Clinical trials: Effect Neonatal
Osteogenesis Imperfecta
Multicenter,Single-arm Study to Evaluate Efficacy, Safety, & Pharmacokinetics of Denosumab in Children w/ OI
This is a prospective, multicenter, single-arm study in children 2 to 17 years of age with OI to evaluate efficacy and safety of denosumab.
- Trial name
- OI (NCT02352753)
- Testing
- Denosumab
- Where
- 49 sites in United States, Australia and 11 more
- Volunteers
- 153 people
- Sponsor
- Amgen
Cystic Adenomatoid Malformation of Lung, Congenital, Bronchopulmonary Sequestration
Effect of Ultrasound-guided Erector Spinae Plane Block on Postoperative Pain and Sleep Quality of Infants With Congenital Pulmonary Cystic Disease After Thoracoscopic Surgery
This study intends to evaluate the effect of erector spinae plane block on postoperative analgesia and sleep quality in infants with congenital cystic pulmonary disease after thoracoscopic surgery, and provides reference for…
- Conditions
- Cystic Adenomatoid Malformation of Lung, Congenital, Bronchopulmonary Sequestration, Bronchogenic Cyst
- Trial name
- NCT06498583
- Testing
- Ropivacaine, erector spinae plane block, Incision infiltration of local anesthesia
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Lei Xiaoming
Hyperbilirubinemia Indirect
Effect of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates Treated With Phototherapy
There is limited local data on the efficacy of ursodeoxycholic acid combined with phototherapy. Therefore, the present study was planned to compare mean serum bilirubin levels in neonates with indirect hyperbilirubinemia…
- Trial name
- NCT07867366
- Testing
- Phototherapy with ursodeoxycholic acid
- Where
- Pakistan
- Volunteers
- 220 people
- Sponsor
- Muhammad Aamir Latif
Phenylketonurias
Preliminary Study of Brain Effects of Palynziq-Related Changes in Phenylalanine in Individuals With PKU
The goal of the proposed study is to elucidate neurologic and neuropsychological improvements associated with Palynziq-related reduction in plasma Phe levels in individuals with PKU.
- Trial name
- NCT05356377
- Testing
- Pegvaliase-Pqpz
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Missouri-Columbia
Atopic Dermatitis
Effects of Abrocitinib Treatment on Skin Barrier Function
Effects of abrocitinib treatment of atopic dermatitis on skin barrier function.
- Trial name
- AbroSkib (NCT05140239)
- Testing
- No Intervention
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Prof. Dr. Stephan Weidinger
Brain Metastases, Radiotherapy Side Effect
GM1 Prophylaxis for WBRT Related Cognitive Dysfunction
To evaluate the efficacy and safety of GM1 for preventing cognitive impairment related to whole brain radiotherapy in breast cancer patients with brain metastases.
- Conditions
- Brain Metastases, Radiotherapy Side Effect, Cognitive Impairment, Gangliosidosis, GM1
- Trial name
- GLORY (NCT04395339)
- Testing
- Monosialotetrahexosyl ganglioside (GM1), Control
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Sun Yat-sen University
Sickle Cell Disease
Study to Evaluate the Effect of Ticagrelor Versus Placebo in Reducing Vaso-Occlusive Crises Rate in Pediatric Patients With Sickle Cell Disease.
The purpose of this study is to compare the effect of ticagrelor vs placebo for the reduction of Vaso-Occlusive crises in paediatric patients with Sickle Cell Disease
- Trial name
- HESTIA5 (NCT04293172)
- Testing
- Brilinta
- Sponsor
- AstraZeneca
Andersen-Tawil Syndrome
Effect of Potassium and Acetazolamide on People With Andersen-Tawil Syndrome
Andersen-Tawil Syndrome (ATS) is a rare genetic disorder that causes episodes of muscle weakness, potentially life-threatening changes in heart rhythm, and skeletal developmental abnormalities.
- Trial name
- NCT00839501
- Testing
- Potassium, Acetazolamide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Rochester
Cystic Fibrosis
Probiotics on Intestinal Inflammation in Cystic Fibrosis
Cystic fibrosis (CF) is a complex systemic disease that mainly involves the respiratory and gastrointestinal (GI) tracts. The polymicrobial community composition of respiratory and GI tracts is influenced by both genetic and…
- Trial name
- NCT01961661
- Testing
- Lactobacillus rhamnosus GG
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Federico II University
Thyroid Eye Disease, Graves Ophthalmopathy
The Effect of Teprotumumab on Thyroid Eye Disease and Thyroid Dysfunction
This protocol studies the clinical outcome of patients with active thyroid disease with visually significant signs and symptoms of proptosis, pain, diplopiam lid/orbital edema, or lid/orbital erythema recommended for treatment…
- Conditions
- Thyroid Eye Disease, Graves Ophthalmopathy, Graves Disease
- Trial name
- Teprotumumab (NCT06275373)
- Testing
- Teprotumumab Injection [Tepezza]
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Cavernous Angioma, Familial, Cerebral Cavernous Malformations
Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins
Cerebral cavernous malformations (CCMs) are clusters of abnormal blood vessels in the brain and spine. CCMs can bleed and cause strokes, seizures, and headaches. In some patients, CCMs affect the blood brain barrier (BBB).
- Conditions
- Cavernous Angioma, Familial, Cerebral Cavernous Malformations, Cerebral Cavernous Hemangioma
- Trial name
- NCT01764451
- Testing
- Simvastatin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of New Mexico
PCOS, Polycystic Ovary Syndrome
Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance
Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome with a variety of metabolic and endocrine abnormalities and clinical symptoms.
- Trial name
- NCT01511822
- Testing
- Drospirenone Ethinyl estradiol, Drospirenone Ethinyl estradiol Myo-inositol
- Where
- Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Congenital Heart Disease in Children
The Effect of DNS Therapy on Asymmetry in Children After Surgery of Congenital Heart Disease
This thesis will examine the consequences of congenital heart disease (CHD) surgery in children. The main goal of this work is to point out the possible development of late consequences after cardiac surgery in childhood (e.g.
- Trial name
- NCT06776822
- Testing
- Dynamic neuromuscular stabilisation
- Where
- Czechia
- Volunteers
- 15 people
- Sponsor
- Charles University, Czech Republic
Morbidity;Newborn
Antenatal Steroids Effect on Mortality and Respiratory Outcomes in Preterm Infants
The aim is to evaluate the impact of a complete course of antenatal steroids treatment on mortality and main morbidities in a current population of preterm infants.
- Trial name
- NCT04214795
- Testing
- Observational study. Postnatal variables are recorded
- Where
- Spain
- Volunteers
- 710 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Fetal Growth Retardation, Fetal Growth Complications
Acute Effects of Maternal Exercise and the Growth Restricted Pregnancy
Objectives / Specific Aims The purpose of this study is to investigate the acute effects of a single bout of moderate intensity maternal exercise on fetal well-being in a pregnancy affected by fetal growth restriction.
- Conditions
- Fetal Growth Retardation, Fetal Growth Complications, Placental Insufficiency
- Trial name
- NCT06039319
- Testing
- Physical activity
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Friedreich Ataxia
A Study to Learn More About the Effects and Long-Term Safety of Omaveloxolone (BIIB141) in Children and Teens With Friedreich's Ataxia
In this study, researchers will learn more about omaveloxolone, also known as BIIB141 or SKYCLARYS®. Omaveloxolone is already approved for people with Friedreich's Ataxia (FA) who are 16 years of age or older.
- Trial name
- BRAVE (NCT06953583)
- Testing
- Omaveloxolone
- Where
- 34 sites in United States, Australia and 14 more
- Volunteers
- 255 people
- Sponsor
- Biogen
Sickle Cell Disease
Propanolol and Red Cell Adhesion Non-asthmatic Children Sickle Cell Disease
Propanolol is a beta blocker which has been found to inhibit the ability of epinephrine to upregulate sickle red cell adhesion to laminin and endothelial cells in vitro.
- Trial name
- NCT02012777
- Testing
- propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Miami
Dry Eye Disease (DED), Graves Ophthalmopathy
Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients With Graves Disease
This prospective, interventional, randomized, controlled, double-blind clinical study evaluates the effect of Low-Level Light Therapy (LLLT) delivered by a polychromatic periocular mask (Eye-light®️) versus a sham device in…
- Trial name
- LLLT-Graves (NCT07332988)
- Testing
- Low Light Level therapy
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Fetal or Neonatal Effect of Damage to Placenta From Caesarean Section
A Multicenter Study of the Efficacy and Safety of Esketamine for Analgesia During Cesarean Section
This study proposed applying intravenous Esketamine to cesarean section in parturient, detecting the plasma concentration of Esketamine in maternal blood, neonatal umbilical venous blood and umbilical arterial blood when the baby…
- Trial name
- NCT04548973
- Testing
- Esketamine, Normal saline
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Sickle Cell Disease
Sleep Apnea in Sickle Cell Disease
Despite the fact that obstructive sleep apnoea (OSA) is highly prevalent in the sickle cell population, studies focusing on the associations of the two diseases and their common pathophysiological mechanisms are scarce.
- Trial name
- DREPAPNEE (NCT03753854)
- Testing
- polysomnography and oxygen saturation exam, calculation of VOC frequency between the first polysomnography and the end of the first year of continuous positive airway pressure treatment, Blood samples
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
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