Clinical trials: Effect of Drugs
Carcinoma, Non-Small-Cell Lung, Drug-Related Side Effects and Adverse Reactions
Side Effects of Anti-PD-(L)-1 and Anti CTLA-A4 in the Non Small Cells Lung Cancer
The immune-related adverse events (irAEs) linked to the important activation of the immune system by new immunotherapy treatments in patients affected by Non-small-cell lung carcinoma (NSCLC) have not received a lot of systematic…
- Trial name
- NCT03125603
- Testing
- Consultation of the patient's medical files at the hospital
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Hypertension
Effect of Home and Remote Blood Pressure Monitoring Via Home BP Monitoring System (HMS) on Adults With Hypertension in Taiwan
The goal of this clinical trial is to learn whether adding case-manager support to app-connected home blood pressure monitoring improves blood pressure control in adults with hypertension.
- Trial name
- NCT07887542
- Testing
- Case-manager surveillance with physician-guided remote titration, Passive data review at clinic visits
- Where
- Taiwan
- Volunteers
- 211 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch
Chemo-brain
Treatment of Post-Chemo Cognitive Impairment w/Transcranial Magnetic Stimulation (Chemobrain TMS)
In this pilot study, the investigators propose to test the efficacy of rTMS for the treatment of PCCI. Efficacy measures will include baseline and post-rTMS neuropsychological testing, functional MRI and biometry data using body…
- Trial name
- NCT04295720
- Testing
- Transcranial magnetic stimulation (TMS)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Arizona
Liver Cancer, Pembrolizumab
The Study Collect Clinical Data From the Treatment of Liver Cancer With New Drugs After 2019 and Integrate Biochemical and Pathological Indicators to Analyze Prognostic Outcomes, Including Overall Survival, Progression-free Survival, and Complications.
Hepatocellular carcinoma (HCC) is one of the most significant cancers in our country. Since 2019, many first-line and second-line therapeutic agents for HCC have been introduced.
- Conditions
- Liver Cancer, Pembrolizumab, Atezolizumab, Lenvatinib
- Trial name
- NCT07233759
- Where
- Taiwan
- Volunteers
- 2,500 people
- Sponsor
- National Taiwan University Hospital
Dyspepsia
Functional Dyspepsia - Effect of Acid-Reducing Treatment and Information.
Study title: Functional dyspepsia -- effect of acid reducing treatment and individualized information. Summary: 15-20% of all people experience dyspepsia each year.
- Trial name
- NCT00437346
- Testing
- Individualized and comprehensive information, Lanzo Melt
- Where
- 5 sites in Norway
- Volunteers
- 35 people
- Sponsor
- Helse Fonna
Tumor
A Drug-drug Interaction Study of Famitinib Malate With a Proton Pump Inhibitor in Healthy Adult Subjects
The primary objective is to evaluate the effect of omeprazole on the pharmacokinetics of famitinib malate in healthy adult subjects.
- Trial name
- NCT05041920
- Testing
- famitinib、omeprazole
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Non Hodgkin Lymphoma, DLBCL
Cardiotoxicity and Other Late Effects After Radiotherapy and Immuno-chemoTherapy in Non-Hodgkin lYmphoma
Survivors of non-Hodgkin lymphoma and a control group will be screened for (sub)clinical cardiovascular disease, to assess the influence of contemporary treatments on risk and burden of (sub)clinical cardiovascular disease and…
- Conditions
- Non Hodgkin Lymphoma, DLBCL, Cardiovascular Diseases, Cardiomyopathies
- Trial name
- CLARITY (NCT07041827)
- Testing
- Cardiovascular assessment
- Where
- Netherlands
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
AIDS
Effect on HIV Medications on EPC Cells
This is a 3 arm, non-Interventional pilot single time point cross sectional study for the duration of 1 year. Total of 30 candidates (10 in each Group) will be enrolled into three different groups taking three different…
- Trial name
- NCT03782142
- Testing
- Tenofovir, Rilpivirine, Prezcobix
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Sabyasachi Sen
Healthy
A Study to Investigate the Effects of Gastric Acid Suppression by Rabeprazole and BMS-986165 on How Fast and Complete The Drug is Absorbed Into the Body of Healthy Participants
The purpose of this study is to evaluate the effects of stomach acid suppression by rabeprazole and BMS-986165 on how fast and complete the drug is absorbed into the body of healthy participants.
- Trial name
- NCT03979248
- Testing
- BMS-986165, Rabeprazole
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Endocrine System Diseases, Gastrointestinal Diseases
Study Evaluating the Effect of Person-centred Care for Patients Admitted for Inpatient Care at an Internal Medicine Unit
Patients admitted to internal medicine care environments have complex care needs and must be treated as persons with resources and responsibilities.
- Trial name
- NCT03725813
- Testing
- Person-centred inpatient care
- Where
- Sweden
- Volunteers
- 177 people
- Sponsor
- Göteborg University
Precocious Puberty
Effect of Prevalence of BMI on Efficacy of Herbal Medicines in Girls' Sexual Precocity
Effect of Prevalence of Overweight and Obesity(Body Mass Index (BMI)) on Efficacy of herbal medicines(ZiYinXieHuo) in girls sexual Precocity
- Trial name
- NCT04665713
- Where
- China
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Medication Errors
Statewide Implementation of Electronic Health Records
To determine the effects of Electronic Health Record use on medication error rates in primary care office practices. Hypothesis: Adoption of Electronic Health Records through this program will reduce medication errors
- Trial name
- NCT00225576
- Testing
- Electronic Health Record Implementation
- Where
- United States
- Volunteers
- 2,030 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Asymptomatic Necrotic Teeth
Effect of Triple Antibiotic Paste as an Intracanal Medication With an Anti-Inflammatory Drug on Post-operative Pain.
The purpose of this study is to determine whether the use of triple antibiotic paste as intracanal medication with an anti-inflammatory drug, compared to a calcium hydroxide will reduce postoperative pain and intracanal bacteria…
- Trial name
- NCT02907489
- Testing
- triple antibiotic paste with an anti-inflammatory drug
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy, HIV Infections
Effect Of Maraviroc On The Pharmacokinetics Of Digoxin
This is an open labelled study to estimate the effect of maraviroc on the pharmacokinetics of digoxin, a probe for p-glycoprotein.
- Trial name
- NCT01056874
- Testing
- Digoxin, Maraviroc
- Where
- Singapore
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Infections
Effect of Leflunomide on T Cell Proliferation in HIV-Infected Patients
This study will evaluate the effect of leflunomide on the life cycle of a specific immune cell called CD4+ T cell in HIV-infected patients.
- Trial name
- NCT00101374
- Testing
- Leflunomide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sleep Problems, Sleep
Impact of Weighted Blankets on Sleep Quality
Weighted blankets have been used to improve sleep quality in children with neurodevelopmental disorders. It is not known, however, whether weighted blankets can improve overnight sleep in healthy adults and those with poor sleep…
- Trial name
- CosyNight (NCT06842797)
- Testing
- Weighted Blanket, Non Weighted Blanket
- Where
- Greece
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Fragile X Syndrome
Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge
The aim of this study is to utilize neurophysiologic assessments, behavioral measures and clinical measures to assess how much deficits associated with Fragile X Syndrome from pre-dose to post-dose using pharmacology.
- Trial name
- NCT05418049
- Testing
- Baclofen, Memantine, Roflumilast
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Parkinson Disease, Dyskinesia, Medication-Induced
AV-101 (L-4-chlorokynurenine) in Parkinson's Disease Subjects With Levodopa-Induced Dyskinesia
This is a randomized, double-blind, placebo-controlled, crossover, proof-of-concept Phase 2 study to test efficacy and safety of AV-101 (L-4-chlorokynurenine) in Parkinson's Disease subjects with levodopa-induced dyskinesia.
- Conditions
- Parkinson Disease, Dyskinesia, Medication-Induced, L-Dopa Causing Adverse Effects in Therapeutic Use
- Trial name
- NCT04147949
- Testing
- AV-101
- Volunteers
- 20 people
- Sponsor
- VistaGen Therapeutics, Inc.
Attention Deficit Disorder With Hyperactivity (ADHD)
ADHD Medication and Predictors of Treatment Outcome
ADHD medication of children and adolescents is becoming increasingly common. Clinical experience and scientific studies have proven that approximately 30% of children/adolescents with ADHD do not benefit from this treatment.
- Trial name
- ADAPT (NCT02136147)
- Testing
- methylphenidate medication, atomoxetine medication, lisdexamphetamine medication
- Where
- Sweden
- Volunteers
- 632 people
- Sponsor
- Karolinska Institutet
Cancer Patients Undergoing Chemotherapy or Radiotherapy
Therapeutic Effects of Traditional Chinese Medicine, Shen-Mai San in Cancer Patient Undergoing Chemotherapy or Radiotherapy
Using Shen-Mai-San for cancer patients undergoing chemotherapy or radiotherapy could help these people improve the quality of life.
- Trial name
- NCT01580358
- Testing
- Shen-Mai San, Starch
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Changhua Christian Hospital
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