatology clinics will be enrolled in this study and randomized to…
- Trial name
- NCT03188653
- Testing
- CeraVe® Eczema Soothing Body Wash, Cetaphil® RestoraDerm® Eczema Calming Body Wash, Dove® Sensitive Skin Body Wash
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Raloxifene, Postmenopausal Women
Raloxifene on Coagulation System in the Postmenopausal Women
Objective: The aim of this study is to assess the effects of raloxifene HCl on coagulation parameters in healthy postmenopausal women.
- Trial name
- NCT04454775
- Testing
- coagulation system parameters; factor 8, von Willebrand factor, protein C, protein S, antithrombin III and fibrinogen were studied.
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Androgen Receptor Abnormal, Endometrial Disorder
The Effect of Androgen Receptor Polymorphism on Endometrial Cancer
Endometrial tissue is a hormonal-dependent tissue in both pre- and postmenopausal period. The endometrial cells are expressing receptors for all sex hormones, mainly for estrogen, progesterone and androgens.
- Trial name
- AREC (NCT05157373)
- Testing
- Endometrial sampling and Peripheral blood collection, FSFI Scale
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
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