Clinical trials: Effect of Drugs
Autoimmune Adverse Effects of Anti-neoplasic Drug
Autoantibodies Prevalence During Checkpoint Inhibitor Treatment
The use of Checkpoint inhibitors (ICIs) is rapidly expanding to the treatment of many cancer types. Autoimmunity and clinical autoimmune diseases represent adverse events of ICIs with variable severity and consequences.
- Trial name
- NCT04220034
- Testing
- Blood sample
- Where
- France
- Volunteers
- 183 people
- Sponsor
- CHU de Reims
Sleep Disorders, Circadian Rhythm
Effects of Vitamin B12 on the Body's Internal Clock
Circadian rhythms are 24-hour cycles that influence natural functions in the body such as heart rate, blood pressure, and body temperature. Circadian rhythms provide the body with an internal clock and affect sleep patterns.
- Trial name
- NCT00120484
- Testing
- Vitamin B12
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy Adults
A Study to Learn About How Food Affects the Uptake of Study Medicine Prifetrastat Into the Blood in Healthy Adults
The purpose of the study is to assess the effect of food (high-fat, high-calorie meal) on the total and peak drug exposure of the planned to be marketed tablet formulation of prifetrastat.
- Trial name
- NCT07731100
- Testing
- Prifetrastat
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Disease
Deprescribing and Health-related Effects
In a primary care settled quality improvement project aiming to deprescribe medication through a medication review intervention, we investigated how the implemented medication changes affected health-related outcomes in real-life…
- Trial name
- NCT05721534
- Testing
- Medication review
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Anne Estrup Olesen
Infertility, Male
The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men
This study is a prospective double blind randomized controlled trial to investigate the effect of red and white bahman on semen parameters, sexual hormones and DNA defragmentation in idiopathic oligospermic men .Include patients…
- Trial name
- NCT02998593
- Testing
- Bahman capsules
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Royan Institute
Healthy
Study of the Effect of Clinical Procedures on Drug Delivery of Mylan Fentanyl Transdermal System 25 µg/hr and Duragesic® 25 µg/hr
The objective of this study was to investigate the effect of clinical procedures on the drug delivery of Fentanyl Transdermal Systems, 25 mcg/h manufactured for Mylan Pharmaceuticals Inc.
- Trial name
- NCT00648414
- Testing
- Mylan Fentanyl Transdermal System 25 mcg/h + Clinical Procedure 1, Mylan Fentanyl Transdermal System 25 mcg/h + Clinical Procedure 2, Mylan Fentanyl Transdermal System 25 mcg/h + Clinical Procedure 3
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mylan Pharmaceuticals Inc
Atrial Fibrillation
A Study to Learn About the Effects of Medicines That Help in Thinning the Blood in People With Atrial Fibrillation (AF) Between 2016 and 2020 in France
The purpose of this study is to look at how many patients with AF had strokes, major bleeding and death in both people who had and had not taken any oral anticoagulant.
- Trial name
- SIFNOS (NCT05838664)
- Testing
- No OAC, VKA, apixaban
- Where
- France
- Volunteers
- 2,140,403 people
- Sponsor
- Pfizer
Tinnitus, Subjective, Tinnitus, Bilateral
Effect of Combined Antioxidant Therapy on Oxidative Stress Markers and Inflammatory Cytokines in Patients With Tinnitus
The main objective of our study is to evaluate the effect of combinated antioxidants therapy with Adepsique® (amitriptyline, perphenazine, and diazepam) on patients with tinnitus chronic symptoms, evaluating the levels of…
- Conditions
- Tinnitus, Subjective, Tinnitus, Bilateral, Antioxidant Therapy, Psychiatric Drugs
- Trial name
- NCT05646693
- Testing
- Drusen Mega®, Sertraline
- Where
- Mexico
- Volunteers
- 58 people
- Sponsor
- University of Guadalajara
Schizophrenia, Major Depression
Effect of Specific Anti-Toxoplasmatic Add-on Medication in Toxoplasma Gondii Seropositive Individuals With Schizophrenia or Major Depression
We investigate whether the add-on specific antitoxoplasmatic medication has positive effects in individuals with schizophrenia or major depression seropositive for Toxoplasma gondii (TG) infection.
- Trial name
- NCT00300404
- Testing
- daraprim, pyrimethamine, folinic acid
- Volunteers
- 40 people
- Sponsor
- Zentrum für Integrative Psychiatrie
Wheelchair Users, Pressure Ulcer Prevention
The Effect of Pressure Injury Training on Knowledge Levels and Wound Prevention in Wheelchair Users
This research is a randomised controlled study conducted to evaluate the effects of training given to wheelchair users to prevent pressure injury on their level of knowledge, prevention of pressure injury and wound healing.
- Conditions
- Wheelchair Users, Pressure Ulcer Prevention, Pressure Ulcer (PU)
- Trial name
- NCT07438899
- Testing
- education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Peritoneal Dialysis-related Infection
Effects of Topical Gentamicin on the Prevention of Peritoneal Dialysis Related Infection
Peritoneal dialysis-related infection is a complication that leads to peritoneal dialysis catheter removal or patient death. The present study aimed to investigate peritoneal dialysis-related infection, causative pathogens…
- Trial name
- NCT05251584
- Testing
- Mupirocin, Gentamicin
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Diffuse Large B-Cell Lymphoma
A Study to Learn About the Effects of Two Study Medicines (Maplirpacept [PF-07901801] And Glofitamab) When Given Together In People With Relapsed Or Refractory Diffuse Large B Cell Lymphoma.
The purpose of this study is to learn about the effects of two study medicines (maplirpacept [PF-07901801] and glofitamab) when given together for the treatment of diffuse large B-cell lymphoma (DLBCL) that is relapsed or is…
- Trial name
- MAPtivate-6 (NCT05896163)
- Testing
- maplirpacept (PF-07901801), Glofitamab, Obinutuzumab
- Where
- 10 sites in United States, Israel and 2 more
- Volunteers
- 40 people
- Sponsor
- Pfizer
Medication Safety, Time Efficiency
Assessing the Role of Pharmaceutical Technical Assistents in Hospital Wards: Measuring Efficiency and Medication Safety
The goal of this interventional study is to evaluate the impact of implementing pharmaceutical technical assistants (PTAs) to support the medication process on hospital wards on operational efficiency and medication safety among…
- Conditions
- Medication Safety, Time Efficiency, Interdepartmental Communication
- Trial name
- NCT06731387
- Testing
- Pharmaceutical technical assistants supported medication dispensation on the hospital ward
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Vitaz
HIV Infections
Safety and Effectiveness of Low-Dose Methotrexate for Reducing Inflammation in HIV-Infected Adults on ARV Medications
People with HIV infection who are taking antiretroviral therapy (ART) could be at risk for cardiovascular disease (CVD), which can be caused by inflammation.
- Trial name
- NCT01949116
- Testing
- LDMTX, Folic acid
- Where
- 22 sites in United States
- Volunteers
- 176 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tardive Dyskinesia, Intellectual Disability
Deutetrabenazine Treatment for Tardive Dyskinesia in Intellectual/Developmental Disabilities
The primary goal of this study is to investigate the efficacy of deutetrabenazine treatment of TD in this previously untreated patient population.
- Conditions
- Tardive Dyskinesia, Intellectual Disability, Developmental Disabilities
- Trial name
- TD-AIDD (NCT06997198)
- Testing
- Deutetrabenazine Oral Capsule
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University Hospitals Cleveland Medical Center
HIV Infections
Effects of Two Anti-HIV Drug Regimens on Quality of Life and Health Care Use Among SMART Study Participants
The purpose of this study is to compare the effects of two different anti-HIV drug regimens on quality of life and health care utilization among SMART study participants.
- Trial name
- NCT00385632
- Testing
- Antiretroviral Regimens
- Where
- 67 sites in United States
- Volunteers
- 1,224 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Necrotic Pulp, Apical Periodontitis
Effect of Diclofenac Sodium Versus Calcium Hydroxide as Intracanal Medication on the Intensity of Postoperative Pain, Bacterial Load Reduction and MMP-9 Levels in Patients With Necrotic Pulp.
the aim of this study is to compare the effect of using Diclofenac Sodium Versus Calcium Hydroxide as Intracanal medication on intensity of postoperative pain, bacterial load reduction after root canal preparation and periapical…
- Trial name
- NCT05582421
- Testing
- Diclofenac Sodium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide for Weight Management in Pubertal Adolescent Subjects With Obesity
This trial is conducted globally. The aim of this trial is to investigate the effect of liraglutide for weight management in pubertal adolescent subjects with obesity.
- Trial name
- NCT02918279
- Testing
- Liraglutide
- Where
- 33 sites in United States, Belgium and 3 more
- Volunteers
- 251 people
- Sponsor
- Novo Nordisk A/S
Healthy
A Study To Investigate The Drug-Drug Interaction Potential Of Rifampin OnThe Investigational Agent Palbociclib (PD-0332991)
This study will compare the plasma pharmacokinetics of a single 125mg oral dose of palbociclib in the presence and absence of rifampin-mediated enzyme induction in a fixed-sequence two-period study.
- Trial name
- NCT01953731
- Testing
- Palbociclib, Rifampin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Pfizer
Arterial Hypertension
Temperature-elevating Armbaths for Arterial Hypertension
The goal of this randomized controlled trial is to learn about the effect of a hydrotherapeutic approach - a temperature-elevating armbath - in people with arterial hypertention.
- Trial name
- NCT05928702
- Testing
- temperature-elevating armbath
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Kliniken Essen-Mitte
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