Clinical trials: Effect of Drugs
Gallbladder Diseases
Effect of Lidocaine Patch for Shoulder Pain in Laparoscopic Cholecystectomy
The primary purpose of this study is to investigate the effect of lidocaine patch on the shoulder pain score after end of surgery.
- Trial name
- NCT02827136
- Testing
- Lidocaine patch and hypafix, hypafix
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Ajou University School of Medicine
Glycemia During Coronary Artery Bypass Graft, Sedation During Pre-anesthetic Medication
The Effect of Clonidine in Glycemia During Coronary Artery Bypass Graft With Cardiopulmonary By-pass
The purpose of this study is the randomized blind research of the assessment of the different levels of glycemia during Coronary Artery Bypass Graft (CABG) with cardiopulmonary by-pass (CPB) between clonidine and placebo.
- Trial name
- NCT01619436
- Testing
- Clonidine, Ringer lactato
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- Federal University of Juiz de Fora
Infection, Human Immunodeficiency Virus
Effect of Carbamazepine on Dolutegravir Pharmacokinetics in Healthy Adult Subjects
This study will be a phase I, open label, three period, fixed sequence crossover study to evaluate the effect of Carbamazepine (CBZ) on the steady-state pharmacokinetics of Dolutegravir (DTG) and on the safety and tolerability of…
- Trial name
- NCT01967771
- Testing
- DTG, CBZ
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Healthy, Dysautonomia
Effects of Osteopathic Technique on Autonomic Nervous System Activity
Cranial osteopathic manipulation technique for brain and cranial nerve function, known as the fourth ventricle compression (CV4), has been recognized.
- Trial name
- Osteo (NCT06554834)
- Testing
- CV4 + RR, CV4, EEG/HRV/RSA (Electroencephalography, Heart Rate Variability, Respiratory Sinus Arrhythmia) Monitoring using Infiniti System
- Where
- Poland
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- SomaticMed
Liver Cancer, Hepatocellular Carcinoma
Pressure-enabled Delivery in Radioembolization (TriNav Study)
The purpose of the study is to determine if the type of catheter used in the mapping procedure prior to radioembolization improves the delivery of radioactivity to tumor(s) in participants with liver cancer.
- Conditions
- Liver Cancer, Hepatocellular Carcinoma, Metastatic Colorectal Cancer
- Trial name
- PEDIR (NCT05128032)
- Testing
- Standard microcatheter, PEDD device
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Cardiotoxicity, Chemotherapeutic Toxicity
Prevention of Chemotherapy-induced Cardiotoxicity in High-risk Patients
In cancer patients, the increase of troponin I soon after chemotherapy is a strong predictor of left ventricular dysfunction and poor cardiologic outcome.
- Trial name
- NCT00292526
- Testing
- Enalapril
- Where
- Italy
- Volunteers
- 114 people
- Sponsor
- European Institute of Oncology
Healthy Participants
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Drug Effects of BMS-986308 in Healthy Participants
The purpose of this study is to evaluate the safety, tolerability, drug levels, and drug effects of BMS-986308 compared to placebo in healthy participants.
- Trial name
- NCT04763226
- Testing
- BMS-986308, Furosemide
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cigarette Smoking
Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity
The central objective of this project is to obtain proof-of-concept data demonstrating the effects of propranolol (a beta-adrenergic antagonist) on neurobiological responses to personal smoking environments and behavioral…
- Trial name
- ProCue (NCT03309943)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
Handwashing Behavior
Game-Based Handwashing Education in Preschool Children
This study aims to evaluate the effect of a game-based handwashing education program, which will be developed based on the Health Belief Model, on the handwashing behaviors of preschool children.
- Trial name
- NCT07607717
- Testing
- Game-Based Handwashing Education
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Psychotic Disorders
Side Effects of Psychiatric Medications - a Nested Case Control Cohort Historical Prospective Study
The study is designed to fill in the gaps in current knowledge by providing a more inclusive and comprehensive understanding of the potential associations between different psychiatric medications, including antipsychotics (APs)…
- Trial name
- NCT05872555
- Testing
- Psychiatric Drugs
- Where
- Israel
- Volunteers
- 22,777 people, healthy volunteers welcome
- Sponsor
- Mark Weiser, MD, Principal Investigator
Focal Segmental Glomerulosclerosis
Effect of Oral Galactose on Focal Segmental Glomerulosclerosis (FSGS) Permeability Factor
This study is a proof-of-concept clinical study designed to test the hypothesis that oral administration of galactose can lower the level of a circulating factor that increases glomerular permeability to albumin in patients with…
- Trial name
- NCT00816478
- Testing
- Galactose
- Volunteers
- 15 people
- Sponsor
- Northwell Health
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Musculoskeletal Pain, Postural; Defect
Posture Training for Middle Schoolers
The goal of this clinical trial is to investigate if posture training can improve back pain and posture in middle school students.
- Trial name
- NCT06909747
- Testing
- Posture Training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Amasya University
Mood Disorders, Medication Adherence
AI-Enabled Smartwatch for Medication Adherence in Outpatient Psychiatry
Medication nonadherence remains difficult to measure objectively in psychiatric care. This completed, single-center exploratory randomized trial evaluated whether four weeks of AI-enabled smartwatch medication monitoring improved…
- Conditions
- Mood Disorders, Medication Adherence, Mental Disorders
- Trial name
- NCT07455916
- Testing
- AI-enabled smartwatch
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Wonkwang University Hospital
Effect of Drugs
Dexmedetomidine Adjuvant to General Anesthesia of Abdominal Hysterectomy
To assess the effect of perioperative Dexmedetomidine infusion on Interleukin 6 and cortisol level in patients undergoing general anesthesia for total abdominal hysterectomy
- Trial name
- NCT03600506
- Testing
- Dexmedetomidine
- Volunteers
- 52 people
- Sponsor
- Suez Canal University
Chronic Rhinosinusitis, Postoperative Care
Effect of Chinese Herbal Medicine Nasal Irrigation on the Postoperative Care of Chronic Rhinosinusitis
Investigators tried to evaluate the efficacy and safety of Chinese herbal medicine nasal irrigation as an adjuvant therapy after FESS.
- Trial name
- Breeze Clear (NCT07340411)
- Testing
- Chinese herbal medicine Powder, Salt Powder
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Veterans General Hospital
Immunomodulatory Drugs, Killer-cell Immunoglobulin-like Receptors (KIRs)
Effect of Immunomodulatory Treatment on IVF (in Vitro Fertilization) Outcomes in Patients With KIR AA Genotype
The aim of the study is to investigate the immune cause of recurrent implantation failure (RIF) and the role of immunomodulatory treatment in IVF (in vitro fertilization) patients that have a KIR AA genotype.
- Conditions
- Immunomodulatory Drugs, Killer-cell Immunoglobulin-like Receptors (KIRs), KIR Alleles (KIR AA)
- Trial name
- NCT06264206
- Testing
- Killer-cell immunoglobulin-like receptors (KIRs) testing
- Where
- Romania
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Calla IVF Center
Motivational Interviewing, Adult
Motivational Interviewing for Adult Kidney Transplant Recipients
Purpose: This study aimed to determine the effect of motivational interviewing on self-management of treatment regimen, medication adherence, and patient outcomes in adult kidney transplant recipients between 3 months and 6…
- Conditions
- Motivational Interviewing, Adult, Kidney Transplantation, Self-Management
- Trial name
- MIAKTR (NCT04956406)
- Testing
- Motivational Interviewing for Adult Kidney Transplant Recipients, Routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Alcohol Reactivity
Effect of Varenicline on Fixed-Dose Alcohol Administration in Participants With Alcohol Use Disorders
The purpose of this study is the examine the effect of varenicline on cognition to a high dose (0.08 g/dL) of alcohol (vs. placebo alcohol) over the ascending and descending limb of the blood alcohol curve.
- Trial name
- NCT01000987
- Testing
- varenicline
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Yale University
Breast Cancer, Chemotherapy-Related Cognitive Impairment
Behavior Change Wheel-Based Music Listening for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients
Breast cancer patients frequently experience chemotherapy-related cognitive impairment (CRCI), which can negatively affect memory, attention, executive function, daily activities, and quality of life.
- Trial name
- BCW-MUSIC (NCT07641114)
- Testing
- BCW-Based Music Listening Intervention, Routine Nursing Care
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
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