Clinical trials: Effect of Drugs
Genital Herpes
Safety and Efficacy Comparator Trial of a New Drug Against Genital Herpes
The aim of the study is to evaluate the safety and efficacy of "AIC316 (pritelivir)" 100 mg once daily compared to valacyclovir 500 mg once daily for the prevention of HSV-2 genital shedding.
- Trial name
- NCT01658826
- Testing
- AIC316, Valacyclovir
- Where
- 4 sites in United States
- Volunteers
- 91 people
- Sponsor
- AiCuris Anti-infective Cures AG
Hypertension
The Effect of Beetroot Juice on Plasma Trimethylamine N-oxide Concentration
The primary aim of the current study is to determine the effect of beetroot juice consumption on plasma trimethylamine N-oxide concentration.
- Trial name
- BRJ_TMAO (NCT05004935)
- Testing
- beetroot juice, nitrate
- Where
- Poland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Anesthesia, Drug Effects
Neural Mechanisms of Sevoflurane Induced Anesthesia: an EEG fMRI Study in Healthy Volunteers
In imaging functional connectivity (FC) analyses of the resting brain, alterations of FC during unconsciousness have been reported.
- Trial name
- NCT02149927
- Testing
- Sevoflurane
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Cataract Patients, Cataract After Surgery
Evaluation of the Effects of Education and Counseling Provided to Patients Via Distance Nursing After Cataract Surgery on Regular Use of Medications and Patient Satisfaction. CAT-TELEMED (Cataract - Telemedicine) TNCat-25 (Tele-Nursing Cataract - 2025)
This randomized controlled study aims to investigate the effects of tele-nursing-based education and counseling on medication adherence and patient satisfaction following cataract surgery.
- Conditions
- Cataract Patients, Cataract After Surgery, Cataract Surgery
- Trial name
- TELE-NURSİNG (NCT07262866)
- Testing
- Structured Tele-Nursing Education and Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Züleyha Sönmez
H. Pylori Infection
Effect of Vitamin D on Drug Resistant Helicobacter Pylori (HP) Eradication Study
Background: Helicobacter pylori infection, which affects over 50% of the global population, is one of the most prevalent infectious diseases in the world. H.
- Trial name
- vDHp (NCT03142620)
- Testing
- Esomeprazole, Amoxicillin-Potassium Clavulanate Combination, Clarithromycin
- Where
- Hong Kong
- Volunteers
- 96 people
- Sponsor
- Chinese University of Hong Kong
Depression, Continuous Antidepressant Abuse
Development of Escitalopram Genomic Device by Using Candidate Gene Approach and Genome-Wide Scanning
To reveal the genetic determinants of the treatment outcome of escitalopram in depressed patients (by using candidate gene approach and whole genome scanning).
- Conditions
- Depression, Continuous Antidepressant Abuse, Adverse Reaction to Drug
- Trial name
- NCT00935246
- Testing
- Escitalopram
- Where
- South Korea
- Volunteers
- 202 people
- Sponsor
- Samsung Medical Center
Healthy Volunteers, Schizophrenia
Phase 1 TAK-041 First-in-Human Safety, Tolerability, and Pharmacokinetics Study
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of TAK-041: 1. Following oral single and multiple doses in healthy participants. 2.
- Trial name
- NCT02748694
- Testing
- TAK-041
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Neurocrine Biosciences
Leukemia, Myeloid, Acute
A Study of Perpetrator Drug Interactions of Enasidenib in AML Patients
This is a 2-part, open-label, interventional study conducted in approximately 42 subjects with AML harboring an IDH2 mutation. The overall study is a 3-arm investigation of the PK effects of enasidenib at steady state on the…
- Trial name
- NCT03720366
- Testing
- enasidenib, Arm 1 probes, Arm 2 Probes
- Where
- 10 sites in Australia, South Korea
- Volunteers
- 40 people
- Sponsor
- Celgene
Premenstrual Syndrome, Anxiety
The Efficacy of Lavender Herbal Tea in Premenstrual Syndrome
Premenstrual syndrome (PMS) is a common but complex condition defined as a combination of emotional, psychological, and physical symptoms that occur during the luteal phase of the menstrual cycle, usually between 2 and 14 days…
- Conditions
- Premenstrual Syndrome, Anxiety, Depression, Stress
- Trial name
- NCT07737366
- Testing
- Lavender herbal tea
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Alzheimer Disease
The Efficacy of Traditional Chinese Herbal Medicine for Alzheimer's Disease
This randomized, double-blinded, placebo-controlled, crossover clinical trial aims to investigate the effect of VGH-AD1, a scientific Chinese medicine powder prescription, on patients with Alzheimer's disease.
- Trial name
- NCT04249869
- Testing
- VGH-AD1
- Volunteers
- 28 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Type 2 Diabetes
A Phase III Study of BMS-512148 (Dapagliflozin) in Patients With Type 2 Diabetes Who Are Not Well Controlled on Metformin Alone
The purpose of this clinical research study is to learn whether dapagliflozin can help reduce blood sugar levels in participants with Type 2 diabetes that is not well controlled on metformin alone.
- Trial name
- NCT00528879
- Testing
- Dapagliflozin, Metformin
- Where
- 75 sites in United States, Argentina and 3 more
- Volunteers
- 915 people
- Sponsor
- AstraZeneca
Cerebral Infarction, Clopidogrel,Poor Metabolism of (Disorder)
The Dynamic Effect of Non-cytochrome P450 Isoenzyme 3A4（CYP3A4）-Metabolized and Cytochrome P450 Isoenzyme 3A4（CYP3A4）-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction
The investigators team had found that the presence of dynamic changes of Clopidogrel resistance are not associated with genetic factors.
- Trial name
- NCT02411903
- Testing
- atorvastatin and clopidogrel, rosuvastatin and clopidogrel
- Volunteers
- 160 people
- Sponsor
- The Third Affiliated Hospital of Guangzhou Medical University
Knee Osteoarthritis, Injection
Effects of Knee Injections on Patients With Knee Osteoarthritis
Using a double-blind, randomized, placebo-controlled design to compare the immediate, short-term, and intermediate-term additional therapeutic effects of ultrasound-guided corticosteroid injection and dextrose injection to…
- Conditions
- Knee Osteoarthritis, Injection, Effect of Drug
- Trial name
- NCT05220527
- Testing
- Triamcinolone plus hyruan, vitagen plus hyruan, normal saline plus hyruan
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University
Anemia, Iron-Deficiency, Kidney Failure, Chronic
Effect of Ferrlecit® Versus Oral Iron on Iron Deficient Chronic Kidney Disease (CKD) Patients Receiving Erythropoietic Agents
This study compares the effect of Ferrlecit® (a form of intravenous iron) to ferrous sulfate (a form of oral iron) in treating anemia and iron deficiency in chronic kidney disease patients who are receiving erythropoietic agents…
- Trial name
- NCT00224042
- Testing
- Sodium Ferric Gluconate complex in sucrose, Ferrous sulfate tablets
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 52 people
- Sponsor
- Watson Pharmaceuticals
Carcinoma, Renal Cell
A Study To Test The Effect Of GW786034 (Pazopanib) On P450 Enzymes
This is a Phase I study to determine the effect of GW786034 (pazopanib) on P450 enzymes. This study will help determine which types of drugs may interact with GW786034.
- Trial name
- NCT00401583
- Testing
- GW786034 (pazopanib), Probe drugs
- Where
- 2 sites in United States, Singapore
- Volunteers
- 24 people
- Sponsor
- GlaxoSmithKline
Acute Coronary Syndromes
Effect of Genetic Variation on Efficacy and Safety of Lipid-Lowering Drugs
The primary end point was to reduce LDL-C levels by at least 50%, while the secondary end point was to achieve an LDL-C level below 55 mg/dL.
- Trial name
- NCT07008794
- Testing
- Atorvastatin 40 mg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Atrial Fibrillation
Effect of Addition of Dronedarone to Standard Rate Control Therapy on Ventricular Rate During Persistent Atrial Fibrillation (AFRODITE)
The primary objective of this study is to: Assess whether the addition of dronedarone to existing conventional rate control therapy leads to a reduced ventricular rate after 1 week in patients with a high Heart Rate (HR) at rest…
- Trial name
- AFRODITE (NCT01047566)
- Testing
- Dronedarone, Beta blocker or calcium antagonist or digoxin
- Where
- Netherlands
- Volunteers
- 183 people
- Sponsor
- Sanofi
Drug-drug Interaction Study
Drug-drug Interaction Study of Rifampin and Anaprazole Sodium
A drug-drug interaction study designed to evaluate the drug-drug interaction between rifampin capsules and anaprazole sodium enteric-coated tablets in healthy adult subjects
- Trial name
- NCT07330531
- Testing
- Anelazol Sodium Enteric-coated Tablets, Rifampicin Capsules
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Xuanzhu Biopharmaceutical Co., Ltd.
Anesthetics, Recovery
Remimazolam Improves the Safety in Elderly Patients Undergoing Gastrointestinal Endoscopy
Gastroenteroscopy diagnosis and treatment drugs need to meet the needs of quick onset, quick recovery and less anesthesia complications. Remimazolam is an anesthetic sedative independently developed by China.
- Conditions
- Anesthetics, Recovery, Drug Effect, Safety
- Trial name
- NCT05406102
- Testing
- Remimazolam, Propofol group
- Where
- 9 sites in China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hereditary Angioedema
An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates
This is an open-label, single sequence study to evaluate the effect of BCX7353 on hepatic and intestinal cytochrome P450 enzymes using probe substrate drugs in healthy subjects.
- Trial name
- NCT02819102
- Testing
- BCX7353 and probes
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BioCryst Pharmaceuticals
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