Clinical trials: Effect of Drugs
Analgesic Drugs, Antinociceptive Agents
Analgesic Effects of Midazolam in Human Volunteers
This study evaluates analgesic properties of midazolam compared to placebo and fentanyl. Each participant will receive all three drugs (midazolam, fentanyl, placebo) on three different occasions (study visits) and the effect on…
- Trial name
- GabA01 (NCT02629146)
- Testing
- Midazolam, Fentanyl, Isotonic saline
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wilhelminenspital Vienna
Pharmacokinetics, Drug Interactions
Evaluating the Effects of Omeprazole on the Pharmacokinetics of XS004 (Dasatinib) Tablets in Healthy Adult Subjects Under Fasting Conditions
In this open label, single-sequence study, subjects received one dose of XS004 Dasatinib Amorphous Solid Dispersion Film-Coated Tablet, 90 mg Test Formulation at the start of study on Day 1 and Day 6.
- Trial name
- NCT05433896
- Testing
- Dasatinib ASD, Omeprazole 40 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Xspray Pharma AB
HIV Infections
HIV Treatment Reinitiation in Women Who Received Anti-HIV Drugs to Prevent Mother-to-Child Transmission of HIV
The purpose of this study is to determine if pregnancy-limited, short-term combination HIV treatment regimens -- which were used solely for the prevention of mother to child transmission of HIV and discontinued postpartum …
- Trial name
- Nearly Naive (NCT00442962)
- Testing
- Efavirenz, Emtricitabine/Tenofovir disoproxil fumarate
- Where
- 9 sites in United States, Brazil and 1 more
- Volunteers
- 54 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Hepatitis C Virus Infection, Treatment Side Effects
Sofosbuvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX) for Patients With Hepatitis C Virus Infection
The investigators aim to assess the effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) for 12 weeks in hepatitis C virus (HCV)-infected patients who fail to prior NS5A-containing DAA regimens and HCV…
- Conditions
- Hepatitis C Virus Infection, Treatment Side Effects, Adherence, Treatment, Effect of Drug
- Trial name
- NCT05092074
- Testing
- Vosevi 400/100/100 Oral Tablet
- Where
- 15 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Stress, Job, Student Burnout
Investigating the Effects of Osteopathic Manipulative Treatment on Stress Management in Medical Students
The goal of this clinical trial is to evaluate stress biomarkers, subjective stress levels, and cognitive function in medical students.
- Conditions
- Stress, Job, Student Burnout, Stress, Physiological, Stress, Psychological
- Trial name
- NCT06125574
- Testing
- Osteopathic Manipulative Medicine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Touro College and University System
Transition
Effect of Post-discharge Phone Calls on Patient Outcomes
The purpose of this study is to determine whether a post-discharge telephone call to general medical patients discharged home will improve quality of care and adherence, and reduce hospital readmission.
- Trial name
- NCT01580774
- Where
- Canada
- Volunteers
- 334 people
- Sponsor
- Mount Sinai Hospital, Canada
Graves Disease, Relapse
Effects of Different Treatment Schemes on the Regulation and Recurrence of Graves' Disease
In this study, the dose of methimazole was adjusted according to the different states of thyroid function, and the effects of conventional therapy and intensive therapy on the cumulative recurrence of Graves' hyperthyroidism…
- Conditions
- Graves Disease, Relapse, Treatment, Drug Withdrawal
- Trial name
- NCT05461820
- Testing
- Methimazole
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Drug Hypersensitivity
Management of Drug Hypersensitivity in Children
The aim of this study is (1) to assess the incidence of suspected drug allergies in a pediatric hospital and the proportion in which these reactions are confirmed to be allergic; (2) to evaluate the diagnostic values of the…
- Trial name
- DHC (NCT02031120)
- Where
- Switzerland
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Rheumatoid Arthritis
Effect of Some Drugs on Rheumatoid Arithritis Activity
Effect of Some Drugs on Rheumatoid Arithritis Activity.
- Trial name
- NCT03770923
- Testing
- Rupatadine, Montelukast
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Sherief Abd-Elsalam
Paroxysmal Nocturnal Hemoglobinuria, Hemoglobinuria
Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013)
Paroxysmal nocturnal hemoglobinuria is an acquired chronic hemolytic anemia,this study is designed to evaluate the safety and efficacy of Levamisole combined with cyclosporine A in patients with Subclinical Paroxysmal Nocturnal…
- Conditions
- Paroxysmal Nocturnal Hemoglobinuria, Hemoglobinuria, Hemoglobinuria, Paroxysmal, Proteinuria
- Trial name
- NCT01760096
- Testing
- Levamisole+cyclosporin A+Glucocorticoids, cyclosporin A+Glucocorticoids, Glucocorticoids
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Hearing, COVID - 19
Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing
Investigation of the Impact of Medications Used in COVID-19 Treatment and COVID-19 Vaccine on Hearing
- Conditions
- Hearing, COVID - 19, Ototoxicity
- Trial name
- NCT07254442
- Testing
- Hearing tests
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Laryngoscopy
The Effect of Rocuronium on the Response of Composite Variability Index (CVI) to Laryngoscopy
Eighty subjects will be recruited from those scheduled for surgery requiring general anesthesia at St Vincent's Hospital. Subjects must have American Society of Anesthesiologists (ASA) status of 1 or 2 (be fairly healthy), a BMI…
- Trial name
- NCT00926718
- Testing
- remifentanil infusion, rocuronium dose + remifentanil infusion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- St. Vincent's Medical Center
Type 2 Diabetes Mellitus, Acute Coronary Syndrome
Telephone Intervention in Patients With Acute Coronary Syndrome (ACS) and Diabetes
Hypothesis To investigate whether telephone counselling by nurse educator between clinic visits with particular emphasis on adherence to medications and lifestyle modification in patients with coronary heart disease and diabetes…
- Trial name
- NCT00816010
- Testing
- telephone contact
- Where
- Hong Kong
- Volunteers
- 137 people
- Sponsor
- Chinese University of Hong Kong
Chronic Apical Periodontitis
Adjunctive Oral Probiotics in Endodontic Retreatment: Effects on Postoperative Pain and RANKL/OPG Levels
This study aimed to evaluate the effect of oral administration of probiotics as an adjunctive treatment to local intracanal medicaments, namely propolis and calcium hydroxide or empty canal, on the levels of receptor activator of…
- Trial name
- RANKL/OPG (NCT07683520)
- Testing
- Linex Adult®, Ca(OH)2 as intracanal medicament, propolis intracanal medication
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Ain Shams University
Healthy Volunteers, Drug-drug Interaction
The Effect of Dicloxacillin on Oral Absorption of Drugs
Worldwide there is an increase in antibiotic resistance which may have fatal long-term consequences. This is due to extensive use and sometimes misuse of antibiotics in the treatment of harmless infections.
- Trial name
- NCT05073627
- Testing
- Dicloxacillin
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Hepatitis C
Effect of Omeprazole and Ritonavir on GSK2336805 Pharmacokinetics in Healthy Adults
This study is a Phase I open label drug interaction study to evaluate the effect of omeprazole and ritonavir on GSK2336805.
- Trial name
- NCT01458054
- Testing
- Cohort 1 (GSK2336805 60mg x 1 dose, Omeprazole 40 mg q24h x 4 days, GSK2336805 60 mg x 1 dose and Omeprazole 40 mg x 1 dose), Cohort 2 (GSK2336805 30mg x 1 dose, Ritonavir 100mg q12h x 4 days, and Ritonavir 100mg q12h x 1 dose)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Positron-Emission Tomography, Magnetic Resonance Imaging
Early Diagnosis of Therapy-associated Cardiotoxicity Basing on Multi-tracer Multimodality PET/MRI
Using Multi-tracer to early diagnosis of therapy-associated cardiotoxicity using multimodality PET/MRI.
- Trial name
- NCT04555642
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Drug Usage
Dosing Study of Remifentanil for Smooth Removal of the Laryngeal Mask Airway (LMA)
The investigators attempted to determine the optimal effect-site concentration of remifentanil for smooth removal of the LMA from propofol anesthesia.
- Trial name
- NCT01931683
- Testing
- remifentanil, laryngeal mask airway (LMA)
- Where
- South Korea
- Volunteers
- 27 people
- Sponsor
- Ajou University School of Medicine
Tobacco Use Disorder
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the…
- Trial name
- NCT03713424
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Prostatic Cancer, Castration-Resistant
Study to Compare the Effects of Drug Darolutamide and Drug Enzalutamide on Physical Function, Including Balance and Daily Activity, in Patients With Castration-resistant Prostate Cancer (CRPC)
Researchers in this study want to compare the effects of drug darolutamide and drug enzalutamide on physical function, including balance and daily activity, in patients with castration-resistant prostate cancer (CRPC).
- Trial name
- DaroAcT (NCT04157088)
- Testing
- Darolutamide (Nubeqa, BAY1841788), Enzalutamide
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Bayer
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